MACROD1 (mono-ADP ribosylhydrolase 1)

Gene

• Entrez ID: 28992
• Gene name: Mono-ADP ribosylhydrolase 1
• Gene symbol: MACROD1
• Synonyms (NCBI Gene): LRP16
• Chromosome: 11
• Chromosome location: 11q13.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023592	hsa-miR-1-3p	Proteomics	18668040
MIRT1124998	hsa-miR-1273	CLIP-seq
MIRT1124999	hsa-miR-1910	CLIP-seq
MIRT1125000	hsa-miR-3154	CLIP-seq
MIRT1125001	hsa-miR-3179	CLIP-seq
MIRT1125002	hsa-miR-3192	CLIP-seq
MIRT1125003	hsa-miR-3621	CLIP-seq
MIRT1125004	hsa-miR-3936	CLIP-seq
MIRT1125005	hsa-miR-4281	CLIP-seq
MIRT1125006	hsa-miR-4300	CLIP-seq
MIRT1125007	hsa-miR-4330	CLIP-seq
MIRT1125008	hsa-miR-4435	CLIP-seq
MIRT1125009	hsa-miR-4449	CLIP-seq
MIRT1125010	hsa-miR-4487	CLIP-seq
MIRT1125011	hsa-miR-455-3p	CLIP-seq
MIRT1125012	hsa-miR-4651	CLIP-seq
MIRT1125013	hsa-miR-4755-3p	CLIP-seq
MIRT1125014	hsa-miR-4781-5p	CLIP-seq
MIRT1125015	hsa-miR-4783-3p	CLIP-seq
MIRT1125016	hsa-miR-608	CLIP-seq
MIRT1125017	hsa-miR-615-5p	CLIP-seq
MIRT1125018	hsa-miR-920	CLIP-seq
MIRT1125013	hsa-miR-4755-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
RARA	Repression	19698236
SP1	Activation	18206366
SPI1	Repression	19698236

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17914104, 20035625, 21483817, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	23474712
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0006974	Process	DNA damage response	IBA
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	23474712
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IDA	23474712
GO:0019213	Function	Deacetylase activity	IDA	21257746
GO:0019213	Function	Deacetylase activity	IEA
GO:0042278	Process	Purine nucleoside metabolic process	IBA
GO:0042278	Process	Purine nucleoside metabolic process	IDA	21257746
GO:0042278	Process	Purine nucleoside metabolic process	IEA
GO:0051725	Process	Protein de-ADP-ribosylation	IDA	23474712
GO:0061463	Function	O-acetyl-ADP-ribose deacetylase activity	IEA
GO:0140291	Process	Peptidyl-glutamate ADP-deribosylation	IDA	23474714
GO:0140291	Process	Peptidyl-glutamate ADP-deribosylation	IEA
GO:0140293	Function	ADP-ribosylglutamate hydrolase activity	IBA
GO:0140293	Function	ADP-ribosylglutamate hydrolase activity	IDA	23474714
GO:0140293	Function	ADP-ribosylglutamate hydrolase activity	IEA

Other IDs

• MIM: 610400
• HGNC: 29598
• e!Ensembl: ENSG00000133315

Protein

• UniProt ID: Q9BQ69
• Protein name: ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD
• Protein function: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474712, PubMed:23474714). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474712, PubMed:23474714). Deacetylates O-acet
• PDB: 2X47, 6LH4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01661	Macro	170 → 283	Macro domain	Domain

• Sequence:

  MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAG
  VGAWGAAAVGRTAGVRTWAPLAMAAKVDLSTSTDWKEAKSFLKGLSDKQREEHYFCKDFV
  RLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSDITKLEVDAIVNAANSSLLGG
  GGVDGCIHRAAGPLLTDECRTLQSCKTGKAKITGGYRLPAKYVIHTVGPIAYGEPSASQA
  AELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPCEAAAEIVLATLREWLEQHKDKVDR
  LIICVFLEKDEDIYRSRLPHYFPVA

• Sequence length: 325