Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2904
Gene name Gene Name - the full gene name approved by the HGNC.	Glutamate ionotropic receptor NMDA type subunit 2B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GRIN2B
Synonyms (NCBI Gene) Gene synonyms aliases	DEE27, EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p13.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The

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SNP ID	Visualize variation	Clinical significance	Consequence
rs138771137	G>A	Conflicting-interpretations-of-pathogenicity, benign, likely-benign	Synonymous variant, coding sequence variant
rs141109968	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs199526748	T>C	Conflicting-interpretations-of-pathogenicity	Missense variant, genic upstream transcript variant, coding sequence variant
rs199707487	G>A,T	Likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Synonymous variant, genic upstream transcript variant, coding sequence variant
rs200608452	G>A	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, genic upstream transcript variant, coding sequence variant
rs201439880	G>A,C	Pathogenic	Stop gained, synonymous variant, coding sequence variant
rs201672517	T>C	Conflicting-interpretations-of-pathogenicity	Missense variant, genic upstream transcript variant, coding sequence variant
rs202223470	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, genic upstream transcript variant, coding sequence variant
rs374746622	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs375217280	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs387906636	G>A	Pathogenic	Intron variant, missense variant, coding sequence variant
rs398122823	->G	Likely-pathogenic, pathogenic	Genic upstream transcript variant, frameshift variant, coding sequence variant
rs398122824	T>C	Pathogenic	Splice acceptor variant
rs796052578	G>-	Likely-pathogenic	Frameshift variant, coding sequence variant
rs797044849	C>A,G,T	Likely-pathogenic, pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs864309560	G>T	Pathogenic	Missense variant, coding sequence variant
rs869312669	T>G	Uncertain-significance, pathogenic	Coding sequence variant, intron variant, missense variant
rs876661055	A>G	Pathogenic-likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs876661064	G>A	Likely-pathogenic	5 prime UTR variant, coding sequence variant, missense variant
rs876661076	T>G	Likely-pathogenic	Coding sequence variant, missense variant
rs876661102	TTC>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs876661167	C>T	Uncertain-significance, pathogenic	Coding sequence variant, missense variant
rs876661219	A>C,G	Likely-pathogenic, pathogenic	Coding sequence variant, intron variant, missense variant
rs879253931	G>A	Pathogenic	Coding sequence variant, stop gained
rs879254013	T>G	Likely-pathogenic	Coding sequence variant, missense variant
rs886041095	C>T	Likely-pathogenic	Coding sequence variant, intron variant, missense variant
rs1057518520	->GAGC	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1057518800	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1057518988	T>C	Likely-pathogenic	Intron variant, missense variant, coding sequence variant
rs1057519611	C>A,T	Likely-pathogenic, pathogenic	Splice donor variant, genic upstream transcript variant
rs1057519612	T>C	Pathogenic	Splice acceptor variant
rs1060499526	GT>-	Pathogenic	Frameshift variant, genic upstream transcript variant, coding sequence variant
rs1064794979	C>T	Pathogenic	Missense variant, coding sequence variant
rs1064796752	G>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1085307547	C>A,T	Likely-pathogenic	Stop gained, missense variant, coding sequence variant
rs1168374610	C>A,G	Likely-pathogenic	Coding sequence variant, missense variant
rs1555101670	TG>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555102552	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1555103150	C>G,T	Pathogenic	Missense variant, coding sequence variant
rs1555103159	T>C	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs1555103646	C>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1555103652	A>C	Likely-pathogenic	Initiator codon variant, missense variant, coding sequence variant
rs1555103971	C>T	Pathogenic, likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant, intron variant
rs1555103995	G>-	Pathogenic	Frameshift variant, coding sequence variant, intron variant
rs1555133006	CA>-	Pathogenic	Frameshift variant, coding sequence variant, genic upstream transcript variant
rs1555133077	C>A	Pathogenic	Stop gained, coding sequence variant, genic upstream transcript variant
rs1565453023	AT>-	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1565457924	C>T	Likely-pathogenic	Missense variant, coding sequence variant, intron variant
rs1591605498	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs1591605549	->G	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1591606580	A>T	Pathogenic	Stop gained, coding sequence variant
rs1591609065	->A	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1591609136	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1591611001	A>C	Likely-pathogenic	5 prime UTR variant, coding sequence variant, missense variant
rs1591612223	T>C	Pathogenic	Intron variant
rs1591612317	T>C	Likely-pathogenic	Missense variant, intron variant, coding sequence variant
rs1591612370	->GGTGAGAAGTCATTAGGTCTCTGGAACTGG	Likely-pathogenic	Intron variant, splice acceptor variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT623746	hsa-miR-126-3p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT657587	hsa-miR-3184-3p	HITS-CLIP	23824327
MIRT657585	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT657584	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT668055	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT668054	hsa-miR-5699-5p	HITS-CLIP	23824327
MIRT668053	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT668052	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT657583	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT623745	hsa-miR-6502-3p	HITS-CLIP	23824327
MIRT623744	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT623743	hsa-miR-1470	HITS-CLIP	23824327
MIRT623742	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT623741	hsa-miR-4469	HITS-CLIP	23824327
MIRT623740	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT623739	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT623738	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT623737	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT634656	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT623736	hsa-miR-495-5p	HITS-CLIP	23824327
