Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
29127
Gene name Gene Name - the full gene name approved by the HGNC.
Rac GTPase activating protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RACGAP1
Synonyms (NCBI Gene) Gene synonyms aliases
CDAN3B, CYK4, HsCYK-4, ID-GAP, MgcRacGAP, RCGAP1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CDAN3B
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This pro
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004859 hsa-miR-192-5p Luciferase reporter assay, qRT-PCR 19074876
MIRT016327 hsa-miR-193b-3p Microarray 20304954
MIRT024375 hsa-miR-215-5p Microarray 19074876
MIRT004859 hsa-miR-192-5p Microarray 19074876
MIRT004859 hsa-miR-192-5p Reporter assay;Microarray;Other 19074876
Transcription factors
Transcription factor Regulation Reference
CUX1 Unknown 21886810
E2F1 Unknown 21886810
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000281 Process Mitotic cytokinesis IDA 11085985, 19468302
GO:0000281 Process Mitotic cytokinesis IMP 16236794, 23235882
GO:0000915 Process Actomyosin contractile ring assembly IMP 16129829
GO:0001669 Component Acrosomal vesicle IEA
GO:0005096 Function GTPase activator activity IDA 10979956
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604980 9804 ENSG00000161800
Protein
UniProt ID Q9H0H5
Protein name Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)
Protein function Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the
PDB 2OVJ , 3W6R , 3WPQ , 3WPS , 4B6D , 5C2J , 5C2K
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00130 C1_1 287 338 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00620 RhoGAP 363 511 RhoGAP domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in testis, thymus and placenta. Expressed at lower levels in spleen and peripheral blood lymphocytes. In testis, expression is restricted to germ cells with the highest levels of expression found in spermatocytes. Expr
Sequence
MDTMMLNVRNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHELGKYKDLLMK
AETERSALDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEE
QKSALAFLNRGQPSSSNAGNKRLSTIDESGSILSDISFDKTDESLDWDSSLVKTFKLKKR
EKRRSTSRQFVDGPPGPVKKTRSIGSAVDQGNESIVAKTTVTVPNDGGPIEAVSTIETVP
YWTRSRRKTGTLQPWNSDSTLNSRQLEPRTETDSVGTPQSNGGMRLHDFVSKTVIKPESC
VPCGKRIKFGKLSLKCRDCRVVSHPECRDRCPLPCIPT
LIGTPVKIGEGMLADFVSQTSP
MIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLSKVDDIHAICS
LLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHL
QRVAQSPHTKMDVANLAKVFGPTIVAHAVPN
PDPVTMLQDIKRQPKVVERLLSLPLEYWS
QFMMVEQENIDPLHVIENSNAFSTPQTPDIKVSLLGPVTTPEHQLLKTPSSSSLSQRVRS
TLTKNTPRFGSKSKSATNLGRQGNFFASPMLK
Sequence length 632
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Rho GTPase cycle
MHC class II antigen presentation
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins