Gene Gene information from NCBI Gene database.
Entrez ID 286205
Gene name Suppressor of cancer cell invasion
Gene symbol SCAI
Synonyms (NCBI Gene)
C9orf126NET40
Chromosome 9
Chromosome location 9q33.3
Summary This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described
miRNA miRNA information provided by mirtarbase database.
1008
miRTarBase ID miRNA Experiments Reference
MIRT684833 hsa-miR-4323 HITS-CLIP 23313552
MIRT684832 hsa-miR-3943 HITS-CLIP 23313552
MIRT684831 hsa-miR-6769a-3p HITS-CLIP 23313552
MIRT684830 hsa-miR-3651 HITS-CLIP 23313552
MIRT684829 hsa-miR-4286 HITS-CLIP 23313552
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
MKL1 Unknown 19625774
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0003714 Function Transcription corepressor activity IBA
GO:0003714 Function Transcription corepressor activity IEA
GO:0003714 Function Transcription corepressor activity IMP 19350017
GO:0005515 Function Protein binding IPI 19350017, 32296183
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619222 26709 ENSG00000173611
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N9R8
Protein name Protein SCAI (Suppressor of cancer cell invasion protein)
Protein function Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. {ECO:0000269|PubMed:193
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12070 SCAI 64 557 Protein SCAI Family
Sequence
Sequence length 606
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RHO GTPases Activate Formins
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma of Lung Associate 36147635
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Inhibit 23936361, 26261546
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 23936361
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 33103723
★☆☆☆☆
Found in Text Mining only
Fanconi Anemia Associate 35156773
★☆☆☆☆
Found in Text Mining only
Flaujeac factor deficiency Associate 1968772
★☆☆☆☆
Found in Text Mining only
Leukemia Megakaryoblastic Acute Associate 38009531
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 23936361, 30180920
★☆☆☆☆
Found in Text Mining only
Neoplasms Inhibit 27884161, 28700933
★☆☆☆☆
Found in Text Mining only
Norrie disease Associate 7908152
★☆☆☆☆
Found in Text Mining only