MRPS18B (mitochondrial ribosomal protein S18B)

Gene

• Entrez ID: 28973
• Gene name: Mitochondrial ribosomal protein S18B
• Gene symbol: MRPS18B
• Synonyms (NCBI Gene): C6orf14, HSPC183, HumanS18a, MRP-S18-2, MRPS18-2, PTD017, S18amt, mS40
• Chromosome: 6
• Chromosome location: 6p21.33
• Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029306	hsa-miR-26b-5p	Microarray	19088304
MIRT041787	hsa-miR-484	CLASH	23622248
MIRT040153	hsa-miR-615-3p	CLASH	23622248
MIRT317415	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT317412	hsa-miR-320a	PAR-CLIP	20371350
MIRT317413	hsa-miR-320b	PAR-CLIP	20371350
MIRT317414	hsa-miR-320c	PAR-CLIP	20371350
MIRT317416	hsa-miR-320d	PAR-CLIP	20371350
MIRT317417	hsa-miR-4429	PAR-CLIP	20371350
MIRT100247	hsa-miR-4445-3p	PAR-CLIP	20371350
MIRT100248	hsa-miR-548al	PAR-CLIP	20371350
MIRT100250	hsa-miR-4682	PAR-CLIP	20371350
MIRT564376	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT100244	hsa-miR-571	PAR-CLIP	20371350
MIRT317420	hsa-miR-8077	PAR-CLIP	20371350
MIRT100249	hsa-miR-4650-3p	PAR-CLIP	20371350
MIRT564375	hsa-miR-3529-5p	PAR-CLIP	20371350
MIRT564374	hsa-miR-379-5p	PAR-CLIP	20371350
MIRT564373	hsa-miR-4451	PAR-CLIP	20371350
MIRT317415	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT317412	hsa-miR-320a	PAR-CLIP	20371350
MIRT317413	hsa-miR-320b	PAR-CLIP	20371350
MIRT317414	hsa-miR-320c	PAR-CLIP	20371350
MIRT317416	hsa-miR-320d	PAR-CLIP	20371350
MIRT317417	hsa-miR-4429	PAR-CLIP	20371350
MIRT100247	hsa-miR-4445-3p	PAR-CLIP	20371350
MIRT100248	hsa-miR-548al	PAR-CLIP	20371350
MIRT100250	hsa-miR-4682	PAR-CLIP	20371350
MIRT564376	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT100244	hsa-miR-571	PAR-CLIP	20371350
MIRT317420	hsa-miR-8077	PAR-CLIP	20371350
MIRT100249	hsa-miR-4650-3p	PAR-CLIP	20371350
MIRT564375	hsa-miR-3529-5p	PAR-CLIP	20371350
MIRT564374	hsa-miR-379-5p	PAR-CLIP	20371350
MIRT564373	hsa-miR-4451	PAR-CLIP	20371350
MIRT1159892	hsa-miR-122	CLIP-seq
MIRT1159893	hsa-miR-1224-3p	CLIP-seq
MIRT1159894	hsa-miR-1245	CLIP-seq
MIRT1159895	hsa-miR-1281	CLIP-seq
MIRT1159896	hsa-miR-1290	CLIP-seq
MIRT1159897	hsa-miR-129-5p	CLIP-seq
MIRT1159898	hsa-miR-134	CLIP-seq
MIRT1159899	hsa-miR-1343	CLIP-seq
MIRT1159900	hsa-miR-181a	CLIP-seq
MIRT1159901	hsa-miR-181b	CLIP-seq
MIRT1159902	hsa-miR-181c	CLIP-seq
MIRT1159903	hsa-miR-181d	CLIP-seq
MIRT1159904	hsa-miR-1909	CLIP-seq
MIRT1159905	hsa-miR-193a-3p	CLIP-seq
MIRT1159906	hsa-miR-193b	CLIP-seq
MIRT1159907	hsa-miR-197	CLIP-seq
MIRT1159908	hsa-miR-3074-5p	CLIP-seq
MIRT1159909	hsa-miR-3118	CLIP-seq
MIRT1159910	hsa-miR-3127-5p	CLIP-seq
MIRT1159911	hsa-miR-3135b	CLIP-seq
MIRT1159912	hsa-miR-3164	CLIP-seq
MIRT1159913	hsa-miR-3167	CLIP-seq
MIRT1159914	hsa-miR-3652	CLIP-seq
MIRT1159915	hsa-miR-3663-5p	CLIP-seq
MIRT1159916	hsa-miR-3672	CLIP-seq
MIRT1159917	hsa-miR-3680	CLIP-seq
MIRT1159918	hsa-miR-3689a-5p	CLIP-seq
MIRT1159919	hsa-miR-3689b	CLIP-seq
MIRT1159920	hsa-miR-3689e	CLIP-seq
MIRT1159921	hsa-miR-3689f	CLIP-seq
MIRT1159922	hsa-miR-3690	CLIP-seq
MIRT1159923	hsa-miR-383	CLIP-seq
MIRT1159924	hsa-miR-3934	CLIP-seq
MIRT1159925	hsa-miR-4254	CLIP-seq
MIRT1159926	hsa-miR-4262	CLIP-seq
MIRT1159927	hsa-miR-4430	CLIP-seq
MIRT1159928	hsa-miR-4455	CLIP-seq
