Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	29093
Gene name	Mitochondrial ribosomal protein L22
Gene symbol	MRPL22
Synonyms (NCBI Gene)	HSPC158L22mtMRP-L22MRP-L25RPML25uL22m
Chromosome	5
Chromosome location	5q33.2
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

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Show/Hide all (239)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029465	hsa-miR-26b-5p	Microarray	19088304
MIRT535852	hsa-miR-4519	PAR-CLIP	22012620
MIRT535851	hsa-miR-4735-5p	PAR-CLIP	22012620
MIRT535850	hsa-miR-4738-3p	PAR-CLIP	22012620
MIRT535849	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT535848	hsa-miR-653-5p	PAR-CLIP	22012620
MIRT535847	hsa-miR-510-3p	PAR-CLIP	22012620
MIRT440215	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT440215	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT535852	hsa-miR-4519	PAR-CLIP	27292025
MIRT535851	hsa-miR-4735-5p	PAR-CLIP	27292025
MIRT535850	hsa-miR-4738-3p	PAR-CLIP	27292025
MIRT535847	hsa-miR-510-3p	PAR-CLIP	27292025
MIRT535849	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT535848	hsa-miR-653-5p	PAR-CLIP	27292025
MIRT535852	hsa-miR-4519	PAR-CLIP	22012620
MIRT535851	hsa-miR-4735-5p	PAR-CLIP	22012620
MIRT535850	hsa-miR-4738-3p	PAR-CLIP	22012620
MIRT535849	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT535848	hsa-miR-653-5p	PAR-CLIP	22012620
MIRT535847	hsa-miR-510-3p	PAR-CLIP	22012620
MIRT1158841	hsa-miR-1227	CLIP-seq
MIRT1158842	hsa-miR-146a	CLIP-seq
MIRT1158843	hsa-miR-146b-5p	CLIP-seq
MIRT1158844	hsa-miR-1914	CLIP-seq
MIRT1158845	hsa-miR-3148	CLIP-seq
MIRT1158846	hsa-miR-3150a-3p	CLIP-seq
MIRT1158847	hsa-miR-3153	CLIP-seq
MIRT1158848	hsa-miR-3163	CLIP-seq
MIRT1158849	hsa-miR-3175	CLIP-seq
MIRT1158850	hsa-miR-340	CLIP-seq
MIRT1158851	hsa-miR-3652	CLIP-seq
MIRT1158852	hsa-miR-3664-3p	CLIP-seq
MIRT1158853	hsa-miR-3943	CLIP-seq
MIRT1158854	hsa-miR-3973	CLIP-seq
MIRT1158855	hsa-miR-4430	CLIP-seq
MIRT1158856	hsa-miR-4496	CLIP-seq
MIRT1158857	hsa-miR-4505	CLIP-seq
MIRT1158858	hsa-miR-4667-5p	CLIP-seq
MIRT1158859	hsa-miR-4668-5p	CLIP-seq
MIRT1158860	hsa-miR-4695-3p	CLIP-seq
MIRT1158861	hsa-miR-4700-5p	CLIP-seq
MIRT1158862	hsa-miR-4709-5p	CLIP-seq
MIRT1158863	hsa-miR-4731-5p	CLIP-seq
MIRT1158864	hsa-miR-4762-3p	CLIP-seq
MIRT1158865	hsa-miR-4766-5p	CLIP-seq
MIRT1158866	hsa-miR-488	CLIP-seq
MIRT1158867	hsa-miR-520g	CLIP-seq
MIRT1158868	hsa-miR-520h	CLIP-seq
MIRT1158869	hsa-miR-544	CLIP-seq
MIRT1158870	hsa-miR-548aa	CLIP-seq
MIRT1158871	hsa-miR-589	CLIP-seq
MIRT1158872	hsa-miR-873	CLIP-seq
MIRT1158873	hsa-miR-939	CLIP-seq
MIRT1158874	hsa-miR-103b	CLIP-seq
MIRT1158875	hsa-miR-1292	CLIP-seq
MIRT1158876	hsa-miR-1293	CLIP-seq
MIRT1158877	hsa-miR-203	CLIP-seq
MIRT1158878	hsa-miR-218	CLIP-seq
MIRT1158879	hsa-miR-221	CLIP-seq
MIRT1158880	hsa-miR-222	CLIP-seq
MIRT1158881	hsa-miR-224	CLIP-seq
MIRT1158882	hsa-miR-3121-5p	CLIP-seq
MIRT1158883	hsa-miR-3127-3p	CLIP-seq
MIRT1158884	hsa-miR-3145-5p	CLIP-seq
MIRT1158846	hsa-miR-3150a-3p	CLIP-seq
MIRT1158849	hsa-miR-3175	CLIP-seq
MIRT1158885	hsa-miR-335	CLIP-seq
MIRT1158886	hsa-miR-34c-3p	CLIP-seq
MIRT1158887	hsa-miR-3612	CLIP-seq
MIRT1158888	hsa-miR-3646	CLIP-seq
MIRT1158889	hsa-miR-3651	CLIP-seq
