Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2870
Gene name Gene Name - the full gene name approved by the HGNC.	G protein-coupled receptor kinase 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GRK6
Synonyms (NCBI Gene) Gene synonyms aliases	GPRK6
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q35.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their de

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050646	hsa-miR-19a-3p	CLASH	23622248
MIRT044541	hsa-miR-320a	CLASH	23622248
MIRT044058	hsa-miR-361-5p	CLASH	23622248
MIRT043626	hsa-miR-326	CLASH	23622248
MIRT039567	hsa-miR-652-3p	CLASH	23622248
MIRT039394	hsa-miR-421	CLASH	23622248
MIRT497274	hsa-miR-652-5p	PAR-CLIP	22291592
MIRT497273	hsa-miR-6732-3p	PAR-CLIP	22291592
MIRT497272	hsa-miR-10a-5p	PAR-CLIP	22291592
MIRT497271	hsa-miR-10b-5p	PAR-CLIP	22291592
MIRT497270	hsa-miR-1298-3p	PAR-CLIP	22291592
MIRT497269	hsa-miR-1285-3p	PAR-CLIP	22291592
MIRT497268	hsa-miR-3187-5p	PAR-CLIP	22291592
MIRT497267	hsa-miR-5189-5p	PAR-CLIP	22291592
MIRT497266	hsa-miR-612	PAR-CLIP	22291592
MIRT497265	hsa-miR-6860	PAR-CLIP	22291592
MIRT497264	hsa-miR-4486	PAR-CLIP	22291592
MIRT497263	hsa-miR-378g	PAR-CLIP	22291592
MIRT497262	hsa-miR-5008-5p	PAR-CLIP	22291592
MIRT497261	hsa-miR-6089	PAR-CLIP	22291592
MIRT497260	hsa-miR-3189-5p	PAR-CLIP	22291592
MIRT497259	hsa-miR-874-5p	PAR-CLIP	22291592
MIRT497258	hsa-miR-2861	PAR-CLIP	22291592
MIRT497274	hsa-miR-652-5p	PAR-CLIP	22291592
MIRT497273	hsa-miR-6732-3p	PAR-CLIP	22291592
MIRT497272	hsa-miR-10a-5p	PAR-CLIP	22291592
MIRT497271	hsa-miR-10b-5p	PAR-CLIP	22291592
MIRT497270	hsa-miR-1298-3p	PAR-CLIP	22291592
MIRT497269	hsa-miR-1285-3p	PAR-CLIP	22291592
MIRT497268	hsa-miR-3187-5p	PAR-CLIP	22291592
MIRT497267	hsa-miR-5189-5p	PAR-CLIP	22291592
MIRT497266	hsa-miR-612	PAR-CLIP	22291592
MIRT497265	hsa-miR-6860	PAR-CLIP	22291592
MIRT497264	hsa-miR-4486	PAR-CLIP	22291592
MIRT497263	hsa-miR-378g	PAR-CLIP	22291592
MIRT497262	hsa-miR-5008-5p	PAR-CLIP	22291592
MIRT497261	hsa-miR-6089	PAR-CLIP	22291592
MIRT497260	hsa-miR-3189-5p	PAR-CLIP	22291592
MIRT497259	hsa-miR-874-5p	PAR-CLIP	22291592
MIRT497258	hsa-miR-2861	PAR-CLIP	22291592
MIRT1034935	hsa-miR-1	CLIP-seq
MIRT1034936	hsa-miR-1184	CLIP-seq
MIRT1034937	hsa-miR-1205	CLIP-seq
MIRT1034938	hsa-miR-1208	CLIP-seq
MIRT1034939	hsa-miR-1225-3p	CLIP-seq
MIRT1034940	hsa-miR-1233	CLIP-seq
MIRT1034941	hsa-miR-1253	CLIP-seq
MIRT1034942	hsa-miR-1266	CLIP-seq
MIRT1034943	hsa-miR-128	CLIP-seq
MIRT1034944	hsa-miR-1285	CLIP-seq
