Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	285313
Gene name	Immunoglobulin superfamily member 10
Gene symbol	IGSF10
Synonyms (NCBI Gene)	CMF608
Chromosome	3
Chromosome location	3q25.1

Show/Hide all (11)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017308	hsa-miR-335-5p	Microarray	18185580
MIRT019294	hsa-miR-148b-3p	Microarray	17612493
MIRT1062463	hsa-miR-1272	CLIP-seq
MIRT1062464	hsa-miR-1322	CLIP-seq
MIRT1062465	hsa-miR-23a	CLIP-seq
MIRT1062466	hsa-miR-23b	CLIP-seq
MIRT1062467	hsa-miR-23c	CLIP-seq
MIRT1062468	hsa-miR-4640-3p	CLIP-seq
MIRT1062469	hsa-miR-5096	CLIP-seq
MIRT1062470	hsa-miR-3613-3p	CLIP-seq
MIRT1062471	hsa-miR-4778-3p	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001503	Process	Ossification	IEA
GO:0005576	Component	Extracellular region	IBA
GO:0005576	Component	Extracellular region	IDA	27137492
GO:0005576	Component	Extracellular region	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:2001222	Process	Regulation of neuron migration	IEA
GO:2001222	Process	Regulation of neuron migration	ISS

MIM	HGNC	e!Ensembl
617351	26384	ENSG00000152580

Q6WRI0

Protein name

Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608)

Protein function

Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity). {ECO:0000250|UniProtKB:Q3V1M

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	81 → 141	Leucine rich repeat	Repeat
PF13855	LRR_8	129 → 186	Leucine rich repeat	Repeat
PF07679	I-set	480 → 568	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	573 → 649		Domain
PF07679	I-set	1650 → 1740	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	1744 → 1824		Domain
PF07679	I-set	1842 → 1934	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	1940 → 2020		Domain
PF07679	I-set	2040 → 2136	Immunoglobulin I-set domain	Domain
PF07679	I-set	2141 → 2230	Immunoglobulin I-set domain	Domain
PF07679	I-set	2243 → 2330	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	2336 → 2415		Domain
PF13927	Ig_3	2431 → 2510		Domain
PF13927	Ig_3	2527 → 2609		Domain

Sequence

MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVE
RINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKL
QKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQ
IFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDV
IKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSS
SAFISPQGFMAPFGSLTLNMTDQSGNEANMVCSIQKPSRTSPIAFTEENDYIVLNTSFST
FLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSETPQLYYKYKQVAPKPEDIFTNIEA
DLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNN
TKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQM
ADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGI
PDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQV
SVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHN
YRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPP
PVVTQLPNIPGEEDDSSGMLALHEEFMVPATKALNLPARTVTADSRTISDSPMTNINYGT
EFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQHSSTVFPLLLGA
TEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTNKLLLESVNTTNSHQTSVRE
VSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRRFGRQRKIGGRG
RIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATAALS
FPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTG
AVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSR
RKIPWQQNFVNNHNPKGRLRNQHKVSLQKSTAVMLPKTSPALPRDKVSPFHFTTLSTSVM
QIPSNTLTTAHHTTTKTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPA
TTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLT
TAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASET
TLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTN
TVVKLHESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKS
QNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSD
FDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTI
HWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSV
VSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVT
VDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESL
KLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIAT
SSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSK
AVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKI
DHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFN
NGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAV
LDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSG
DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIF
LTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR
NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISK
TTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIP
KPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVP
VMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHG
SEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI

Sequence length

2623

Interactions

View interactions

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs16863403	RCV005928212
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs756015608	RCV004560324
IGSF10-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	rs9871952, rs12487205, rs17204557, rs147678532, rs7619322, rs151226002, rs6798252, rs34197438, rs34114908, rs9864533, rs7624011, rs114161831, rs142214363, rs41401648, rs2172250 View all (62 more)	RCV003968454 RCV003923481 RCV003978502 RCV003913573 RCV003984228 RCV003923661 RCV003978757 RCV003913660 RCV003923615 RCV003978699 RCV003978775 RCV003978776 RCV003933339 RCV003978847 RCV003978683 RCV003978684 RCV003978714 RCV003978768 RCV003916355 RCV003933439 RCV003936340 RCV003936341 RCV003936342 RCV003963415 RCV003936381 RCV003906413 RCV003906414 RCV003943614 RCV003961268 RCV003926625 RCV003963565 RCV003418891 RCV003421128 RCV003929222 RCV003929238 RCV003904363 RCV003974246 RCV003942055 RCV003961693 RCV003934442 RCV003926992 RCV003924716 RCV003949116 RCV003956713 RCV003971440 RCV003915902 RCV003970667 RCV003915810 RCV003903180 RCV003978246 RCV003928471 RCV003928472 RCV003962926 RCV003918463 RCV003962893 RCV003962894 RCV003943217 RCV003928473 RCV003972934 RCV003935926 RCV003918525 RCV003972935 RCV003916223 RCV003940379 RCV003968004 RCV003930800 RCV003930843 RCV003930480 RCV003968169 RCV003940733 RCV003902834 RCV003958268 RCV003940811 RCV003950503 RCV003968243 RCV003950753 RCV003895565
Lung cancer	Benign	rs16863403	RCV005928215
Martsolf syndrome 1	Uncertain significance	rs371153588	RCV002305663
Premature ovarian failure	Conflicting classifications of pathogenicity; Uncertain significance	rs35667704, rs1577654964, rs147801336, rs370577610	RCV001002737 RCV001002746 RCV001002735 RCV001002745
Squamous cell carcinoma of the head and neck	Likely benign	rs371140788	RCV005931327
Thymoma	Benign	rs16863403	RCV005928213
Thyroid cancer, nonmedullary, 1	Benign	rs16863403	RCV005928214
Uterine corpus endometrial carcinoma	Benign	rs16863403, rs184928959	RCV005928216 RCV005926648

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Inhibit	34351868
Arthritis Rheumatoid	Associate	37019382
Breast Neoplasms	Inhibit	33550915
Combined Pituitary Hormone Deficiency	Associate	32612575
Idiopathic Hypogonadotropic Hypogonadism	Associate	33208564
Lung Neoplasms	Inhibit	31789390
Neoplasms	Inhibit	34351868
Primary Ovarian Insufficiency	Associate	31042289
Puberty Delayed	Associate	32612575

IGSF10 (immunoglobulin superfamily member 10)