Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	29102
Gene name Gene Name - the full gene name approved by the HGNC.	Drosha ribonuclease III
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DROSHA
Synonyms (NCBI Gene) Gene synonyms aliases	ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023847	hsa-miR-1-3p	Proteomics	18668040
MIRT049958	hsa-miR-30a-5p	CLASH	23622248
MIRT047817	hsa-miR-30d-5p	CLASH	23622248
MIRT041036	hsa-miR-505-3p	CLASH	23622248
MIRT036738	hsa-miR-760	CLASH	23622248
MIRT543400	hsa-miR-148a-5p	PAR-CLIP	21572407
MIRT543399	hsa-miR-16-2-3p	PAR-CLIP	21572407
MIRT543398	hsa-miR-195-3p	PAR-CLIP	21572407
MIRT543397	hsa-miR-4660	PAR-CLIP	21572407
MIRT543396	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT543395	hsa-miR-1301-3p	PAR-CLIP	21572407
MIRT543394	hsa-miR-5047	PAR-CLIP	21572407
MIRT543393	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT526257	hsa-miR-216a-5p	PAR-CLIP	22012620
MIRT526255	hsa-miR-8485	PAR-CLIP	22012620
MIRT526256	hsa-miR-4762-5p	PAR-CLIP	22012620
MIRT526254	hsa-miR-6872-3p	PAR-CLIP	22012620
MIRT526253	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT526252	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT526251	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT526250	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT526249	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT526248	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT526247	hsa-miR-4290	PAR-CLIP	22012620
MIRT526257	hsa-miR-216a-5p	PAR-CLIP	26701625
MIRT526257	hsa-miR-216a-5p	PAR-CLIP	26701625
MIRT526257	hsa-miR-216a-5p	PAR-CLIP	26701625
MIRT526257	hsa-miR-216a-5p	PAR-CLIP	26701625
MIRT526257	hsa-miR-216a-5p	PAR-CLIP	26701625
MIRT526249	hsa-miR-371a-5p	PAR-CLIP	26701625
MIRT526249	hsa-miR-371a-5p	PAR-CLIP	26701625
MIRT526249	hsa-miR-371a-5p	PAR-CLIP	26701625
MIRT526249	hsa-miR-371a-5p	PAR-CLIP	26701625
MIRT526249	hsa-miR-371a-5p	PAR-CLIP	26701625
MIRT526252	hsa-miR-371b-5p	PAR-CLIP	26701625
MIRT526252	hsa-miR-371b-5p	PAR-CLIP	26701625
MIRT526252	hsa-miR-371b-5p	PAR-CLIP	26701625
MIRT526252	hsa-miR-371b-5p	PAR-CLIP	26701625
MIRT526252	hsa-miR-371b-5p	PAR-CLIP	26701625
MIRT526248	hsa-miR-372-5p	PAR-CLIP	26701625
MIRT526248	hsa-miR-372-5p	PAR-CLIP	26701625
MIRT526248	hsa-miR-372-5p	PAR-CLIP	26701625
MIRT526248	hsa-miR-372-5p	PAR-CLIP	26701625
MIRT526248	hsa-miR-372-5p	PAR-CLIP	26701625
MIRT526251	hsa-miR-373-5p	PAR-CLIP	26701625
MIRT526251	hsa-miR-373-5p	PAR-CLIP	26701625
MIRT526251	hsa-miR-373-5p	PAR-CLIP	26701625
MIRT526251	hsa-miR-373-5p	PAR-CLIP	26701625
MIRT526251	hsa-miR-373-5p	PAR-CLIP	26701625
MIRT526247	hsa-miR-4290	PAR-CLIP	26701625
MIRT526247	hsa-miR-4290	PAR-CLIP	26701625
MIRT526247	hsa-miR-4290	PAR-CLIP	26701625
MIRT526247	hsa-miR-4290	PAR-CLIP	26701625
MIRT526247	hsa-miR-4290	PAR-CLIP	26701625
MIRT526256	hsa-miR-4762-5p	PAR-CLIP	26701625
MIRT526256	hsa-miR-4762-5p	PAR-CLIP	26701625
MIRT526256	hsa-miR-4762-5p	PAR-CLIP	26701625
MIRT526256	hsa-miR-4762-5p	PAR-CLIP	26701625
MIRT526256	hsa-miR-4762-5p	PAR-CLIP	26701625
MIRT526250	hsa-miR-616-5p	PAR-CLIP	26701625
MIRT526250	hsa-miR-616-5p	PAR-CLIP	26701625
MIRT526250	hsa-miR-616-5p	PAR-CLIP	26701625
MIRT526250	hsa-miR-616-5p	PAR-CLIP	26701625
MIRT526250	hsa-miR-616-5p	PAR-CLIP	26701625
MIRT526254	hsa-miR-6872-3p	PAR-CLIP	26701625
MIRT526254	hsa-miR-6872-3p	PAR-CLIP	26701625
MIRT526254	hsa-miR-6872-3p	PAR-CLIP	26701625
MIRT526254	hsa-miR-6872-3p	PAR-CLIP	26701625
MIRT526254	hsa-miR-6872-3p	PAR-CLIP	26701625
MIRT526253	hsa-miR-6892-3p	PAR-CLIP	26701625
MIRT526253	hsa-miR-6892-3p	PAR-CLIP	26701625
MIRT526253	hsa-miR-6892-3p	PAR-CLIP	26701625
MIRT526253	hsa-miR-6892-3p	PAR-CLIP	26701625
MIRT526253	hsa-miR-6892-3p	PAR-CLIP	26701625
MIRT526255	hsa-miR-8485	PAR-CLIP	26701625
MIRT526255	hsa-miR-8485	PAR-CLIP	26701625
MIRT526255	hsa-miR-8485	PAR-CLIP	26701625
MIRT526255	hsa-miR-8485	PAR-CLIP	26701625
MIRT526255	hsa-miR-8485	PAR-CLIP	26701625
MIRT526257	hsa-miR-216a-5p	PAR-CLIP	27292025
MIRT526257	hsa-miR-216a-5p	PAR-CLIP	27292025
MIRT526249	hsa-miR-371a-5p	PAR-CLIP	27292025
MIRT526249	hsa-miR-371a-5p	PAR-CLIP	27292025
MIRT526252	hsa-miR-371b-5p	PAR-CLIP	27292025
MIRT526252	hsa-miR-371b-5p	PAR-CLIP	27292025
MIRT526248	hsa-miR-372-5p	PAR-CLIP	27292025
MIRT526248	hsa-miR-372-5p	PAR-CLIP	27292025
MIRT526251	hsa-miR-373-5p	PAR-CLIP	27292025
MIRT526251	hsa-miR-373-5p	PAR-CLIP	27292025
MIRT526247	hsa-miR-4290	PAR-CLIP	27292025
MIRT526247	hsa-miR-4290	PAR-CLIP	27292025
MIRT526256	hsa-miR-4762-5p	PAR-CLIP	27292025
MIRT526256	hsa-miR-4762-5p	PAR-CLIP	27292025
MIRT526250	hsa-miR-616-5p	PAR-CLIP	27292025
MIRT526250	hsa-miR-616-5p	PAR-CLIP	27292025
MIRT526254	hsa-miR-6872-3p	PAR-CLIP	27292025
MIRT526254	hsa-miR-6872-3p	PAR-CLIP	27292025
MIRT526253	hsa-miR-6892-3p	PAR-CLIP	27292025
MIRT526253	hsa-miR-6892-3p	PAR-CLIP	27292025
MIRT526255	hsa-miR-8485	PAR-CLIP	27292025
MIRT526255	hsa-miR-8485	PAR-CLIP	27292025
MIRT543400	hsa-miR-148a-5p	PAR-CLIP	21572407
MIRT543399	hsa-miR-16-2-3p	PAR-CLIP	21572407
MIRT543398	hsa-miR-195-3p	PAR-CLIP	21572407
MIRT543397	hsa-miR-4660	PAR-CLIP	21572407
MIRT543396	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT543395	hsa-miR-1301-3p	PAR-CLIP	21572407
MIRT543394	hsa-miR-5047	PAR-CLIP	21572407
MIRT543393	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT526257	hsa-miR-216a-5p	PAR-CLIP	22012620
MIRT526255	hsa-miR-8485	PAR-CLIP	22012620
MIRT526256	hsa-miR-4762-5p	PAR-CLIP	22012620
MIRT526254	hsa-miR-6872-3p	PAR-CLIP	22012620
MIRT526253	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT526252	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT526251	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT526250	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT526249	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT526248	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT526247	hsa-miR-4290	PAR-CLIP	22012620
MIRT945399	hsa-miR-106a	CLIP-seq
MIRT945400	hsa-miR-106b	CLIP-seq
MIRT945401	hsa-miR-17	CLIP-seq
MIRT945402	hsa-miR-20a	CLIP-seq
MIRT945403	hsa-miR-20b	CLIP-seq
MIRT945404	hsa-miR-299-5p	CLIP-seq
MIRT945405	hsa-miR-325	CLIP-seq
MIRT945406	hsa-miR-3609	CLIP-seq
MIRT945407	hsa-miR-3614-5p	CLIP-seq
MIRT945408	hsa-miR-3689a-3p	CLIP-seq
MIRT945409	hsa-miR-3689c	CLIP-seq
MIRT945410	hsa-miR-4728-5p	CLIP-seq
MIRT945411	hsa-miR-4796-3p	CLIP-seq
MIRT945412	hsa-miR-502-5p	CLIP-seq
MIRT945413	hsa-miR-519d	CLIP-seq
MIRT945414	hsa-miR-548ah	CLIP-seq
MIRT945415	hsa-miR-595	CLIP-seq
MIRT945416	hsa-miR-617	CLIP-seq
MIRT945417	hsa-miR-628-3p	CLIP-seq
MIRT945418	hsa-miR-644	CLIP-seq
MIRT945419	hsa-miR-663b	CLIP-seq
MIRT945420	hsa-miR-93	CLIP-seq
MIRT945421	hsa-miR-1206	CLIP-seq
MIRT945422	hsa-miR-3616-5p	CLIP-seq
MIRT945423	hsa-miR-3647-5p	CLIP-seq
MIRT945424	hsa-miR-4635	CLIP-seq
MIRT945425	hsa-miR-573	CLIP-seq
MIRT1979878	hsa-miR-128	CLIP-seq
MIRT1979879	hsa-miR-132	CLIP-seq
MIRT1979880	hsa-miR-212	CLIP-seq
MIRT1979881	hsa-miR-27a	CLIP-seq
MIRT1979882	hsa-miR-27b	CLIP-seq
MIRT1979883	hsa-miR-4704-3p	CLIP-seq
MIRT1979884	hsa-miR-4709-5p	CLIP-seq
MIRT1979885	hsa-miR-935	CLIP-seq
MIRT1979878	hsa-miR-128	CLIP-seq
MIRT1979879	hsa-miR-132	CLIP-seq
MIRT1979880	hsa-miR-212	CLIP-seq
MIRT1979881	hsa-miR-27a	CLIP-seq
MIRT1979882	hsa-miR-27b	CLIP-seq
MIRT1979883	hsa-miR-4704-3p	CLIP-seq
MIRT1979884	hsa-miR-4709-5p	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
E2F1	Activation	24909689