MIRT1159929	hsa-miR-450b-3p	CLIP-seq
MIRT1159930	hsa-miR-4690-3p	CLIP-seq
MIRT1159931	hsa-miR-4701-5p	CLIP-seq
MIRT1159932	hsa-miR-4713-3p	CLIP-seq
MIRT1159933	hsa-miR-4733-5p	CLIP-seq
MIRT1159934	hsa-miR-4772-3p	CLIP-seq
MIRT1159935	hsa-miR-4772-5p	CLIP-seq
MIRT1159936	hsa-miR-5096	CLIP-seq
MIRT1159937	hsa-miR-543	CLIP-seq
MIRT1159938	hsa-miR-545	CLIP-seq
MIRT1159939	hsa-miR-548u	CLIP-seq
MIRT1159940	hsa-miR-552	CLIP-seq
MIRT1159941	hsa-miR-579	CLIP-seq
MIRT1159942	hsa-miR-588	CLIP-seq
MIRT1159943	hsa-miR-638	CLIP-seq
MIRT1159944	hsa-miR-664	CLIP-seq
MIRT1159945	hsa-miR-668	CLIP-seq
MIRT1159946	hsa-miR-767-5p	CLIP-seq
MIRT1159947	hsa-miR-769-3p	CLIP-seq
MIRT1159948	hsa-miR-876-5p	CLIP-seq
MIRT1159949	hsa-miR-891b	CLIP-seq
MIRT1159892	hsa-miR-122	CLIP-seq
MIRT1159898	hsa-miR-134	CLIP-seq
MIRT1159899	hsa-miR-1343	CLIP-seq
MIRT1159904	hsa-miR-1909	CLIP-seq
MIRT1159905	hsa-miR-193a-3p	CLIP-seq
MIRT1159906	hsa-miR-193b	CLIP-seq
MIRT1159909	hsa-miR-3118	CLIP-seq
MIRT1159910	hsa-miR-3127-5p	CLIP-seq
MIRT1159911	hsa-miR-3135b	CLIP-seq
MIRT1159912	hsa-miR-3164	CLIP-seq
MIRT1159914	hsa-miR-3652	CLIP-seq
MIRT1159915	hsa-miR-3663-5p	CLIP-seq
MIRT1159918	hsa-miR-3689a-5p	CLIP-seq
MIRT1159919	hsa-miR-3689b	CLIP-seq
MIRT1159920	hsa-miR-3689e	CLIP-seq
MIRT1159921	hsa-miR-3689f	CLIP-seq
MIRT2045931	hsa-miR-371-5p	CLIP-seq
MIRT2045932	hsa-miR-371b-5p	CLIP-seq
MIRT1159927	hsa-miR-4430	CLIP-seq
MIRT1159928	hsa-miR-4455	CLIP-seq
MIRT1159929	hsa-miR-450b-3p	CLIP-seq
MIRT2045933	hsa-miR-4643	CLIP-seq
MIRT2045934	hsa-miR-466	CLIP-seq
MIRT1159931	hsa-miR-4701-5p	CLIP-seq
MIRT1159932	hsa-miR-4713-3p	CLIP-seq
MIRT1159933	hsa-miR-4733-5p	CLIP-seq
MIRT2045935	hsa-miR-4789-3p	CLIP-seq
MIRT2045936	hsa-miR-554	CLIP-seq
MIRT1159942	hsa-miR-588	CLIP-seq
MIRT1159943	hsa-miR-638	CLIP-seq
MIRT1159945	hsa-miR-668	CLIP-seq
MIRT1159947	hsa-miR-769-3p	CLIP-seq
MIRT2274975	hsa-miR-106a	CLIP-seq
MIRT2274976	hsa-miR-106b	CLIP-seq
MIRT1159893	hsa-miR-1224-3p	CLIP-seq
MIRT1159895	hsa-miR-1281	CLIP-seq
MIRT1159896	hsa-miR-1290	CLIP-seq
MIRT1159898	hsa-miR-134	CLIP-seq
MIRT1159899	hsa-miR-1343	CLIP-seq
MIRT2274977	hsa-miR-17	CLIP-seq
MIRT1159900	hsa-miR-181a	CLIP-seq
MIRT1159901	hsa-miR-181b	CLIP-seq
MIRT1159902	hsa-miR-181c	CLIP-seq
MIRT1159903	hsa-miR-181d	CLIP-seq
MIRT1159905	hsa-miR-193a-3p	CLIP-seq
MIRT1159906	hsa-miR-193b	CLIP-seq
MIRT1159907	hsa-miR-197	CLIP-seq
MIRT2274978	hsa-miR-20a	CLIP-seq
MIRT2274979	hsa-miR-20b	CLIP-seq
MIRT2274980	hsa-miR-302a	CLIP-seq
MIRT2274981	hsa-miR-302b	CLIP-seq
MIRT2274982	hsa-miR-302c	CLIP-seq
MIRT2274983	hsa-miR-302d	CLIP-seq
MIRT2274984	hsa-miR-302e	CLIP-seq
MIRT1159908	hsa-miR-3074-5p	CLIP-seq
MIRT1159909	hsa-miR-3118	CLIP-seq
MIRT1159910	hsa-miR-3127-5p	CLIP-seq
MIRT1159912	hsa-miR-3164	CLIP-seq
MIRT1159913	hsa-miR-3167	CLIP-seq
MIRT1159915	hsa-miR-3663-5p	CLIP-seq
MIRT1159918	hsa-miR-3689a-5p	CLIP-seq
MIRT1159919	hsa-miR-3689b	CLIP-seq
MIRT1159920	hsa-miR-3689e	CLIP-seq
MIRT1159921	hsa-miR-3689f	CLIP-seq
MIRT1159922	hsa-miR-3690	CLIP-seq
MIRT2045931	hsa-miR-371-5p	CLIP-seq
MIRT2045932	hsa-miR-371b-5p	CLIP-seq
MIRT2274985	hsa-miR-372	CLIP-seq
MIRT2274986	hsa-miR-373	CLIP-seq
MIRT1159925	hsa-miR-4254	CLIP-seq