MIRT1158851	hsa-miR-3652	CLIP-seq
MIRT1158852	hsa-miR-3664-3p	CLIP-seq
MIRT1158890	hsa-miR-3679-3p	CLIP-seq
MIRT1158891	hsa-miR-3691-3p	CLIP-seq
MIRT1158853	hsa-miR-3943	CLIP-seq
MIRT1158854	hsa-miR-3973	CLIP-seq
MIRT1158892	hsa-miR-4323	CLIP-seq
MIRT1158855	hsa-miR-4430	CLIP-seq
MIRT1158893	hsa-miR-4443	CLIP-seq
MIRT1158894	hsa-miR-4471	CLIP-seq
MIRT1158895	hsa-miR-4483	CLIP-seq
MIRT1158856	hsa-miR-4496	CLIP-seq
MIRT1158857	hsa-miR-4505	CLIP-seq
MIRT1158896	hsa-miR-4666-5p	CLIP-seq
MIRT1158858	hsa-miR-4667-5p	CLIP-seq
MIRT1158897	hsa-miR-4691-3p	CLIP-seq
MIRT1158898	hsa-miR-4694-3p	CLIP-seq
MIRT1158899	hsa-miR-4699-3p	CLIP-seq
MIRT1158861	hsa-miR-4700-5p	CLIP-seq
MIRT1158863	hsa-miR-4731-5p	CLIP-seq
MIRT1158900	hsa-miR-4802-5p	CLIP-seq
MIRT1158901	hsa-miR-494	CLIP-seq
MIRT1158867	hsa-miR-520g	CLIP-seq
MIRT1158868	hsa-miR-520h	CLIP-seq
MIRT1158869	hsa-miR-544	CLIP-seq
MIRT1158902	hsa-miR-636	CLIP-seq
MIRT1158903	hsa-miR-650	CLIP-seq
MIRT1158872	hsa-miR-873	CLIP-seq
MIRT1158873	hsa-miR-939	CLIP-seq
MIRT2045530	hsa-miR-2277-3p	CLIP-seq
MIRT1158846	hsa-miR-3150a-3p	CLIP-seq
MIRT1158849	hsa-miR-3175	CLIP-seq
MIRT1158851	hsa-miR-3652	CLIP-seq
MIRT1158852	hsa-miR-3664-3p	CLIP-seq
MIRT1158854	hsa-miR-3973	CLIP-seq
MIRT2045531	hsa-miR-4297	CLIP-seq
MIRT1158855	hsa-miR-4430	CLIP-seq
MIRT2045532	hsa-miR-4450	CLIP-seq
MIRT1158856	hsa-miR-4496	CLIP-seq
MIRT1158857	hsa-miR-4505	CLIP-seq
MIRT2045533	hsa-miR-4643	CLIP-seq
MIRT1158896	hsa-miR-4666-5p	CLIP-seq
MIRT1158858	hsa-miR-4667-5p	CLIP-seq
MIRT1158897	hsa-miR-4691-3p	CLIP-seq
MIRT2045534	hsa-miR-4696	CLIP-seq
MIRT1158861	hsa-miR-4700-5p	CLIP-seq
MIRT2045535	hsa-miR-4717-3p	CLIP-seq
MIRT1158863	hsa-miR-4731-5p	CLIP-seq
MIRT2045536	hsa-miR-4802-3p	CLIP-seq
MIRT2045537	hsa-miR-515-3p	CLIP-seq
MIRT2045538	hsa-miR-519e	CLIP-seq
MIRT1158867	hsa-miR-520g	CLIP-seq
MIRT1158868	hsa-miR-520h	CLIP-seq
MIRT1158869	hsa-miR-544	CLIP-seq
MIRT2045539	hsa-miR-642b	CLIP-seq
MIRT1158872	hsa-miR-873	CLIP-seq
MIRT1158873	hsa-miR-939	CLIP-seq
MIRT2274540	hsa-miR-1197	CLIP-seq
MIRT2274541	hsa-miR-1205	CLIP-seq
MIRT2274542	hsa-miR-1286	CLIP-seq
MIRT1158842	hsa-miR-146a	CLIP-seq
MIRT1158843	hsa-miR-146b-5p	CLIP-seq
MIRT2274543	hsa-miR-2467-3p	CLIP-seq
MIRT2274544	hsa-miR-2681	CLIP-seq
MIRT2274545	hsa-miR-3117-5p	CLIP-seq
MIRT1158846	hsa-miR-3150a-3p	CLIP-seq
MIRT1158848	hsa-miR-3163	CLIP-seq
MIRT1158849	hsa-miR-3175	CLIP-seq
MIRT1158850	hsa-miR-340	CLIP-seq
MIRT1158888	hsa-miR-3646	CLIP-seq
MIRT1158851	hsa-miR-3652	CLIP-seq
MIRT1158852	hsa-miR-3664-3p	CLIP-seq
MIRT2274546	hsa-miR-3680	CLIP-seq
MIRT1158854	hsa-miR-3973	CLIP-seq
MIRT1158855	hsa-miR-4430	CLIP-seq
MIRT2274547	hsa-miR-4436a	CLIP-seq
MIRT1158856	hsa-miR-4496	CLIP-seq
MIRT1158857	hsa-miR-4505	CLIP-seq
MIRT2045533	hsa-miR-4643	CLIP-seq
MIRT1158896	hsa-miR-4666-5p	CLIP-seq
MIRT1158858	hsa-miR-4667-5p	CLIP-seq
MIRT1158897	hsa-miR-4691-3p	CLIP-seq
MIRT1158860	hsa-miR-4695-3p	CLIP-seq
MIRT1158861	hsa-miR-4700-5p	CLIP-seq
MIRT2274548	hsa-miR-4704-5p	CLIP-seq
MIRT2045535	hsa-miR-4717-3p	CLIP-seq
MIRT2274549	hsa-miR-4722-5p	CLIP-seq
MIRT1158863	hsa-miR-4731-5p	CLIP-seq
MIRT1158867	hsa-miR-520g	CLIP-seq
MIRT1158868	hsa-miR-520h	CLIP-seq
MIRT1158869	hsa-miR-544	CLIP-seq
