Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	29101
Gene name	SSU72 homolog, RNA polymerase II CTD phosphatase
Gene symbol	SSU72
Synonyms (NCBI Gene)	HSPC182PNAS-120
Chromosome	1
Chromosome location	1p36.33

227

Show/Hide all (227)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025930	hsa-miR-7-5p	Microarray	19073608
MIRT031949	hsa-miR-16-5p	Proteomics	18668040
MIRT447335	hsa-miR-548n	PAR-CLIP	20371350
MIRT518417	hsa-miR-548l	PAR-CLIP	20371350
MIRT518414	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT518412	hsa-miR-4476	PAR-CLIP	20371350
MIRT518411	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT518410	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT518409	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT447330	hsa-miR-3148	PAR-CLIP	20371350
MIRT518408	hsa-miR-4533	PAR-CLIP	20371350
MIRT447335	hsa-miR-548n	PAR-CLIP	20371350
MIRT518417	hsa-miR-548l	PAR-CLIP	20371350
MIRT518416	hsa-miR-7-1-3p	PAR-CLIP	20371350
MIRT518415	hsa-miR-7-2-3p	PAR-CLIP	20371350
MIRT518414	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT518413	hsa-miR-513b-3p	PAR-CLIP	20371350
MIRT518412	hsa-miR-4476	PAR-CLIP	20371350
MIRT518411	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT518410	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT518409	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT447330	hsa-miR-3148	PAR-CLIP	20371350
MIRT518408	hsa-miR-4533	PAR-CLIP	20371350
MIRT447335	hsa-miR-548n	PAR-CLIP	20371350
MIRT518417	hsa-miR-548l	PAR-CLIP	20371350
MIRT518414	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT518413	hsa-miR-513b-3p	PAR-CLIP	20371350
MIRT518412	hsa-miR-4476	PAR-CLIP	20371350
MIRT518411	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT518410	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT518409	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT447330	hsa-miR-3148	PAR-CLIP	20371350
MIRT518408	hsa-miR-4533	PAR-CLIP	20371350
MIRT551740	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT551739	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031949	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT551738	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT551737	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT551736	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT551735	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT551734	hsa-miR-2277-3p	PAR-CLIP	21572407
MIRT551733	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT551732	hsa-miR-107	PAR-CLIP	21572407
MIRT518429	hsa-miR-548ac	PAR-CLIP	23446348
MIRT518428	hsa-miR-548bb-3p	PAR-CLIP	23446348
MIRT518427	hsa-miR-548d-3p	PAR-CLIP	23446348
MIRT518426	hsa-miR-548h-3p	PAR-CLIP	23446348
MIRT518425	hsa-miR-548z	PAR-CLIP	23446348
MIRT518424	hsa-miR-548ae-3p	PAR-CLIP	23446348
MIRT518423	hsa-miR-548ah-3p	PAR-CLIP	23446348
MIRT518422	hsa-miR-548aj-3p	PAR-CLIP	23446348
MIRT518421	hsa-miR-548am-3p	PAR-CLIP	23446348
MIRT518420	hsa-miR-548aq-3p	PAR-CLIP	23446348
MIRT518419	hsa-miR-548j-3p	PAR-CLIP	23446348
MIRT518418	hsa-miR-548x-3p	PAR-CLIP	23446348
MIRT447335	hsa-miR-548n	PAR-CLIP	23446348
MIRT518417	hsa-miR-548l	PAR-CLIP	23446348
MIRT518416	hsa-miR-7-1-3p	PAR-CLIP	23446348
MIRT518415	hsa-miR-7-2-3p	PAR-CLIP	23446348
MIRT518414	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT518413	hsa-miR-513b-3p	PAR-CLIP	23446348
MIRT518412	hsa-miR-4476	PAR-CLIP	23446348
MIRT518411	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT518410	hsa-miR-873-5p	PAR-CLIP	23446348
MIRT518409	hsa-miR-1252-5p	PAR-CLIP	23446348
MIRT447330	hsa-miR-3148	PAR-CLIP	23446348
MIRT518408	hsa-miR-4533	PAR-CLIP	23446348
MIRT447335	hsa-miR-548n	PAR-CLIP	22100165
MIRT447334	hsa-miR-548az-5p	PAR-CLIP	22100165
MIRT447333	hsa-miR-548t-5p	PAR-CLIP	22100165
MIRT447332	hsa-miR-4796-3p	PAR-CLIP	22100165
MIRT447330	hsa-miR-3148	PAR-CLIP	22100165
MIRT447331	hsa-miR-6124	PAR-CLIP	22100165
MIRT439536	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT439536	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT447335	hsa-miR-548n	PAR-CLIP	20371350
