SIRPB2 (signal regulatory protein beta 2)

Gene

• Entrez ID: 284759
• Gene name: Signal regulatory protein beta 2
• Gene symbol: SIRPB2
• Synonyms (NCBI Gene): PTPN1L, PTPNS1L3, dJ776F14.2
• Chromosome: 20
• Chromosome location: 20p13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT437535	hsa-miR-19b-3p	Immunoprecipitaion	22382630
MIRT722765	hsa-miR-510-5p	HITS-CLIP	19536157
MIRT722764	hsa-miR-3140-5p	HITS-CLIP	19536157
MIRT722763	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT722762	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT722761	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT722760	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT722759	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT722758	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT722757	hsa-miR-4539	HITS-CLIP	19536157
MIRT722756	hsa-miR-3663-5p	HITS-CLIP	19536157
MIRT722755	hsa-miR-4680-5p	HITS-CLIP	19536157
MIRT722754	hsa-miR-6131	HITS-CLIP	19536157
MIRT722753	hsa-miR-6843-3p	HITS-CLIP	19536157
MIRT722752	hsa-miR-6848-3p	HITS-CLIP	19536157
MIRT722765	hsa-miR-510-5p	HITS-CLIP	19536157
MIRT722764	hsa-miR-3140-5p	HITS-CLIP	19536157
MIRT722763	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT722762	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT722761	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT722760	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT722759	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT722758	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT722757	hsa-miR-4539	HITS-CLIP	19536157
MIRT722756	hsa-miR-3663-5p	HITS-CLIP	19536157
MIRT722755	hsa-miR-4680-5p	HITS-CLIP	19536157
MIRT722754	hsa-miR-6131	HITS-CLIP	19536157
MIRT722753	hsa-miR-6843-3p	HITS-CLIP	19536157
MIRT722752	hsa-miR-6848-3p	HITS-CLIP	19536157
MIRT1349989	hsa-miR-122	CLIP-seq
MIRT1349990	hsa-miR-130a	CLIP-seq
MIRT1349991	hsa-miR-130b	CLIP-seq
MIRT1349992	hsa-miR-301a	CLIP-seq
MIRT1349993	hsa-miR-301b	CLIP-seq
MIRT1349994	hsa-miR-3135b	CLIP-seq
MIRT1349995	hsa-miR-3652	CLIP-seq
MIRT1349996	hsa-miR-3666	CLIP-seq
MIRT1349997	hsa-miR-4295	CLIP-seq
MIRT1349998	hsa-miR-4423-5p	CLIP-seq
MIRT1349999	hsa-miR-4430	CLIP-seq
MIRT1350000	hsa-miR-454	CLIP-seq
MIRT1350001	hsa-miR-4634	CLIP-seq
MIRT1350002	hsa-miR-4695-3p	CLIP-seq
MIRT1350003	hsa-miR-652	CLIP-seq
MIRT1350004	hsa-miR-661	CLIP-seq
MIRT1350005	hsa-miR-106a	CLIP-seq
MIRT1350006	hsa-miR-106b	CLIP-seq
