DCPS (decapping enzyme, scavenger)

Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
28960
Gene name Gene Name - the full gene name approved by the HGNC.
Decapping enzyme, scavenger
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DCPS
Synonyms (NCBI Gene) Gene synonyms aliases
ARS, DCS1, HINT-5, HINT5, HSL1, HSPC015
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q24.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosom
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
SNP ID Visualize variation Clinical significance Consequence
rs138737928 C>T Pathogenic Coding sequence variant, missense variant
rs147935593 G>T Conflicting-interpretations-of-pathogenicity Missense variant, coding sequence variant
rs556401323 C>T Likely-pathogenic Missense variant, coding sequence variant
rs770528538 G>A,T Pathogenic Splice donor variant
rs1057519083 T>C Pathogenic Missense variant, coding sequence variant, splice donor variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(190)
miRTarBase ID miRNA Experiments Reference
MIRT041500 hsa-miR-193b-3p CLASH 23622248
MIRT461052 hsa-miR-4695-5p HITS-CLIP 23706177
MIRT461051 hsa-miR-1910-3p HITS-CLIP 23706177
MIRT461050 hsa-miR-6511a-5p HITS-CLIP 23706177
MIRT461049 hsa-miR-3174 HITS-CLIP 23706177
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(28)
GO ID Ontology Definition Evidence Reference
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS 12198172, 15383679, 22985415
GO:0000290 Process Deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
GO:0000290 Process Deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
GO:0000340 Function RNA 7-methylguanosine cap binding IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
610534 29812 ENSG00000110063
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q96C86
Protein name m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS)
Protein function Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosph
PDB 1ST0 , 1ST4 , 1XML , 1XMM , 3BL7 , 3BL9 , 3BLA , 4QDE , 4QDV , 4QEB , 5OSY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05652 DcpS 43 → 146 Scavenger mRNA decapping enzyme (DcpS) N-terminal Family
PF11969 DcpS_C 174 → 294 Family
Tissue specificity TISSUE SPECIFICITY: Detected in liver, brain, kidney, testis and prostate. {ECO:0000269|PubMed:12871939}.
Sequence
Sequence length 337
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  RNA degradation   mRNA decay by 3' to 5' exoribonuclease
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
AL-Raqad Syndrome al-raqad syndrome rs1057519083, rs770528538, rs138737928 N/A
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Acute Myeloid Leukemia Acute myeloid leukemia Here, we show that the mRNA decapping enzyme scavenger (DCPS) gene is essential for AML cell survival. 29478914 CBGDA
Non-Syndromic Intellectual Disability autosomal recessive non-syndromic intellectual disability N/A N/A GenCC
Show/Hide Text Mining Associations (16)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Antisynthetase syndrome Associate 28586844
Carcinoma Renal Cell Associate 36478716
Colorectal Neoplasms Stimulate 38064867
Conversion Disorder Associate 25701870
Craniofacial Abnormalities Associate 25712129
Genetic Diseases Inborn Associate 35749470
Intellectual Disability Associate 25701870, 25712129
Leukemia Myeloid Acute Associate 35749470
Muscular Atrophy Spinal Associate 18839960, 26001796
Myositis Associate 28586844