Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2900
Gene name Gene Name - the full gene name approved by the HGNC.	Glutamate ionotropic receptor kainate type subunit 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GRIK4
Synonyms (NCBI Gene) Gene synonyms aliases	EAA1, GRIK, GluK4, GluK4-2, KA1
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane

Show/Hide all(2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1954787	T>C	Benign, drug-response	Intron variant, genic upstream transcript variant
rs869312699	CTGGCGCAGGAGGCC>GCT	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, inframe deletion

Show/Hide all(98)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017088	hsa-miR-335-5p	Microarray	18185580
MIRT048273	hsa-miR-196a-5p	CLASH	23622248
MIRT625181	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT625180	hsa-miR-4511	HITS-CLIP	23824327
MIRT625179	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT625177	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625174	hsa-miR-3686	HITS-CLIP	23824327
MIRT625173	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT625172	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625181	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT625180	hsa-miR-4511	HITS-CLIP	23824327
MIRT625179	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625177	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625174	hsa-miR-3686	HITS-CLIP	23824327
MIRT625173	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT625172	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT625181	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT625180	hsa-miR-4511	HITS-CLIP	23824327
MIRT625179	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT625177	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625174	hsa-miR-3686	HITS-CLIP	23824327
MIRT625173	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT625172	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625181	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT625180	hsa-miR-4511	HITS-CLIP	23824327
MIRT625179	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625177	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625174	hsa-miR-3686	HITS-CLIP	23824327
MIRT625173	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT625172	hsa-miR-4652-3p	HITS-CLIP	23824327

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8263508
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0007215	Process	Glutamate receptor signaling pathway	IEA
GO:0007215	Process	Glutamate receptor signaling pathway	TAS	8263508
GO:0007268	Process	Chemical synaptic transmission	TAS	8263508
GO:0015276	Function	Ligand-gated monoatomic ion channel activity	IEA
GO:0015277	Function	Kainate selective glutamate receptor activity	IBA
GO:0015277	Function	Kainate selective glutamate receptor activity	TAS	8263508
GO:0016020	Component	Membrane	IEA
GO:0032983	Component	Kainate selective glutamate receptor complex	IBA
GO:0032983	Component	Kainate selective glutamate receptor complex	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0035235	Process	Ionotropic glutamate receptor signaling pathway	IEA
GO:0035249	Process	Synaptic transmission, glutamatergic	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0042734	Component	Presynaptic membrane	IBA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IBA
GO:0060078	Process	Regulation of postsynaptic membrane potential	IEA
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IBA
GO:0099505	Process	Regulation of presynaptic membrane potential	IEA
GO:0099507	Function	Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA	20026616
GO:0099507	Function	Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA
GO:0099507	Function	Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP	20026616
GO:0099507	Function	Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	NAS	20026616
GO:1904315	Function	Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA

MIM	HGNC	e!Ensembl
600282	4582	ENSG00000149403

Protein

UniProt ID

Q16099

Protein name

Glutamate receptor ionotropic, kainate 4 (GluK4) (Excitatory amino acid receptor 1) (EAA1) (Glutamate receptor KA-1) (KA1)

Protein function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel. Cannot form functional channels on its own (PubMed:8263508). Shows channel activity only in heteromeric assembly with GRIK1, GRIK2 and GRIK3 subunits (B

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01094	ANF_receptor	41 → 385	Receptor family ligand binding region	Family
PF10613	Lig_chan-Glu_bd	416 → 530	Ligated ion channel L-glutamate- and glycine-binding site	Domain
PF00060	Lig_chan	544 → 816	Ligand-gated ion channel	Family

Sequence

MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLG
KAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFK
VAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR
QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY
YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG
PALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT
GHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVV
TTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANG
TWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL
DPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFP
VGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA
DQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF
LLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILK
RKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVS
VCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQ
LAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWEKTTNSSEPE

Sequence length

956

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Glutamatergic synapse		Activation of Ca-permeable Kainate Receptor

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Attention Deficit Hyperactivity Disorder	Attention deficit hyperactivity disorder	N/A	N/A	GWAS
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Arthritis Rheumatoid	Associate	24812308
Autism Spectrum Disorder	Associate	22543975
Autistic Disorder	Associate	31844109
Bipolar Disorder	Associate	18824690
Cerebral Palsy	Associate	34098570
Chromosome Aberrations	Associate	18824690
Cognition Disorders	Associate	32245654
Coronary Artery Disease	Associate	24812308
Depressive Disorder	Associate	32245654
Depressive Disorder Major	Associate	32245654
Disease	Associate	31844109
Epilepsy Temporal Lobe	Associate	22698689
Intellectual Disability	Associate	18824690, 31844109
Learning Disabilities	Associate	18824690
Melanoma	Associate	24189654
Neoplasms	Associate	20061814, 28631555
Neurodegenerative Diseases	Associate	32245654
Schizophrenia	Associate	18824690, 29032150, 31844109

GRIK4 (glutamate ionotropic receptor kainate type subunit 4)