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001530	Function	Lipopolysaccharide binding	IDA	20180804
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	IPI	31507089
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004521	Function	RNA endonuclease activity	IEA
GO:0004525	Function	Ribonuclease III activity	IBA
GO:0004525	Function	Ribonuclease III activity	IDA	14508493, 15574589
GO:0004525	Function	Ribonuclease III activity	IEA
GO:0005515	Function	Protein binding	IPI	15574589, 18548003, 19626115, 22222205, 22796965, 23232809, 23995758, 24219989, 24581491, 26496610, 33961781, 35914814, 39251607
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006364	Process	RRNA processing	IEA
GO:0006396	Process	RNA processing	IEA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0010586	Process	MiRNA metabolic process	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0017151	Function	DEAD/H-box RNA helicase binding	IPI	18548003
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0031053	Process	Primary miRNA processing	IBA
GO:0031053	Process	Primary miRNA processing	IDA	14508493, 15574589
GO:0031053	Process	Primary miRNA processing	IMP	14508493
GO:0031054	Process	Pre-miRNA processing	IBA
GO:0031054	Process	Pre-miRNA processing	IEA
GO:0031054	Process	Pre-miRNA processing	IEA
GO:0035196	Process	MiRNA processing	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	15574589
GO:0043226	Component	Organelle	IEA
GO:0045589	Process	Regulation of regulatory T cell differentiation	IEA
GO:0046332	Function	SMAD binding	IPI	18548003
GO:0046872	Function	Metal ion binding	IEA
GO:0050727	Process	Regulation of inflammatory response	IEA
GO:0050829	Process	Defense response to Gram-negative bacterium	IDA	20180804
GO:0050830	Process	Defense response to Gram-positive bacterium	IDA	20180804
GO:0070412	Function	R-SMAD binding	IPI	18548003
GO:0070877	Component	Microprocessor complex	IBA
GO:0070877	Component	Microprocessor complex	IDA	15574589
GO:0070877	Component	Microprocessor complex	IPI	24581491
GO:0070878	Function	Primary miRNA binding	IEA
GO:0070878	Function	Primary miRNA binding	IPI	31507089
GO:0070878	Function	Primary miRNA binding	NAS	15574589
GO:0098978	Component	Glutamatergic synapse	IEA
GO:2000628	Process	Regulation of miRNA metabolic process	IEA

