Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	290
Gene name	Alanyl aminopeptidase, membrane
Gene symbol	ANPEP
Synonyms (NCBI Gene)	AP-MAP-NAPNCD13GP150LAP1P150PEPNhAPN
Chromosome	15
Chromosome location	15q26.1
Summary	Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastri

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Show/Hide all (143)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005211	hsa-miR-30a-5p	pSILAC	18668040
MIRT001389	hsa-miR-1-3p	pSILAC	18668040
MIRT020955	hsa-miR-155-5p	Proteomics	18668040
MIRT022990	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT001389	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT005211	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT030575	hsa-miR-24-3p	Microarray	19748357
MIRT031867	hsa-miR-16-5p	Proteomics	18668040
MIRT786199	hsa-miR-1587	CLIP-seq
MIRT786200	hsa-miR-299-3p	CLIP-seq
MIRT786201	hsa-miR-3192	CLIP-seq
MIRT786202	hsa-miR-3652	CLIP-seq
MIRT786203	hsa-miR-3689a-3p	CLIP-seq
MIRT786204	hsa-miR-3689c	CLIP-seq
MIRT786205	hsa-miR-3689d	CLIP-seq
MIRT786206	hsa-miR-3907	CLIP-seq
MIRT786207	hsa-miR-3925-5p	CLIP-seq
MIRT786208	hsa-miR-4269	CLIP-seq
MIRT786209	hsa-miR-4417	CLIP-seq
MIRT786210	hsa-miR-4430	CLIP-seq
MIRT786211	hsa-miR-4492	CLIP-seq
MIRT786212	hsa-miR-4498	CLIP-seq
MIRT786213	hsa-miR-4514	CLIP-seq
MIRT786214	hsa-miR-4643	CLIP-seq
MIRT786215	hsa-miR-4656	CLIP-seq
MIRT786216	hsa-miR-4675	CLIP-seq
MIRT786217	hsa-miR-4692	CLIP-seq
MIRT786218	hsa-miR-4728-5p	CLIP-seq
MIRT786219	hsa-miR-4741	CLIP-seq
MIRT786220	hsa-miR-4742-5p	CLIP-seq
MIRT786221	hsa-miR-513a-5p	CLIP-seq
MIRT786222	hsa-miR-642b	CLIP-seq
MIRT786223	hsa-miR-661	CLIP-seq
MIRT786224	hsa-miR-762	CLIP-seq
MIRT2435353	hsa-miR-125a-5p	CLIP-seq
MIRT2435354	hsa-miR-125b	CLIP-seq
MIRT2435355	hsa-miR-1273	CLIP-seq
MIRT2435356	hsa-miR-1291	CLIP-seq
MIRT786199	hsa-miR-1587	CLIP-seq
MIRT2435357	hsa-miR-1908	CLIP-seq
MIRT2435358	hsa-miR-1915	CLIP-seq
MIRT2435359	hsa-miR-2355-3p	CLIP-seq
MIRT2435360	hsa-miR-24	CLIP-seq
MIRT2435361	hsa-miR-3126-3p	CLIP-seq
MIRT2435362	hsa-miR-3135	CLIP-seq
MIRT2435363	hsa-miR-3135b	CLIP-seq
MIRT2435364	hsa-miR-3141	CLIP-seq
MIRT2435365	hsa-miR-3176	CLIP-seq
MIRT2435366	hsa-miR-3184	CLIP-seq
MIRT2435367	hsa-miR-328	CLIP-seq
MIRT2435368	hsa-miR-3622b-5p	CLIP-seq
MIRT786202	hsa-miR-3652	CLIP-seq
MIRT2435369	hsa-miR-378g	CLIP-seq
MIRT2435370	hsa-miR-3922-3p	CLIP-seq
MIRT786207	hsa-miR-3925-5p	CLIP-seq
MIRT2435371	hsa-miR-423-5p	CLIP-seq
MIRT2435372	hsa-miR-4254	CLIP-seq
MIRT2435373	hsa-miR-4284	CLIP-seq
MIRT2435374	hsa-miR-4308	CLIP-seq
MIRT2435375	hsa-miR-4319	CLIP-seq
MIRT2435376	hsa-miR-4323	CLIP-seq
MIRT2435377	hsa-miR-4324	CLIP-seq
MIRT786209	hsa-miR-4417	CLIP-seq
MIRT786210	hsa-miR-4430	CLIP-seq
