Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2873
Gene name	G protein pathway suppressor 1
Gene symbol	GPS1
Synonyms (NCBI Gene)	COPS1CSN1SGN1
Chromosome	17
Chromosome location	17q25.3
Summary	This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024116	hsa-let-7i-5p	Western blot	21530537
MIRT032090	hsa-let-7f-5p	Western blot	21530537
MIRT032096	hsa-let-7e-3p	Western blot	21530537
MIRT032191	hsa-let-7c-5p	Western blot	21530537
MIRT048796	hsa-miR-93-5p	CLASH	23622248
MIRT042663	hsa-miR-196b-5p	CLASH	23622248
MIRT042619	hsa-miR-423-3p	CLASH	23622248
MIRT496148	hsa-miR-1306-5p	PAR-CLIP	22291592
MIRT496147	hsa-miR-1224-3p	PAR-CLIP	22291592
MIRT496146	hsa-miR-4286	PAR-CLIP	22291592
MIRT496145	hsa-miR-1281	PAR-CLIP	22291592
MIRT496144	hsa-miR-668-5p	PAR-CLIP	22291592
MIRT496143	hsa-miR-566	PAR-CLIP	22291592
MIRT496148	hsa-miR-1306-5p	PAR-CLIP	22291592
MIRT496147	hsa-miR-1224-3p	PAR-CLIP	22291592
MIRT496146	hsa-miR-4286	PAR-CLIP	22291592
MIRT496145	hsa-miR-1281	PAR-CLIP	22291592
MIRT496144	hsa-miR-668-5p	PAR-CLIP	22291592
MIRT496143	hsa-miR-566	PAR-CLIP	22291592
MIRT1032329	hsa-miR-1231	CLIP-seq
MIRT1032330	hsa-miR-3130-3p	CLIP-seq
MIRT1032331	hsa-miR-3136-5p	CLIP-seq
MIRT1032332	hsa-miR-3197	CLIP-seq
MIRT1032333	hsa-miR-346	CLIP-seq
MIRT1032334	hsa-miR-3622a-3p	CLIP-seq
MIRT1032335	hsa-miR-3622b-3p	CLIP-seq
MIRT1032336	hsa-miR-4288	CLIP-seq
MIRT1032337	hsa-miR-4439	CLIP-seq
MIRT1032338	hsa-miR-4513	CLIP-seq
MIRT1032339	hsa-miR-4649-3p	CLIP-seq
MIRT1032340	hsa-miR-4793-3p	CLIP-seq
MIRT1032341	hsa-miR-627	CLIP-seq
MIRT1032342	hsa-miR-632	CLIP-seq
MIRT1032343	hsa-miR-767-3p	CLIP-seq
MIRT1032344	hsa-miR-924	CLIP-seq
MIRT1032345	hsa-miR-1227	CLIP-seq
MIRT1032346	hsa-miR-2964a-5p	CLIP-seq
MIRT1032347	hsa-miR-3153	CLIP-seq
MIRT1032348	hsa-miR-3192	CLIP-seq
MIRT1032332	hsa-miR-3197	CLIP-seq
MIRT1032349	hsa-miR-3612	CLIP-seq
MIRT1032350	hsa-miR-4252	CLIP-seq
MIRT1032351	hsa-miR-4292	CLIP-seq
MIRT1032352	hsa-miR-4308	CLIP-seq
MIRT1032353	hsa-miR-4314	CLIP-seq
MIRT1032354	hsa-miR-4443	CLIP-seq
MIRT1032355	hsa-miR-4459	CLIP-seq
MIRT1032356	hsa-miR-4646-5p	CLIP-seq
MIRT1032357	hsa-miR-4668-5p	CLIP-seq
MIRT1032358	hsa-miR-4779	CLIP-seq
MIRT1032359	hsa-miR-522	CLIP-seq
MIRT1032360	hsa-miR-622	CLIP-seq
MIRT1032361	hsa-miR-650	CLIP-seq
MIRT1032362	hsa-miR-661	CLIP-seq
MIRT1032343	hsa-miR-767-3p	CLIP-seq
MIRT1032363	hsa-miR-939	CLIP-seq
MIRT1032345	hsa-miR-1227	CLIP-seq
MIRT1032329	hsa-miR-1231	CLIP-seq
MIRT1032330	hsa-miR-3130-3p	CLIP-seq
MIRT1032331	hsa-miR-3136-5p	CLIP-seq
MIRT1032347	hsa-miR-3153	CLIP-seq
MIRT1032348	hsa-miR-3192	CLIP-seq
MIRT1032333	hsa-miR-346	CLIP-seq
MIRT1032334	hsa-miR-3622a-3p	CLIP-seq
MIRT1032335	hsa-miR-3622b-3p	CLIP-seq
MIRT1032336	hsa-miR-4288	CLIP-seq
MIRT1032353	hsa-miR-4314	CLIP-seq
MIRT1032337	hsa-miR-4439	CLIP-seq
MIRT1032338	hsa-miR-4513	CLIP-seq
MIRT1032356	hsa-miR-4646-5p	CLIP-seq
MIRT1032357	hsa-miR-4668-5p	CLIP-seq