MIRT1034945	hsa-miR-1286	CLIP-seq
MIRT1034946	hsa-miR-1289	CLIP-seq
MIRT1034947	hsa-miR-1304	CLIP-seq
MIRT1034948	hsa-miR-1323	CLIP-seq
MIRT1034949	hsa-miR-15a	CLIP-seq
MIRT1034950	hsa-miR-15b	CLIP-seq
MIRT1034951	hsa-miR-16	CLIP-seq
MIRT1034952	hsa-miR-181a	CLIP-seq
MIRT1034953	hsa-miR-181b	CLIP-seq
MIRT1034954	hsa-miR-181c	CLIP-seq
MIRT1034955	hsa-miR-181d	CLIP-seq
MIRT1034956	hsa-miR-1827	CLIP-seq
MIRT1034957	hsa-miR-1909	CLIP-seq
MIRT1034958	hsa-miR-1915	CLIP-seq
MIRT1034959	hsa-miR-195	CLIP-seq
MIRT1034960	hsa-miR-1972	CLIP-seq
MIRT1034961	hsa-miR-19a	CLIP-seq
MIRT1034962	hsa-miR-19b	CLIP-seq
MIRT1034963	hsa-miR-206	CLIP-seq
MIRT1034964	hsa-miR-2110	CLIP-seq
MIRT1034965	hsa-miR-214	CLIP-seq
MIRT1034966	hsa-miR-2355-5p	CLIP-seq
MIRT1034967	hsa-miR-24	CLIP-seq
MIRT1034968	hsa-miR-2467-3p	CLIP-seq
MIRT1034969	hsa-miR-296-3p	CLIP-seq
MIRT1034970	hsa-miR-296-5p	CLIP-seq
MIRT1034971	hsa-miR-30a	CLIP-seq
MIRT1034972	hsa-miR-30b	CLIP-seq
MIRT1034973	hsa-miR-30c	CLIP-seq
MIRT1034974	hsa-miR-30d	CLIP-seq
MIRT1034975	hsa-miR-30e	CLIP-seq
MIRT1034976	hsa-miR-3126-3p	CLIP-seq
MIRT1034977	hsa-miR-3138	CLIP-seq
MIRT1034978	hsa-miR-3154	CLIP-seq
MIRT1034979	hsa-miR-3157-5p	CLIP-seq
MIRT1034980	hsa-miR-3158-5p	CLIP-seq
MIRT1034981	hsa-miR-3160-3p	CLIP-seq
MIRT1034982	hsa-miR-3179	CLIP-seq
MIRT1034983	hsa-miR-3184	CLIP-seq
MIRT1034984	hsa-miR-3202	CLIP-seq
MIRT1034985	hsa-miR-320e	CLIP-seq
MIRT1034986	hsa-miR-346	CLIP-seq
MIRT1034987	hsa-miR-34a	CLIP-seq
MIRT1034988	hsa-miR-34c-5p	CLIP-seq
MIRT1034989	hsa-miR-3607-3p	CLIP-seq
MIRT1034990	hsa-miR-3619-5p	CLIP-seq
MIRT1034991	hsa-miR-3663-5p	CLIP-seq
MIRT1034992	hsa-miR-3714	CLIP-seq
MIRT1034993	hsa-miR-423-5p	CLIP-seq
MIRT1034994	hsa-miR-424	CLIP-seq
MIRT1034995	hsa-miR-4251	CLIP-seq
MIRT1034996	hsa-miR-4262	CLIP-seq
MIRT1034997	hsa-miR-4271	CLIP-seq
MIRT1034998	hsa-miR-4288	CLIP-seq
MIRT1034999	hsa-miR-4293	CLIP-seq
MIRT1035000	hsa-miR-4300	CLIP-seq
MIRT1035001	hsa-miR-4417	CLIP-seq
MIRT1035002	hsa-miR-4434	CLIP-seq
MIRT1035003	hsa-miR-4435	CLIP-seq
MIRT1035004	hsa-miR-4436a	CLIP-seq
MIRT1035005	hsa-miR-4436b-3p	CLIP-seq
MIRT1035006	hsa-miR-4455	CLIP-seq
MIRT1035007	hsa-miR-4475	CLIP-seq
MIRT1035008	hsa-miR-4481	CLIP-seq
MIRT1035009	hsa-miR-4487	CLIP-seq
MIRT1035010	hsa-miR-4493	CLIP-seq
MIRT1035011	hsa-miR-449a	CLIP-seq
MIRT1035012	hsa-miR-449b	CLIP-seq
MIRT1035013	hsa-miR-4516	CLIP-seq
MIRT1035014	hsa-miR-4518	CLIP-seq
MIRT1035015	hsa-miR-4524	CLIP-seq
MIRT1035016	hsa-miR-4533	CLIP-seq
