CCDC66 (coiled-coil domain containing 66)

Gene

• Entrez ID: 285331
• Gene name: Coiled-coil domain containing 66
• Gene symbol: CCDC66
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3p14.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT869607	hsa-miR-300	CLIP-seq
MIRT869608	hsa-miR-374a	CLIP-seq
MIRT869609	hsa-miR-374b	CLIP-seq
MIRT869610	hsa-miR-376c	CLIP-seq
MIRT869611	hsa-miR-381	CLIP-seq
MIRT869612	hsa-miR-4666-3p	CLIP-seq
MIRT869613	hsa-miR-7	CLIP-seq
MIRT869607	hsa-miR-300	CLIP-seq
MIRT2195032	hsa-miR-3120-3p	CLIP-seq
MIRT869610	hsa-miR-376c	CLIP-seq
MIRT869611	hsa-miR-381	CLIP-seq
MIRT2195033	hsa-miR-4310	CLIP-seq
MIRT869612	hsa-miR-4666-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000132	Process	Establishment of mitotic spindle orientation	IMP	35849559
GO:0001578	Process	Microtubule bundle formation	IDA	35849559
GO:0001578	Process	Microtubule bundle formation	IMP	28235840
GO:0001750	Component	Photoreceptor outer segment	IEA
GO:0001895	Process	Retina homeostasis	ISS
GO:0001917	Component	Photoreceptor inner segment	IBA
GO:0001917	Component	Photoreceptor inner segment	IDA	19777273
GO:0001917	Component	Photoreceptor inner segment	IEA
GO:0005515	Function	Protein binding	IPI	28235840, 32453716, 35849559, 36606424
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	28235840, 35849559, 36606424
GO:0005813	Component	Centrosome	IEA
GO:0005819	Component	Spindle	IDA	35849559
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IDA	28235840
GO:0005874	Component	Microtubule	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005929	Component	Cilium	IBA
GO:0005929	Component	Cilium	IDA	28235840, 36606424
GO:0005929	Component	Cilium	IEA
GO:0005930	Component	Axoneme	IDA	36606424
GO:0007020	Process	Microtubule nucleation	IMP	35849559
GO:0007052	Process	Mitotic spindle organization	IMP	35849559
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	35849559
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IDA	28235840
GO:0030030	Process	Cell projection organization	IEA
GO:0030054	Component	Cell junction	IDA
GO:0030496	Component	Midbody	IDA	35849559
GO:0030496	Component	Midbody	IEA
GO:0032465	Process	Regulation of cytokinesis	IMP	35849559
GO:0034451	Component	Centriolar satellite	IDA	26638075, 28235840, 35849559, 36606424
GO:0034451	Component	Centriolar satellite	IEA
GO:0035869	Component	Ciliary transition zone	IDA	28235840
GO:0036064	Component	Ciliary basal body	IDA	28235840, 36606424
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0042995	Component	Cell projection	IEA
GO:0050908	Process	Detection of light stimulus involved in visual perception	IEA
GO:0051301	Process	Cell division	IEA
GO:0060271	Process	Cilium assembly	IBA
GO:0060271	Process	Cilium assembly	IMP	28235840, 36606424
GO:0090307	Process	Mitotic spindle assembly	IMP	35849559
GO:0090543	Component	Flemming body	IDA
GO:1902850	Process	Microtubule cytoskeleton organization involved in mitosis	IMP	35849559
GO:1903564	Process	Regulation of protein localization to cilium	IMP	28235840
GO:1905349	Process	Ciliary transition zone assembly	IMP	36606424

Other IDs

• MIM: 619287
• HGNC: 27709
• e!Ensembl: ENSG00000180376

Protein

• UniProt ID: A2RUB6
• Protein name: Coiled-coil domain-containing protein 66
• Protein function: Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15236	CCDC66	411 → 564	Coiled-coil domain-containing protein 66	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed (at protein level) (PubMed:28235840). Expressed in retina, mainly in photoreceptors but also in outer plexiform and ganglion cell layers (at protein level) (PubMed:19777273). {ECO:0000269|PubMed:19777273, ECO:0000269|P
• Sequence:

  MNLGDGLKLETELLDGKTKLILSPYEHKSKISVKMGNKAKIAKCPLRTKTGHILKSTQDT
  CIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKDLCKQCIDKDCLHIQKEISPATPNMQK
  TRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQLQQILMTVNQGNRSLSLTENGKEA
  KSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENE
  WKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKI
  IWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEH
  DRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSE
  EEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRR
  KKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQ
  ELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTY
  MNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQ
  ELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYP
  KQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNRGISPEIFHSSHQETESKLRWHLVKKE
  EEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLHLPLKNSSYERENLISGSNQTELSSGI
  SESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPN
  MVKNRDRQQAILKGLSELRQGLLQKQKELESSLLPLAENQEESFGSSF

• Sequence length: 948

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Familial cancer of breast	Uncertain significance	rs779707940	RCV005932449
Hepatocellular carcinoma	Likely benign	rs556945544	RCV005929072
Nonpapillary renal cell carcinoma	Likely benign	rs556945544	RCV005929073

Associations from Text Mining
Disease Name	Relationship Type	References
Colorectal Neoplasms	Associate	35069793
Glioma	Associate	34252882
Neoplasm Metastasis	Associate	34252882
Neoplasms	Associate	34252882, 34979511, 35264065
Osteoarthritis	Stimulate	34979511
Retinal Degeneration	Associate	28235840, 31582766
Thyroid Cancer Papillary	Associate	35264065