Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2909
Gene name Gene Name - the full gene name approved by the HGNC.
Rho GTPase activating protein 35
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ARHGAP35
Synonyms (NCBI Gene) Gene synonyms aliases
GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.32
Summary Summary of gene provided in NCBI Entrez Gene.
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequence
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047266 hsa-miR-181b-5p CLASH 23622248
MIRT038489 hsa-miR-296-3p CLASH 23622248
MIRT613638 hsa-miR-6768-3p HITS-CLIP 23824327
MIRT613637 hsa-miR-6501-3p HITS-CLIP 23824327
MIRT613636 hsa-miR-5196-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001843 Process Neural tube closure IEA
GO:0003677 Function DNA binding IEA
GO:0003924 Function GTPase activity IEA
GO:0005096 Function GTPase activator activity IDA 19673492
GO:0005096 Function GTPase activator activity TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605277 4591 ENSG00000160007
Protein
UniProt ID Q9NRY4
Protein name Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)
Protein function Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRK
PDB 2K85 , 3C5H , 3FK2 , 6PXC , 6WAY , 8DGQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 154 249 Ras family Domain
PF16512 RhoGAP-FF1 261 340 p190-A and -B Rho GAPs FF domain Domain
PF01846 FF 487 547 FF domain Family
PF00620 RhoGAP 1262 1413 RhoGAP domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in neutrophils (at protein level). {ECO:0000269|PubMed:1894621}.
Sequence
MMMARKQDVRIPTYNISVVGLSGTEKEKGQCGIGKSCLCNRFVRPSADEFHLDHTSVLST
SDFGGRVVNNDHFLYWGEVSRSLEDCVECKMHIVEQTEFIDDQTFQPHRSTALQPYIKRA
AATKLASAEKLMYFCTDQLGLEQDFEQKQMPDGKLLVDGFLLGIDVSRGMNRNFDDQLKF
VSNLYNQLAKTKKPIVVVLTKCDEGVERYIRDAHTFALSKKNLQVVETSARSNVNVDLAF
STLVQLIDK
SRGKTKIIPYFEALKQQSQQIATAKDKYEWLVSRIVKNHNENWLSVSRKMQ
ASPEYQDYVYLEGTQKAKKLFLQHIHRLKHEHIERRRKLY
LAALPLAFEALIPNLDEIDH
LSCIKAKKLLETKPEFLKWFVVLEETPWDATSHIDNMENERIPFDLMDTVPAEQLYEAHL
EKLRNERKRVEMRRAFKENLETSPFITPGKPWEEARSFIMNEDFYQWLEESVYMDIYGKH
QKQIIDKAKEEFQELLLEYSELFYELELDAKPSKEKMGVIQDVLGEEQRFKALQKLQAER
DALILKH
IHFVYHPTKETCPSCPACVDAKIEHLISSRFIRPSDRNQKNSLSDPNIDRINL
VILGKDGLARELANEIRALCTNDDKYVIDGKMYELSLRPIEGNVRLPVNSFQTPTFQPHG
CLCLYNSKESLSYVVESIEKSRESTLGRRDNHLVHLPLTLILVNKRGDTSGETLHSLIQQ
GQQIASKLQCVFLDPASAGIGYGRNINEKQISQVLKGLLDSKRNLNLVSSTASIKDLADV
DLRIVMCLMCGDPFSADDILFPVLQSQTCKSSHCGSNNSVLLELPIGLHKKRIELSVLSY
HSSFSIRKSRLVHGYIVFYSAKRKASLAMLRAFLCEVQDIIPIQLVALTDGAVDVLDNDL
SREQLTEGEEIAQEIDGRFTSIPCSQPQHKLEIFHPFFKDVVEKKNIIEATHMYDNAAEA
CSTTEEVFNSPRAGSPLCNSNLQDSEEDIEPSYSLFREDTSLPSLSKDHSKLSMELEGND
GLSFIMSNFESKLNNKVPPPVKPKPPVHFEITKGDLSYLDQGHRDGQRKSVSSSPWLPQD
GFDPSDYAEPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQSNGSGNGSDSEMDT
SSLERGRKVSIVSKPVLYRTRCTRLGRFASYRTSFSVGSDDELGPIRKKEEDQASQGYKG
DNAVIPYETDEDPRRRNILRSLRRNTKKPKPKPRPSITKATWESNYFGVPLTTVVTPEKP
IPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGA
MKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLN
KVSHNNKVNLMTSENLSICFWPTLMRPDFSTMD
ALTATRTYQTIIELFIQQCPFFFYNRP
ITEPPGARPSSPSAVASTVPFLTSTPVTSQPSPPQSPPPTPQSPMQPLLPSQLQAEHTL
Sequence length 1499
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Focal adhesion
Platelet activation
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
  Rho GTPase cycle
Sema4D mediated inhibition of cell attachment and migration
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
27158780
Unknown
Disease term Disease name Evidence References Source
Multiple Congenital Anomalies multiple congenital anomalies/dysmorphic syndrome GenCC
Neurodevelopmental Disorders complex neurodevelopmental disorder, neurodevelopmental disorder GenCC
Associations from Text Mining
Disease Name Relationship Type References
Carcinogenesis Associate 32457342
Carcinogenesis Inhibit 37995182
Carcinoma Hepatocellular Associate 30107175
Colorectal Neoplasms Associate 24465899
Endometrial Neoplasms Associate 32457342
Glioma Associate 27560795, 31734653
Hypoxia Stimulate 27560795
Hypoxia Brain Associate 27560795
Idiopathic Pulmonary Fibrosis Inhibit 29995590
Intervertebral Disc Displacement Associate 36516886