Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	29088
Gene name	Mitochondrial ribosomal protein L15
Gene symbol	MRPL15
Synonyms (NCBI Gene)	HSPC145L15mtMRP-L15MRP-L7RPML7uL15m
Chromosome	8
Chromosome location	8q11.23
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052376	hsa-let-7a-5p	CLASH	23622248
MIRT2045380	hsa-miR-3689a-3p	CLIP-seq
MIRT2045381	hsa-miR-3689c	CLIP-seq
MIRT2045382	hsa-miR-4768-5p	CLIP-seq
MIRT2045383	hsa-miR-635	CLIP-seq
MIRT2274417	hsa-miR-1299	CLIP-seq
MIRT2274418	hsa-miR-184	CLIP-seq
MIRT2274419	hsa-miR-2115	CLIP-seq
MIRT2274420	hsa-miR-3148	CLIP-seq
MIRT2274421	hsa-miR-3189-3p	CLIP-seq
MIRT2274422	hsa-miR-3647-3p	CLIP-seq
MIRT2274423	hsa-miR-4475	CLIP-seq
MIRT2274424	hsa-miR-4681	CLIP-seq
MIRT2274425	hsa-miR-4712-5p	CLIP-seq
MIRT2274426	hsa-miR-4769-3p	CLIP-seq
MIRT2274427	hsa-miR-4789-5p	CLIP-seq
MIRT2274428	hsa-miR-4804-5p	CLIP-seq
MIRT2274429	hsa-miR-499-3p	CLIP-seq
MIRT2274430	hsa-miR-499a-3p	CLIP-seq
MIRT2274431	hsa-miR-502-5p	CLIP-seq
MIRT2274432	hsa-miR-516a-3p	CLIP-seq
MIRT2274433	hsa-miR-548a-5p	CLIP-seq
MIRT2274434	hsa-miR-548ab	CLIP-seq
MIRT2274435	hsa-miR-548ak	CLIP-seq
MIRT2274436	hsa-miR-548b-5p	CLIP-seq
MIRT2274437	hsa-miR-548c-5p	CLIP-seq
MIRT2274438	hsa-miR-548d-5p	CLIP-seq
MIRT2274439	hsa-miR-548h	CLIP-seq
MIRT2274440	hsa-miR-548i	CLIP-seq
MIRT2274441	hsa-miR-548j	CLIP-seq
MIRT2274442	hsa-miR-548n	CLIP-seq
MIRT2274443	hsa-miR-548w	CLIP-seq
MIRT2274444	hsa-miR-548y	CLIP-seq
MIRT2274445	hsa-miR-559	CLIP-seq
MIRT2274446	hsa-miR-587	CLIP-seq
MIRT2274447	hsa-miR-770-5p	CLIP-seq
MIRT2274448	hsa-miR-802	CLIP-seq
MIRT2274449	hsa-miR-875-3p	CLIP-seq
MIRT2454463	hsa-miR-4316	CLIP-seq
MIRT2454464	hsa-miR-4726-3p	CLIP-seq
MIRT2454465	hsa-miR-548b-3p	CLIP-seq
MIRT2454463	hsa-miR-4316	CLIP-seq
MIRT2454464	hsa-miR-4726-3p	CLIP-seq
MIRT2454465	hsa-miR-548b-3p	CLIP-seq
MIRT2274417	hsa-miR-1299	CLIP-seq
MIRT2573293	hsa-miR-145	CLIP-seq
MIRT2573294	hsa-miR-205	CLIP-seq
MIRT2274420	hsa-miR-3148	CLIP-seq
MIRT2573295	hsa-miR-3157-5p	CLIP-seq
MIRT2274422	hsa-miR-3647-3p	CLIP-seq
MIRT2454463	hsa-miR-4316	CLIP-seq
MIRT2274423	hsa-miR-4475	CLIP-seq
MIRT2573296	hsa-miR-4690-3p	CLIP-seq
MIRT2274425	hsa-miR-4712-5p	CLIP-seq
MIRT2454464	hsa-miR-4726-3p	CLIP-seq
MIRT2274427	hsa-miR-4789-5p	CLIP-seq
MIRT2274429	hsa-miR-499-3p	CLIP-seq
MIRT2274430	hsa-miR-499a-3p	CLIP-seq
MIRT2274433	hsa-miR-548a-5p	CLIP-seq
MIRT2274434	hsa-miR-548ab	CLIP-seq
MIRT2274435	hsa-miR-548ak	CLIP-seq
MIRT2454465	hsa-miR-548b-3p	CLIP-seq
MIRT2274436	hsa-miR-548b-5p	CLIP-seq
MIRT2274437	hsa-miR-548c-5p	CLIP-seq
MIRT2274438	hsa-miR-548d-5p	CLIP-seq
MIRT2274439	hsa-miR-548h	CLIP-seq
MIRT2274440	hsa-miR-548i	CLIP-seq
MIRT2274441	hsa-miR-548j	CLIP-seq
MIRT2274442	hsa-miR-548n	CLIP-seq
MIRT2274443	hsa-miR-548w	CLIP-seq
MIRT2274444	hsa-miR-548y	CLIP-seq
MIRT2274445	hsa-miR-559	CLIP-seq
MIRT2274447	hsa-miR-770-5p	CLIP-seq
MIRT2274448	hsa-miR-802	CLIP-seq
MIRT2274449	hsa-miR-875-3p	CLIP-seq
MIRT2274417	hsa-miR-1299	CLIP-seq
MIRT2573293	hsa-miR-145	CLIP-seq
MIRT2573294	hsa-miR-205	CLIP-seq
MIRT2274419	hsa-miR-2115	CLIP-seq
MIRT2274420	hsa-miR-3148	CLIP-seq
MIRT2573295	hsa-miR-3157-5p	CLIP-seq
MIRT2274421	hsa-miR-3189-3p	CLIP-seq
MIRT2274422	hsa-miR-3647-3p	CLIP-seq
MIRT2454463	hsa-miR-4316	CLIP-seq
MIRT2274423	hsa-miR-4475	CLIP-seq
MIRT2573296	hsa-miR-4690-3p	CLIP-seq
MIRT2274425	hsa-miR-4712-5p	CLIP-seq
MIRT2454464	hsa-miR-4726-3p	CLIP-seq
MIRT2274427	hsa-miR-4789-5p	CLIP-seq
MIRT2274429	hsa-miR-499-3p	CLIP-seq
MIRT2274430	hsa-miR-499a-3p	CLIP-seq
MIRT2274431	hsa-miR-502-5p	CLIP-seq
MIRT2274432	hsa-miR-516a-3p	CLIP-seq
MIRT2274433	hsa-miR-548a-5p	CLIP-seq
MIRT2274434	hsa-miR-548ab	CLIP-seq
MIRT2274435	hsa-miR-548ak	CLIP-seq
MIRT2454465	hsa-miR-548b-3p	CLIP-seq
MIRT2274436	hsa-miR-548b-5p	CLIP-seq
MIRT2274437	hsa-miR-548c-5p	CLIP-seq
MIRT2274438	hsa-miR-548d-5p	CLIP-seq
MIRT2274439	hsa-miR-548h	CLIP-seq
MIRT2274440	hsa-miR-548i	CLIP-seq
MIRT2274441	hsa-miR-548j	CLIP-seq
MIRT2274442	hsa-miR-548n	CLIP-seq
MIRT2274443	hsa-miR-548w	CLIP-seq
MIRT2274444	hsa-miR-548y	CLIP-seq
MIRT2274445	hsa-miR-559	CLIP-seq
MIRT2274447	hsa-miR-770-5p	CLIP-seq
MIRT2274448	hsa-miR-802	CLIP-seq
MIRT2274449	hsa-miR-875-3p	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	28892042
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005762	Component	Mitochondrial large ribosomal subunit	IBA
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	25278503, 28892042
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	25278503
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611828	14054	ENSG00000137547

