GRK6 (G protein-coupled receptor kinase 6)

Gene

• Entrez ID: 2870
• Gene name: G protein-coupled receptor kinase 6
• Gene symbol: GRK6
• Synonyms (NCBI Gene): GPRK6
• Chromosome: 5
• Chromosome location: 5q35.3
• Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their de

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050646	hsa-miR-19a-3p	CLASH	23622248
MIRT044541	hsa-miR-320a	CLASH	23622248
MIRT044058	hsa-miR-361-5p	CLASH	23622248
MIRT043626	hsa-miR-326	CLASH	23622248
MIRT039567	hsa-miR-652-3p	CLASH	23622248
MIRT039394	hsa-miR-421	CLASH	23622248
MIRT497274	hsa-miR-652-5p	PAR-CLIP	22291592
MIRT497273	hsa-miR-6732-3p	PAR-CLIP	22291592
MIRT497272	hsa-miR-10a-5p	PAR-CLIP	22291592
MIRT497271	hsa-miR-10b-5p	PAR-CLIP	22291592
MIRT497270	hsa-miR-1298-3p	PAR-CLIP	22291592
MIRT497269	hsa-miR-1285-3p	PAR-CLIP	22291592
MIRT497268	hsa-miR-3187-5p	PAR-CLIP	22291592
MIRT497267	hsa-miR-5189-5p	PAR-CLIP	22291592
MIRT497266	hsa-miR-612	PAR-CLIP	22291592
MIRT497265	hsa-miR-6860	PAR-CLIP	22291592
MIRT497264	hsa-miR-4486	PAR-CLIP	22291592
MIRT497263	hsa-miR-378g	PAR-CLIP	22291592
MIRT497262	hsa-miR-5008-5p	PAR-CLIP	22291592
MIRT497261	hsa-miR-6089	PAR-CLIP	22291592
MIRT497260	hsa-miR-3189-5p	PAR-CLIP	22291592
MIRT497259	hsa-miR-874-5p	PAR-CLIP	22291592
MIRT497258	hsa-miR-2861	PAR-CLIP	22291592
MIRT497274	hsa-miR-652-5p	PAR-CLIP	22291592
MIRT497273	hsa-miR-6732-3p	PAR-CLIP	22291592
MIRT497272	hsa-miR-10a-5p	PAR-CLIP	22291592
MIRT497271	hsa-miR-10b-5p	PAR-CLIP	22291592
MIRT497270	hsa-miR-1298-3p	PAR-CLIP	22291592
MIRT497269	hsa-miR-1285-3p	PAR-CLIP	22291592
MIRT497268	hsa-miR-3187-5p	PAR-CLIP	22291592
MIRT497267	hsa-miR-5189-5p	PAR-CLIP	22291592
MIRT497266	hsa-miR-612	PAR-CLIP	22291592
MIRT497265	hsa-miR-6860	PAR-CLIP	22291592
MIRT497264	hsa-miR-4486	PAR-CLIP	22291592
MIRT497263	hsa-miR-378g	PAR-CLIP	22291592
MIRT497262	hsa-miR-5008-5p	PAR-CLIP	22291592
MIRT497261	hsa-miR-6089	PAR-CLIP	22291592
MIRT497260	hsa-miR-3189-5p	PAR-CLIP	22291592
MIRT497259	hsa-miR-874-5p	PAR-CLIP	22291592
MIRT497258	hsa-miR-2861	PAR-CLIP	22291592
MIRT1034935	hsa-miR-1	CLIP-seq
MIRT1034936	hsa-miR-1184	CLIP-seq
MIRT1034937	hsa-miR-1205	CLIP-seq
MIRT1034938	hsa-miR-1208	CLIP-seq
MIRT1034939	hsa-miR-1225-3p	CLIP-seq
MIRT1034940	hsa-miR-1233	CLIP-seq
MIRT1034941	hsa-miR-1253	CLIP-seq
MIRT1034942	hsa-miR-1266	CLIP-seq
MIRT1034943	hsa-miR-128	CLIP-seq
MIRT1034944	hsa-miR-1285	CLIP-seq