MIRT1349989	hsa-miR-122	CLIP-seq
MIRT1350007	hsa-miR-1224-5p	CLIP-seq
MIRT1349990	hsa-miR-130a	CLIP-seq
MIRT1349991	hsa-miR-130b	CLIP-seq
MIRT1350008	hsa-miR-150	CLIP-seq
MIRT1350009	hsa-miR-17	CLIP-seq
MIRT1350010	hsa-miR-185	CLIP-seq
MIRT1350011	hsa-miR-20a	CLIP-seq
MIRT1350012	hsa-miR-20b	CLIP-seq
MIRT1349992	hsa-miR-301a	CLIP-seq
MIRT1349993	hsa-miR-301b	CLIP-seq
MIRT1350013	hsa-miR-302a	CLIP-seq
MIRT1350014	hsa-miR-302b	CLIP-seq
MIRT1350015	hsa-miR-302c	CLIP-seq
MIRT1350016	hsa-miR-302d	CLIP-seq
MIRT1350017	hsa-miR-302e	CLIP-seq
MIRT1349994	hsa-miR-3135b	CLIP-seq
MIRT1350018	hsa-miR-3150b-3p	CLIP-seq
MIRT1350019	hsa-miR-3199	CLIP-seq
MIRT1349995	hsa-miR-3652	CLIP-seq
MIRT1349996	hsa-miR-3666	CLIP-seq
MIRT1350020	hsa-miR-372	CLIP-seq
MIRT1350021	hsa-miR-373	CLIP-seq
MIRT1350022	hsa-miR-3915	CLIP-seq
MIRT1349997	hsa-miR-4295	CLIP-seq
MIRT1350023	hsa-miR-4306	CLIP-seq
MIRT1349998	hsa-miR-4423-5p	CLIP-seq
MIRT1349999	hsa-miR-4430	CLIP-seq
MIRT1350024	hsa-miR-4499	CLIP-seq
MIRT1350000	hsa-miR-454	CLIP-seq
MIRT1350001	hsa-miR-4634	CLIP-seq
MIRT1350025	hsa-miR-4644	CLIP-seq
MIRT1350026	hsa-miR-4666-5p	CLIP-seq
MIRT1350027	hsa-miR-4689	CLIP-seq
MIRT1350002	hsa-miR-4695-3p	CLIP-seq
MIRT1350028	hsa-miR-4731-5p	CLIP-seq
MIRT1350029	hsa-miR-4740-5p	CLIP-seq
MIRT1350030	hsa-miR-4784	CLIP-seq
MIRT1350031	hsa-miR-512-3p	CLIP-seq
MIRT1350032	hsa-miR-519d	CLIP-seq
MIRT1350033	hsa-miR-520a-3p	CLIP-seq
MIRT1350034	hsa-miR-520b	CLIP-seq
MIRT1350035	hsa-miR-520c-3p	CLIP-seq
MIRT1350036	hsa-miR-520d-3p	CLIP-seq
MIRT1350037	hsa-miR-520e	CLIP-seq
MIRT1350038	hsa-miR-520g	CLIP-seq
MIRT1350039	hsa-miR-520h	CLIP-seq
MIRT1350003	hsa-miR-652	CLIP-seq
MIRT1350040	hsa-miR-93	CLIP-seq
MIRT2327853	hsa-miR-4727-5p	CLIP-seq
MIRT2327854	hsa-miR-4769-3p	CLIP-seq
MIRT2327855	hsa-miR-1184	CLIP-seq
MIRT1349989	hsa-miR-122	CLIP-seq
MIRT2327856	hsa-miR-125a-3p	CLIP-seq
MIRT1349990	hsa-miR-130a	CLIP-seq
MIRT1349991	hsa-miR-130b	CLIP-seq
MIRT1349992	hsa-miR-301a	CLIP-seq
MIRT1349993	hsa-miR-301b	CLIP-seq
MIRT1349994	hsa-miR-3135b	CLIP-seq
MIRT2327857	hsa-miR-3165	CLIP-seq
MIRT1349995	hsa-miR-3652	CLIP-seq
MIRT1349996	hsa-miR-3666	CLIP-seq
MIRT2327858	hsa-miR-3934	CLIP-seq
MIRT1349997	hsa-miR-4295	CLIP-seq
MIRT2327859	hsa-miR-4418	CLIP-seq
MIRT1349998	hsa-miR-4423-5p	CLIP-seq
MIRT1349999	hsa-miR-4430	CLIP-seq
MIRT1350000	hsa-miR-454	CLIP-seq
MIRT1350001	hsa-miR-4634	CLIP-seq
MIRT1350002	hsa-miR-4695-3p	CLIP-seq
MIRT2327860	hsa-miR-4728-3p	CLIP-seq