MIRT1035017	hsa-miR-4640-3p	CLIP-seq
MIRT1035018	hsa-miR-4640-5p	CLIP-seq
MIRT1035019	hsa-miR-4648	CLIP-seq
MIRT1035020	hsa-miR-4654	CLIP-seq
MIRT1035021	hsa-miR-4658	CLIP-seq
MIRT1035022	hsa-miR-4667-3p	CLIP-seq
MIRT1035023	hsa-miR-4685-5p	CLIP-seq
MIRT1035024	hsa-miR-4691-3p	CLIP-seq
MIRT1035025	hsa-miR-4716-3p	CLIP-seq
MIRT1035026	hsa-miR-4717-5p	CLIP-seq
MIRT1035027	hsa-miR-4722-5p	CLIP-seq
MIRT1035028	hsa-miR-4723-5p	CLIP-seq
MIRT1035029	hsa-miR-4725-3p	CLIP-seq
MIRT1035030	hsa-miR-4726-5p	CLIP-seq
MIRT1035031	hsa-miR-4745-5p	CLIP-seq
MIRT1035032	hsa-miR-4758-3p	CLIP-seq
MIRT1035033	hsa-miR-4758-5p	CLIP-seq
MIRT1035034	hsa-miR-4769-5p	CLIP-seq
MIRT1035035	hsa-miR-486-3p	CLIP-seq
MIRT1035036	hsa-miR-497	CLIP-seq
MIRT1035037	hsa-miR-503	CLIP-seq
MIRT1035038	hsa-miR-512-3p	CLIP-seq
MIRT1035039	hsa-miR-548a-3p	CLIP-seq
MIRT1035040	hsa-miR-548e	CLIP-seq
MIRT1035041	hsa-miR-548f	CLIP-seq
MIRT1035042	hsa-miR-548g	CLIP-seq
MIRT1035043	hsa-miR-548o	CLIP-seq
MIRT1035044	hsa-miR-553	CLIP-seq
MIRT1035045	hsa-miR-563	CLIP-seq
MIRT1035046	hsa-miR-613	CLIP-seq
MIRT1035047	hsa-miR-632	CLIP-seq
MIRT1035048	hsa-miR-646	CLIP-seq
MIRT1035049	hsa-miR-761	CLIP-seq
MIRT1035050	hsa-miR-920	CLIP-seq
MIRT2006871	hsa-miR-1202	CLIP-seq
MIRT1034944	hsa-miR-1285	CLIP-seq
MIRT2006872	hsa-miR-1587	CLIP-seq
MIRT1034952	hsa-miR-181a	CLIP-seq
MIRT1034953	hsa-miR-181b	CLIP-seq
MIRT1034954	hsa-miR-181c	CLIP-seq
MIRT1034955	hsa-miR-181d	CLIP-seq
MIRT1034956	hsa-miR-1827	CLIP-seq
MIRT1034957	hsa-miR-1909	CLIP-seq
MIRT1034965	hsa-miR-214	CLIP-seq
MIRT1034968	hsa-miR-2467-3p	CLIP-seq
MIRT1034976	hsa-miR-3126-3p	CLIP-seq
MIRT2006873	hsa-miR-3194-3p	CLIP-seq
MIRT2006874	hsa-miR-3194-5p	CLIP-seq
MIRT1034984	hsa-miR-3202	CLIP-seq
MIRT2006875	hsa-miR-329	CLIP-seq
MIRT1034987	hsa-miR-34a	CLIP-seq
MIRT1034988	hsa-miR-34c-5p	CLIP-seq
MIRT2006876	hsa-miR-3612	CLIP-seq
MIRT1034990	hsa-miR-3619-5p	CLIP-seq
MIRT2006877	hsa-miR-3622a-5p	CLIP-seq
MIRT2006878	hsa-miR-362-3p	CLIP-seq
MIRT1034991	hsa-miR-3663-5p	CLIP-seq
MIRT1034992	hsa-miR-3714	CLIP-seq
MIRT2006879	hsa-miR-3941	CLIP-seq
MIRT2006880	hsa-miR-3960	CLIP-seq
MIRT2006881	hsa-miR-3972	CLIP-seq
MIRT1034996	hsa-miR-4262	CLIP-seq
MIRT2006882	hsa-miR-4267	CLIP-seq
MIRT2006883	hsa-miR-4268	CLIP-seq
MIRT1035000	hsa-miR-4300	CLIP-seq
MIRT1035001	hsa-miR-4417	CLIP-seq
MIRT1035005	hsa-miR-4436b-3p	CLIP-seq
MIRT1035009	hsa-miR-4487	CLIP-seq
MIRT2006884	hsa-miR-4492	CLIP-seq
MIRT2006885	hsa-miR-4498	CLIP-seq
MIRT1035011	hsa-miR-449a	CLIP-seq