MIRT1032340	hsa-miR-4793-3p	CLIP-seq
MIRT1032359	hsa-miR-522	CLIP-seq
MIRT1032342	hsa-miR-632	CLIP-seq
MIRT2542578	hsa-miR-1205	CLIP-seq
MIRT2542579	hsa-miR-1233	CLIP-seq
MIRT2542580	hsa-miR-1293	CLIP-seq
MIRT2542581	hsa-miR-1321	CLIP-seq
MIRT2542582	hsa-miR-15a	CLIP-seq
MIRT2542583	hsa-miR-15b	CLIP-seq
MIRT2542584	hsa-miR-16	CLIP-seq
MIRT2542585	hsa-miR-1915	CLIP-seq
MIRT2542586	hsa-miR-195	CLIP-seq
MIRT1032346	hsa-miR-2964a-5p	CLIP-seq
MIRT2542587	hsa-miR-3130-5p	CLIP-seq
MIRT2542588	hsa-miR-3173-5p	CLIP-seq
MIRT2542589	hsa-miR-3202	CLIP-seq
MIRT1032349	hsa-miR-3612	CLIP-seq
MIRT2542590	hsa-miR-3616-3p	CLIP-seq
MIRT2542591	hsa-miR-3667-3p	CLIP-seq
MIRT2542592	hsa-miR-3677-5p	CLIP-seq
MIRT2542593	hsa-miR-424	CLIP-seq
MIRT2542594	hsa-miR-4270	CLIP-seq
MIRT2542595	hsa-miR-4323	CLIP-seq
MIRT2542596	hsa-miR-4435	CLIP-seq
MIRT2542597	hsa-miR-4438	CLIP-seq
MIRT2542598	hsa-miR-4441	CLIP-seq
MIRT1032354	hsa-miR-4443	CLIP-seq
MIRT2542599	hsa-miR-4476	CLIP-seq
MIRT2542600	hsa-miR-4482	CLIP-seq
MIRT2542601	hsa-miR-4483	CLIP-seq
MIRT2542602	hsa-miR-4505	CLIP-seq
MIRT2542603	hsa-miR-4514	CLIP-seq
MIRT2542604	hsa-miR-4524	CLIP-seq
MIRT2542605	hsa-miR-4537	CLIP-seq
MIRT2542606	hsa-miR-4650-5p	CLIP-seq
MIRT2542607	hsa-miR-4690-3p	CLIP-seq
MIRT2542608	hsa-miR-4692	CLIP-seq
MIRT2542609	hsa-miR-4739	CLIP-seq
MIRT2542610	hsa-miR-4755-3p	CLIP-seq
MIRT2542611	hsa-miR-4756-5p	CLIP-seq
MIRT2542612	hsa-miR-4757-5p	CLIP-seq
MIRT2542613	hsa-miR-4763-5p	CLIP-seq
MIRT2542614	hsa-miR-497	CLIP-seq
MIRT2542615	hsa-miR-503	CLIP-seq
MIRT2542616	hsa-miR-646	CLIP-seq
MIRT1032361	hsa-miR-650	CLIP-seq
MIRT2542617	hsa-miR-665	CLIP-seq
MIRT1032363	hsa-miR-939	CLIP-seq
MIRT2542578	hsa-miR-1205	CLIP-seq
MIRT2542579	hsa-miR-1233	CLIP-seq
MIRT2542580	hsa-miR-1293	CLIP-seq
MIRT2542581	hsa-miR-1321	CLIP-seq
MIRT2542582	hsa-miR-15a	CLIP-seq
MIRT2542583	hsa-miR-15b	CLIP-seq
MIRT2542584	hsa-miR-16	CLIP-seq
MIRT2542585	hsa-miR-1915	CLIP-seq
MIRT2542586	hsa-miR-195	CLIP-seq
MIRT1032346	hsa-miR-2964a-5p	CLIP-seq
MIRT2542587	hsa-miR-3130-5p	CLIP-seq
MIRT2542588	hsa-miR-3173-5p	CLIP-seq
MIRT2542589	hsa-miR-3202	CLIP-seq
MIRT1032349	hsa-miR-3612	CLIP-seq
MIRT2542590	hsa-miR-3616-3p	CLIP-seq
MIRT2542591	hsa-miR-3667-3p	CLIP-seq
MIRT2542592	hsa-miR-3677-5p	CLIP-seq
MIRT2542593	hsa-miR-424	CLIP-seq
MIRT2542594	hsa-miR-4270	CLIP-seq
MIRT2542595	hsa-miR-4323	CLIP-seq
MIRT2542596	hsa-miR-4435	CLIP-seq
MIRT2542597	hsa-miR-4438	CLIP-seq
MIRT2542598	hsa-miR-4441	CLIP-seq
MIRT1032354	hsa-miR-4443	CLIP-seq
MIRT2542599	hsa-miR-4476	CLIP-seq
MIRT2542600	hsa-miR-4482	CLIP-seq
MIRT2542601	hsa-miR-4483	CLIP-seq
MIRT2542602	hsa-miR-4505	CLIP-seq
MIRT2542604	hsa-miR-4524	CLIP-seq
MIRT2542605	hsa-miR-4537	CLIP-seq
MIRT2542606	hsa-miR-4650-5p	CLIP-seq
MIRT2542607	hsa-miR-4690-3p	CLIP-seq
MIRT2542609	hsa-miR-4739	CLIP-seq
MIRT2542610	hsa-miR-4755-3p	CLIP-seq
MIRT2542611	hsa-miR-4756-5p	CLIP-seq
MIRT2542612	hsa-miR-4757-5p	CLIP-seq