MIM	HGNC	e!Ensembl
608828	17904	ENSG00000113360

Protein

UniProt ID

Q9NRR4

Protein name

Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241)

Protein function

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) t

PDB

2KHX , 2NA2 , 5B16 , 6LXD , 6LXE , 6V5B , 6V5C , 9ASM , 9ASN , 9ASO , 9ASP , 9ASQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14622	Ribonucleas_3_3	958 → 1071	Ribonuclease-III-like	Family
PF00636	Ribonuclease_3	1144 → 1233	Ribonuclease III domain	Family
PF00035	dsrm	1261 → 1332	Double-stranded RNA binding motif	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10948199}.

Sequence

MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPS
TTFSNSPAPNFLPPRPDFVPFPPPMPPSAQGPLPPCPIRPPFPNHQMRHPFPVPPCFPPM
PPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGR
GERHRSLDRRERGRSPDRRRQDSRYRSDYDRGRTPSRHRSYERSRERERERHRHRDNRRS
PSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSEN
YYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESS
SESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYI
FEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELY
DWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIA
NMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPA
QLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTV
ELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHP
SHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPS
RINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDR
FMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLN
YPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTL
GHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYA
ITNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWND
PKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQA
EMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPDETEDIKK

Sequence length

1374

Interactions

View interactions

	KEGG		Reactome
	Ribosome biogenesis in eukaryotes Proteoglycans in cancer		MicroRNA (miRNA) biogenesis

DROSHA (drosha ribonuclease III)