MIRT1035012	hsa-miR-449b	CLIP-seq
MIRT1035016	hsa-miR-4533	CLIP-seq
MIRT1035019	hsa-miR-4648	CLIP-seq
MIRT1035020	hsa-miR-4654	CLIP-seq
MIRT2006886	hsa-miR-4656	CLIP-seq
MIRT2006887	hsa-miR-4675	CLIP-seq
MIRT1035023	hsa-miR-4685-5p	CLIP-seq
MIRT1035025	hsa-miR-4716-3p	CLIP-seq
MIRT1035028	hsa-miR-4723-5p	CLIP-seq
MIRT2006888	hsa-miR-4727-5p	CLIP-seq
MIRT2006889	hsa-miR-4741	CLIP-seq
MIRT2006890	hsa-miR-4769-3p	CLIP-seq
MIRT1035034	hsa-miR-4769-5p	CLIP-seq
MIRT1035035	hsa-miR-486-3p	CLIP-seq
MIRT2006891	hsa-miR-603	CLIP-seq
MIRT2006892	hsa-miR-650	CLIP-seq
MIRT1035049	hsa-miR-761	CLIP-seq
MIRT2006893	hsa-miR-762	CLIP-seq
MIRT1035050	hsa-miR-920	CLIP-seq
MIRT2239389	hsa-miR-1197	CLIP-seq
MIRT1034938	hsa-miR-1208	CLIP-seq
MIRT1034941	hsa-miR-1253	CLIP-seq
MIRT2239390	hsa-miR-1271	CLIP-seq
MIRT1034948	hsa-miR-1323	CLIP-seq
MIRT2239391	hsa-miR-182	CLIP-seq
MIRT2239392	hsa-miR-184	CLIP-seq
MIRT1034957	hsa-miR-1909	CLIP-seq
MIRT1034958	hsa-miR-1915	CLIP-seq
MIRT1034960	hsa-miR-1972	CLIP-seq
MIRT1034961	hsa-miR-19a	CLIP-seq
MIRT1034962	hsa-miR-19b	CLIP-seq
MIRT1034964	hsa-miR-2110	CLIP-seq
MIRT1034965	hsa-miR-214	CLIP-seq
MIRT1034966	hsa-miR-2355-5p	CLIP-seq
MIRT1034971	hsa-miR-30a	CLIP-seq
MIRT1034972	hsa-miR-30b	CLIP-seq
MIRT1034973	hsa-miR-30c	CLIP-seq
MIRT1034974	hsa-miR-30d	CLIP-seq
MIRT1034975	hsa-miR-30e	CLIP-seq
MIRT2239393	hsa-miR-3144-5p	CLIP-seq
MIRT2239394	hsa-miR-3191	CLIP-seq
MIRT2006875	hsa-miR-329	CLIP-seq
MIRT1034989	hsa-miR-3607-3p	CLIP-seq
MIRT2006876	hsa-miR-3612	CLIP-seq
MIRT1034990	hsa-miR-3619-5p	CLIP-seq
MIRT2006877	hsa-miR-3622a-5p	CLIP-seq
MIRT2006878	hsa-miR-362-3p	CLIP-seq
MIRT2006879	hsa-miR-3941	CLIP-seq
MIRT1034997	hsa-miR-4271	CLIP-seq
MIRT1035005	hsa-miR-4436b-3p	CLIP-seq
MIRT2239395	hsa-miR-4446-3p	CLIP-seq
MIRT1035007	hsa-miR-4475	CLIP-seq
MIRT2239396	hsa-miR-4652-5p	CLIP-seq
MIRT2239397	hsa-miR-4667-5p	CLIP-seq
MIRT1035023	hsa-miR-4685-5p	CLIP-seq
MIRT2239398	hsa-miR-4700-5p	CLIP-seq
MIRT1035025	hsa-miR-4716-3p	CLIP-seq
MIRT1035026	hsa-miR-4717-5p	CLIP-seq
MIRT1035028	hsa-miR-4723-5p	CLIP-seq
MIRT1035029	hsa-miR-4725-3p	CLIP-seq
MIRT1035039	hsa-miR-548a-3p	CLIP-seq
MIRT1035040	hsa-miR-548e	CLIP-seq
MIRT1035041	hsa-miR-548f	CLIP-seq
MIRT1035042	hsa-miR-548g	CLIP-seq
MIRT1035043	hsa-miR-548o	CLIP-seq
MIRT1035044	hsa-miR-553	CLIP-seq
MIRT2006891	hsa-miR-603	CLIP-seq
MIRT2006892	hsa-miR-650	CLIP-seq
MIRT1035049	hsa-miR-761	CLIP-seq
MIRT2239399	hsa-miR-96	CLIP-seq
MIRT2006871	hsa-miR-1202	CLIP-seq
