Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
29102
Gene name Gene Name - the full gene name approved by the HGNC.
Drosha ribonuclease III
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DROSHA
Synonyms (NCBI Gene) Gene synonyms aliases
ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023847 hsa-miR-1-3p Proteomics 18668040
MIRT049958 hsa-miR-30a-5p CLASH 23622248
MIRT047817 hsa-miR-30d-5p CLASH 23622248
MIRT041036 hsa-miR-505-3p CLASH 23622248
MIRT036738 hsa-miR-760 CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
E2F1 Activation 24909689
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001530 Function Lipopolysaccharide binding IDA 20180804
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003725 Function Double-stranded RNA binding IBA 21873635
GO:0004525 Function Ribonuclease III activity IBA 21873635
GO:0004525 Function Ribonuclease III activity IDA 14508493, 15574589
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608828 17904 ENSG00000113360
Protein
UniProt ID Q9NRR4
Protein name Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241)
Protein function Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) t
PDB 2KHX , 2NA2 , 5B16 , 6LXD , 6LXE , 6V5B , 6V5C , 9ASM , 9ASN , 9ASO , 9ASP , 9ASQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14622 Ribonucleas_3_3 958 1071 Ribonuclease-III-like Family
PF00636 Ribonuclease_3 1144 1233 Ribonuclease III domain Family
PF00035 dsrm 1261 1332 Double-stranded RNA binding motif Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10948199}.
Sequence
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPS
TTFSNSPAPNFLPPRPDFVPFPPPMPPSAQGPLPPCPIRPPFPNHQMRHPFPVPPCFPPM
PPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGR
GERHRSLDRRERGRSPDRRRQDSRYRSDYDRGRTPSRHRSYERSRERERERHRHRDNRRS
PSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSEN
YYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESS
SESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYI
FEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELY
DWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIA
NMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPA
QLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTV
ELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHP
SHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPS
RINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDR
FMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFND
PDLREVWLN
YPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTL
GHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYA
ITNDKTKRPVALRTKTLADLLESFIAALYIDKD
LEYVHTFMNVCFFPRLKEFILNQDWND
PKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQA
EMGAAMDALEKY
NFPQMAHQKRFIERKYRQELKEMRWEREHQEREPDETEDIKK
Sequence length 1374
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ribosome biogenesis in eukaryotes
Proteoglycans in cancer
  MicroRNA (miRNA) biogenesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Nephroblastoma Nephroblastoma rs1553551874, rs1555913934, rs769116796 28825729
Wilms tumor Bilateral Wilms Tumor rs121918261, rs2116574924, rs587776573, rs587776574, rs121907900, rs121907901, rs587776576, rs121907909, rs121907906, rs587776577, rs121907911, rs80359604, rs80358785, rs104894855, rs122453119
View all (13 more)
28825729
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 27519051
Adenocarcinoma Associate 21102586
Adenomyosis Associate 36515351
Adrenocortical Carcinoma Associate 23671264
Amyotrophic Lateral Sclerosis Associate 25756586
Angina Stable Associate 27519051
Atherosclerosis Associate 33620673
Brain Injuries Traumatic Associate 38200156
Breast Neoplasms Associate 21898071, 22639842, 24574065, 25390939, 27380242, 28598829, 36911928
Carcinogenesis Associate 29475968