CCDC59 (coiled-coil domain containing 59)

Gene

• Entrez ID: 29080
• Gene name: Coiled-coil domain containing 59
• Gene symbol: CCDC59
• Synonyms (NCBI Gene): BR22, HSPC128, TAP26
• Chromosome: 12
• Chromosome location: 12q21.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019739	hsa-miR-375	Microarray	20215506
MIRT030420	hsa-miR-24-3p	Microarray	19748357
MIRT051306	hsa-miR-16-5p	CLASH	23622248
MIRT711772	hsa-miR-216a-5p	HITS-CLIP	19536157
MIRT711771	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT711770	hsa-miR-5582-5p	HITS-CLIP	19536157
MIRT711769	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT711768	hsa-miR-128-3p	HITS-CLIP	19536157
MIRT711767	hsa-miR-216a-3p	HITS-CLIP	19536157
MIRT711766	hsa-miR-3681-3p	HITS-CLIP	19536157
MIRT711765	hsa-miR-3065-3p	HITS-CLIP	19536157
MIRT711764	hsa-miR-383-3p	HITS-CLIP	19536157
MIRT711763	hsa-miR-4269	HITS-CLIP	19536157
MIRT711762	hsa-miR-6715b-5p	HITS-CLIP	19536157
MIRT711761	hsa-miR-5693	HITS-CLIP	19536157
MIRT711760	hsa-miR-4645-5p	HITS-CLIP	19536157
MIRT711759	hsa-miR-4673	HITS-CLIP	19536157
MIRT711758	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT711757	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT711756	hsa-miR-4755-3p	HITS-CLIP	19536157
MIRT711755	hsa-miR-4284	HITS-CLIP	19536157
MIRT030420	hsa-miR-24-3p	HITS-CLIP	19536157
MIRT711754	hsa-miR-1972	HITS-CLIP	19536157
MIRT711753	hsa-miR-6895-5p	HITS-CLIP	19536157
MIRT442571	hsa-miR-548u	PAR-CLIP	22100165
MIRT442570	hsa-miR-7161-5p	PAR-CLIP	22100165
MIRT442569	hsa-miR-936	PAR-CLIP	22100165
MIRT442568	hsa-miR-199a-3p	PAR-CLIP	22100165
MIRT442567	hsa-miR-199b-3p	PAR-CLIP	22100165
MIRT442566	hsa-miR-3129-5p	PAR-CLIP	22100165
MIRT442565	hsa-miR-4797-3p	PAR-CLIP	22100165
MIRT442564	hsa-miR-137	PAR-CLIP	22100165
MIRT442563	hsa-miR-222-5p	PAR-CLIP	22100165
MIRT442562	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT711772	hsa-miR-216a-5p	HITS-CLIP	19536157
MIRT711771	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT711770	hsa-miR-5582-5p	HITS-CLIP	19536157
MIRT711769	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT711768	hsa-miR-128-3p	HITS-CLIP	19536157
MIRT711767	hsa-miR-216a-3p	HITS-CLIP	19536157
MIRT711766	hsa-miR-3681-3p	HITS-CLIP	19536157
MIRT711765	hsa-miR-3065-3p	HITS-CLIP	19536157
MIRT711764	hsa-miR-383-3p	HITS-CLIP	19536157
MIRT711763	hsa-miR-4269	HITS-CLIP	19536157
MIRT711762	hsa-miR-6715b-5p	HITS-CLIP	19536157
MIRT711761	hsa-miR-5693	HITS-CLIP	19536157
MIRT711760	hsa-miR-4645-5p	HITS-CLIP	19536157
MIRT711759	hsa-miR-4673	HITS-CLIP	19536157
MIRT711758	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT711757	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT711756	hsa-miR-4755-3p	HITS-CLIP	19536157
MIRT711755	hsa-miR-4284	HITS-CLIP	19536157
MIRT030420	hsa-miR-24-3p	HITS-CLIP	19536157
MIRT711754	hsa-miR-1972	HITS-CLIP	19536157
MIRT711753	hsa-miR-6895-5p	HITS-CLIP	19536157
MIRT442571	hsa-miR-548u	PAR-CLIP	22100165
MIRT442570	hsa-miR-7161-5p	PAR-CLIP	22100165
MIRT442569	hsa-miR-936	PAR-CLIP	22100165
MIRT442568	hsa-miR-199a-3p	PAR-CLIP	22100165
MIRT442567	hsa-miR-199b-3p	PAR-CLIP	22100165
MIRT442566	hsa-miR-3129-5p	PAR-CLIP	22100165
MIRT442565	hsa-miR-4797-3p	PAR-CLIP	22100165
MIRT442564	hsa-miR-137	PAR-CLIP	22100165
MIRT442563	hsa-miR-222-5p	PAR-CLIP	22100165
MIRT442562	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT869328	hsa-miR-1271	CLIP-seq
MIRT869329	hsa-miR-145	CLIP-seq
MIRT869330	hsa-miR-182	CLIP-seq
MIRT869331	hsa-miR-31	CLIP-seq
MIRT869332	hsa-miR-3192	CLIP-seq
MIRT869333	hsa-miR-3612	CLIP-seq
MIRT869334	hsa-miR-3689a-3p	CLIP-seq
MIRT869335	hsa-miR-3689c	CLIP-seq
MIRT869336	hsa-miR-3908	CLIP-seq
MIRT869337	hsa-miR-3942-5p	CLIP-seq
MIRT869338	hsa-miR-409-3p	CLIP-seq
MIRT869339	hsa-miR-4272	CLIP-seq
MIRT869340	hsa-miR-4277	CLIP-seq
MIRT869341	hsa-miR-4420	CLIP-seq
MIRT869342	hsa-miR-4650-5p	CLIP-seq
MIRT869343	hsa-miR-4666-5p	CLIP-seq
MIRT869344	hsa-miR-4703-5p	CLIP-seq
MIRT869345	hsa-miR-4728-5p	CLIP-seq
MIRT869346	hsa-miR-4731-5p	CLIP-seq
MIRT869347	hsa-miR-4756-3p	CLIP-seq
MIRT869348	hsa-miR-4766-3p	CLIP-seq
MIRT869349	hsa-miR-4795-3p	CLIP-seq
MIRT869350	hsa-miR-548b-3p	CLIP-seq
MIRT869351	hsa-miR-548l	CLIP-seq
MIRT869352	hsa-miR-548n	CLIP-seq
MIRT869353	hsa-miR-635	CLIP-seq
MIRT869354	hsa-miR-650	CLIP-seq
MIRT869355	hsa-miR-96	CLIP-seq
MIRT1957933	hsa-miR-1253	CLIP-seq
MIRT1957934	hsa-miR-3611	CLIP-seq
MIRT869341	hsa-miR-4420	CLIP-seq
MIRT1957935	hsa-miR-4469	CLIP-seq
MIRT1957936	hsa-miR-4528	CLIP-seq
MIRT1957937	hsa-miR-4733-5p	CLIP-seq
MIRT1957938	hsa-miR-493	CLIP-seq
MIRT1957939	hsa-miR-587	CLIP-seq
MIRT1957940	hsa-miR-758	CLIP-seq
MIRT869329	hsa-miR-145	CLIP-seq
MIRT2194910	hsa-miR-2682	CLIP-seq
MIRT2194911	hsa-miR-3117-5p	CLIP-seq
MIRT2194912	hsa-miR-3145-3p	CLIP-seq
MIRT2194913	hsa-miR-3151	CLIP-seq
MIRT2194914	hsa-miR-3170	CLIP-seq
MIRT869332	hsa-miR-3192	CLIP-seq
MIRT869333	hsa-miR-3612	CLIP-seq
MIRT869334	hsa-miR-3689a-3p	CLIP-seq
MIRT869335	hsa-miR-3689c	CLIP-seq
MIRT869336	hsa-miR-3908	CLIP-seq
MIRT869337	hsa-miR-3942-5p	CLIP-seq
MIRT869340	hsa-miR-4277	CLIP-seq
MIRT2194915	hsa-miR-4318	CLIP-seq
MIRT869341	hsa-miR-4420	CLIP-seq
MIRT2194916	hsa-miR-4447	CLIP-seq
MIRT2194917	hsa-miR-4472	CLIP-seq
MIRT2194918	hsa-miR-449c	CLIP-seq
MIRT1957936	hsa-miR-4528	CLIP-seq
MIRT869342	hsa-miR-4650-5p	CLIP-seq
MIRT869344	hsa-miR-4703-5p	CLIP-seq
MIRT869345	hsa-miR-4728-5p	CLIP-seq
MIRT869346	hsa-miR-4731-5p	CLIP-seq
MIRT869348	hsa-miR-4766-3p	CLIP-seq
MIRT2194919	hsa-miR-491-5p	CLIP-seq
MIRT869350	hsa-miR-548b-3p	CLIP-seq
MIRT1957939	hsa-miR-587	CLIP-seq
MIRT869354	hsa-miR-650	CLIP-seq
MIRT2194920	hsa-miR-922	CLIP-seq
MIRT2194921	hsa-miR-940	CLIP-seq
MIRT1957937	hsa-miR-4733-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	11152647, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS

Other IDs

• MIM: 619280
• HGNC: 25005
• e!Ensembl: ENSG00000133773

Protein

• UniProt ID: Q9P031
• Protein name: Thyroid transcription factor 1-associated protein 26 (TTF-1-associated protein 26) (Coiled-coil domain-containing protein 59) (TTF-1-associated protein BR2)
• Protein function: Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities. {ECO:0000269|PubMed:12882447, ECO:0000269|PubMed:1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08524	rRNA_processing	50 → 240	rRNA processing	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed. In lung, expression is restricted to the alveolar epithelial cells. {ECO:0000269|PubMed:11152647}.
• Sequence:

  MAPVRRSAKWRPGGIEARGEGVSTVGYRNKNVRQKTWRPNHPQAFVGSVREGQGFAFRRK
  LKIQQSYKKLLRKEKKAQTSLESQFTDRYPDNLKHLYLAEEERHRKQARKVDHPLSEQVH
  QPLLEEQCSIDEPLFEDQCSFDQPQPEEQCIKTVNSFTIPKKNKKKTSNQKAQEEYEQIQ
  AKRAAKKQEFERRKQEREEAQRQYKKKKMEVFKILNKKTKKGQPNLNVQMEYLLQKIQEK
  C

• Sequence length: 241

Pathways

Reactome:

Surfactant metabolism