Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
284996
Gene name Gene Name - the full gene name approved by the HGNC.
Ring finger protein 149
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RNF149
Synonyms (NCBI Gene) Gene synonyms aliases
DNAPTP2
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q11.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002520 hsa-miR-373-3p Microarray 15685193
MIRT002520 hsa-miR-373-3p Microarray;Other 15685193
MIRT031790 hsa-miR-16-5p Sequencing 20371350
MIRT046533 hsa-miR-15b-5p CLASH 23622248
MIRT045180 hsa-miR-186-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005737 Component Cytoplasm IBA 21873635
GO:0006511 Process Ubiquitin-dependent protein catabolic process IBA 21873635
GO:0016020 Component Membrane HDA 19946888
GO:0016021 Component Integral component of membrane IEA
GO:0016567 Process Protein ubiquitination IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein
UniProt ID Q8NC42
Protein name E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149)
Protein function E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02225 PA 76 171 PA domain Family
PF13639 zf-RING_2 267 310 Ring finger domain Domain
Sequence
MAWRRREASVGARGVLALALLALALCVPGARGRALEWFSAVVNIEYVDPQTNLTVWSVSE
SGRFGDSSPKEGAHGLVGVPWAPGGDLEGCAPDTRFFVPEPGGRGAAPWVALVARGGCTF
KDKVLVAARRNASAVVLYNEERYGNITLPMSHAGTGNIVVIMISYPKGREI
LELVQKGIP
VTMTIGVGTRHVQEFISGQSVVFVAIAFITMMIISLAWLIFYYIQRFLYTGSQIGSQSHR
KETKKVIGQLLLHTVKHGEKGIDVDAENCAVCIENFKVKDIIRILPCKHIFHRICIDPWL
LDHRTCPMCK
LDVIKALGYWGEPGDVQEMPAPESPPGRDPAANLSLALPDDDGSDDSSPP
SASPAESEPQCDPSFKGDAGENTALLEAGRSDSRHGGPIS
Sequence length 400
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Associations from Text Mining
Disease Name Relationship Type References
Cataract Age Related Nuclear Associate 29182452
Heart Defects Congenital Associate 37404133
Hypoplastic Left Heart Syndrome Associate 37404133
Thromboangiitis Obliterans Associate 38275601