MIRT518417	hsa-miR-548l	PAR-CLIP	20371350
MIRT518414	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT518412	hsa-miR-4476	PAR-CLIP	20371350
MIRT518411	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT518410	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT518409	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT447330	hsa-miR-3148	PAR-CLIP	20371350
MIRT518408	hsa-miR-4533	PAR-CLIP	20371350
MIRT447335	hsa-miR-548n	PAR-CLIP	20371350
MIRT518417	hsa-miR-548l	PAR-CLIP	20371350
MIRT518416	hsa-miR-7-1-3p	PAR-CLIP	20371350
MIRT518415	hsa-miR-7-2-3p	PAR-CLIP	20371350
MIRT518414	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT518413	hsa-miR-513b-3p	PAR-CLIP	20371350
MIRT518412	hsa-miR-4476	PAR-CLIP	20371350
MIRT518411	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT518410	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT518409	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT447330	hsa-miR-3148	PAR-CLIP	20371350
MIRT518408	hsa-miR-4533	PAR-CLIP	20371350
MIRT447335	hsa-miR-548n	PAR-CLIP	20371350
MIRT518417	hsa-miR-548l	PAR-CLIP	20371350
MIRT518414	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT518413	hsa-miR-513b-3p	PAR-CLIP	20371350
MIRT518412	hsa-miR-4476	PAR-CLIP	20371350
MIRT518411	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT518410	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT518409	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT447330	hsa-miR-3148	PAR-CLIP	20371350
MIRT518408	hsa-miR-4533	PAR-CLIP	20371350
MIRT551740	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT551739	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031949	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT551738	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT551737	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT551736	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT551735	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT551734	hsa-miR-2277-3p	PAR-CLIP	21572407
MIRT551733	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT551732	hsa-miR-107	PAR-CLIP	21572407
MIRT518429	hsa-miR-548ac	PAR-CLIP	23446348
MIRT518428	hsa-miR-548bb-3p	PAR-CLIP	23446348
MIRT518427	hsa-miR-548d-3p	PAR-CLIP	23446348
MIRT518426	hsa-miR-548h-3p	PAR-CLIP	23446348
MIRT518425	hsa-miR-548z	PAR-CLIP	23446348
MIRT518424	hsa-miR-548ae-3p	PAR-CLIP	23446348
MIRT518423	hsa-miR-548ah-3p	PAR-CLIP	23446348
MIRT518422	hsa-miR-548aj-3p	PAR-CLIP	23446348
MIRT518421	hsa-miR-548am-3p	PAR-CLIP	23446348
MIRT518420	hsa-miR-548aq-3p	PAR-CLIP	23446348
MIRT518419	hsa-miR-548j-3p	PAR-CLIP	23446348
MIRT518418	hsa-miR-548x-3p	PAR-CLIP	23446348
MIRT447335	hsa-miR-548n	PAR-CLIP	23446348
MIRT518417	hsa-miR-548l	PAR-CLIP	23446348
MIRT518416	hsa-miR-7-1-3p	PAR-CLIP	23446348
MIRT518415	hsa-miR-7-2-3p	PAR-CLIP	23446348
MIRT518414	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT518413	hsa-miR-513b-3p	PAR-CLIP	23446348
MIRT518412	hsa-miR-4476	PAR-CLIP	23446348
MIRT518411	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT518410	hsa-miR-873-5p	PAR-CLIP	23446348
MIRT518409	hsa-miR-1252-5p	PAR-CLIP	23446348
MIRT447330	hsa-miR-3148	PAR-CLIP	23446348
MIRT518408	hsa-miR-4533	PAR-CLIP	23446348
MIRT447335	hsa-miR-548n	PAR-CLIP	22100165
MIRT447334	hsa-miR-548az-5p	PAR-CLIP	22100165
MIRT447333	hsa-miR-548t-5p	PAR-CLIP	22100165
MIRT447332	hsa-miR-4796-3p	PAR-CLIP	22100165
MIRT447330	hsa-miR-3148	PAR-CLIP	22100165
MIRT447331	hsa-miR-6124	PAR-CLIP	22100165
MIRT1392909	hsa-miR-1271	CLIP-seq
MIRT1392910	hsa-miR-150	CLIP-seq
MIRT1392911	hsa-miR-1537	CLIP-seq
MIRT1392912	hsa-miR-182	CLIP-seq
MIRT1392913	hsa-miR-214	CLIP-seq
MIRT1392914	hsa-miR-3126-3p	CLIP-seq
MIRT1392915	hsa-miR-3160-5p	CLIP-seq
MIRT1392916	hsa-miR-3183	CLIP-seq
MIRT1392917	hsa-miR-3619-5p	CLIP-seq
MIRT1392918	hsa-miR-4279	CLIP-seq
MIRT1392919	hsa-miR-451	CLIP-seq
MIRT1392920	hsa-miR-4642	CLIP-seq
MIRT1392921	hsa-miR-4713-5p	CLIP-seq
MIRT1392922	hsa-miR-4723-3p	CLIP-seq