MIRT2435378	hsa-miR-4486	CLIP-seq
MIRT2435379	hsa-miR-4487	CLIP-seq
MIRT786211	hsa-miR-4492	CLIP-seq
MIRT786212	hsa-miR-4498	CLIP-seq
MIRT786213	hsa-miR-4514	CLIP-seq
MIRT2435380	hsa-miR-4633-3p	CLIP-seq
MIRT2435381	hsa-miR-4642	CLIP-seq
MIRT2435382	hsa-miR-4646-3p	CLIP-seq
MIRT2435383	hsa-miR-4649-5p	CLIP-seq
MIRT2435384	hsa-miR-4650-5p	CLIP-seq
MIRT786215	hsa-miR-4656	CLIP-seq
MIRT2435385	hsa-miR-4659a-5p	CLIP-seq
MIRT2435386	hsa-miR-4659b-5p	CLIP-seq
MIRT786216	hsa-miR-4675	CLIP-seq
MIRT2435387	hsa-miR-4685-5p	CLIP-seq
MIRT2435388	hsa-miR-4690-3p	CLIP-seq
MIRT786217	hsa-miR-4692	CLIP-seq
MIRT2435389	hsa-miR-4732-3p	CLIP-seq
MIRT786219	hsa-miR-4741	CLIP-seq
MIRT2435390	hsa-miR-4755-3p	CLIP-seq
MIRT786221	hsa-miR-513a-5p	CLIP-seq
MIRT2435391	hsa-miR-552	CLIP-seq
MIRT2435392	hsa-miR-663	CLIP-seq
MIRT2435393	hsa-miR-670	CLIP-seq
MIRT2435394	hsa-miR-676	CLIP-seq
MIRT786224	hsa-miR-762	CLIP-seq
MIRT2435395	hsa-miR-764	CLIP-seq
MIRT2435396	hsa-miR-767-3p	CLIP-seq
MIRT2435360	hsa-miR-24	CLIP-seq
MIRT786207	hsa-miR-3925-5p	CLIP-seq
MIRT2435373	hsa-miR-4284	CLIP-seq
MIRT786213	hsa-miR-4514	CLIP-seq
MIRT786217	hsa-miR-4692	CLIP-seq
MIRT786221	hsa-miR-513a-5p	CLIP-seq
MIRT786199	hsa-miR-1587	CLIP-seq
MIRT2435359	hsa-miR-2355-3p	CLIP-seq
MIRT2435360	hsa-miR-24	CLIP-seq
MIRT2435363	hsa-miR-3135b	CLIP-seq
MIRT2435366	hsa-miR-3184	CLIP-seq
MIRT786202	hsa-miR-3652	CLIP-seq
MIRT786207	hsa-miR-3925-5p	CLIP-seq
MIRT2435371	hsa-miR-423-5p	CLIP-seq
MIRT2435373	hsa-miR-4284	CLIP-seq
MIRT786209	hsa-miR-4417	CLIP-seq
MIRT786210	hsa-miR-4430	CLIP-seq
MIRT786211	hsa-miR-4492	CLIP-seq
MIRT786212	hsa-miR-4498	CLIP-seq
MIRT786213	hsa-miR-4514	CLIP-seq
MIRT2435382	hsa-miR-4646-3p	CLIP-seq
MIRT786215	hsa-miR-4656	CLIP-seq
MIRT786216	hsa-miR-4675	CLIP-seq
MIRT786217	hsa-miR-4692	CLIP-seq
MIRT786219	hsa-miR-4741	CLIP-seq
MIRT786221	hsa-miR-513a-5p	CLIP-seq
MIRT2435394	hsa-miR-676	CLIP-seq
MIRT786224	hsa-miR-762	CLIP-seq
MIRT2675059	hsa-miR-1197	CLIP-seq
MIRT786199	hsa-miR-1587	CLIP-seq
MIRT2435359	hsa-miR-2355-3p	CLIP-seq
MIRT2435360	hsa-miR-24	CLIP-seq
MIRT2435363	hsa-miR-3135b	CLIP-seq
MIRT2435366	hsa-miR-3184	CLIP-seq
MIRT786202	hsa-miR-3652	CLIP-seq
MIRT786207	hsa-miR-3925-5p	CLIP-seq
MIRT2435371	hsa-miR-423-5p	CLIP-seq
MIRT2435373	hsa-miR-4284	CLIP-seq
MIRT786209	hsa-miR-4417	CLIP-seq
MIRT786210	hsa-miR-4430	CLIP-seq
MIRT786211	hsa-miR-4492	CLIP-seq
MIRT786212	hsa-miR-4498	CLIP-seq
MIRT786213	hsa-miR-4514	CLIP-seq
MIRT2435382	hsa-miR-4646-3p	CLIP-seq
MIRT786215	hsa-miR-4656	CLIP-seq
MIRT786216	hsa-miR-4675	CLIP-seq
MIRT786217	hsa-miR-4692	CLIP-seq
MIRT786219	hsa-miR-4741	CLIP-seq
MIRT786221	hsa-miR-513a-5p	CLIP-seq
MIRT2435394	hsa-miR-676	CLIP-seq
MIRT786224	hsa-miR-762	CLIP-seq

Show/Hide all (3)

Transcription factor	Regulation	Reference
ETS1	Activation	14507917
ETS2	Activation	14507917
MYB	Unknown	10477683

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001618	Function	Virus receptor activity	IEA
GO:0002003	Process	Angiotensin maturation	IBA
GO:0002003	Process	Angiotensin maturation	IEA
GO:0004177	Function	Aminopeptidase activity	IEA
GO:0004177	Function	Aminopeptidase activity	TAS	10734069
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	25645918
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IDA	15308636
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	2564851
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	TAS	2564851
GO:0008270	Function	Zinc ion binding	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016285	Function	Alanyl aminopeptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0038023	Function	Signaling receptor activity	TAS	1350662
GO:0043171	Process	Peptide catabolic process	IBA
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070006	Function	Metalloaminopeptidase activity	IBA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0070062	Component	Extracellular exosome	IDA	15326289, 21082674

MIM	HGNC	e!Ensembl
151530	500	ENSG00000166825

P15144

Protein name

Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13)

Protein function

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, suc

PDB

4FYQ , 4FYR , 4FYS , 4FYT , 5LHD , 6ATK , 6U7E , 6U7F , 6U7G , 6XWD , 7AEW , 7VPQ , 8WDE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17900	Peptidase_M1_N	81 → 279		Domain
PF01433	Peptidase_M1	316 → 543	Peptidase family M1 domain	Domain
PF11838	ERAP1_C	619 → 946	ERAP1-like C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also express

Sequence

MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPA
SATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVI
IIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDS
EFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHP
KDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLI
RIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLV
TYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYL
GADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKG
ASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIM
NRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY
WLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQ
IINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKN
YLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM
ENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWI
LNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSN
LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQ
WFTENSK

Sequence length

967

Interactions

View interactions

	KEGG		Reactome
	Glutathione metabolism Metabolic pathways Renin-angiotensin system Hematopoietic cell lineage		Neutrophil degranulation

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
ANPEP-related disorder	Likely benign	rs143245843, rs144282919, rs146926671	RCV003919476 RCV003930733 RCV003940613
Cholangiocarcinoma	Benign	rs17240268	RCV005920446
Colorectal cancer	Benign	rs17240268	RCV005920445
Ovarian serous cystadenocarcinoma	Likely benign	rs144282919	RCV005904801