MIRT1158870	hsa-miR-548aa	CLIP-seq
MIRT1158871	hsa-miR-589	CLIP-seq
MIRT2045539	hsa-miR-642b	CLIP-seq
MIRT1158872	hsa-miR-873	CLIP-seq
MIRT1158873	hsa-miR-939	CLIP-seq
MIRT1158878	hsa-miR-218	CLIP-seq
MIRT2274543	hsa-miR-2467-3p	CLIP-seq
MIRT2274544	hsa-miR-2681	CLIP-seq
MIRT1158846	hsa-miR-3150a-3p	CLIP-seq
MIRT1158849	hsa-miR-3175	CLIP-seq
MIRT1158851	hsa-miR-3652	CLIP-seq
MIRT1158852	hsa-miR-3664-3p	CLIP-seq
MIRT1158854	hsa-miR-3973	CLIP-seq
MIRT1158855	hsa-miR-4430	CLIP-seq
MIRT2454466	hsa-miR-4452	CLIP-seq
MIRT1158856	hsa-miR-4496	CLIP-seq
MIRT1158857	hsa-miR-4505	CLIP-seq
MIRT1158858	hsa-miR-4667-5p	CLIP-seq
MIRT1158861	hsa-miR-4700-5p	CLIP-seq
MIRT1158863	hsa-miR-4731-5p	CLIP-seq
MIRT2454467	hsa-miR-4778-5p	CLIP-seq
MIRT1158867	hsa-miR-520g	CLIP-seq
MIRT1158868	hsa-miR-520h	CLIP-seq
MIRT1158869	hsa-miR-544	CLIP-seq
MIRT1158902	hsa-miR-636	CLIP-seq
MIRT1158872	hsa-miR-873	CLIP-seq
MIRT1158873	hsa-miR-939	CLIP-seq
MIRT2274544	hsa-miR-2681	CLIP-seq
MIRT1158846	hsa-miR-3150a-3p	CLIP-seq
MIRT1158849	hsa-miR-3175	CLIP-seq
MIRT1158851	hsa-miR-3652	CLIP-seq
MIRT1158852	hsa-miR-3664-3p	CLIP-seq
MIRT1158854	hsa-miR-3973	CLIP-seq
MIRT1158855	hsa-miR-4430	CLIP-seq
MIRT1158856	hsa-miR-4496	CLIP-seq
MIRT1158857	hsa-miR-4505	CLIP-seq
MIRT1158858	hsa-miR-4667-5p	CLIP-seq
MIRT1158861	hsa-miR-4700-5p	CLIP-seq
MIRT1158863	hsa-miR-4731-5p	CLIP-seq
MIRT1158867	hsa-miR-520g	CLIP-seq
MIRT1158868	hsa-miR-520h	CLIP-seq
MIRT1158869	hsa-miR-544	CLIP-seq
MIRT1158872	hsa-miR-873	CLIP-seq
MIRT1158873	hsa-miR-939	CLIP-seq
MIRT1158846	hsa-miR-3150a-3p	CLIP-seq
MIRT1158849	hsa-miR-3175	CLIP-seq
MIRT1158851	hsa-miR-3652	CLIP-seq
MIRT1158852	hsa-miR-3664-3p	CLIP-seq
MIRT1158854	hsa-miR-3973	CLIP-seq
MIRT1158855	hsa-miR-4430	CLIP-seq
MIRT1158856	hsa-miR-4496	CLIP-seq
MIRT1158857	hsa-miR-4505	CLIP-seq
MIRT1158858	hsa-miR-4667-5p	CLIP-seq
MIRT1158861	hsa-miR-4700-5p	CLIP-seq
MIRT1158863	hsa-miR-4731-5p	CLIP-seq
MIRT1158867	hsa-miR-520g	CLIP-seq
MIRT1158868	hsa-miR-520h	CLIP-seq
MIRT1158869	hsa-miR-544	CLIP-seq
MIRT1158872	hsa-miR-873	CLIP-seq
MIRT1158873	hsa-miR-939	CLIP-seq
MIRT1158846	hsa-miR-3150a-3p	CLIP-seq
MIRT1158849	hsa-miR-3175	CLIP-seq
MIRT1158851	hsa-miR-3652	CLIP-seq
MIRT1158852	hsa-miR-3664-3p	CLIP-seq
MIRT1158854	hsa-miR-3973	CLIP-seq
MIRT1158855	hsa-miR-4430	CLIP-seq
MIRT1158856	hsa-miR-4496	CLIP-seq
MIRT1158857	hsa-miR-4505	CLIP-seq
MIRT1158858	hsa-miR-4667-5p	CLIP-seq
MIRT1158861	hsa-miR-4700-5p	CLIP-seq
MIRT1158863	hsa-miR-4731-5p	CLIP-seq
MIRT1158867	hsa-miR-520g	CLIP-seq
MIRT1158868	hsa-miR-520h	CLIP-seq
MIRT1158869	hsa-miR-544	CLIP-seq
MIRT1158872	hsa-miR-873	CLIP-seq
MIRT1158873	hsa-miR-939	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	28892042
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	ISS
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005762	Component	Mitochondrial large ribosomal subunit	IBA
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	25278503, 28892042
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	25278503
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IBA
GO:0006412	Process	Translation	IEA
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611835	14480	ENSG00000082515

