Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	28964
Gene name Gene Name - the full gene name approved by the HGNC.	GIT ArfGAP 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GIT1
Synonyms (NCBI Gene) Gene synonyms aliases	p95-APP1
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q11.2

Show/Hide all(181)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025756	hsa-miR-7-5p	Microarray	19073608
MIRT042200	hsa-miR-484	CLASH	23622248
MIRT054625	hsa-miR-149-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24608434
MIRT054625	hsa-miR-149-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24608434
MIRT438167	hsa-miR-491-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24335959
MIRT438167	hsa-miR-491-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24335959
MIRT438167	hsa-miR-491-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24335959
MIRT438167	hsa-miR-491-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24335959
MIRT731825	hsa-miR-34c-5p	Immunohistochemistry, Luciferase reporter assay, Western blot	27698902
MIRT731825	hsa-miR-34c-5p	Immunohistochemistry, Luciferase reporter assay, Western blot	27698902
MIRT732112	hsa-miR-125a-3p	Luciferase reporter assay, qRT-PCR, Western blot	28101188
MIRT732112	hsa-miR-125a-3p	Luciferase reporter assay, qRT-PCR, Western blot	28101188
MIRT1019448	hsa-miR-138	CLIP-seq
MIRT1019449	hsa-miR-3173-3p	CLIP-seq
MIRT1019450	hsa-miR-361-3p	CLIP-seq
MIRT1019451	hsa-miR-3688-5p	CLIP-seq
MIRT1019452	hsa-miR-3943	CLIP-seq
MIRT1019453	hsa-miR-4313	CLIP-seq
MIRT1019454	hsa-miR-4456	CLIP-seq
MIRT1019455	hsa-miR-4492	CLIP-seq
MIRT1019456	hsa-miR-4498	CLIP-seq
MIRT1019457	hsa-miR-4690-3p	CLIP-seq
MIRT1019458	hsa-miR-4779	CLIP-seq
MIRT1019459	hsa-miR-520d-5p	CLIP-seq
MIRT1019460	hsa-miR-524-5p	CLIP-seq
MIRT1019461	hsa-miR-548v	CLIP-seq
MIRT1019462	hsa-miR-644	CLIP-seq
MIRT1019463	hsa-miR-762	CLIP-seq
MIRT1019464	hsa-miR-885-3p	CLIP-seq
MIRT1019465	hsa-miR-1207-3p	CLIP-seq
MIRT1019466	hsa-miR-1207-5p	CLIP-seq
MIRT1019467	hsa-miR-1286	CLIP-seq
MIRT1019468	hsa-miR-1321	CLIP-seq
MIRT1019469	hsa-miR-1827	CLIP-seq
MIRT1019470	hsa-miR-2277-3p	CLIP-seq
MIRT1019471	hsa-miR-3612	CLIP-seq
MIRT1019472	hsa-miR-4270	CLIP-seq
MIRT1019473	hsa-miR-4441	CLIP-seq
MIRT1019474	hsa-miR-4462	CLIP-seq
MIRT1019475	hsa-miR-4652-5p	CLIP-seq
MIRT1019457	hsa-miR-4690-3p	CLIP-seq
MIRT1019476	hsa-miR-4691-3p	CLIP-seq
MIRT1019477	hsa-miR-4728-5p	CLIP-seq
MIRT1019478	hsa-miR-4736	CLIP-seq
MIRT1019479	hsa-miR-4739	CLIP-seq
MIRT1019480	hsa-miR-4756-5p	CLIP-seq
MIRT1019481	hsa-miR-4763-3p	CLIP-seq
MIRT1019482	hsa-miR-4772-5p	CLIP-seq
MIRT1019483	hsa-miR-512-5p	CLIP-seq
MIRT1019484	hsa-miR-650	CLIP-seq
MIRT2001896	hsa-miR-122	CLIP-seq
MIRT2001897	hsa-miR-1245	CLIP-seq
MIRT2001898	hsa-miR-1294	CLIP-seq
MIRT2001899	hsa-miR-1296	CLIP-seq
MIRT1019448	hsa-miR-138	CLIP-seq
MIRT2001900	hsa-miR-140-3p	CLIP-seq
MIRT2001901	hsa-miR-1910	CLIP-seq
MIRT2001902	hsa-miR-1915	CLIP-seq
MIRT2001903	hsa-miR-196a	CLIP-seq
MIRT2001904	hsa-miR-196b	CLIP-seq
MIRT2001905	hsa-miR-214	CLIP-seq
MIRT1019470	hsa-miR-2277-3p	CLIP-seq
MIRT2001906	hsa-miR-24	CLIP-seq
MIRT2001907	hsa-miR-2467-3p	CLIP-seq
MIRT2001908	hsa-miR-2861	CLIP-seq
MIRT2001909	hsa-miR-3136-3p	CLIP-seq
MIRT2001910	hsa-miR-3176	CLIP-seq
MIRT2001911	hsa-miR-3185	CLIP-seq
MIRT2001912	hsa-miR-3202	CLIP-seq
MIRT2001913	hsa-miR-346	CLIP-seq
MIRT1019450	hsa-miR-361-3p	CLIP-seq
MIRT2001914	hsa-miR-3614-3p	CLIP-seq
MIRT2001915	hsa-miR-3619-5p	CLIP-seq
MIRT2001916	hsa-miR-3649	CLIP-seq
MIRT2001917	hsa-miR-3665	CLIP-seq
MIRT2001918	hsa-miR-3677-5p	CLIP-seq
MIRT2001919	hsa-miR-3678-3p	CLIP-seq
