CCDC66 (coiled-coil domain containing 66)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
285331
Gene name Gene Name - the full gene name approved by the HGNC.
Coiled-coil domain containing 66
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCDC66
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p14.3
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(13)
miRTarBase ID miRNA Experiments Reference
MIRT869607 hsa-miR-300 CLIP-seq
MIRT869608 hsa-miR-374a CLIP-seq
MIRT869609 hsa-miR-374b CLIP-seq
MIRT869610 hsa-miR-376c CLIP-seq
MIRT869611 hsa-miR-381 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(24)
GO ID Ontology Definition Evidence Reference
GO:0001578 Process Microtubule bundle formation IMP 28235840
GO:0001750 Component Photoreceptor outer segment IEA
GO:0001895 Process Retina homeostasis ISS
GO:0001917 Component Photoreceptor inner segment IBA 21873635
GO:0001917 Component Photoreceptor inner segment IDA 19777273
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
619287 27709 ENSG00000180376
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID A2RUB6
Protein name Coiled-coil domain-containing protein 66
Protein function Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15236 CCDC66 411 → 564 Coiled-coil domain-containing protein 66 Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Widely expressed (at protein level) (PubMed:28235840). Expressed in retina, mainly in photoreceptors but also in outer plexiform and ganglion cell layers (at protein level) (PubMed:19777273). {ECO:0000269|PubMed:19777273, ECO:0000269|P
Sequence 
MNLGDGLKLETELLDGKTKLILSPYEHKSKISVKMGNKAKIAKCPLRTKTGHILKSTQDT
CIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKDLCKQCIDKDCLHIQKEISPATPNMQK
TRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQLQQILMTVNQGNRSLSLTENGKEA
KSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENE
WKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKI
IWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEH
DRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSE
EEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRR
KKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQ
ELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTY
MNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQ
ELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYP
KQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNRGISPEIFHSSHQETESKLRWHLVKKE
EEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLHLPLKNSSYERENLISGSNQTELSSGI
SESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPN
MVKNRDRQQAILKGLSELRQGLLQKQKELESSLLPLAENQEESFGSSF
Sequence length 948
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Gastritis Gastritis GWAS
Show/Hide Text Mining Associations (7)
Associations from Text Mining
Disease Name Relationship Type References
Colorectal Neoplasms Associate 35069793
Glioma Associate 34252882
Neoplasm Metastasis Associate 34252882
Neoplasms Associate 34252882, 34979511, 35264065
Osteoarthritis Stimulate 34979511
Retinal Degeneration Associate 28235840, 31582766
Thyroid Cancer Papillary Associate 35264065