Q9NWU5

Protein name

Large ribosomal subunit protein uL22m (39S ribosomal protein L22, mitochondrial) (L22mt) (MRP-L22) (39S ribosomal protein L25, mitochondrial) (L25mt) (MRP-L25)

PDB

3J7Y , 5OOL , 5OOM , 6NU2 , 6NU3 , 6ZM5 , 6ZM6 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF2 , 7OF3 , 7OF4 , 7OF5 , 7OF6 , 7OF7 , 7OG4 , 7OI6 , 7OI7 , 7OI8 , 7OI9 , 7OIA , 7OIB , 7OIC , 7OID , 7OIE , 7PD3 , 7PO4 , 7QH6 , 7QH7 , 7QI4 , 7QI5 , 7QI6 , 8ANY , 8K2A , 8K2B , 8OIR , 8OIT , 8PK0 , 8QSJ , 8QU1 , 8QU5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00237	Ribosomal_L22	69 → 173	Ribosomal protein L22p/L17e	Domain

Sequence

MAAAVLGQLGALWIHNLRSRGKLALGVLPQSYIHTSASLDISRKWEKKNKIVYPPQLPGE
PRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQD
MAVRDHNVEFRSNLYIAESTSGRGQCLKRIRYHGRGRFGIMEKVYCHYFVKLVEGPPPPP
EPPKTAVAHAKEYIQQLRSRTIVHTL

Sequence length

206

Interactions

View interactions

	KEGG		Reactome
	Ribosome		Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Cerebral Infarction	Associate	37322932	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Associate	35830453	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Associate	33883344	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma B Cell	Associate	33883344	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Associate	27718532	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Associate	35830453	★★★★★ ★☆☆☆☆ Found in Text Mining only

MRPL22 (mitochondrial ribosomal protein L22)