Gene Gene information from NCBI Gene database.
Entrez ID 2899
Gene name Glutamate ionotropic receptor kainate type subunit 3
Gene symbol GRIK3
Synonyms (NCBI Gene)
EAA5GLR7GLUR7GluK3GluR7a
Chromosome 1
Chromosome location 1p34.3
Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are com
miRNA miRNA information provided by mirtarbase database.
569
miRTarBase ID miRNA Experiments Reference
MIRT709920 hsa-miR-4686 HITS-CLIP 19536157
MIRT709919 hsa-miR-6728-3p HITS-CLIP 19536157
MIRT709918 hsa-miR-93-3p HITS-CLIP 19536157
MIRT709917 hsa-miR-3692-5p HITS-CLIP 19536157
MIRT709916 hsa-miR-617 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
44
GO ID Ontology Definition Evidence Reference
GO:0001640 Function Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IDA 9144652
GO:0004970 Function Glutamate-gated receptor activity IDA 11124978
GO:0004970 Function Glutamate-gated receptor activity ISS
GO:0005216 Function Monoatomic ion channel activity IEA
GO:0005886 Component Plasma membrane IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
138243 4581 ENSG00000163873
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13003
Protein name Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7)
Protein function Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, le
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01094 ANF_receptor 55 401 Receptor family ligand binding region Family
PF10613 Lig_chan-Glu_bd 434 548 Ligated ion channel L-glutamate- and glycine-binding site Domain
PF00060 Lig_chan 562 832 Ligand-gated ion channel Family
Sequence
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDG
LEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPN
GTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGL
VLSVLVAV
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMACSTSLAPVFP
Sequence length 919
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Neuroactive ligand-receptor interaction
Glutamatergic synapse
  Activation of Ca-permeable Kainate Receptor
Presynaptic function of Kainate receptors
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial cancer of breast Benign rs115323841 RCV005907665
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 24369052
Autism Spectrum Disorder Associate 31844109
Autistic Disorder Associate 31844109
Carcinoma Renal Cell Associate 40149981
Colorectal Neoplasms Associate 34127015
Disease Associate 31844109
Hearing Loss Noise Induced Associate 29301492
Intellectual Disability Associate 31844109
Lymphatic Metastasis Stimulate 28631555
Neoplasms Associate 28631555