GPR35 (G protein-coupled receptor 35)

Gene

• Entrez ID: 2859
• Gene name: G protein-coupled receptor 35
• Gene symbol: GPR35
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2q37.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT458672	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT458671	hsa-miR-7515	PAR-CLIP	23592263
MIRT458670	hsa-miR-3179	PAR-CLIP	23592263
MIRT458668	hsa-miR-298	PAR-CLIP	23592263
MIRT458669	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT458667	hsa-miR-4271	PAR-CLIP	23592263
MIRT458666	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT458665	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT458664	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT443549	hsa-miR-451b	PAR-CLIP	22100165
MIRT443548	hsa-miR-3185	PAR-CLIP	22100165
MIRT443547	hsa-miR-4480	PAR-CLIP	22100165
MIRT458672	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT458671	hsa-miR-7515	PAR-CLIP	23592263
MIRT458670	hsa-miR-3179	PAR-CLIP	23592263
MIRT458668	hsa-miR-298	PAR-CLIP	23592263
MIRT458669	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT458667	hsa-miR-4271	PAR-CLIP	23592263
MIRT458666	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT458665	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT458664	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT443549	hsa-miR-451b	PAR-CLIP	22100165
MIRT443548	hsa-miR-3185	PAR-CLIP	22100165
MIRT443547	hsa-miR-4480	PAR-CLIP	22100165
MIRT1031330	hsa-miR-1910	CLIP-seq
MIRT1031331	hsa-miR-3157-3p	CLIP-seq
MIRT1031332	hsa-miR-3909	CLIP-seq
MIRT1031333	hsa-miR-4264	CLIP-seq
MIRT1031334	hsa-miR-455-3p	CLIP-seq
MIRT1031335	hsa-miR-4646-3p	CLIP-seq
MIRT1031336	hsa-miR-874	CLIP-seq
MIRT1031337	hsa-miR-938	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	16754668, 17940199
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	9479505
GO:0004950	Function	Chemokine receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	16754668
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9479505
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	16754668
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	9479505
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IMP	25411203
GO:0016020	Component	Membrane	IEA
GO:0016494	Function	C-X-C chemokine receptor activity	IDA	29068046, 29875152
GO:0016494	Function	C-X-C chemokine receptor activity	IMP	25411203
GO:0070098	Process	Chemokine-mediated signaling pathway	IDA	25411203
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA
GO:0070098	Process	Chemokine-mediated signaling pathway	IMP	25411203
GO:1901386	Process	Negative regulation of voltage-gated calcium channel activity	IMP	17940199

Other IDs

• MIM: 602646
• HGNC: 4492
• e!Ensembl: ENSG00000178623

Protein

• UniProt ID: Q9HC97
• Protein name: G-protein coupled receptor 35 (Kynurenic acid receptor) (KYNA receptor)
• Protein function: G-protein coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation
• PDB: 8H8J
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	37 → 276	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in immune and gastrointestinal tissues. {ECO:0000269|PubMed:16754668}.
• Sequence:

  MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMT
  NLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRH
  PLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGF
  YLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVR
  LAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKS
  QDSLCVTLA

• Sequence length: 309

Pathways

KEGG:

Neuroactive ligand-receptor interaction

Reactome:

Class A/1 (Rhodopsin-like receptors)