MIRT1034945	hsa-miR-1286	CLIP-seq
MIRT1034946	hsa-miR-1289	CLIP-seq
MIRT1034947	hsa-miR-1304	CLIP-seq
MIRT1034948	hsa-miR-1323	CLIP-seq
MIRT1034949	hsa-miR-15a	CLIP-seq
MIRT1034950	hsa-miR-15b	CLIP-seq
MIRT1034951	hsa-miR-16	CLIP-seq
MIRT1034952	hsa-miR-181a	CLIP-seq
MIRT1034953	hsa-miR-181b	CLIP-seq
MIRT1034954	hsa-miR-181c	CLIP-seq
MIRT1034955	hsa-miR-181d	CLIP-seq
MIRT1034956	hsa-miR-1827	CLIP-seq
MIRT1034957	hsa-miR-1909	CLIP-seq
MIRT1034958	hsa-miR-1915	CLIP-seq
MIRT1034959	hsa-miR-195	CLIP-seq
MIRT1034960	hsa-miR-1972	CLIP-seq
MIRT1034961	hsa-miR-19a	CLIP-seq
MIRT1034962	hsa-miR-19b	CLIP-seq
MIRT1034963	hsa-miR-206	CLIP-seq
MIRT1034964	hsa-miR-2110	CLIP-seq
MIRT1034965	hsa-miR-214	CLIP-seq
MIRT1034966	hsa-miR-2355-5p	CLIP-seq
MIRT1034967	hsa-miR-24	CLIP-seq
MIRT1034968	hsa-miR-2467-3p	CLIP-seq
MIRT1034969	hsa-miR-296-3p	CLIP-seq
MIRT1034970	hsa-miR-296-5p	CLIP-seq
MIRT1034971	hsa-miR-30a	CLIP-seq
MIRT1034972	hsa-miR-30b	CLIP-seq
MIRT1034973	hsa-miR-30c	CLIP-seq
MIRT1034974	hsa-miR-30d	CLIP-seq
MIRT1034975	hsa-miR-30e	CLIP-seq
MIRT1034976	hsa-miR-3126-3p	CLIP-seq
MIRT1034977	hsa-miR-3138	CLIP-seq
MIRT1034978	hsa-miR-3154	CLIP-seq
MIRT1034979	hsa-miR-3157-5p	CLIP-seq
MIRT1034980	hsa-miR-3158-5p	CLIP-seq
MIRT1034981	hsa-miR-3160-3p	CLIP-seq
MIRT1034982	hsa-miR-3179	CLIP-seq
MIRT1034983	hsa-miR-3184	CLIP-seq
MIRT1034984	hsa-miR-3202	CLIP-seq
MIRT1034985	hsa-miR-320e	CLIP-seq
MIRT1034986	hsa-miR-346	CLIP-seq
MIRT1034987	hsa-miR-34a	CLIP-seq
MIRT1034988	hsa-miR-34c-5p	CLIP-seq
MIRT1034989	hsa-miR-3607-3p	CLIP-seq
MIRT1034990	hsa-miR-3619-5p	CLIP-seq
MIRT1034991	hsa-miR-3663-5p	CLIP-seq
MIRT1034992	hsa-miR-3714	CLIP-seq
MIRT1034993	hsa-miR-423-5p	CLIP-seq
MIRT1034994	hsa-miR-424	CLIP-seq
MIRT1034995	hsa-miR-4251	CLIP-seq
MIRT1034996	hsa-miR-4262	CLIP-seq
MIRT1034997	hsa-miR-4271	CLIP-seq
MIRT1034998	hsa-miR-4288	CLIP-seq
MIRT1034999	hsa-miR-4293	CLIP-seq
MIRT1035000	hsa-miR-4300	CLIP-seq
MIRT1035001	hsa-miR-4417	CLIP-seq
MIRT1035002	hsa-miR-4434	CLIP-seq
MIRT1035003	hsa-miR-4435	CLIP-seq
MIRT1035004	hsa-miR-4436a	CLIP-seq
MIRT1035005	hsa-miR-4436b-3p	CLIP-seq
MIRT1035006	hsa-miR-4455	CLIP-seq
MIRT1035007	hsa-miR-4475	CLIP-seq
MIRT1035008	hsa-miR-4481	CLIP-seq
MIRT1035009	hsa-miR-4487	CLIP-seq
MIRT1035010	hsa-miR-4493	CLIP-seq
MIRT1035011	hsa-miR-449a	CLIP-seq
MIRT1035012	hsa-miR-449b	CLIP-seq
MIRT1035013	hsa-miR-4516	CLIP-seq
