Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2899
Gene name Gene Name - the full gene name approved by the HGNC.
Glutamate ionotropic receptor kainate type subunit 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GRIK3
Synonyms (NCBI Gene) Gene synonyms aliases
EAA5, GLR7, GLUR7, GluK3, GluR7a
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.3
Summary Summary of gene provided in NCBI Entrez Gene.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are com
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT709920 hsa-miR-4686 HITS-CLIP 19536157
MIRT709919 hsa-miR-6728-3p HITS-CLIP 19536157
MIRT709918 hsa-miR-93-3p HITS-CLIP 19536157
MIRT709917 hsa-miR-3692-5p HITS-CLIP 19536157
MIRT709916 hsa-miR-617 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001640 Function Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IDA 9144652
GO:0004970 Function Ionotropic glutamate receptor activity IDA 11124978
GO:0004970 Function Ionotropic glutamate receptor activity ISS
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
138243 4581 ENSG00000163873
Protein
UniProt ID Q13003
Protein name Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7)
Protein function Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, le
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01094 ANF_receptor 55 401 Receptor family ligand binding region Family
PF10613 Lig_chan-Glu_bd 434 548 Ligated ion channel L-glutamate- and glycine-binding site Domain
PF00060 Lig_chan 562 832 Ligand-gated ion channel Family
Sequence
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDG
LEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPN
GTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGL
VLSVLVAV
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMACSTSLAPVFP
Sequence length 919
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Glutamatergic synapse
  Activation of Ca-permeable Kainate Receptor
Presynaptic function of Kainate receptors
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Lung carcinoma Small cell carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
22941189
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
16325263, 19921975, 15897672, 19995671, 19022628
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder 20052609 ClinVar
Neuroticism Neuroticism GWAS
Anxiety Disorder Anxiety Disorder GWAS
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 24369052
Autism Spectrum Disorder Associate 31844109
Autistic Disorder Associate 31844109
Carcinoma Renal Cell Associate 40149981
Colorectal Neoplasms Associate 34127015
Disease Associate 31844109
Hearing Loss Noise Induced Associate 29301492
Intellectual Disability Associate 31844109
Lymphatic Metastasis Stimulate 28631555
Neoplasms Associate 28631555