Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	28972
Gene name Gene Name - the full gene name approved by the HGNC.	Signal peptidase complex subunit 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SPCS1
Synonyms (NCBI Gene) Gene synonyms aliases	HSPC033, SPC1, SPC12, YJR010C-A
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p21.1

Show/Hide all(131)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020721	hsa-miR-155-5p	Proteomics	18668040
MIRT641713	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT641712	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT641711	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT641710	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT641709	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT641708	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT641707	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT641706	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT641705	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT641704	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT641703	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT641702	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT641701	hsa-miR-302e	HITS-CLIP	23824327
MIRT641700	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT641699	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT641698	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT641697	hsa-miR-520b	HITS-CLIP	23824327
MIRT641696	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT641695	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT641694	hsa-miR-520e	HITS-CLIP	23824327
MIRT641693	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT641692	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT641691	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT641689	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT641690	hsa-miR-1976	HITS-CLIP	23824327
MIRT641688	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT641687	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT641685	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT641686	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT519289	hsa-miR-1228-3p	PAR-CLIP	23446348
MIRT519288	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT519287	hsa-miR-4794	PAR-CLIP	23446348
MIRT519286	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT519285	hsa-miR-6069	PAR-CLIP	23446348
MIRT519284	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT519283	hsa-miR-4732-5p	PAR-CLIP	23446348
MIRT519281	hsa-miR-3674	PAR-CLIP	23446348
MIRT519282	hsa-miR-3149	PAR-CLIP	23446348
MIRT519280	hsa-miR-129-5p	PAR-CLIP	23446348
MIRT641713	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT641712	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT641711	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT641710	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT641709	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT641708	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT641707	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT641706	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT641705	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT641704	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT641703	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT641702	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT641701	hsa-miR-302e	HITS-CLIP	23824327
MIRT641700	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT641699	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT641698	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT641697	hsa-miR-520b	HITS-CLIP	23824327
MIRT641696	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT641695	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT641694	hsa-miR-520e	HITS-CLIP	23824327
MIRT641693	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT641692	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT641691	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT641689	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT641690	hsa-miR-1976	HITS-CLIP	23824327
