Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
29126
Gene name Gene Name - the full gene name approved by the HGNC.
CD274 molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CD274
Synonyms (NCBI Gene) Gene synonyms aliases
ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9p24.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobu
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003923 hsa-miR-513a-5p Luciferase reporter assay, Western blot 19155478
MIRT003923 hsa-miR-513a-5p Luciferase reporter assay, Western blot 19155478
MIRT027156 hsa-miR-103a-3p Sequencing 20371350
MIRT031920 hsa-miR-16-5p Sequencing 20371350
MIRT053484 hsa-miR-570-3p Immunohistochemistry, Luciferase reporter assay, qRT-PCR 22190470
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0002845 Process Positive regulation of tolerance induction to tumor cell IMP 28813410, 28813417
GO:0005515 Function Protein binding IPI 18585785, 20587542, 21982860, 23417675, 28813410, 28813417, 31000591
GO:0005654 Component Nucleoplasm IDA
GO:0005886 Component Plasma membrane IDA 28813410, 28813417
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605402 17635 ENSG00000120217
Protein
UniProt ID Q9NZQ7
Protein name Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Protein function Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cell
PDB 3BIK , 3BIS , 3FN3 , 3SBW , 4Z18 , 4ZQK , 5C3T , 5GGT , 5GRJ , 5IUS , 5J89 , 5J8O , 5JDR , 5JDS , 5N2D , 5N2F , 5NIU , 5O45 , 5O4Y , 5X8L , 5X8M , 5XJ4 , 5XXY , 6L8R , 6NM7 , 6NM8 , 6NNV , 6NOJ , 6NOS , 6NP9 , 6PV9 , 6R3K , 6RPG , 6VQN , 6YCR , 7BEA , 7C88 , 7CZD , 7DCV , 7DY7 , 7NLD , 7OUN , 7SJQ , 7TPS , 7UX5 , 7UXO , 7UXP , 7UXQ , 7VUN , 7XAD , 7XAE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 22 131 Immunoglobulin V-set domain Domain
PF08205 C2-set_2 135 220 CD80-like C2-set immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. {ECO:0000269|PubMed:10581
Sequence
Sequence length 290
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cell adhesion molecules
PD-L1 expression and PD-1 checkpoint pathway in cancer
  PD-1 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diffuse lymphoma Diffuse Large B-Cell Lymphoma rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 27692344
Lymphoma Lymphoma rs11540652, rs1592119138, rs1592123162, rs1599367044 28736328
Unknown
Disease term Disease name Evidence References Source
Diabetes Mellitus neonatal diabetes mellitus GenCC
Hypothyroidism Hypothyroidism GWAS
Polycystic Ovary Syndrome Polycystic Ovary Syndrome GWAS
Rheumatoid arthritis Rheumatoid arthritis GWAS
Associations from Text Mining
Disease Name Relationship Type References
3 Hydroxy 3 Methylglutaryl CoA Lyase Deficiency Associate 30783096
3 methylcrotonyl CoA carboxylase 1 deficiency Associate 25550797, 34071045
Abortion Spontaneous Associate 26261529
Achalasia Addisonianism Alacrimia syndrome Associate 36088477
Acidemia isovaleric Associate 30964601
Acidosis Stimulate 35927628
Acquired Immunodeficiency Syndrome Associate 12468426, 40450975
Acrocephalosyndactylia Associate 32430334, 37499395
Actinic cheilitis Associate 21442435, 35195152
Acute On Chronic Liver Failure Associate 35502507