MIRT1035014	hsa-miR-4518	CLIP-seq
MIRT1035015	hsa-miR-4524	CLIP-seq
MIRT1035016	hsa-miR-4533	CLIP-seq
MIRT1035017	hsa-miR-4640-3p	CLIP-seq
MIRT1035018	hsa-miR-4640-5p	CLIP-seq
MIRT1035019	hsa-miR-4648	CLIP-seq
MIRT1035020	hsa-miR-4654	CLIP-seq
MIRT1035021	hsa-miR-4658	CLIP-seq
MIRT1035022	hsa-miR-4667-3p	CLIP-seq
MIRT1035023	hsa-miR-4685-5p	CLIP-seq
MIRT1035024	hsa-miR-4691-3p	CLIP-seq
MIRT1035025	hsa-miR-4716-3p	CLIP-seq
MIRT1035026	hsa-miR-4717-5p	CLIP-seq
MIRT1035027	hsa-miR-4722-5p	CLIP-seq
MIRT1035028	hsa-miR-4723-5p	CLIP-seq
MIRT1035029	hsa-miR-4725-3p	CLIP-seq
MIRT1035030	hsa-miR-4726-5p	CLIP-seq
MIRT1035031	hsa-miR-4745-5p	CLIP-seq
MIRT1035032	hsa-miR-4758-3p	CLIP-seq
MIRT1035033	hsa-miR-4758-5p	CLIP-seq
MIRT1035034	hsa-miR-4769-5p	CLIP-seq
MIRT1035035	hsa-miR-486-3p	CLIP-seq
MIRT1035036	hsa-miR-497	CLIP-seq
MIRT1035037	hsa-miR-503	CLIP-seq
MIRT1035038	hsa-miR-512-3p	CLIP-seq
MIRT1035039	hsa-miR-548a-3p	CLIP-seq
MIRT1035040	hsa-miR-548e	CLIP-seq
MIRT1035041	hsa-miR-548f	CLIP-seq
MIRT1035042	hsa-miR-548g	CLIP-seq
MIRT1035043	hsa-miR-548o	CLIP-seq
MIRT1035044	hsa-miR-553	CLIP-seq
MIRT1035045	hsa-miR-563	CLIP-seq
MIRT1035046	hsa-miR-613	CLIP-seq
MIRT1035047	hsa-miR-632	CLIP-seq
MIRT1035048	hsa-miR-646	CLIP-seq
MIRT1035049	hsa-miR-761	CLIP-seq
MIRT1035050	hsa-miR-920	CLIP-seq
MIRT2006871	hsa-miR-1202	CLIP-seq
MIRT1034944	hsa-miR-1285	CLIP-seq
MIRT2006872	hsa-miR-1587	CLIP-seq
MIRT1034952	hsa-miR-181a	CLIP-seq
MIRT1034953	hsa-miR-181b	CLIP-seq
MIRT1034954	hsa-miR-181c	CLIP-seq
MIRT1034955	hsa-miR-181d	CLIP-seq
MIRT1034956	hsa-miR-1827	CLIP-seq
MIRT1034957	hsa-miR-1909	CLIP-seq
MIRT1034965	hsa-miR-214	CLIP-seq
MIRT1034968	hsa-miR-2467-3p	CLIP-seq
MIRT1034976	hsa-miR-3126-3p	CLIP-seq
MIRT2006873	hsa-miR-3194-3p	CLIP-seq
MIRT2006874	hsa-miR-3194-5p	CLIP-seq
MIRT1034984	hsa-miR-3202	CLIP-seq
MIRT2006875	hsa-miR-329	CLIP-seq
MIRT1034987	hsa-miR-34a	CLIP-seq
MIRT1034988	hsa-miR-34c-5p	CLIP-seq
MIRT2006876	hsa-miR-3612	CLIP-seq
MIRT1034990	hsa-miR-3619-5p	CLIP-seq
MIRT2006877	hsa-miR-3622a-5p	CLIP-seq
MIRT2006878	hsa-miR-362-3p	CLIP-seq
MIRT1034991	hsa-miR-3663-5p	CLIP-seq
MIRT1034992	hsa-miR-3714	CLIP-seq
MIRT2006879	hsa-miR-3941	CLIP-seq
MIRT2006880	hsa-miR-3960	CLIP-seq
MIRT2006881	hsa-miR-3972	CLIP-seq
MIRT1034996	hsa-miR-4262	CLIP-seq
MIRT2006882	hsa-miR-4267	CLIP-seq
MIRT2006883	hsa-miR-4268	CLIP-seq