MIRT623735	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT657582	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT623734	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT623746	hsa-miR-126-3p	HITS-CLIP	23824327
MIRT657591	hsa-miR-3614-3p	HITS-CLIP	23824327
MIRT657590	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT657589	hsa-miR-4297	HITS-CLIP	23824327
MIRT657588	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT657587	hsa-miR-3184-3p	HITS-CLIP	23824327
MIRT657586	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT657585	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT657584	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT657583	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT623745	hsa-miR-6502-3p	HITS-CLIP	23824327
MIRT623744	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT623741	hsa-miR-4469	HITS-CLIP	23824327
MIRT623740	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT623737	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT634656	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT623736	hsa-miR-495-5p	HITS-CLIP	23824327
MIRT623735	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT657582	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT623734	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT623744	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT623743	hsa-miR-1470	HITS-CLIP	23824327
MIRT623742	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT623741	hsa-miR-4469	HITS-CLIP	23824327
MIRT623739	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT623738	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT623737	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT634656	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT623740	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT523392	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT523387	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT523384	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT636493	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT636492	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT623746	hsa-miR-126-3p	HITS-CLIP	23824327
MIRT636491	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT636490	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT636489	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT623745	hsa-miR-6502-3p	HITS-CLIP	23824327
MIRT623744	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT623743	hsa-miR-1470	HITS-CLIP	23824327
MIRT623742	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT623741	hsa-miR-4469	HITS-CLIP	23824327
MIRT623737	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT634656	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT623740	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT623746	hsa-miR-126-3p	HITS-CLIP	23824327
MIRT523392	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT523387	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT523384	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT623745	hsa-miR-6502-3p	HITS-CLIP	23824327
MIRT623744	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT623743	hsa-miR-1470	HITS-CLIP	23824327
MIRT623742	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT623741	hsa-miR-4469	HITS-CLIP	23824327
MIRT623740	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT623739	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT623738	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT623737	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT623736	hsa-miR-495-5p	HITS-CLIP	23824327
MIRT623735	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT623734	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT523392	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT523387	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT523384	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT523392	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT523387	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT523384	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT523392	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT523391	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT523390	hsa-miR-567	PAR-CLIP	21572407
MIRT523389	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT523388	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT523387	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT523386	hsa-miR-3924	PAR-CLIP	21572407
MIRT523385	hsa-miR-297	PAR-CLIP	21572407
MIRT523384	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT537030	hsa-miR-1179	PAR-CLIP	22012620
MIRT537029	hsa-miR-6858-3p	PAR-CLIP	22012620
MIRT537028	hsa-miR-4267	PAR-CLIP	22012620
MIRT537027	hsa-miR-7110-3p	PAR-CLIP	22012620
MIRT537026	hsa-miR-6817-3p	PAR-CLIP	22012620
MIRT537025	hsa-miR-1199-5p	PAR-CLIP	22012620
MIRT537024	hsa-miR-6751-3p	PAR-CLIP	22012620
MIRT537023	hsa-miR-6873-3p	PAR-CLIP	22012620
MIRT537022	hsa-miR-4303	PAR-CLIP	22012620
MIRT537021	hsa-miR-6807-5p	PAR-CLIP	22012620
MIRT537019	hsa-miR-4768-5p	PAR-CLIP	22012620
MIRT537020	hsa-miR-6833-3p	PAR-CLIP	22012620
MIRT523392	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT523391	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT523390	hsa-miR-567	PAR-CLIP	23446348
MIRT523389	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT523388	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT523387	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT523386	hsa-miR-3924	PAR-CLIP	23446348
MIRT523385	hsa-miR-297	PAR-CLIP	23446348
MIRT523384	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT732627	hsa-miR-223-3p	RNA-seq	31775160
MIRT623746	hsa-miR-126-3p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT657587	hsa-miR-3184-3p	HITS-CLIP	23824327
MIRT657585	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT657584	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT668055	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT668054	hsa-miR-5699-5p	HITS-CLIP	23824327
MIRT668053	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT668052	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT657583	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT623745	hsa-miR-6502-3p	HITS-CLIP	23824327
MIRT623744	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT623743	hsa-miR-1470	HITS-CLIP	23824327