MIRT2006874	hsa-miR-3194-5p	CLIP-seq
MIRT2006881	hsa-miR-3972	CLIP-seq
MIRT2006882	hsa-miR-4267	CLIP-seq
MIRT2006883	hsa-miR-4268	CLIP-seq
MIRT2006888	hsa-miR-4727-5p	CLIP-seq
MIRT2006890	hsa-miR-4769-3p	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004703	Function	G protein-coupled receptor kinase activity	IBA
GO:0004703	Function	G protein-coupled receptor kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	20729810, 22939624, 32707033, 32814053, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	8077221
GO:0009966	Process	Regulation of signal transduction	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0047696	Function	Beta-adrenergic receptor kinase activity	IDA	20038610
GO:0047696	Function	Beta-adrenergic receptor kinase activity	IMP	20038610
GO:0047696	Function	Beta-adrenergic receptor kinase activity	TAS

MIM	HGNC	e!Ensembl
600869	4545	ENSG00000198055

Protein

UniProt ID

P43250

Protein name

G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)

Protein function

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seem

PDB

2ACX , 3NYN , 3NYO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00615	RGS	52 → 170	Regulator of G protein signaling domain	Domain
PF00069	Pkinase	186 → 448	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:8415712}.

Sequence

MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ
PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE
VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK
VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE
DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE
RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC
SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI
EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK
GQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL

Sequence length

576

Interactions

View interactions

	KEGG		Reactome
	Chemokine signaling pathway Endocytosis Morphine addiction		G alpha (s) signalling events

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Hypertension	Hypertension (confirmatory factor analysis Factor 12)	N/A	N/A	GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Inhibit	30984536
Alzheimer Disease	Inhibit	34164834
Carcinoma Hepatocellular	Associate	23375037
Medulloblastoma	Associate	23497290
Neoplasm Metastasis	Associate	23375037
Neoplasm Metastasis	Inhibit	23497290
Stomach Neoplasms	Associate	36553500
Thyroid Cancer Papillary	Associate	29805156

GRK6 (G protein-coupled receptor kinase 6)