Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	285676
Gene name	Zinc finger protein 454
Gene symbol	ZNF454
Synonyms (NCBI Gene)	-
Chromosome	5
Chromosome location	5q35.3

Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT714329	hsa-miR-106a-5p	HITS-CLIP	19536157
MIRT714328	hsa-miR-106b-5p	HITS-CLIP	19536157
MIRT714327	hsa-miR-17-5p	HITS-CLIP	19536157
MIRT714326	hsa-miR-20a-5p	HITS-CLIP	19536157
MIRT714325	hsa-miR-20b-5p	HITS-CLIP	19536157
MIRT714324	hsa-miR-519d-3p	HITS-CLIP	19536157
MIRT714323	hsa-miR-526b-3p	HITS-CLIP	19536157
MIRT714322	hsa-miR-93-5p	HITS-CLIP	19536157
MIRT714321	hsa-miR-302a-3p	HITS-CLIP	19536157
MIRT714320	hsa-miR-302b-3p	HITS-CLIP	19536157
MIRT714319	hsa-miR-302c-3p	HITS-CLIP	19536157
MIRT714318	hsa-miR-302d-3p	HITS-CLIP	19536157
MIRT714317	hsa-miR-302e	HITS-CLIP	19536157
MIRT714316	hsa-miR-372-3p	HITS-CLIP	19536157
MIRT714315	hsa-miR-373-3p	HITS-CLIP	19536157
MIRT714314	hsa-miR-520a-3p	HITS-CLIP	19536157
MIRT714313	hsa-miR-520b	HITS-CLIP	19536157
MIRT714312	hsa-miR-520c-3p	HITS-CLIP	19536157
MIRT714311	hsa-miR-520d-3p	HITS-CLIP	19536157
MIRT714310	hsa-miR-520e	HITS-CLIP	19536157
MIRT714309	hsa-miR-520g-3p	HITS-CLIP	19536157
MIRT714308	hsa-miR-520h	HITS-CLIP	19536157
MIRT714307	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT714306	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT714305	hsa-miR-1234-3p	HITS-CLIP	19536157
MIRT714304	hsa-miR-7107-5p	HITS-CLIP	19536157
MIRT714303	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT714302	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT714301	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT680178	hsa-miR-4438	HITS-CLIP	23824327
MIRT680177	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT680176	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT680175	hsa-miR-3199	HITS-CLIP	23824327
MIRT680174	hsa-miR-8052	HITS-CLIP	23824327
MIRT680173	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT680172	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT680171	hsa-miR-5095	HITS-CLIP	23824327
MIRT680170	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT714329	hsa-miR-106a-5p	HITS-CLIP	19536157
MIRT714328	hsa-miR-106b-5p	HITS-CLIP	19536157
MIRT714327	hsa-miR-17-5p	HITS-CLIP	19536157
MIRT714326	hsa-miR-20a-5p	HITS-CLIP	19536157
MIRT714325	hsa-miR-20b-5p	HITS-CLIP	19536157
MIRT714324	hsa-miR-519d-3p	HITS-CLIP	19536157
MIRT714323	hsa-miR-526b-3p	HITS-CLIP	19536157
MIRT714322	hsa-miR-93-5p	HITS-CLIP	19536157
MIRT714321	hsa-miR-302a-3p	HITS-CLIP	19536157
MIRT714320	hsa-miR-302b-3p	HITS-CLIP	19536157
MIRT714319	hsa-miR-302c-3p	HITS-CLIP	19536157
MIRT714318	hsa-miR-302d-3p	HITS-CLIP	19536157
MIRT714317	hsa-miR-302e	HITS-CLIP	19536157
MIRT714316	hsa-miR-372-3p	HITS-CLIP	19536157
MIRT714315	hsa-miR-373-3p	HITS-CLIP	19536157
MIRT714314	hsa-miR-520a-3p	HITS-CLIP	19536157
MIRT714313	hsa-miR-520b	HITS-CLIP	19536157
MIRT714312	hsa-miR-520c-3p	HITS-CLIP	19536157
MIRT714311	hsa-miR-520d-3p	HITS-CLIP	19536157
MIRT714310	hsa-miR-520e	HITS-CLIP	19536157
MIRT714309	hsa-miR-520g-3p	HITS-CLIP	19536157
MIRT714308	hsa-miR-520h	HITS-CLIP	19536157
MIRT714307	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT714306	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT714305	hsa-miR-1234-3p	HITS-CLIP	19536157
MIRT714304	hsa-miR-7107-5p	HITS-CLIP	19536157
MIRT714303	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT714302	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT714301	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT680178	hsa-miR-4438	HITS-CLIP	23824327
MIRT680177	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT680176	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT680175	hsa-miR-3199	HITS-CLIP	23824327
MIRT680174	hsa-miR-8052	HITS-CLIP	23824327
MIRT680173	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT680172	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT680171	hsa-miR-5095	HITS-CLIP	23824327
MIRT680170	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT1525455	hsa-miR-4252	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q8N9F8

Protein name

Zinc finger protein 454

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	13 → 54	KRAB box	Family
PF00096	zf-C2H2	178 → 200	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	216 → 238	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	244 → 266	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	272 → 294	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	328 → 350	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	356 → 378	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	384 → 406	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	412 → 434	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	440 → 462	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	468 → 490	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	496 → 518	Zinc finger, C2H2 type	Domain

Sequence

MAVSHLPTMVQESVTFKDVAILFTQEEWGQLSPAQRALYRDVMLENYSNLVSLGLLGPKP
DTFSQLEKREVWMPEDTPGGFCLDWMTMPASKKSTVKAEIPEEELDQWTIKERFSSSSHW
KCASLLEWQCGGQEISLQRVVLTHPNTPSQECDESGSTMSSSLHSDQSQGFQPSKNAFEC
SECGKVFSKSSTLNKHQKIHNEKNANQKIHIKEKRYECRECGKAFHQSTHLIHHQRIHTG
EKPYECKECGKAFSVSSSLTYHQKIHTGEKPFECNLCGKAFIRNIHLAHHHRIHTGEKPF
KCNICEKAFVCRAHLTKHQNIHSGEKPYKCNECGKAFNQSTSFLQHQRIHTGEKPFECNE
CGKAFRVNSSLTEHQRIHTGEKPYKCNECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKA
FRDQSALAQHQRIHTGEKPYTCNICEKAFSDHSALTQHKRIHTREKPYKCKICEKAFIRS
THLTQHQRIHTGEKPYKCNKCGKAFNQTANLIQHQRHHIGEK

Sequence length

522

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LEBER CONGENITAL AMAUROSIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIGHT BLINDNESS, CONGENITAL STATIONARY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Squamous Cell	Associate	32016477	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms Squamous Cell	Associate	32016477	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF454 (zinc finger protein 454)