MIRT641688	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT641687	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT641685	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT641686	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT519289	hsa-miR-1228-3p	PAR-CLIP	23446348
MIRT519288	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT519287	hsa-miR-4794	PAR-CLIP	23446348
MIRT519286	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT519285	hsa-miR-6069	PAR-CLIP	23446348
MIRT519284	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT519283	hsa-miR-4732-5p	PAR-CLIP	23446348
MIRT519281	hsa-miR-3674	PAR-CLIP	23446348
MIRT519282	hsa-miR-3149	PAR-CLIP	23446348
MIRT519280	hsa-miR-129-5p	PAR-CLIP	23446348
MIRT1383161	hsa-miR-1227	CLIP-seq
MIRT1383162	hsa-miR-1276	CLIP-seq
MIRT1383163	hsa-miR-1284	CLIP-seq
MIRT1383164	hsa-miR-142-5p	CLIP-seq
MIRT1383165	hsa-miR-146a	CLIP-seq
MIRT1383166	hsa-miR-146b-5p	CLIP-seq
MIRT1383167	hsa-miR-147	CLIP-seq
MIRT1383168	hsa-miR-2355-5p	CLIP-seq
MIRT1383169	hsa-miR-340	CLIP-seq
MIRT1383170	hsa-miR-3646	CLIP-seq
MIRT1383171	hsa-miR-378g	CLIP-seq
MIRT1383172	hsa-miR-3925-5p	CLIP-seq
MIRT1383173	hsa-miR-4311	CLIP-seq
MIRT1383174	hsa-miR-4330	CLIP-seq
MIRT1383175	hsa-miR-4652-3p	CLIP-seq
MIRT1383176	hsa-miR-4672	CLIP-seq
MIRT1383177	hsa-miR-4789-5p	CLIP-seq
MIRT1383178	hsa-miR-485-3p	CLIP-seq
MIRT1383179	hsa-miR-581	CLIP-seq
MIRT1383180	hsa-miR-583	CLIP-seq
MIRT2114573	hsa-miR-3126-3p	CLIP-seq
MIRT2114574	hsa-miR-4667-5p	CLIP-seq
MIRT2114575	hsa-miR-4700-5p	CLIP-seq
MIRT2114576	hsa-miR-637	CLIP-seq
MIRT1383161	hsa-miR-1227	CLIP-seq
MIRT1383167	hsa-miR-147	CLIP-seq
MIRT2631018	hsa-miR-3163	CLIP-seq
MIRT1383169	hsa-miR-340	CLIP-seq
MIRT2631019	hsa-miR-3662	CLIP-seq
MIRT2631020	hsa-miR-3665	CLIP-seq
MIRT2631021	hsa-miR-3978	CLIP-seq
MIRT2631022	hsa-miR-4261	CLIP-seq
MIRT2631023	hsa-miR-4325	CLIP-seq
MIRT1383175	hsa-miR-4652-3p	CLIP-seq
MIRT2631024	hsa-miR-4764-3p	CLIP-seq
MIRT1383178	hsa-miR-485-3p	CLIP-seq
MIRT2631025	hsa-miR-494	CLIP-seq
MIRT2631026	hsa-miR-522	CLIP-seq
MIRT2631027	hsa-miR-548a-3p	CLIP-seq
MIRT2631028	hsa-miR-548e	CLIP-seq
MIRT2631029	hsa-miR-548f	CLIP-seq
MIRT2631030	hsa-miR-570	CLIP-seq
MIRT1383179	hsa-miR-581	CLIP-seq
MIRT2631031	hsa-miR-764	CLIP-seq
MIRT2631018	hsa-miR-3163	CLIP-seq
MIRT1383169	hsa-miR-340	CLIP-seq
MIRT2631020	hsa-miR-3665	CLIP-seq
MIRT2631027	hsa-miR-548a-3p	CLIP-seq
MIRT2631028	hsa-miR-548e	CLIP-seq
MIRT2631029	hsa-miR-548f	CLIP-seq
MIRT2631030	hsa-miR-570	CLIP-seq
MIRT2631031	hsa-miR-764	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	24009510, 29593046
GO:0005787	Component	Signal peptidase complex	IBA	21873635
GO:0005787	Component	Signal peptidase complex	TAS	8632014
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006465	Process	Signal peptide processing	IBA	21873635
GO:0006508	Process	Proteolysis	TAS	8632014
GO:0008233	Function	Peptidase activity	IEA
GO:0019068	Process	Virion assembly	IMP	24009510, 29593046
GO:0019082	Process	Viral protein processing	IMP	27383988
GO:0030176	Component	Integral component of endoplasmic reticulum membrane	IBA	21873635
GO:0030176	Component	Integral component of endoplasmic reticulum membrane	IDA	8632014
GO:0043022	Function	Ribosome binding	IEA
GO:0045047	Process	Protein targeting to ER	IBA	21873635

MIM	HGNC	e!Ensembl
610358	23401	ENSG00000114902

Protein

UniProt ID

Q9Y6A9

Protein name

Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit)

Protein function

Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Dispensable for SPC enzymat

PDB

7P2P , 7P2Q

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06645	SPC12	12 → 82	Microsomal signal peptidase 12 kDa subunit (SPC12)	Family

Sequence

MARGGDTGCTGPSETSASGAAAIALPGLEGPATDAQCQTLPLTVLKSRSPSPRSLPPALS
CPPPQPAMLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYVAEQFGWTVYIVM
AGFAFSCLLTLPPWPIYRRHPLKWLPVQESSTDDKKPGERKIKRHAKNN

Sequence length

169

Interactions

View interactions

	KEGG		Reactome
	Protein export		Synthesis, secretion, and deacylation of Ghrelin

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Major Depressive Disorder		22472876	ClinVar

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Multiple Myeloma	Associate	35192775
Neoplasms	Associate	24114764
Osteoarthritis	Associate	24886551
Osteoarthritis Knee	Associate	29942097

SPCS1 (signal peptidase complex subunit 1)