MIRT1035000	hsa-miR-4300	CLIP-seq
MIRT1035001	hsa-miR-4417	CLIP-seq
MIRT1035005	hsa-miR-4436b-3p	CLIP-seq
MIRT1035009	hsa-miR-4487	CLIP-seq
MIRT2006884	hsa-miR-4492	CLIP-seq
MIRT2006885	hsa-miR-4498	CLIP-seq
MIRT1035011	hsa-miR-449a	CLIP-seq
MIRT1035012	hsa-miR-449b	CLIP-seq
MIRT1035016	hsa-miR-4533	CLIP-seq
MIRT1035019	hsa-miR-4648	CLIP-seq
MIRT1035020	hsa-miR-4654	CLIP-seq
MIRT2006886	hsa-miR-4656	CLIP-seq
MIRT2006887	hsa-miR-4675	CLIP-seq
MIRT1035023	hsa-miR-4685-5p	CLIP-seq
MIRT1035025	hsa-miR-4716-3p	CLIP-seq
MIRT1035028	hsa-miR-4723-5p	CLIP-seq
MIRT2006888	hsa-miR-4727-5p	CLIP-seq
MIRT2006889	hsa-miR-4741	CLIP-seq
MIRT2006890	hsa-miR-4769-3p	CLIP-seq
MIRT1035034	hsa-miR-4769-5p	CLIP-seq
MIRT1035035	hsa-miR-486-3p	CLIP-seq
MIRT2006891	hsa-miR-603	CLIP-seq
MIRT2006892	hsa-miR-650	CLIP-seq
MIRT1035049	hsa-miR-761	CLIP-seq
MIRT2006893	hsa-miR-762	CLIP-seq
MIRT1035050	hsa-miR-920	CLIP-seq
MIRT2239389	hsa-miR-1197	CLIP-seq
MIRT1034938	hsa-miR-1208	CLIP-seq
MIRT1034941	hsa-miR-1253	CLIP-seq
MIRT2239390	hsa-miR-1271	CLIP-seq
MIRT1034948	hsa-miR-1323	CLIP-seq
MIRT2239391	hsa-miR-182	CLIP-seq
MIRT2239392	hsa-miR-184	CLIP-seq
MIRT1034957	hsa-miR-1909	CLIP-seq
MIRT1034958	hsa-miR-1915	CLIP-seq
MIRT1034960	hsa-miR-1972	CLIP-seq
MIRT1034961	hsa-miR-19a	CLIP-seq
MIRT1034962	hsa-miR-19b	CLIP-seq
MIRT1034964	hsa-miR-2110	CLIP-seq
MIRT1034965	hsa-miR-214	CLIP-seq
MIRT1034966	hsa-miR-2355-5p	CLIP-seq
MIRT1034971	hsa-miR-30a	CLIP-seq
MIRT1034972	hsa-miR-30b	CLIP-seq
MIRT1034973	hsa-miR-30c	CLIP-seq
MIRT1034974	hsa-miR-30d	CLIP-seq
MIRT1034975	hsa-miR-30e	CLIP-seq
MIRT2239393	hsa-miR-3144-5p	CLIP-seq
MIRT2239394	hsa-miR-3191	CLIP-seq
MIRT2006875	hsa-miR-329	CLIP-seq
MIRT1034989	hsa-miR-3607-3p	CLIP-seq
MIRT2006876	hsa-miR-3612	CLIP-seq
MIRT1034990	hsa-miR-3619-5p	CLIP-seq
MIRT2006877	hsa-miR-3622a-5p	CLIP-seq
MIRT2006878	hsa-miR-362-3p	CLIP-seq
MIRT2006879	hsa-miR-3941	CLIP-seq
MIRT1034997	hsa-miR-4271	CLIP-seq
MIRT1035005	hsa-miR-4436b-3p	CLIP-seq
MIRT2239395	hsa-miR-4446-3p	CLIP-seq
MIRT1035007	hsa-miR-4475	CLIP-seq
MIRT2239396	hsa-miR-4652-5p	CLIP-seq
MIRT2239397	hsa-miR-4667-5p	CLIP-seq
MIRT1035023	hsa-miR-4685-5p	CLIP-seq
MIRT2239398	hsa-miR-4700-5p	CLIP-seq
MIRT1035025	hsa-miR-4716-3p	CLIP-seq
MIRT1035026	hsa-miR-4717-5p	CLIP-seq
MIRT1035028	hsa-miR-4723-5p	CLIP-seq
MIRT1035029	hsa-miR-4725-3p	CLIP-seq
MIRT1035039	hsa-miR-548a-3p	CLIP-seq