MIRT2327861	hsa-miR-4735-5p	CLIP-seq
MIRT2327862	hsa-miR-4742-3p	CLIP-seq
MIRT2327863	hsa-miR-4775	CLIP-seq
MIRT2327864	hsa-miR-498	CLIP-seq
MIRT2327865	hsa-miR-509-3-5p	CLIP-seq
MIRT2327866	hsa-miR-509-5p	CLIP-seq
MIRT2327867	hsa-miR-590-3p	CLIP-seq
MIRT1350003	hsa-miR-652	CLIP-seq
MIRT2394558	hsa-miR-5095	CLIP-seq
MIRT2394559	hsa-miR-552	CLIP-seq
MIRT2394560	hsa-miR-764	CLIP-seq
MIRT2327855	hsa-miR-1184	CLIP-seq
MIRT2459416	hsa-miR-129-5p	CLIP-seq
MIRT2459417	hsa-miR-3149	CLIP-seq
MIRT2459418	hsa-miR-411	CLIP-seq
MIRT2327859	hsa-miR-4418	CLIP-seq
MIRT1350001	hsa-miR-4634	CLIP-seq
MIRT1350002	hsa-miR-4695-3p	CLIP-seq
MIRT2327861	hsa-miR-4735-5p	CLIP-seq
MIRT2327863	hsa-miR-4775	CLIP-seq
MIRT2459419	hsa-miR-4794	CLIP-seq
MIRT2327864	hsa-miR-498	CLIP-seq
MIRT2327865	hsa-miR-509-3-5p	CLIP-seq
MIRT2394558	hsa-miR-5095	CLIP-seq
MIRT2327866	hsa-miR-509-5p	CLIP-seq
MIRT2394559	hsa-miR-552	CLIP-seq
MIRT2327867	hsa-miR-590-3p	CLIP-seq
MIRT2394560	hsa-miR-764	CLIP-seq
MIRT2466031	hsa-miR-1270	CLIP-seq
MIRT2327857	hsa-miR-3165	CLIP-seq
MIRT2466032	hsa-miR-4683	CLIP-seq
MIRT2327860	hsa-miR-4728-3p	CLIP-seq
MIRT2466033	hsa-miR-620	CLIP-seq
MIRT2327855	hsa-miR-1184	CLIP-seq
MIRT1349989	hsa-miR-122	CLIP-seq
MIRT2622855	hsa-miR-1224-3p	CLIP-seq
MIRT2622856	hsa-miR-1234	CLIP-seq
MIRT2327856	hsa-miR-125a-3p	CLIP-seq
MIRT2459416	hsa-miR-129-5p	CLIP-seq
MIRT1349990	hsa-miR-130a	CLIP-seq
MIRT1349991	hsa-miR-130b	CLIP-seq
MIRT1349992	hsa-miR-301a	CLIP-seq
MIRT1349993	hsa-miR-301b	CLIP-seq
MIRT1349994	hsa-miR-3135b	CLIP-seq
MIRT2459417	hsa-miR-3149	CLIP-seq
MIRT1349995	hsa-miR-3652	CLIP-seq
MIRT1349996	hsa-miR-3666	CLIP-seq
MIRT2327858	hsa-miR-3934	CLIP-seq
MIRT2459418	hsa-miR-411	CLIP-seq
MIRT1349997	hsa-miR-4295	CLIP-seq
MIRT2327859	hsa-miR-4418	CLIP-seq
MIRT1349998	hsa-miR-4423-5p	CLIP-seq
MIRT1349999	hsa-miR-4430	CLIP-seq
MIRT1350000	hsa-miR-454	CLIP-seq
MIRT1350001	hsa-miR-4634	CLIP-seq
MIRT1350002	hsa-miR-4695-3p	CLIP-seq
MIRT2327861	hsa-miR-4735-5p	CLIP-seq
MIRT2327863	hsa-miR-4775	CLIP-seq
MIRT2459419	hsa-miR-4794	CLIP-seq
MIRT2327864	hsa-miR-498	CLIP-seq
MIRT2327865	hsa-miR-509-3-5p	CLIP-seq
MIRT2394558	hsa-miR-5095	CLIP-seq
MIRT2327866	hsa-miR-509-5p	CLIP-seq
MIRT2622857	hsa-miR-510	CLIP-seq
MIRT2394559	hsa-miR-552	CLIP-seq
MIRT2327867	hsa-miR-590-3p	CLIP-seq
MIRT2622858	hsa-miR-640	CLIP-seq
MIRT1350003	hsa-miR-652	CLIP-seq
MIRT2394560	hsa-miR-764	CLIP-seq
MIRT2327855	hsa-miR-1184	CLIP-seq