MIRT2001920	hsa-miR-3679-3p	CLIP-seq
MIRT2001921	hsa-miR-371b-5p	CLIP-seq
MIRT2001922	hsa-miR-3922-3p	CLIP-seq
MIRT2001923	hsa-miR-3925-3p	CLIP-seq
MIRT2001924	hsa-miR-4264	CLIP-seq
MIRT2001925	hsa-miR-4267	CLIP-seq
MIRT2001926	hsa-miR-4297	CLIP-seq
MIRT2001927	hsa-miR-4435	CLIP-seq
MIRT1019454	hsa-miR-4456	CLIP-seq
MIRT1019455	hsa-miR-4492	CLIP-seq
MIRT1019456	hsa-miR-4498	CLIP-seq
MIRT2001928	hsa-miR-4512	CLIP-seq
MIRT2001929	hsa-miR-455-3p	CLIP-seq
MIRT2001930	hsa-miR-4632	CLIP-seq
MIRT2001931	hsa-miR-4648	CLIP-seq
MIRT2001932	hsa-miR-4651	CLIP-seq
MIRT2001933	hsa-miR-4676-5p	CLIP-seq
MIRT1019457	hsa-miR-4690-3p	CLIP-seq
MIRT2001934	hsa-miR-4691-5p	CLIP-seq
MIRT2001935	hsa-miR-4726-3p	CLIP-seq
MIRT2001936	hsa-miR-516b	CLIP-seq
MIRT2001937	hsa-miR-520a-5p	CLIP-seq
MIRT2001938	hsa-miR-525-5p	CLIP-seq
MIRT2001939	hsa-miR-541	CLIP-seq
MIRT2001940	hsa-miR-575	CLIP-seq
MIRT2001941	hsa-miR-603	CLIP-seq
MIRT2001942	hsa-miR-608	CLIP-seq
MIRT2001943	hsa-miR-654-5p	CLIP-seq
MIRT2001944	hsa-miR-657	CLIP-seq
MIRT2001945	hsa-miR-663b	CLIP-seq
MIRT2001946	hsa-miR-761	CLIP-seq
MIRT1019463	hsa-miR-762	CLIP-seq
MIRT2001947	hsa-miR-764	CLIP-seq
MIRT2001948	hsa-miR-766	CLIP-seq
MIRT2001949	hsa-miR-939	CLIP-seq
MIRT1019448	hsa-miR-138	CLIP-seq
MIRT2001906	hsa-miR-24	CLIP-seq
MIRT1019454	hsa-miR-4456	CLIP-seq
MIRT1019466	hsa-miR-1207-5p	CLIP-seq
MIRT2001896	hsa-miR-122	CLIP-seq
MIRT2234964	hsa-miR-1224-3p	CLIP-seq
MIRT2234965	hsa-miR-1227	CLIP-seq
MIRT2234966	hsa-miR-1231	CLIP-seq
MIRT2234967	hsa-miR-1267	CLIP-seq
MIRT2001898	hsa-miR-1294	CLIP-seq
MIRT2001899	hsa-miR-1296	CLIP-seq
MIRT1019448	hsa-miR-138	CLIP-seq
MIRT2001900	hsa-miR-140-3p	CLIP-seq
MIRT2001902	hsa-miR-1915	CLIP-seq
MIRT2001906	hsa-miR-24	CLIP-seq
MIRT2001908	hsa-miR-2861	CLIP-seq
MIRT2001909	hsa-miR-3136-3p	CLIP-seq
MIRT2234968	hsa-miR-3147	CLIP-seq
MIRT2234969	hsa-miR-3151	CLIP-seq
MIRT2234970	hsa-miR-3170	CLIP-seq
MIRT2001911	hsa-miR-3185	CLIP-seq
MIRT2234971	hsa-miR-342-5p	CLIP-seq
MIRT1019450	hsa-miR-361-3p	CLIP-seq
MIRT2001918	hsa-miR-3677-5p	CLIP-seq
MIRT2001925	hsa-miR-4267	CLIP-seq
MIRT2234972	hsa-miR-4284	CLIP-seq
MIRT2234973	hsa-miR-4425	CLIP-seq
MIRT2001927	hsa-miR-4435	CLIP-seq
MIRT2234974	hsa-miR-4436b-3p	CLIP-seq
MIRT2234975	hsa-miR-4450	CLIP-seq
MIRT2001928	hsa-miR-4512	CLIP-seq
MIRT2001932	hsa-miR-4651	CLIP-seq
MIRT2234976	hsa-miR-4664-5p	CLIP-seq
MIRT1019481	hsa-miR-4763-3p	CLIP-seq
MIRT2001936	hsa-miR-516b	CLIP-seq
MIRT1019461	hsa-miR-548v	CLIP-seq
MIRT2001942	hsa-miR-608	CLIP-seq
MIRT2234977	hsa-miR-654-3p	CLIP-seq
MIRT2001945	hsa-miR-663b	CLIP-seq
MIRT2234978	hsa-miR-760	CLIP-seq
MIRT2001947	hsa-miR-764	CLIP-seq
MIRT2234979	hsa-miR-892b	CLIP-seq
MIRT2001949	hsa-miR-939	CLIP-seq
MIRT2001949	hsa-miR-939	CLIP-seq
MIRT2234964	hsa-miR-1224-3p	CLIP-seq
MIRT2538765	hsa-miR-1260	CLIP-seq
MIRT2538766	hsa-miR-1260b	CLIP-seq
MIRT2538767	hsa-miR-1280	CLIP-seq
MIRT2001899	hsa-miR-1296	CLIP-seq
MIRT1019448	hsa-miR-138	CLIP-seq
MIRT2538768	hsa-miR-185	CLIP-seq
MIRT2001902	hsa-miR-1915	CLIP-seq
MIRT1019470	hsa-miR-2277-3p	CLIP-seq
MIRT2001908	hsa-miR-2861	CLIP-seq
MIRT2538769	hsa-miR-3150a-3p	CLIP-seq
MIRT2538770	hsa-miR-3175	CLIP-seq
MIRT2001911	hsa-miR-3185	CLIP-seq
MIRT2001913	hsa-miR-346	CLIP-seq
MIRT1019450	hsa-miR-361-3p	CLIP-seq
MIRT2538771	hsa-miR-4306	CLIP-seq
MIRT1019454	hsa-miR-4456	CLIP-seq
MIRT1019474	hsa-miR-4462	CLIP-seq
MIRT2538772	hsa-miR-4487	CLIP-seq
MIRT2001928	hsa-miR-4512	CLIP-seq
MIRT2538773	hsa-miR-4644	CLIP-seq
MIRT1019457	hsa-miR-4690-3p	CLIP-seq
MIRT2001939	hsa-miR-541	CLIP-seq
MIRT2001943	hsa-miR-654-5p	CLIP-seq
MIRT2001949	hsa-miR-939	CLIP-seq