Show/Hide Text Mining Associations (110)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acne Vulgaris	Associate	16778789
Adenocarcinoma	Associate	25879366
Adenomatous Polyposis Coli	Inhibit	36748835
Anemia Refractory with Excess of Blasts	Stimulate	20662087
Arthritis	Associate	7829125
Arthritis Rheumatoid	Associate	12355480, 25219368, 8099341
Asthma	Associate	34198852
Ataxia Telangiectasia	Associate	23687089
Atypical Squamous Cells of the Cervix	Associate	35938646
Autoimmune Diseases	Associate	16778789
Barrett Esophagus	Associate	17636545
Bone Marrow Diseases	Associate	2049307
Breast Neoplasms	Associate	28160560, 7907609
Bronchiolitis Obliterans Syndrome	Associate	17925486
Carcinoma Hepatocellular	Associate	16189153, 20448342, 27121124, 28572700, 29630108, 32662250, 38022651
Carcinoma Merkel Cell	Associate	30993371
Carcinoma Non Small Cell Lung	Associate	25879366, 34633989
Carcinoma Renal Cell	Associate	16985214, 23019229, 25926002, 7743667, 7829125, 9486416, 9587627
Carcinoma Renal Cell	Inhibit	18216146
Carcinoma Squamous Cell	Associate	25879366
Cardiovascular Diseases	Inhibit	31152980
Cholangiocarcinoma	Associate	16189153
Choriocarcinoma	Associate	7961121
Colonic Neoplasms	Associate	9587627
Colorectal Neoplasms	Associate	19236378, 23721165, 30753380, 36748835
Colorectal Neoplasms	Inhibit	34285715
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	36748835
COVID 19	Associate	32199615, 32581077, 32894568, 37574128, 40168094
Cystic Fibrosis	Associate	10853863
Drug Hypersensitivity	Associate	18336727
Epilepsy Tonic Clonic	Associate	14632756
Esophageal Neoplasms	Associate	32356485
Fibrosarcoma	Associate	1978569
Gallbladder Neoplasms	Stimulate	34876625
Heart Diseases	Associate	32174066
Heart Septal Defects Ventricular	Associate	32877226
Heavy Chain Disease	Associate	21123968
Hereditary Breast and Ovarian Cancer Syndrome	Associate	7907609
Holoprosencephaly recurrent infections and monocytosis	Associate	30334354
Hypoxia	Associate	30867055
Infections	Associate	37574128
Inflammation	Associate	16778789, 21339174, 28739875, 32581077, 37892170, 40168094
Inflammation	Stimulate	27467268
Intervertebral Disc Degeneration	Associate	31851863
Isodicentric Chromosome 15 Syndrome	Associate	19781775
Kidney Neoplasms	Associate	11173527, 18216146, 29272308, 31855296
Leukemia	Associate	15493582, 19562339, 26655501, 27634205, 3048438, 3261183, 35973983, 37892170, 7513207, 9207434
Leukemia B Cell	Associate	12521365, 19562339, 30198568
Leukemia Biphenotypic Acute	Associate	33988307, 7687860
Leukemia Hairy Cell	Associate	23347903
Leukemia Lymphocytic Chronic B Cell	Stimulate	18431797
Leukemia Lymphocytic Chronic B Cell	Associate	2049307, 22664111
Leukemia Lymphoid	Associate	8556956
Leukemia Lymphoma Adult T Cell	Associate	10435360
Leukemia Megakaryoblastic Acute	Associate	25361478
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	35283406, 36831265
Leukemia Myeloid	Associate	1675638, 2790202
Leukemia Myeloid Acute	Associate	10354136, 10781684, 10910899, 12717686, 14716122, 15493582, 16415515, 18085638, 19781775, 2364166, 24528030, 26655501, 30809981, 7579404, 7908235, 9662278 View all (1 more)
Leukemia Myelomonocytic Chronic	Associate	30334354
Leukemia Myelomonocytic Juvenile	Associate	32966606
Leukemia Prolymphocytic T Cell	Associate	22664111
Leukemia Promyelocytic Acute	Associate	12521365, 15114596, 22535601, 25045197, 9734655
Leukemia Promyelocytic Acute	Stimulate	32847610, 33301193
Leukemia T Cell	Associate	11260074
Liver Failure	Associate	16189153
Lung Diseases Interstitial	Associate	10607488
Lung Diseases Interstitial	Stimulate	13680152
Lung Neoplasms	Associate	19789337, 37073135
Lymphoma	Stimulate	30198568
Lymphoma B Cell	Associate	30198568
Lymphoma B Cell Marginal Zone	Associate	21123968
Lymphoproliferative Disorders	Associate	2049307
Malignant mesenchymal tumor	Associate	1978569
Mast Cell Activation Disorders	Associate	16144874
Melanoma	Associate	16685268, 17649820, 1978569, 29048432
Meningioma	Associate	19236378, 35212813
Mitral Valve Insufficiency	Associate	30581499
Multiple Sclerosis	Associate	10877455, 9883968
Mycosis Fungoides	Associate	17340024
Myelodysplastic Syndromes	Associate	20662087, 33462268, 33577137, 34964228, 7528567
Neoplasm Metastasis	Associate	24063007, 29328441, 7743667
Neoplasm Residual	Associate	15493582
Neoplasms	Associate	11407911, 11493472, 12554354, 16685268, 16985214, 17363734, 17363739, 17649820, 19236378, 20448342, 21339174, 21412686, 23024775, 24063007, 25879366 View all (16 more)
Neoplasms	Inhibit	18216146, 22335271
Obesity	Associate	23488598, 35692099
Oncocytoma renal	Inhibit	18216146
Osteosarcoma	Associate	33308057
Ovarian Neoplasms	Associate	32977853
Pancreatic Neoplasms	Associate	22335271
Personality Disorders	Inhibit	19236378
Philadelphia Chromosome	Associate	36858620
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	19562339, 27028865, 36951610
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	11260074, 21365622, 23975177, 28134942, 36448578, 36629681, 36951610, 8920985
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	11260074, 25246708, 30028023
Prostatic Neoplasms	Associate	11256475, 15509525, 20021671, 22075945, 34019593
Prostatic Neoplasms	Inhibit	23322201
Prostatitis	Associate	21060327
Pulmonary Arterial Hypertension	Associate	32877226
Sepsis	Associate	35681439
Small Cell Lung Carcinoma	Associate	1978569
Status Asthmaticus	Associate	12554354
Stomach Diseases	Associate	8562384
Stomach Neoplasms	Associate	26774363, 30915355
Tetra amelia with ectodermal dysplasia and lacrimal duct abnormalities	Stimulate	37156894
Thyroid Neoplasms	Associate	21412686
Urethral Neoplasms	Associate	26827254
Urinary Bladder Neoplasms	Associate	22159600, 29328441
Uterine Cervical Neoplasms	Associate	17622526, 23024775, 36768623
Vascular Diseases	Associate	13680152
Waldenstrom Macroglobulinemia	Associate	30198568

ANPEP (alanyl aminopeptidase, membrane)