MIRT2542613	hsa-miR-4763-5p	CLIP-seq
MIRT2542614	hsa-miR-497	CLIP-seq
MIRT2542615	hsa-miR-503	CLIP-seq
MIRT2542616	hsa-miR-646	CLIP-seq
MIRT1032361	hsa-miR-650	CLIP-seq
MIRT2542617	hsa-miR-665	CLIP-seq
MIRT1032363	hsa-miR-939	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000338	Process	Protein deneddylation	IDA	19141280
GO:0005095	Function	GTPase inhibitor activity	TAS	8943324
GO:0005515	Function	Protein binding	IPI	17337451, 18850735, 19444310, 19615732, 20399188, 21145461, 24421388, 25043011, 27029275, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	24421388
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	24421388
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007254	Process	JNK cascade	TAS	8943324
GO:0008180	Component	COP9 signalosome	IBA
GO:0008180	Component	COP9 signalosome	IDA	18850735
GO:0008180	Component	COP9 signalosome	IEA
GO:0008180	Component	COP9 signalosome	IPI	25043011
GO:0008180	Component	COP9 signalosome	ISS
GO:0045116	Process	Protein neddylation	NAS	24421388
GO:2000434	Process	Regulation of protein neddylation	NAS	24421388

MIM	HGNC	e!Ensembl
601934	4549	ENSG00000169727

Q13098

Protein name

COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)

Protein function

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of

PDB

4D10 , 4D18 , 4WSN , 6R6H , 6R7F , 6R7H , 6R7I , 6R7N , 8H38 , 8H3A , 8H3F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10602	RPN7	127 → 309	26S proteasome subunit RPN7	Family
PF01399	PCI	324 → 428	PCI domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:8943324}.

Sequence

MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERL
QFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLRELQNAPDAIPESG
VEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSN
ALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDS
QTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALAT
FDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAP
HVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSH
SKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTP
ANSQSRMSTNM

Sequence length

491

Interactions

View interactions

	Reactome
			DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	32416156	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	38289496	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Associate	27325650	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Associate	37705202	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis B	Associate	38289496	★★★★★ ★☆☆☆☆ Found in Text Mining only
Moyamoya Disease	Associate	23518061	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	37705202	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	27325650	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	38289496	★★★★★ ★☆☆☆☆ Found in Text Mining only
Penile Neoplasms	Inhibit	27325650	★★★★★ ★☆☆☆☆ Found in Text Mining only

GPS1 (G protein pathway suppressor 1)