Show/Hide all(84)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IEA
GO:0001771	Process	Immunological synapse formation	IEA
GO:0001957	Process	Intramembranous ossification	IEA
GO:0001957	Process	Intramembranous ossification	ISS
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	15182672, 15383276, 16169070, 16628223, 16717130, 16787945, 18369319, 19041750, 21295525, 21706016, 21900206, 23108400, 23455922, 25852190, 27012601, 31980649, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005768	Component	Endosome	IEA
GO:0005813	Component	Centrosome	IDA	27012601
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IDA
GO:0005925	Component	Focal adhesion	IEA
GO:0007420	Process	Brain development	IBA
GO:0007420	Process	Brain development	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IBA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	9826657
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0019903	Function	Protein phosphatase binding	IEA
GO:0030027	Component	Lamellipodium	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030426	Component	Growth cone	IEA
GO:0031267	Function	Small GTPase binding	IBA
GO:0031267	Function	Small GTPase binding	IEA
GO:0032012	Process	Regulation of ARF protein signal transduction	IBA
GO:0032012	Process	Regulation of ARF protein signal transduction	IEA
GO:0032013	Process	Negative regulation of ARF protein signal transduction	IEA
GO:0032465	Process	Regulation of cytokinesis	IDA	23108400
GO:0032691	Process	Negative regulation of interleukin-1 beta production	IEA
GO:0032691	Process	Negative regulation of interleukin-1 beta production	ISS
GO:0036465	Process	Synaptic vesicle recycling	IBA
GO:0042802	Function	Identical protein binding	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0043015	Function	Gamma-tubulin binding	IDA	27012601
GO:0044305	Component	Calyx of Held	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0045454	Process	Cell redox homeostasis	IEA
GO:0045454	Process	Cell redox homeostasis	ISS
GO:0045820	Process	Negative regulation of glycolytic process	IEA
GO:0045820	Process	Negative regulation of glycolytic process	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048013	Process	Ephrin receptor signaling pathway	IEA
GO:0048666	Process	Neuron development	IEA
GO:0060076	Component	Excitatory synapse	IEA
GO:0060077	Component	Inhibitory synapse	IEA
GO:0060996	Process	Dendritic spine development	IEA
GO:0061743	Process	Motor learning	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	IEA
GO:0090063	Process	Positive regulation of microtubule nucleation	IMP	27012601
GO:0097110	Function	Scaffold protein binding	IEA
GO:0097431	Component	Mitotic spindle pole	IDA	27012601
GO:0098793	Component	Presynapse	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	IBA
GO:0098794	Component	Postsynapse	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0098794	Component	Postsynapse	ISS
GO:0098879	Function	Structural constituent of postsynaptic specialization	IEA
GO:0098880	Process	Maintenance of postsynaptic specialization structure	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA
GO:0099645	Process	Neurotransmitter receptor localization to postsynaptic specialization membrane	IEA
GO:0106015	Process	Negative regulation of inflammatory response to wounding	IEA
GO:0106015	Process	Negative regulation of inflammatory response to wounding	ISS
GO:1990782	Function	Protein tyrosine kinase binding	IEA
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA
GO:2000646	Process	Positive regulation of receptor catabolic process	IEA