MIRT623742	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT623741	hsa-miR-4469	HITS-CLIP	23824327
MIRT623740	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT623739	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT623738	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT623737	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT634656	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT623736	hsa-miR-495-5p	HITS-CLIP	23824327
MIRT623735	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT657582	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT623734	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT623746	hsa-miR-126-3p	HITS-CLIP	23824327
MIRT657591	hsa-miR-3614-3p	HITS-CLIP	23824327
MIRT657590	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT657589	hsa-miR-4297	HITS-CLIP	23824327
MIRT657588	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT657587	hsa-miR-3184-3p	HITS-CLIP	23824327
MIRT657586	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT657585	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT657584	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT657583	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT623745	hsa-miR-6502-3p	HITS-CLIP	23824327
MIRT623744	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT623741	hsa-miR-4469	HITS-CLIP	23824327
MIRT623740	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT623737	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT634656	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT623736	hsa-miR-495-5p	HITS-CLIP	23824327
MIRT623735	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT657582	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT623734	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT623744	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT623743	hsa-miR-1470	HITS-CLIP	23824327
MIRT623742	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT623741	hsa-miR-4469	HITS-CLIP	23824327
MIRT623739	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT623738	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT623737	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT634656	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT623740	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT523392	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT523387	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT523384	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT636493	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT636492	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT623746	hsa-miR-126-3p	HITS-CLIP	23824327
MIRT636491	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT636490	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT636489	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT623745	hsa-miR-6502-3p	HITS-CLIP	23824327
MIRT623744	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT623743	hsa-miR-1470	HITS-CLIP	23824327
MIRT623742	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT623741	hsa-miR-4469	HITS-CLIP	23824327
MIRT623737	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT634656	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT623740	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT623746	hsa-miR-126-3p	HITS-CLIP	23824327
MIRT523392	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT523387	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT523384	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT623745	hsa-miR-6502-3p	HITS-CLIP	23824327
MIRT623744	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT623743	hsa-miR-1470	HITS-CLIP	23824327
MIRT623742	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT623741	hsa-miR-4469	HITS-CLIP	23824327
MIRT623740	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT623739	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT623738	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT623737	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT623736	hsa-miR-495-5p	HITS-CLIP	23824327
MIRT623735	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT623734	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT523392	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT523387	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT523384	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT523392	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT614963	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT523387	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT614962	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT523384	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT523392	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT523391	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT523390	hsa-miR-567	PAR-CLIP	21572407
MIRT523389	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT523388	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT523387	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT523386	hsa-miR-3924	PAR-CLIP	21572407
MIRT523385	hsa-miR-297	PAR-CLIP	21572407
MIRT523384	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT537030	hsa-miR-1179	PAR-CLIP	22012620
MIRT537029	hsa-miR-6858-3p	PAR-CLIP	22012620
MIRT537028	hsa-miR-4267	PAR-CLIP	22012620
MIRT537027	hsa-miR-7110-3p	PAR-CLIP	22012620
MIRT537026	hsa-miR-6817-3p	PAR-CLIP	22012620
MIRT537025	hsa-miR-1199-5p	PAR-CLIP	22012620
MIRT537024	hsa-miR-6751-3p	PAR-CLIP	22012620
MIRT537023	hsa-miR-6873-3p	PAR-CLIP	22012620
MIRT537022	hsa-miR-4303	PAR-CLIP	22012620
MIRT537021	hsa-miR-6807-5p	PAR-CLIP	22012620
MIRT537019	hsa-miR-4768-5p	PAR-CLIP	22012620
MIRT537020	hsa-miR-6833-3p	PAR-CLIP	22012620
MIRT523392	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT523391	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT523390	hsa-miR-567	PAR-CLIP	23446348
MIRT523389	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT523388	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT523387	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT523386	hsa-miR-3924	PAR-CLIP	23446348
MIRT523385	hsa-miR-297	PAR-CLIP	23446348
MIRT523384	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT2006802	hsa-miR-3120-5p	CLIP-seq
MIRT2006803	hsa-miR-3187-3p	CLIP-seq
MIRT2006804	hsa-miR-374c	CLIP-seq
MIRT2006805	hsa-miR-4529-5p	CLIP-seq
MIRT2006806	hsa-miR-4742-3p	CLIP-seq
MIRT2006807	hsa-miR-4802-3p	CLIP-seq
MIRT2006808	hsa-miR-655	CLIP-seq
MIRT2388774	hsa-miR-331-3p	CLIP-seq
MIRT2388775	hsa-miR-370	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
HDAC1	Activation	19081374

Show/Hide all(93)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	NAS	26719327
GO:0004972	Function	NMDA glutamate receptor activity	IBA
GO:0004972	Function	NMDA glutamate receptor activity	IDA	24272827, 26919761, 38538865
GO:0004972	Function	NMDA glutamate receptor activity	IEA
GO:0004972	Function	NMDA glutamate receptor activity	ISS
GO:0004972	Function	NMDA glutamate receptor activity	TAS	8768735, 17526495
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005515	Function	Protein binding	IPI	11937501, 17047094, 17997397, 19453375, 20018661, 24550280, 28130356, 30126976, 34321660, 35914814
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS	17526495
GO:0005764	Component	Lysosome	IEA
GO:0005764	Component	Lysosome	ISS
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IEA
GO:0005770	Component	Late endosome	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	26875626, 26919761, 27839871
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	NAS	34321660
GO:0005886	Component	Plasma membrane	TAS	8768735
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0007215	Process	Glutamate receptor signaling pathway	TAS	8768735
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	10485705
GO:0007420	Process	Brain development	NAS	17526495
GO:0007611	Process	Learning or memory	ISS
GO:0007611	Process	Learning or memory	TAS	10485705
GO:0008270	Function	Zinc ion binding	ISS
GO:0009986	Component	Cell surface	ISS	17526495
GO:0014069	Component	Postsynaptic density	ISS
GO:0015276	Function	Ligand-gated monoatomic ion channel activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016594	Function	Glycine binding	IDA	17047094
GO:0016595	Function	Glutamate binding	ISS
GO:0017146	Component	NMDA selective glutamate receptor complex	IBA
GO:0017146	Component	NMDA selective glutamate receptor complex	IDA	10480938, 17047094, 26875626, 26919761
GO:0017146	Component	NMDA selective glutamate receptor complex	IEA
GO:0017146	Component	NMDA selective glutamate receptor complex	IPI	34321660
GO:0017146	Component	NMDA selective glutamate receptor complex	ISS
GO:0017146	Component	NMDA selective glutamate receptor complex	TAS	17526495
GO:0019722	Process	Calcium-mediated signaling	IEA
GO:0022849	Function	Glutamate-gated calcium ion channel activity	IDA	26875626
GO:0022849	Function	Glutamate-gated calcium ion channel activity	IMP	27839871
GO:0030425	Component	Dendrite	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0035235	Process	Ionotropic glutamate receptor signaling pathway	ISS
GO:0035235	Process	Ionotropic glutamate receptor signaling pathway	NAS	34321660
GO:0035249	Process	Synaptic transmission, glutamatergic	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0042391	Process	Regulation of membrane potential	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	ISS
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	ISS
GO:0045211	Component	Postsynaptic membrane	NAS	15317856
GO:0045211	Component	Postsynaptic membrane	TAS	24607229
GO:0045471	Process	Response to ethanol	IDA	18445116
GO:0045471	Process	Response to ethanol	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048167	Process	Regulation of synaptic plasticity	ISS
GO:0048167	Process	Regulation of synaptic plasticity	ISS
GO:0048167	Process	Regulation of synaptic plasticity	NAS	17526495
GO:0048168	Process	Regulation of neuronal synaptic plasticity	NAS	15003177
GO:0051290	Process	Protein heterotetramerization	ISS
GO:0051968	Process	Positive regulation of synaptic transmission, glutamatergic	ISS
GO:0051968	Process	Positive regulation of synaptic transmission, glutamatergic	NAS	15003177
GO:0060079	Process	Excitatory postsynaptic potential	IBA
GO:0060291	Process	Long-term synaptic potentiation	IBA
GO:0097060	Component	Synaptic membrane	ISS
GO:0097553	Process	Calcium ion transmembrane import into cytosol	IDA	26875626
GO:0097553	Process	Calcium ion transmembrane import into cytosol	IEA
GO:0097553	Process	Calcium ion transmembrane import into cytosol	IMP	27839871
GO:0098655	Process	Monoatomic cation transmembrane transport	IDA	24272827, 38538865
GO:0098655	Process	Monoatomic cation transmembrane transport	IDA	38538865
GO:0098655	Process	Monoatomic cation transmembrane transport	ISS
GO:0098655	Process	Monoatomic cation transmembrane transport	NAS	34321660
GO:0098839	Component	Postsynaptic density membrane	IBA
GO:0098976	Process	Excitatory chemical synaptic transmission	NAS	17526495
GO:0099505	Process	Regulation of presynaptic membrane potential	IEA
GO:0099507	Function	Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA	19666514
GO:0099507	Function	Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP	19666514
GO:0099507	Function	Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	NAS	19666514
GO:1902951	Process	Negative regulation of dendritic spine maintenance	ISS
GO:1904062	Process	Regulation of monoatomic cation transmembrane transport	ISS
GO:1904062	Process	Regulation of monoatomic cation transmembrane transport	NAS	34321660
GO:1904315	Function	Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA
GO:2000463	Process	Positive regulation of excitatory postsynaptic potential	ISS
GO:2000463	Process	Positive regulation of excitatory postsynaptic potential	NAS	15003177