MIRT1392923	hsa-miR-519a	CLIP-seq
MIRT1392924	hsa-miR-519b-3p	CLIP-seq
MIRT1392925	hsa-miR-519c-3p	CLIP-seq
MIRT1392926	hsa-miR-532-3p	CLIP-seq
MIRT1392927	hsa-miR-760	CLIP-seq
MIRT1392928	hsa-miR-761	CLIP-seq
MIRT1392929	hsa-miR-96	CLIP-seq
MIRT1392913	hsa-miR-214	CLIP-seq
MIRT1392917	hsa-miR-3619-5p	CLIP-seq
MIRT1392927	hsa-miR-760	CLIP-seq
MIRT1392928	hsa-miR-761	CLIP-seq
MIRT2117922	hsa-miR-939	CLIP-seq
MIRT2339894	hsa-miR-1225-5p	CLIP-seq
MIRT2339895	hsa-miR-1226	CLIP-seq
MIRT1392909	hsa-miR-1271	CLIP-seq
MIRT1392910	hsa-miR-150	CLIP-seq
MIRT1392911	hsa-miR-1537	CLIP-seq
MIRT2339896	hsa-miR-155	CLIP-seq
MIRT1392912	hsa-miR-182	CLIP-seq
MIRT1392913	hsa-miR-214	CLIP-seq
MIRT1392914	hsa-miR-3126-3p	CLIP-seq
MIRT1392916	hsa-miR-3183	CLIP-seq
MIRT1392917	hsa-miR-3619-5p	CLIP-seq
MIRT1392918	hsa-miR-4279	CLIP-seq
MIRT1392919	hsa-miR-451	CLIP-seq
MIRT2339897	hsa-miR-4530	CLIP-seq
MIRT1392920	hsa-miR-4642	CLIP-seq
MIRT1392921	hsa-miR-4713-5p	CLIP-seq
MIRT1392922	hsa-miR-4723-3p	CLIP-seq
MIRT2339898	hsa-miR-4733-3p	CLIP-seq
MIRT1392923	hsa-miR-519a	CLIP-seq
MIRT1392924	hsa-miR-519b-3p	CLIP-seq
MIRT1392925	hsa-miR-519c-3p	CLIP-seq
MIRT1392926	hsa-miR-532-3p	CLIP-seq
MIRT2339899	hsa-miR-548ae	CLIP-seq
MIRT2339900	hsa-miR-548aj	CLIP-seq
MIRT2339901	hsa-miR-548am	CLIP-seq
MIRT2339902	hsa-miR-548x	CLIP-seq
MIRT2339903	hsa-miR-555	CLIP-seq
MIRT2339904	hsa-miR-634	CLIP-seq
MIRT1392927	hsa-miR-760	CLIP-seq
MIRT1392928	hsa-miR-761	CLIP-seq
MIRT2339905	hsa-miR-922	CLIP-seq
MIRT2117922	hsa-miR-939	CLIP-seq
MIRT1392929	hsa-miR-96	CLIP-seq
MIRT1392913	hsa-miR-214	CLIP-seq
MIRT1392917	hsa-miR-3619-5p	CLIP-seq
MIRT1392927	hsa-miR-760	CLIP-seq
MIRT1392928	hsa-miR-761	CLIP-seq
MIRT1392913	hsa-miR-214	CLIP-seq
MIRT1392917	hsa-miR-3619-5p	CLIP-seq
MIRT1392927	hsa-miR-760	CLIP-seq
MIRT1392928	hsa-miR-761	CLIP-seq
MIRT1392913	hsa-miR-214	CLIP-seq
MIRT1392917	hsa-miR-3619-5p	CLIP-seq
MIRT1392927	hsa-miR-760	CLIP-seq
MIRT1392928	hsa-miR-761	CLIP-seq
MIRT1392913	hsa-miR-214	CLIP-seq
MIRT1392917	hsa-miR-3619-5p	CLIP-seq
MIRT1392927	hsa-miR-760	CLIP-seq
MIRT1392928	hsa-miR-761	CLIP-seq
MIRT2117922	hsa-miR-939	CLIP-seq
MIRT1392913	hsa-miR-214	CLIP-seq
MIRT1392917	hsa-miR-3619-5p	CLIP-seq
MIRT1392927	hsa-miR-760	CLIP-seq
MIRT1392928	hsa-miR-761	CLIP-seq
MIRT2117922	hsa-miR-939	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	20818333, 20861839, 29158257, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005847	Component	MRNA cleavage and polyadenylation specificity factor complex	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006369	Process	Termination of RNA polymerase II transcription	IBA
GO:0006397	Process	MRNA processing	IEA
GO:0008420	Function	RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA
GO:0008420	Function	RNA polymerase II CTD heptapeptide repeat phosphatase activity	IDA	20861839
GO:0008420	Function	RNA polymerase II CTD heptapeptide repeat phosphatase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031124	Process	MRNA 3'-end processing	IEA
GO:0180010	Process	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	IMP	20861839

MIM	HGNC	e!Ensembl
617680	25016	ENSG00000160075

Q9NP77

Protein name

RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16)

Protein function

Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. {ECO:0000269|PubMed:

PDB

3O2Q , 3O2S , 4H3H , 4H3K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04722	Ssu72	6 → 194	Ssu72-like protein	Family

Sequence

MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTT
YDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVV
EDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFE
EKSGRTFLHTVCFY

Sequence length

194

Interactions

View interactions

	KEGG		Reactome
	mRNA surveillance pathway		RNA polymerase II transcribes snRNA genes

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OSTEOPETROSIS, AUTOSOMAL RECESSIVE 4	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

SSU72 (SSU72 homolog, RNA polymerase II CTD phosphatase)