MIM	HGNC	e!Ensembl
608434	4272	ENSG00000108262

Protein

UniProt ID

Q9Y2X7

Protein name

ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)

Protein function

GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, f

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01412	ArfGap	1 → 120	Putative GTPase activating protein for Arf	Domain
PF12796	Ank_2	137 → 229	Ankyrin repeats (3 copies)	Repeat
PF08518	GIT_SHD	264 → 292	Spa2 homology domain (SHD) of GIT	Family
PF08518	GIT_SHD	328 → 356	Spa2 homology domain (SHD) of GIT	Family
PF16559	GIT_CC	409 → 474	GIT coiled-coil Rho guanine nucleotide exchange factor	Coiled-coil
PF12205	GIT1_C	638 → 754	G protein-coupled receptor kinase-interacting protein 1 C term	Domain

Sequence

MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL
LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL
PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT
LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD
HKNGHYIIPQMADSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQ
NHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSL
SSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDGA
VTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPT
PPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRLQPFHSTELE
DDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYEN
TQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELL
RAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTV
PPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ

Sequence length

761

Interactions

View interactions

	KEGG		Reactome
	Endocytosis Regulation of actin cytoskeleton Epithelial cell signaling in Helicobacter pylori infection		Ephrin signaling

GIT1 (GIT ArfGAP 1)