MIRT1159926	hsa-miR-4262	CLIP-seq
MIRT2274987	hsa-miR-4433	CLIP-seq
MIRT2045933	hsa-miR-4643	CLIP-seq
MIRT2274988	hsa-miR-4645-3p	CLIP-seq
MIRT2045934	hsa-miR-466	CLIP-seq
MIRT1159930	hsa-miR-4690-3p	CLIP-seq
MIRT2274989	hsa-miR-4700-3p	CLIP-seq
MIRT1159931	hsa-miR-4701-5p	CLIP-seq
MIRT2274990	hsa-miR-4731-5p	CLIP-seq
MIRT2274991	hsa-miR-4732-5p	CLIP-seq
MIRT1159933	hsa-miR-4733-5p	CLIP-seq
MIRT1159934	hsa-miR-4772-3p	CLIP-seq
MIRT2045935	hsa-miR-4789-3p	CLIP-seq
MIRT2274992	hsa-miR-5095	CLIP-seq
MIRT1159936	hsa-miR-5096	CLIP-seq
MIRT2274993	hsa-miR-512-3p	CLIP-seq
MIRT2274994	hsa-miR-519d	CLIP-seq
MIRT2274995	hsa-miR-520a-3p	CLIP-seq
MIRT2274996	hsa-miR-520b	CLIP-seq
MIRT2274997	hsa-miR-520c-3p	CLIP-seq
MIRT2274998	hsa-miR-520d-3p	CLIP-seq
MIRT2274999	hsa-miR-520e	CLIP-seq
MIRT2275000	hsa-miR-520g	CLIP-seq
MIRT2275001	hsa-miR-520h	CLIP-seq
MIRT1159937	hsa-miR-543	CLIP-seq
MIRT1159938	hsa-miR-545	CLIP-seq
MIRT1159941	hsa-miR-579	CLIP-seq
MIRT1159942	hsa-miR-588	CLIP-seq
MIRT1159944	hsa-miR-664	CLIP-seq
MIRT1159945	hsa-miR-668	CLIP-seq
MIRT1159948	hsa-miR-876-5p	CLIP-seq
MIRT2275002	hsa-miR-93	CLIP-seq
MIRT2275003	hsa-miR-936	CLIP-seq
MIRT2391075	hsa-miR-1236	CLIP-seq
MIRT1159894	hsa-miR-1245	CLIP-seq
MIRT1159895	hsa-miR-1281	CLIP-seq
MIRT1159897	hsa-miR-129-5p	CLIP-seq
MIRT1159899	hsa-miR-1343	CLIP-seq
MIRT2573975	hsa-miR-3149	CLIP-seq
MIRT2573976	hsa-miR-3170	CLIP-seq
MIRT2573977	hsa-miR-338-5p	CLIP-seq
MIRT1159916	hsa-miR-3672	CLIP-seq
MIRT1159924	hsa-miR-3934	CLIP-seq
MIRT1159929	hsa-miR-450b-3p	CLIP-seq
MIRT1159930	hsa-miR-4690-3p	CLIP-seq
MIRT2573978	hsa-miR-4699-3p	CLIP-seq
MIRT1159932	hsa-miR-4713-3p	CLIP-seq
MIRT2573979	hsa-miR-4735-5p	CLIP-seq
MIRT2573980	hsa-miR-4775	CLIP-seq
MIRT1159939	hsa-miR-548u	CLIP-seq
MIRT1159940	hsa-miR-552	CLIP-seq
MIRT2573981	hsa-miR-590-3p	CLIP-seq
MIRT1159943	hsa-miR-638	CLIP-seq
MIRT1159946	hsa-miR-767-5p	CLIP-seq
MIRT1159947	hsa-miR-769-3p	CLIP-seq
MIRT1159897	hsa-miR-129-5p	CLIP-seq
MIRT2573975	hsa-miR-3149	CLIP-seq
MIRT2573977	hsa-miR-338-5p	CLIP-seq
MIRT1159916	hsa-miR-3672	CLIP-seq
MIRT1159924	hsa-miR-3934	CLIP-seq
MIRT1159930	hsa-miR-4690-3p	CLIP-seq
MIRT2573978	hsa-miR-4699-3p	CLIP-seq
MIRT2573979	hsa-miR-4735-5p	CLIP-seq
MIRT2573980	hsa-miR-4775	CLIP-seq
MIRT1159940	hsa-miR-552	CLIP-seq
MIRT2573981	hsa-miR-590-3p	CLIP-seq
MIRT1159946	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	ISS	11402041
GO:0003735	Function	Structural constituent of ribosome	NAS	11279123
GO:0005515	Function	Protein binding	IPI	18391203, 22003127, 28514442, 30021884, 32296183, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005763	Component	Mitochondrial small ribosomal subunit	IDA	25838379
GO:0005763	Component	Mitochondrial small ribosomal subunit	IEA
GO:0005763	Component	Mitochondrial small ribosomal subunit	ISS	11402041
GO:0005763	Component	Mitochondrial small ribosomal subunit	NAS	11279123, 25838379
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	11279123
GO:0030054	Component	Cell junction	IDA
GO:0032543	Process	Mitochondrial translation	IEA
GO:0032543	Process	Mitochondrial translation	ISS	11402041
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 611982
• HGNC: 14516
• e!Ensembl: ENSG00000204568

