Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
2878
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Glutathione peroxidase 3 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
GPX3 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
GPx-P, GSHPx-3, GSHPx-P |
Chromosome
Chromosome number
|
5 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
5q33.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozy |
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Adenocarcinoma |
Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular |
rs121913530, rs886039394, rs121913474 |
21552421 |
Carcinoma |
Carcinoma, Cribriform, Carcinoma, Granular Cell |
rs121912654, rs555607708, rs786202962, rs1564055259 |
21552421 |
Fanconi syndrome |
De Toni-Debre-Fanconi Syndrome, Fanconi Syndrome, Adult Fanconi syndrome |
rs398124646 |
9851889 |
Fanconi-bickel syndrome |
Fanconi-Bickel Syndrome |
rs121909742, rs121909743, rs121909744, rs121909745, rs1715390589, rs780067980, rs771477447, rs28928874, rs1576838294, rs121909746, rs121909747, rs1114167428, rs371977235, rs1553785033, rs769888108, rs756874949, rs1553784980, rs1553785722, rs1553786361, rs1560035336, rs1560033414, rs1447936042, rs1318756243 View all (8 more) |
9851889 |
Lung cancer |
Malignant neoplasm of lung |
rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 |
21552421, 19180532 |
Obesity |
Obesity |
rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs193922650, rs193922685, rs193922687, rs751160202, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829 View all (27 more) |
11328671, 19270708 |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
17804715 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Endometriosis |
Endometriosis |
|
20864642, 21063030 |
ClinVar |
Inflammatory Bowel Disease |
Inflammatory Bowel Disease |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma |
Associate
|
24167362, 30509602 |
Adenocarcinoma of Lung |
Associate
|
38204755, 40179422 |
Adenoma |
Associate
|
23778325, 30469315 |
Alveolitis Extrinsic Allergic |
Associate
|
37800807 |
Amyotrophic Lateral Sclerosis |
Associate
|
33541344, 37328865 |
Arthritis Juvenile |
Inhibit
|
39389271 |
Arthritis Psoriatic |
Inhibit
|
39389271 |
Arthritis Rheumatoid |
Associate
|
37087463 |
Ascites |
Associate
|
30509602 |
Asthma |
Associate
|
15038835, 35858526 |
Atrial Fibrillation |
Associate
|
32197906 |
Atypical Squamous Cells of the Cervix |
Associate
|
24167362 |
Balkan Nephropathy |
Associate
|
37629712 |
Barrett Esophagus |
Inhibit
|
16229808 |
Barrett Esophagus |
Associate
|
18664505 |
Bipolar Disorder |
Associate
|
34387669, 36476443 |
Blood Coagulation Disorders |
Associate
|
37790850 |
Bowen's Disease |
Associate
|
36085041 |
Breast Neoplasms |
Associate
|
24278290 |
Breast Neoplasms |
Inhibit
|
37923090 |
Bronchiolitis |
Associate
|
37751795 |
Carcinogenesis |
Inhibit
|
16229808 |
Carcinogenesis |
Associate
|
25970749, 37790850 |
Carcinoma Hepatocellular |
Inhibit
|
27965980 |
Carcinoma Non Small Cell Lung |
Associate
|
28837649 |
Carcinoma Renal Cell |
Associate
|
25970749, 32316597 |
Carcinoma Squamous Cell |
Associate
|
36085041, 40179422 |
Cardiovascular Diseases |
Stimulate
|
25923078 |
Cataract |
Associate
|
31814699 |
Cataract Age Related Nuclear |
Associate
|
31814699 |
Cerebral Infarction |
Associate
|
17122425, 20946167, 28738977 |
Colonic Neoplasms |
Associate