MIRT1349989	hsa-miR-122	CLIP-seq
MIRT2622855	hsa-miR-1224-3p	CLIP-seq
MIRT2622856	hsa-miR-1234	CLIP-seq
MIRT2327856	hsa-miR-125a-3p	CLIP-seq
MIRT2459416	hsa-miR-129-5p	CLIP-seq
MIRT1349990	hsa-miR-130a	CLIP-seq
MIRT1349991	hsa-miR-130b	CLIP-seq
MIRT2690799	hsa-miR-1321	CLIP-seq
MIRT2690800	hsa-miR-1827	CLIP-seq
MIRT2690801	hsa-miR-2467-3p	CLIP-seq
MIRT1349992	hsa-miR-301a	CLIP-seq
MIRT1349993	hsa-miR-301b	CLIP-seq
MIRT1349994	hsa-miR-3135b	CLIP-seq
MIRT2459417	hsa-miR-3149	CLIP-seq
MIRT2690802	hsa-miR-3612	CLIP-seq
MIRT1349995	hsa-miR-3652	CLIP-seq
MIRT1349996	hsa-miR-3666	CLIP-seq
MIRT2327858	hsa-miR-3934	CLIP-seq
MIRT2690803	hsa-miR-4270	CLIP-seq
MIRT1349997	hsa-miR-4295	CLIP-seq
MIRT2327859	hsa-miR-4418	CLIP-seq
MIRT1349998	hsa-miR-4423-5p	CLIP-seq
MIRT1349999	hsa-miR-4430	CLIP-seq
MIRT2690804	hsa-miR-4441	CLIP-seq
MIRT1350000	hsa-miR-454	CLIP-seq
MIRT1350001	hsa-miR-4634	CLIP-seq
MIRT1350002	hsa-miR-4695-3p	CLIP-seq
MIRT2690805	hsa-miR-4695-5p	CLIP-seq
MIRT2327861	hsa-miR-4735-5p	CLIP-seq
MIRT2690806	hsa-miR-4739	CLIP-seq
MIRT2690807	hsa-miR-4756-5p	CLIP-seq
MIRT2327863	hsa-miR-4775	CLIP-seq
MIRT2459419	hsa-miR-4794	CLIP-seq
MIRT2327864	hsa-miR-498	CLIP-seq
MIRT2327865	hsa-miR-509-3-5p	CLIP-seq
MIRT2394558	hsa-miR-5095	CLIP-seq
MIRT2327866	hsa-miR-509-5p	CLIP-seq
MIRT2622857	hsa-miR-510	CLIP-seq
MIRT2394559	hsa-miR-552	CLIP-seq
MIRT2327867	hsa-miR-590-3p	CLIP-seq
MIRT2622858	hsa-miR-640	CLIP-seq
MIRT2690808	hsa-miR-650	CLIP-seq
MIRT1350003	hsa-miR-652	CLIP-seq
MIRT2394560	hsa-miR-764	CLIP-seq
MIRT2690809	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5JXA9
• Protein name: Signal-regulatory protein beta-2 (SIRP-beta-2) (Protein tyrosine phosphatase non-receptor type substrate 1-like 3) (Protein tyrosine phosphatase non-receptor type substrate protein)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	43 → 150	Immunoglobulin V-set domain	Domain
  PF07686	V-set	162 → 264	Immunoglobulin V-set domain	Domain

• Sequence:

  MCSTMSAPTCLAHLPPCFLLLALVLVPSDASGQSSRNDWQVLQPEGPMLVAEGETLLLRC
  MVVGSCTDGMIKWVKVSTQDQQEIYNFKRGSFPGVMPMIQRTSEPLNCDYSIYIHNVTRE
  HTGTYHCVRFDGLSEHSEMKSDEGTSVLVKGAGDPEPDLWIIQPQELVLGTTGDTVFLNC
  TVLGDGPPGPIRWFQGAGLSREAIYNFGGISHPKETAVQASNNDFSILLQNVSSEDAGTY
  YCVKFQRKPNRQYLSGQGTSLKVKAKSTSSKEAEFTSEPATEMSPTGLLVVFAPVVLGLK
  AITLAALLLALATSRRSPGQEDVKTTGPAGAMNTLAWSKGQE

• Sequence length: 342

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations