Gene Gene information from NCBI Gene database.
Entrez ID 2909
Gene name Rho GTPase activating protein 35
Gene symbol ARHGAP35
Synonyms (NCBI Gene)
GRF-1GRLF1P190-AP190Ap190ARhoGAPp190RhoGAP
Chromosome 19
Chromosome location 19q13.32
Summary The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequence
miRNA miRNA information provided by mirtarbase database.
1060
miRTarBase ID miRNA Experiments Reference
MIRT047266 hsa-miR-181b-5p CLASH 23622248
MIRT038489 hsa-miR-296-3p CLASH 23622248
MIRT613638 hsa-miR-6768-3p HITS-CLIP 23824327
MIRT613637 hsa-miR-6501-3p HITS-CLIP 23824327
MIRT613636 hsa-miR-5196-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
61
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001843 Process Neural tube closure IEA
GO:0003677 Function DNA binding IEA
GO:0003924 Function GTPase activity IEA
GO:0005096 Function GTPase activator activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605277 4591 ENSG00000160007
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NRY4
Protein name Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)
Protein function Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRK
PDB 2K85 , 3C5H , 3FK2 , 6PXC , 6WAY , 8DGQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 154 249 Ras family Domain
PF16512 RhoGAP-FF1 261 340 p190-A and -B Rho GAPs FF domain Domain
PF01846 FF 487 547 FF domain Family
PF00620 RhoGAP 1262 1413 RhoGAP domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in neutrophils (at protein level). {ECO:0000269|PubMed:1894621}.
Sequence
MMMARKQDVRIPTYNISVVGLSGTEKEKGQCGIGKSCLCNRFVRPSADEFHLDHTSVLST
SDFGGRVVNNDHFLYWGEVSRSLEDCVECKMHIVEQTEFIDDQTFQPHRSTALQPYIKRA
AATKLASAEKLMYFCTDQLGLEQDFEQKQMPDGKLLVDGFLLGIDVSRGMNRNFDDQLKF
VSNLYNQLAKTKKPIVVVLTKCDEGVERYIRDAHTFALSKKNLQVVETSARSNVNVDLAF
STLVQLIDK
SRGKTKIIPYFEALKQQSQQIATAKDKYEWLVSRIVKNHNENWLSVSRKMQ
ASPEYQDYVYLEGTQKAKKLFLQHIHRLKHEHIERRRKLY
LAALPLAFEALIPNLDEIDH
LSCIKAKKLLETKPEFLKWFVVLEETPWDATSHIDNMENERIPFDLMDTVPAEQLYEAHL
EKLRNERKRVEMRRAFKENLETSPFITPGKPWEEARSFIMNEDFYQWLEESVYMDIYGKH
QKQIIDKAKEEFQELLLEYSELFYELELDAKPSKEKMGVIQDVLGEEQRFKALQKLQAER
DALILKH
IHFVYHPTKETCPSCPACVDAKIEHLISSRFIRPSDRNQKNSLSDPNIDRINL
VILGKDGLARELANEIRALCTNDDKYVIDGKMYELSLRPIEGNVRLPVNSFQTPTFQPHG
CLCLYNSKESLSYVVESIEKSRESTLGRRDNHLVHLPLTLILVNKRGDTSGETLHSLIQQ
GQQIASKLQCVFLDPASAGIGYGRNINEKQISQVLKGLLDSKRNLNLVSSTASIKDLADV
DLRIVMCLMCGDPFSADDILFPVLQSQTCKSSHCGSNNSVLLELPIGLHKKRIELSVLSY
HSSFSIRKSRLVHGYIVFYSAKRKASLAMLRAFLCEVQDIIPIQLVALTDGAVDVLDNDL
SREQLTEGEEIAQEIDGRFTSIPCSQPQHKLEIFHPFFKDVVEKKNIIEATHMYDNAAEA
CSTTEEVFNSPRAGSPLCNSNLQDSEEDIEPSYSLFREDTSLPSLSKDHSKLSMELEGND
GLSFIMSNFESKLNNKVPPPVKPKPPVHFEITKGDLSYLDQGHRDGQRKSVSSSPWLPQD
GFDPSDYAEPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQSNGSGNGSDSEMDT
SSLERGRKVSIVSKPVLYRTRCTRLGRFASYRTSFSVGSDDELGPIRKKEEDQASQGYKG
DNAVIPYETDEDPRRRNILRSLRRNTKKPKPKPRPSITKATWESNYFGVPLTTVVTPEKP
IPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGA
MKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLN
KVSHNNKVNLMTSENLSICFWPTLMRPDFSTMD
ALTATRTYQTIIELFIQQCPFFFYNRP
ITEPPGARPSSPSAVASTVPFLTSTPVTSQPSPPQSPPPTPQSPMQPLLPSQLQAEHTL
Sequence length 1499
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Focal adhesion
Platelet activation
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
  Rho GTPase cycle
Sema4D mediated inhibition of cell attachment and migration
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
24
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Bilateral microphthalmos Pathogenic rs1063735 RCV002460354
Irido-corneo-trabecular dysgenesis Pathogenic rs2514235402 RCV002460353
Martsolf syndrome 1 Likely pathogenic rs188397648, rs2514162911, rs2514163537, rs1324454897, rs2514156770, rs2514156784, rs2514157003, rs2514159829, rs2122336841 RCV002305655
RCV002305656
RCV002305660
RCV002305667
RCV002305668
RCV002305669
RCV002305670
RCV002305671
RCV002305672
Neurodevelopmental disorder Likely pathogenic; Pathogenic rs2056190516, rs2514161964 RCV002273230
RCV003225665
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Anophthalmia Uncertain significance rs2514235207 RCV002460355
Breast ductal adenocarcinoma Uncertain significance rs869312173 RCV000207060
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Carcinogenesis Associate 32457342
Carcinogenesis Inhibit 37995182
Carcinoma Hepatocellular Associate 30107175
Colorectal Neoplasms Associate 24465899
Endometrial Neoplasms Associate 32457342
Glioma Associate 27560795, 31734653
Hypoxia Stimulate 27560795
Hypoxia Brain Associate 27560795
Idiopathic Pulmonary Fibrosis Inhibit 29995590
Intervertebral Disc Displacement Associate 36516886