Q9P015

Protein name

Large ribosomal subunit protein uL15m (39S ribosomal protein L15, mitochondrial) (L15mt) (MRP-L15)

PDB

3J7Y , 3J9M , 5OOL , 5OOM , 6I9R , 6NU2 , 6NU3 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5H , 7A5I , 7A5J , 7A5K , 7L08 , 7L20 , 7O9K , 7O9M , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF2 , 7OF3 , 7OF4 , 7OF5 , 7OF6 , 7OF7 , 7OG4 , 7OI6 , 7OI7 , 7OI8 , 7OI9 , 7OIA , 7OIB , 7OIC , 7OID , 7OIE , 7PD3 , 7PO4 , 7QH6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00828	Ribosomal_L27A	45 → 176	Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A	Family

Sequence

MAGPLQGGGARALDLLRGLPRVSLANLKPNPGSKKPERRPRGRRRGRKCGRGHKGERQRG
TRPRLGFEGGQTPFYIRIPKYGFNEGHSFRRQYKPLSLNRLQYLIDLGRVDPSQPIDLTQ
LVNGRGVTIQPLKRDYGVQLVEEGADTFTAKVNIEVQLASELAIAAIEKNGGVVTTAFYD
PRSLDIVCKPVPFFLRGQPIPKRMLPPEELVPYYTDAKNRGYLADPAKFPEARLELARKY
GYILPDITKDELFKMLCTRKDPRQIFFGLAPGWVVNMADKKILKPTDENLLKYYTS

Sequence length

296

Interactions

View interactions

	KEGG		Reactome
	Ribosome		Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC LYMPHOCYTIC LEUKEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	34016794, 35788655	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Associate	33934540	★★★★★ ★☆☆☆☆ Found in Text Mining only
Musculoskeletal Diseases	Associate	35788655	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	33934540	★★★★★ ★☆☆☆☆ Found in Text Mining only

MRPL15 (mitochondrial ribosomal protein L15)