MIM	HGNC	e!Ensembl
138252	4586	ENSG00000273079

Protein

UniProt ID

Q13224

Protein name

Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)

Protein function

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626,

PDB

5EWJ , 5EWL , 5EWM , 7EU8 , 7KL0 , 7KL1 , 7KL2 , 7UIS , 7UJP , 7UJQ , 7UJR , 7UJS , 7UJT , 8VUU , 8VUV , 9D37 , 9D38 , 9D39 , 9D3A , 9D3B , 9D3C

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01094	ANF_receptor	60 → 371	Receptor family ligand binding region	Family
PF10613	Lig_chan-Glu_bd	404 → 542	Ligated ion channel L-glutamate- and glycine-binding site	Domain
PF00060	Lig_chan	555 → 829	Ligand-gated ion channel	Family
PF10565	NMDAR2_C	840 → 1484	N-methyl D-aspartate receptor 2B3 C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. {ECO:0000269|PubMed:9547169}.

Sequence

MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN
LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD
RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA
RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV

Sequence length

1484

Interactions

View interactions

	KEGG		Reactome
	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment Long-term potentiation Glutamatergic synapse Dopaminergic synapse Alzheimer disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Amphetamine addiction Nicotine addiction Alcoholism Systemic lupus erythematosus		EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation RAF/MAP kinase cascade Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors

Show/Hide Causal Diseases (2)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Developmental And Epileptic Encephalopathy	Developmental and epileptic encephalopathy, 27	rs1135401799, rs397514556, rs1591638805, rs672601376, rs879253931, rs774592932, rs1060499659, rs672601377, rs1591609136, rs886041295, rs876661151	N/A
Mental retardation	intellectual disability, Intellectual disability, autosomal dominant 6	rs398122823, rs1555110818, rs876661064, rs1591612317, rs1057519004, rs397514556, rs796052571, rs876661151, rs1591612370, rs1057518700, rs1135401799, rs1555110843, rs876661041, rs763436882, rs774592932 View all (33 more)	N/A

