SLC6A16 (solute carrier family 6 member 16)

Gene

• Entrez ID: 28968
• Gene name: Solute carrier family 6 member 16
• Gene symbol: SLC6A16
• Synonyms (NCBI Gene): NT5, NTT5
• Chromosome: 19
• Chromosome location: 19q13.33
• Summary: SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[suppli

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018187	hsa-miR-335-5p	Microarray	18185580
MIRT025508	hsa-miR-34a-5p	Proteomics	21566225
MIRT029566	hsa-miR-26b-5p	Microarray	19088304
MIRT1366118	hsa-miR-421	CLIP-seq
MIRT1366119	hsa-miR-4270	CLIP-seq
MIRT1366120	hsa-miR-4441	CLIP-seq
MIRT1366121	hsa-miR-4683	CLIP-seq
MIRT1366122	hsa-miR-4685-5p	CLIP-seq
MIRT1366123	hsa-miR-4709-5p	CLIP-seq
MIRT2108700	hsa-miR-3647-3p	CLIP-seq
MIRT2108701	hsa-miR-3662	CLIP-seq
MIRT2108702	hsa-miR-4274	CLIP-seq
MIRT2108703	hsa-miR-4302	CLIP-seq
MIRT2108704	hsa-miR-4519	CLIP-seq
MIRT2108705	hsa-miR-4524	CLIP-seq
MIRT2108706	hsa-miR-511	CLIP-seq
MIRT2108707	hsa-miR-654-3p	CLIP-seq
MIRT2332299	hsa-miR-3646	CLIP-seq
MIRT2108700	hsa-miR-3647-3p	CLIP-seq
MIRT2108701	hsa-miR-3662	CLIP-seq
MIRT2108702	hsa-miR-4274	CLIP-seq
MIRT2108703	hsa-miR-4302	CLIP-seq
MIRT2108704	hsa-miR-4519	CLIP-seq
MIRT2108705	hsa-miR-4524	CLIP-seq
MIRT2108706	hsa-miR-511	CLIP-seq
MIRT2108707	hsa-miR-654-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	NAS	11112352
GO:0005886	Component	Plasma membrane	IBA
GO:0006836	Process	Neurotransmitter transport	IEA
GO:0006836	Process	Neurotransmitter transport	NAS	11112352
GO:0006865	Process	Amino acid transport	IBA
GO:0015293	Function	Symporter activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0035725	Process	Sodium ion transmembrane transport	IBA

Other IDs

• MIM: 607972
• HGNC: 13622
• e!Ensembl: ENSG00000063127

Protein

• UniProt ID: Q9GZN6
• Protein name: Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 (Solute carrier family 6 member 16)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00209	SNF	103 → 685	Sodium:neurotransmitter symporter family	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate.
• Sequence:

  MKTEAQPSTSLLANTSWTGTVISDSVPGSQTWEDKGSLTRSATSWTSEAQVSAARVAEAQ
  ARTSQPKQISVLEALTASALNQKPTHEKVQMTEKKESEVLLARPFWSSKTEYILAQVGFS
  MKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAP
  WIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMNSSGFDPECERT
  TPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLL
  PCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASL
  ASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLIN
  LGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFA
  FLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIV
  GVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTI
  LLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWAL
  LLMITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTASTSLPLSHQLTPSKEVQKEEI
  LQVDETKYPSTCNVTS

• Sequence length: 736

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cervical cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations