Gene Gene information from NCBI Gene database.
Entrez ID 284996
Gene name Ring finger protein 149
Gene symbol RNF149
Synonyms (NCBI Gene)
DNAPTP2
Chromosome 2
Chromosome location 2q11.2
miRNA miRNA information provided by mirtarbase database.
386
miRTarBase ID miRNA Experiments Reference
MIRT002520 hsa-miR-373-3p Microarray 15685193
MIRT002520 hsa-miR-373-3p Microarray;Other 15685193
MIRT031790 hsa-miR-16-5p Sequencing 20371350
MIRT046533 hsa-miR-15b-5p CLASH 23622248
MIRT045180 hsa-miR-186-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0005737 Component Cytoplasm IBA
GO:0005770 Component Late endosome IBA
GO:0005783 Component Endoplasmic reticulum IBA
GO:0005794 Component Golgi apparatus IBA
GO:0006511 Process Ubiquitin-dependent protein catabolic process IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NC42
Protein name E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149)
Protein function E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02225 PA 76 171 PA domain Family
PF13639 zf-RING_2 267 310 Ring finger domain Domain
Sequence
MAWRRREASVGARGVLALALLALALCVPGARGRALEWFSAVVNIEYVDPQTNLTVWSVSE
SGRFGDSSPKEGAHGLVGVPWAPGGDLEGCAPDTRFFVPEPGGRGAAPWVALVARGGCTF
KDKVLVAARRNASAVVLYNEERYGNITLPMSHAGTGNIVVIMISYPKGREI
LELVQKGIP
VTMTIGVGTRHVQEFISGQSVVFVAIAFITMMIISLAWLIFYYIQRFLYTGSQIGSQSHR
KETKKVIGQLLLHTVKHGEKGIDVDAENCAVCIENFKVKDIIRILPCKHIFHRICIDPWL
LDHRTCPMCK
LDVIKALGYWGEPGDVQEMPAPESPPGRDPAANLSLALPDDDGSDDSSPP
SASPAESEPQCDPSFKGDAGENTALLEAGRSDSRHGGPIS
Sequence length 400
Interactions View interactions