Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2859
Gene name Gene Name - the full gene name approved by the HGNC.	G protein-coupled receptor 35
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GPR35
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q37.3

Show/Hide all(32)

miRTarBase ID	miRNA	Experiments	Reference
MIRT458672	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT458671	hsa-miR-7515	PAR-CLIP	23592263
MIRT458670	hsa-miR-3179	PAR-CLIP	23592263
MIRT458668	hsa-miR-298	PAR-CLIP	23592263
MIRT458669	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT458667	hsa-miR-4271	PAR-CLIP	23592263
MIRT458666	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT458665	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT458664	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT443549	hsa-miR-451b	PAR-CLIP	22100165
MIRT443548	hsa-miR-3185	PAR-CLIP	22100165
MIRT443547	hsa-miR-4480	PAR-CLIP	22100165
MIRT458672	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT458671	hsa-miR-7515	PAR-CLIP	23592263
MIRT458670	hsa-miR-3179	PAR-CLIP	23592263
MIRT458668	hsa-miR-298	PAR-CLIP	23592263
MIRT458669	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT458667	hsa-miR-4271	PAR-CLIP	23592263
MIRT458666	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT458665	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT458664	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT443549	hsa-miR-451b	PAR-CLIP	22100165
MIRT443548	hsa-miR-3185	PAR-CLIP	22100165
MIRT443547	hsa-miR-4480	PAR-CLIP	22100165
MIRT1031330	hsa-miR-1910	CLIP-seq
MIRT1031331	hsa-miR-3157-3p	CLIP-seq
MIRT1031332	hsa-miR-3909	CLIP-seq
MIRT1031333	hsa-miR-4264	CLIP-seq
MIRT1031334	hsa-miR-455-3p	CLIP-seq
MIRT1031335	hsa-miR-4646-3p	CLIP-seq
MIRT1031336	hsa-miR-874	CLIP-seq
MIRT1031337	hsa-miR-938	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	16754668, 17940199
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	9479505
GO:0004950	Function	Chemokine receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	16754668
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9479505
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	16754668
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	9479505
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IMP	25411203
GO:0016020	Component	Membrane	IEA
GO:0016494	Function	C-X-C chemokine receptor activity	IDA	29068046, 29875152
GO:0016494	Function	C-X-C chemokine receptor activity	IMP	25411203
GO:0070098	Process	Chemokine-mediated signaling pathway	IDA	25411203
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA
GO:0070098	Process	Chemokine-mediated signaling pathway	IMP	25411203
GO:1901386	Process	Negative regulation of voltage-gated calcium channel activity	IMP	17940199

MIM	HGNC	e!Ensembl
602646	4492	ENSG00000178623

Protein

UniProt ID

Q9HC97

Protein name

G-protein coupled receptor 35 (Kynurenic acid receptor) (KYNA receptor)

Protein function

G-protein coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation

PDB

8H8J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	37 → 276	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in immune and gastrointestinal tissues. {ECO:0000269|PubMed:16754668}.

Sequence

MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMT
NLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRH
PLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGF
YLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVR
LAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKS
QDSLCVTLA

Sequence length

309

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		Class A/1 (Rhodopsin-like receptors)

Show/Hide Unknown Diseases (5)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Ankylosing Spondylitis	Ankylosing spondylitis	N/A	N/A	GWAS
Bipolar Disorder	Bipolar I disorder	N/A	N/A	GWAS
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease, Inflammatory bowel disease (MTAG)	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Bacterial Infections	Associate	35933013
Carcinogenesis	Associate	36637186
Colorectal Neoplasms	Associate	31250711, 36637186, 37005662
COVID 19	Associate	36734721
Crohn Disease	Associate	25489960
Diabetes Mellitus Type 2	Associate	15696418
Heart Failure	Associate	24347166
Inflammatory Bowel Diseases	Associate	19915574, 30285606, 35933013
Neoplasm Metastasis	Associate	37005662
Neoplasms	Associate	36637186, 37005662
Pain	Associate	24347166
Pancreatic Neoplasms	Associate	36637186
Stomach Neoplasms	Associate	24347166, 36614059

GPR35 (G protein-coupled receptor 35)