Show/Hide Unknown Diseases (12)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Anxiety Disorder	Anxiety	N/A	N/A	GWAS
Barrett esophagus	Barrett's esophagus	N/A	N/A	GWAS
Epileptic encephalopathy	epileptic encephalopathy	N/A	N/A	ClinVar
Infantile Spasms	infantile spasms	N/A	N/A	GenCC
Keratoconus	Keratoconus	N/A	N/A	GWAS
Landau-Kleffner Syndrome	landau-kleffner syndrome	N/A	N/A	ClinVar
Mental Depression	Major depressive disorder	N/A	N/A	GWAS
Myopia	Myopia	N/A	N/A	GWAS
Neurodevelopmental Disorders	complex neurodevelopmental disorder	N/A	N/A	GenCC
Non-Syndromic Intellectual Disability	autosomal dominant non-syndromic intellectual disability	N/A	N/A	GenCC
Schizophrenia	Schizophrenia	N/A	N/A	GWAS
seizure	Seizure	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (97)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Akathisia Drug Induced	Associate	23226551
Alcohol Related Disorders	Associate	35893069
Alcoholism	Associate	19736238, 27498914
Alzheimer Disease	Inhibit	15287897
Alzheimer Disease	Associate	20197096, 20882066, 22800732, 33522999, 35246269, 36006974, 37930868, 39210294
Androgen Insensitivity Syndrome	Associate	24863970
Anti N Methyl D Aspartate Receptor Encephalitis	Associate	23648631, 32771066
Anxiety	Associate	29921740
Attention Deficit and Disruptive Behavior Disorders	Inhibit	29864525
Attention Deficit Disorder with Hyperactivity	Associate	17010153, 23718928, 34440367, 34923109, 37578679, 37667328
Auditory Perceptual Disorders	Associate	17010153, 34440367
Autism Spectrum Disorder	Associate	21572417, 22495309, 22833210, 23160955, 27616045, 32918531, 34615535, 34726335, 37031308, 37414777
Autism Spectrum Disorder	Stimulate	32193494
Autistic Disorder	Associate	25656819, 32918531
Basal Ganglia Diseases	Associate	35393335
Bipolar Disorder	Associate	16380905, 18007143, 24490167
Brain Diseases	Associate	25014031, 34212862
Brain Injury Chronic	Stimulate	36224339
Breast Neoplasms	Associate	22037257
Brunner Syndrome	Associate	34923109
Carcinoma Non Small Cell Lung	Associate	21639937
Carcinoma Renal Cell	Associate	23462807
Carcinoma Squamous Cell	Associate	21639937
Central Nervous System Diseases	Associate	35186144
Cholangiocarcinoma	Associate	22446083
Cognition Disorders	Associate	21281445, 35843716
Colorectal Neoplasms	Associate	35512400
Delirium	Associate	39210294
Depressive Disorder	Associate	29921740
Developmental Disabilities	Associate	27086544, 30168177, 34726335, 35393335, 35893069, 36450799, 36758276
Diabetes Mellitus Type 1	Associate	33029194, 33827531
Disease	Associate	22833210, 34726335, 35893069
Disruptive Impulse Control and Conduct Disorders	Associate	17010153, 23718928, 25896831
Dyslexia	Associate	28839234, 37667328, 40424442
Epilepsies Partial	Associate	27029629
Epilepsy	Associate	15030493, 27839871, 28273943, 28837158, 34247411, 34726335, 35393335, 35893069, 37385334