MIRT1035040	hsa-miR-548e	CLIP-seq
MIRT1035041	hsa-miR-548f	CLIP-seq
MIRT1035042	hsa-miR-548g	CLIP-seq
MIRT1035043	hsa-miR-548o	CLIP-seq
MIRT1035044	hsa-miR-553	CLIP-seq
MIRT2006891	hsa-miR-603	CLIP-seq
MIRT2006892	hsa-miR-650	CLIP-seq
MIRT1035049	hsa-miR-761	CLIP-seq
MIRT2239399	hsa-miR-96	CLIP-seq
MIRT2006871	hsa-miR-1202	CLIP-seq
MIRT2006874	hsa-miR-3194-5p	CLIP-seq
MIRT2006881	hsa-miR-3972	CLIP-seq
MIRT2006882	hsa-miR-4267	CLIP-seq
MIRT2006883	hsa-miR-4268	CLIP-seq
MIRT2006888	hsa-miR-4727-5p	CLIP-seq
MIRT2006890	hsa-miR-4769-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004703	Function	G protein-coupled receptor kinase activity	IBA
GO:0004703	Function	G protein-coupled receptor kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	20729810, 22939624, 32707033, 32814053, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	8077221
GO:0009966	Process	Regulation of signal transduction	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0047696	Function	Beta-adrenergic receptor kinase activity	IDA	20038610
GO:0047696	Function	Beta-adrenergic receptor kinase activity	IMP	20038610
GO:0047696	Function	Beta-adrenergic receptor kinase activity	TAS

Other IDs

• MIM: 600869
• HGNC: 4545
• e!Ensembl: ENSG00000198055

Protein

• UniProt ID: P43250
• Protein name: G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
• Protein function: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seem
• PDB: 2ACX, 3NYN, 3NYO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00615	RGS	52 → 170	Regulator of G protein signaling domain	Domain
  PF00069	Pkinase	186 → 448	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:8415712}.
• Sequence:

  MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ
  PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE
  VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP
  VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK
  VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE
  DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE
  RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC
  SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI
  EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK
  GQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL

• Sequence length: 576

Pathways

KEGG:

Chemokine signaling pathway
Endocytosis
Morphine addiction

Reactome:

G alpha (s) signalling events