Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2917
Gene name Gene Name - the full gene name approved by the HGNC.
Glutamate metabotropic receptor 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GRM7
Synonyms (NCBI Gene) Gene synonyms aliases
GLUR7, GPRC1G, MGLU7, MGLUR7, NEDSHBA, PPP1R87
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NEDSHBA
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p26.1
Summary Summary of gene provided in NCBI Entrez Gene.
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be pert
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1114167298 T>C Likely-pathogenic Missense variant, upstream transcript variant, genic upstream transcript variant, non coding transcript variant, coding sequence variant
rs1114167300 C>T Likely-pathogenic Missense variant, non coding transcript variant, coding sequence variant
rs1114167301 C>A,T Likely-pathogenic Missense variant, non coding transcript variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000073 hsa-miR-34a-5p Review, qRT-PCR 20388499
MIRT000073 hsa-miR-34a-5p Review, qRT-PCR 20388499
MIRT000073 hsa-miR-34a-5p Reporter assay;Proteomics 21566225
MIRT1035267 hsa-miR-205 CLIP-seq
MIRT1035268 hsa-miR-3124-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001640 Function Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA 21873635
GO:0001642 Function Group III metabotropic glutamate receptor activity IBA 21873635
GO:0001642 Function Group III metabotropic glutamate receptor activity IDA 9144652, 9473604
GO:0001662 Process Behavioral fear response IMP 17167337
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604101 4599 ENSG00000196277
Protein
UniProt ID Q14831
Protein name Metabotropic glutamate receptor 7 (mGluR7)
Protein function G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274). Ligand binding causes a conformation change that triggers signaling via gu
PDB 3MQ4 , 5C5C , 7EPC , 7EPD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01094 ANF_receptor 77 486 Receptor family ligand binding region Family
PF07562 NCD3G 519 569 Nine Cysteines Domain of family 3 GPCR Family
PF00003 7tm_3 602 847 7 transmembrane sweet-taste receptor of 3 GCPR Family
Tissue specificity TISSUE SPECIFICITY: Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. {ECO:0000269|PubMed:12052533
Sequence
MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTN
TSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRP
NENRTGCQDIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYI
IIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
Sequence length 915
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
  G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Attention deficit hyperactivity disorder Attention Deficit Disorder, Attention deficit hyperactivity disorder rs786205019 22138692
Developmental delay Global developmental delay rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291
View all (32 more)
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 24185611
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
19638256, 19351574, 26254163, 18329248
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder, Unipolar Depression, Major Depressive Disorder 20038947, 22287544, 23059104, 20423346, 24596089, 20398908, 21813496, 20638442, 24278217 ClinVar
Panic Disorder Panic Disorder GWAS
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 26083657
Age Related Hearing Impairment 1 Associate 20068591, 24146964, 29455378, 30100543
Alzheimer Disease Associate 32694537
Anxiety Associate 21368711
Anxiety Disorders Associate 23295062
Atrophy Associate 32286009, 34273994
Attention Deficit Disorder with Hyperactivity Associate 22138692, 23295062, 37964012
Autism Spectrum Disorder Associate 31707215
Bipolar Disorder Associate 24804643, 27063557
Breast Neoplasms Associate 21688152