Epilepsy Temporal Lobe	Associate	20197096, 29864525
Esophageal Neoplasms	Associate	35879265
Fabry Disease	Associate	40233852
Focal Cortical Dysplasia	Associate	10961623
Food Addiction	Associate	22433450
Frailty	Associate	30475886
Glaucoma Open Angle	Associate	25893192
Heredodegenerative Disorders Nervous System	Associate	27839871, 29937144
Huntington Disease	Associate	10217265, 26148071
Hyperkinesis	Associate	23718928, 34440367
Hyperkinesis	Inhibit	35246269
Hyperplasia	Associate	30543306
Hypokinesia	Associate	23226551
Hypothyroidism	Inhibit	35186144
Hypoxia Ischemia Brain	Associate	38015765
Intellectual Disability	Associate	22833210, 27839871, 28228639, 29937144, 34247411, 36450799, 36758276, 37385334
Intestinal Diseases	Associate	32705857
Iron Overload	Associate	34057756
Irritable Bowel Syndrome	Associate	32705857
Lafora Disease	Associate	34212862
Language Disorders	Associate	29937144
Lennox Gastaut Syndrome	Associate	35893069
Lymphoma Large B Cell Diffuse	Associate	18288132
Macular dystrophy corneal type 1	Associate	35393335
Malformations of Cortical Development	Associate	10961623, 24613745, 28377535, 35393335
Megalencephaly	Associate	23160955, 35893069
Memory Disorders	Associate	21281445
Mental Disorders	Associate	22521361, 23718928, 24795156, 28228639, 28558131
Mental Retardation Autosomal Recessive 1	Associate	35893069
Microcephaly	Associate	23160955
Mood Disorders	Associate	32705857
Multiple Sclerosis	Associate	35008743
Muscle Hypotonia	Associate	28228639, 36758276
Neoplasms	Associate	18288132, 21639937, 26447864
Neoplasms	Inhibit	35993362
Nerve Degeneration	Associate	32771066, 38015765
Nerve Degeneration	Stimulate	39684851
Neuralgia	Associate	36224339
Neurodegenerative Diseases	Associate	25893192, 28837158, 35110392
Neurologic Manifestations	Associate	28228639
Neurotoxicity Syndromes	Stimulate	15749123
Night blindness congenital stationary	Stimulate	35246269
Obsessive Compulsive Disorder	Associate	19324536, 22433450, 36641432
Osteoarthritis	Associate	30031924
Pain	Associate	36224339
Paraneoplastic Syndromes	Associate	32771066
Parkinson Disease	Associate	25896831, 26627941, 36006974
Phosphoenolpyruvate carboxykinase deficiency	Associate	24863970
Pulmonary Arterial Hypertension	Associate	30543306
Sarcoma Kaposi	Associate	35393335
Schizophrenia	Associate	21281445, 22833210, 27616045, 36641432, 8613785
Seizures	Associate	15030493, 23782156, 27839871
Sleep Bruxism	Associate	39684851
Sleep Wake Disorders	Associate	23718928
Smith Magenis Syndrome	Associate	24863970
Spasms Infantile	Associate	35893069
Status Epilepticus	Associate	24613745
Stomach Neoplasms	Associate	18158559
Teratoma	Associate	20930449, 32771066
Thyroid Diseases	Associate	35186144
Vision Disorders	Associate	26350515

GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B)