Protein

• UniProt ID: Q9Y676
• Protein name: Small ribosomal subunit protein mS40 (28S ribosomal protein S18-2, mitochondrial) (MRP-S18-2) (28S ribosomal protein S18b, mitochondrial) (MRP-S18-b) (Mrps18-b) (S18mt-b) (Small ribosomal subunit protein bS18b)
• PDB: 3J9M, 6NU2, 6NU3, 6RW4, 6RW5, 6VLZ, 6VMI, 6ZM5, 6ZM6, 6ZS9, 6ZSA, 6ZSB, 6ZSC, 6ZSD, 6ZSE, 6ZSG, 7A5F, 7A5G, 7A5I, 7A5K, 7L08, 7OG4, 7P2E, 7PNX, 7PNY, 7PNZ, 7PO0, 7PO1, 7PO2, 7PO3, 7QI4, 7QI5, 7QI6, 8ANY, 8CSP, 8CSQ, 8CSR, 8CSS, 8CST, 8CSU, 8K2A, 8OIR, 8OIS, 8QRK, 8QRL, 8QRM, 8QRN, 8RRI, 8XT0, 8XT2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01084	Ribosomal_S18	111 → 163	Ribosomal protein S18	Family

• Sequence:

  MAASVLNTVLRRLPMLSLFRGSHRVQVPLQTLCTKAPSEEDSLSSVPISPYKDEPWKYLE
  SEEYQERYGSRPVWADYRRNHKGGVPPQRTRKTCIRRNKVVGNPCPICRDHKLHVDFRNV
  KLLEQFVCAHTGIIFYAPYTGVCVKQHKRLTQAIQKARDHGLLIYHIPQVEPRDLDFSTS
  HGAVSATPPAPTLVSGDPWYPWYNWKQPPERELSRLRRLYQGHLQEESGPPPESMPKMPP
  RTPAEASSTGQTGPQSAL

• Sequence length: 258

Pathways

KEGG:

Viral carcinogenesis

Reactome:

Mitochondrial translation elongation
Mitochondrial translation termination