|
34564978, 38179743 |
Colorectal Neoplasms |
Associate
|
34364366, 36105798, 37664836 |
COVID 19 |
Associate
|
38003341 |
Dementia |
Associate
|
37328865 |
Diabetes Mellitus Type 1 |
Associate
|
37537394 |
Diabetes Mellitus Type 2 |
Associate
|
25923078, 30537708, 32049633 |
Diabetic Nephropathies |
Associate
|
34545296 |
Endometriosis |
Associate
|
39408909 |
Esophageal Squamous Cell Carcinoma |
Associate
|
25050929 |
Fetal Growth Retardation |
Associate
|
38069155 |
Gallbladder Neoplasms |
Associate
|
24167362 |
Gastrointestinal Diseases |
Associate
|
23778325 |
Glutamate Monosodium Sensitivity |
Associate
|
29520099 |
Graves Disease |
Associate
|
36768762 |
Hearing Loss Sensorineural |
Associate
|
28738977 |
Heart Defects Congenital |
Associate
|
26612412 |
Heat Stress Disorders |
Associate
|
29520099 |
Hemoglobin SC Disease |
Associate
|
24167362 |
Idiopathic Noncirrhotic Portal Hypertension |
Associate
|
26549939 |
Infarction Anterior Cerebral Artery |
Associate
|
17122425, 20946167 |
Inflammation |
Associate
|
32049633 |
Inflammation |
Stimulate
|
37664836 |
Inflammatory Breast Neoplasms |
Inhibit
|
24790704 |
Insulin Resistance |
Associate
|
30537708 |
Intracranial Thrombosis |
Associate
|
28738977 |
Kashin Beck Disease |
Associate
|
30153510, 33455417 |
Leukemia |
Associate
|
27891827 |
Leukemia Myelogenous Chronic BCR ABL Positive |
Associate
|
26261521 |
Leukemia Myeloid Acute |
Associate
|
26045745, 27891827, 33369453 |
Leukemia Myeloid Acute |
Inhibit
|
33202543 |
Lung Neoplasms |
Associate
|
19887610, 23374247, 27484907, 30260967 |
Lymphatic Metastasis |
Inhibit
|
23071548 |
Lymphatic Metastasis |
Associate
|
24167362 |
Macular Degeneration |
Associate
|
28651595 |
Muscular Diseases |
Associate
|
39438952 |
Myelodysplastic Syndromes |
Associate
|
23339595, 27891827, 32967500 |
Myocardial Infarction |
Associate
|
36553589 |
Myoma |
Inhibit
|
24518545 |
Neoplasm Metastasis |
Associate
|
35914155 |
Neoplasms |
Associate
|
15899813, 23699600, 30153510, 33545567, 34364366, 35914155, 37629712, 37664836, 38179743, 38204755, 38299269 |
Neoplasms |
Inhibit
|
22539223, 24790704, 25970749, 26045745, 27484907, 30260967 |
Neoplasms |
Stimulate
|
25050929 |
Obesity |
Associate
|
30537708 |
Osteoarthritis |
Inhibit
|
17075858 |
Osteoarthritis |
Associate
|
33455417 |
Ovarian Neoplasms |
Associate
|
30509602, 38299269 |
Pancreatic Neoplasms |
Associate
|
34660806 |
Parkinson Disease |
Associate
|
31199560 |
Polycystic Ovary Syndrome |
Associate
|
24279306, 36246893 |
Post Acute COVID 19 Syndrome |
Associate
|
37373377 |
Prostatic Neoplasms |
Associate
|
15899813, 23143801, 24769028, 25284284, 31115550 |
Psoriasis |
Associate
|
27364786 |
Psychological Distress |
Associate
|
36768762 |
Rectal Neoplasms |
Associate
|
22371331 |
Renal Insufficiency Chronic |
Associate
|
39519573 |
Respiratory Distress Syndrome |
Stimulate
|
22321564 |
Retinitis Pigmentosa |
Stimulate
|
27297950 |
Sepsis |
Associate
|
39438952 |
Squamous Cell Carcinoma of Head and Neck |
Associate
|
29802697, 33545567 |
Status Asthmaticus |
Associate
|
15038835 |
Stomach Neoplasms |
Inhibit
|
23071548 |
Stomach Neoplasms |
Associate
|
24014049, 30114685, 34773716, 34840985, 35601155, 37790850, 38042786, 39527470, 39762768 |
Urethral Neoplasms |
Associate
|
37629712 |
Venous Thromboembolism |
Associate
|
27742707 |
Weight Loss |
Stimulate
|
30537708 |
|