Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	2900
Gene name	Glutamate ionotropic receptor kainate type subunit 4
Gene symbol	GRIK4
Synonyms (NCBI Gene)	EAA1GRIKGluK4GluK4-2KA1
Chromosome	11
Chromosome location	11q23.3
Summary	This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane

Show/Hide all (2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1954787	T>C	Benign, drug-response	Intron variant, genic upstream transcript variant
rs869312699	CTGGCGCAGGAGGCC>GCT	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, inframe deletion

Show/Hide all (98)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017088	hsa-miR-335-5p	Microarray	18185580
MIRT048273	hsa-miR-196a-5p	CLASH	23622248
MIRT625181	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT625180	hsa-miR-4511	HITS-CLIP	23824327
MIRT625179	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT625177	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625174	hsa-miR-3686	HITS-CLIP	23824327
MIRT625173	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT625172	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625181	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT625180	hsa-miR-4511	HITS-CLIP	23824327
MIRT625179	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625177	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625174	hsa-miR-3686	HITS-CLIP	23824327
MIRT625173	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT625172	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT625181	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT625180	hsa-miR-4511	HITS-CLIP	23824327
MIRT625179	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT625177	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625174	hsa-miR-3686	HITS-CLIP	23824327
MIRT625173	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT625172	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625189	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625188	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625187	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625186	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625185	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625184	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625183	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625182	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT625181	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT625180	hsa-miR-4511	HITS-CLIP	23824327
MIRT625179	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT625178	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT625177	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT625176	hsa-miR-4775	HITS-CLIP	23824327
MIRT625175	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT625174	hsa-miR-3686	HITS-CLIP	23824327
MIRT625173	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT625172	hsa-miR-4652-3p	HITS-CLIP	23824327

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8263508
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0007215	Process	Glutamate receptor signaling pathway	IEA
GO:0007215	Process	Glutamate receptor signaling pathway	TAS	8263508
GO:0007268	Process	Chemical synaptic transmission	TAS	8263508
GO:0015276	Function	Ligand-gated monoatomic ion channel activity	IEA
GO:0015277	Function	Kainate selective glutamate receptor activity	IBA
GO:0015277	Function	Kainate selective glutamate receptor activity	TAS	8263508
GO:0016020	Component	Membrane	IEA
GO:0032983	Component	Kainate selective glutamate receptor complex	IBA
GO:0032983	Component	Kainate selective glutamate receptor complex	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0035235	Process	Ionotropic glutamate receptor signaling pathway	IEA
GO:0035249	Process	Synaptic transmission, glutamatergic	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0042734	Component	Presynaptic membrane	IBA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IBA
GO:0060078	Process	Regulation of postsynaptic membrane potential	IEA
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IBA
GO:0099505	Process	Regulation of presynaptic membrane potential	IEA
GO:0099507	Function	Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA	20026616
GO:0099507	Function	Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA
GO:0099507	Function	Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP	20026616
GO:0099507	Function	Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	NAS	20026616
GO:1904315	Function	Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA

MIM	HGNC	e!Ensembl
600282	4582	ENSG00000149403

Q16099

Protein name

Glutamate receptor ionotropic, kainate 4 (GluK4) (Excitatory amino acid receptor 1) (EAA1) (Glutamate receptor KA-1) (KA1)

Protein function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel. Cannot form functional channels on its own (PubMed:8263508). Shows channel activity only in heteromeric assembly with GRIK1, GRIK2 and GRIK3 subunits (B

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01094	ANF_receptor	41 → 385	Receptor family ligand binding region	Family
PF10613	Lig_chan-Glu_bd	416 → 530	Ligated ion channel L-glutamate- and glycine-binding site	Domain
PF00060	Lig_chan	544 → 816	Ligand-gated ion channel	Family

Sequence

MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLG
KAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFK
VAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR
QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY
YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG
PALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT
GHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVV
TTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANG
TWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL
DPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFP
VGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA
DQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF
LLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILK
RKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVS
VCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQ
LAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWEKTTNSSEPE

Sequence length

956

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Glutamatergic synapse		Activation of Ca-permeable Kainate Receptor

GRIK4 (glutamate ionotropic receptor kainate type subunit 4)