Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2868
Gene name	G protein-coupled receptor kinase 4
Gene symbol	GRK4
Synonyms (NCBI Gene)	GPRK2LGPRK4GRK4aIT11
Chromosome	4
Chromosome location	4p16.3
Summary	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deac

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miRTarBase ID	miRNA	Experiments	Reference
MIRT437523	hsa-miR-19b-3p	Immunoprecipitaion	22382630
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT679705	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT679704	hsa-miR-7113-5p	HITS-CLIP	23824327
MIRT679703	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT679702	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633343	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633342	hsa-miR-1976	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633339	hsa-miR-5693	HITS-CLIP	23824327
MIRT633338	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT633337	hsa-miR-4284	HITS-CLIP	23824327
MIRT633336	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633343	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633342	hsa-miR-1976	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633339	hsa-miR-5693	HITS-CLIP	23824327
MIRT633338	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT633337	hsa-miR-4284	HITS-CLIP	23824327
MIRT633336	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT617543	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT617542	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT617541	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT617540	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT617539	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT617538	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT617543	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT617542	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT617541	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT617540	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT617539	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT617538	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT679705	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT679704	hsa-miR-7113-5p	HITS-CLIP	23824327
MIRT679703	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT679702	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633343	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633342	hsa-miR-1976	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633339	hsa-miR-5693	HITS-CLIP	23824327
MIRT633338	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT633337	hsa-miR-4284	HITS-CLIP	23824327
MIRT633336	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633343	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633342	hsa-miR-1976	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633339	hsa-miR-5693	HITS-CLIP	23824327
MIRT633338	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT633337	hsa-miR-4284	HITS-CLIP	23824327
MIRT633336	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT617543	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT617542	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT617541	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT617540	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT617539	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT617538	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT617543	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT617542	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT617541	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT617540	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT617539	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT617538	hsa-miR-5582-3p	HITS-CLIP	23824327

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IBA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004703	Function	G protein-coupled receptor kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	32707033, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005938	Component	Cell cortex	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	1338872
GO:0009966	Process	Regulation of signal transduction	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0022400	Process	Regulation of opsin-mediated signaling pathway	TAS
GO:0031623	Process	Receptor internalization	IDA	20074556
GO:0050254	Function	Rhodopsin kinase activity	TAS
GO:0097381	Component	Photoreceptor disc membrane	TAS

MIM	HGNC	e!Ensembl
137026	4543	ENSG00000125388

P32298

Protein name

G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1)

Protein function

Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with

PDB

4YHJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00615	RGS	52 → 171	Regulator of G protein signaling domain	Domain
PF00069	Pkinase	187 → 449	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium. {ECO:0000269|PubMed:16636192, ECO:0000269|PubMed:8626439}.

Sequence

MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK
NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC

Sequence length

578

Interactions

View interactions

	KEGG		Reactome
	Chemokine signaling pathway Endocytosis Morphine addiction		Inactivation, recovery and regulation of the phototransduction cascade

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ESSENTIAL HYPERTENSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE ACUTE RESPIRATORY SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	35769816	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Associate	22949529	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Associate	23133444	★★★★★ ★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Associate	25732908, 34297769	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertension	Associate	22949529, 23133444, 23509080, 25732908, 26134571, 33899625, 34297769	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	30115642	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Associate	22949529	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephrosclerosis	Associate	19119263	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Associate	25768006	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Associate	22949529	★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Germ Cell Tumor	Associate	34621245	★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Neoplasms	Associate	30115642	★★★★★ ★☆☆☆☆ Found in Text Mining only

GRK4 (G protein-coupled receptor kinase 4)