EPHA10 (EPH receptor A10)

Gene

• Entrez ID: 284656
• Gene name: EPH receptor A10
• Gene symbol: EPHA10
• Synonyms (NCBI Gene): DFNA88
• Chromosome: 1
• Chromosome location: 1p34.3
• Summary: Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT966226	hsa-miR-1207-5p	CLIP-seq
MIRT966227	hsa-miR-1224-5p	CLIP-seq
MIRT966228	hsa-miR-124	CLIP-seq
MIRT966229	hsa-miR-1270	CLIP-seq
MIRT966230	hsa-miR-1275	CLIP-seq
MIRT966231	hsa-miR-1321	CLIP-seq
MIRT966232	hsa-miR-143	CLIP-seq
MIRT966233	hsa-miR-1915	CLIP-seq
MIRT966234	hsa-miR-193a-5p	CLIP-seq
MIRT966235	hsa-miR-2110	CLIP-seq
MIRT966236	hsa-miR-2278	CLIP-seq
MIRT966237	hsa-miR-2467-5p	CLIP-seq
MIRT966238	hsa-miR-296-5p	CLIP-seq
MIRT966239	hsa-miR-29a	CLIP-seq
MIRT966240	hsa-miR-29b	CLIP-seq
MIRT966241	hsa-miR-29c	CLIP-seq
MIRT966242	hsa-miR-3127-5p	CLIP-seq
MIRT966243	hsa-miR-3135b	CLIP-seq
MIRT966244	hsa-miR-3153	CLIP-seq
MIRT966245	hsa-miR-3160-3p	CLIP-seq
MIRT966246	hsa-miR-3171	CLIP-seq
MIRT966247	hsa-miR-3189-3p	CLIP-seq
MIRT966248	hsa-miR-3194-3p	CLIP-seq
MIRT966249	hsa-miR-3199	CLIP-seq
MIRT966250	hsa-miR-345	CLIP-seq
MIRT966251	hsa-miR-3654	CLIP-seq
MIRT966252	hsa-miR-3663-3p	CLIP-seq
MIRT966253	hsa-miR-3675-5p	CLIP-seq
MIRT966254	hsa-miR-3973	CLIP-seq
MIRT966255	hsa-miR-4268	CLIP-seq
MIRT966256	hsa-miR-4270	CLIP-seq
MIRT966257	hsa-miR-4271	CLIP-seq
MIRT966258	hsa-miR-4300	CLIP-seq
MIRT966259	hsa-miR-4441	CLIP-seq
MIRT966260	hsa-miR-4446-3p	CLIP-seq
MIRT966261	hsa-miR-4448	CLIP-seq
MIRT966262	hsa-miR-4459	CLIP-seq
MIRT966263	hsa-miR-4480	CLIP-seq
MIRT966264	hsa-miR-4492	CLIP-seq
MIRT966265	hsa-miR-4498	CLIP-seq
MIRT966266	hsa-miR-4505	CLIP-seq
MIRT966267	hsa-miR-4506	CLIP-seq
MIRT966268	hsa-miR-4514	CLIP-seq
MIRT966269	hsa-miR-4515	CLIP-seq
MIRT966270	hsa-miR-4525	CLIP-seq
MIRT966271	hsa-miR-4532	CLIP-seq
MIRT966272	hsa-miR-4645-5p	CLIP-seq
MIRT966273	hsa-miR-4648	CLIP-seq
MIRT966274	hsa-miR-4651	CLIP-seq
MIRT966275	hsa-miR-4652-5p	CLIP-seq
MIRT966276	hsa-miR-4654	CLIP-seq
MIRT966277	hsa-miR-4665-5p	CLIP-seq
MIRT966278	hsa-miR-4668-5p	CLIP-seq
MIRT966279	hsa-miR-4673	CLIP-seq
MIRT966280	hsa-miR-4683	CLIP-seq
MIRT966281	hsa-miR-4688	CLIP-seq
MIRT966282	hsa-miR-4692	CLIP-seq
MIRT966283	hsa-miR-4722-3p	CLIP-seq
MIRT966284	hsa-miR-4723-5p	CLIP-seq
MIRT966285	hsa-miR-4725-3p	CLIP-seq
MIRT966286	hsa-miR-4726-3p	CLIP-seq
MIRT966287	hsa-miR-4731-5p	CLIP-seq
MIRT966288	hsa-miR-4733-3p	CLIP-seq
MIRT966289	hsa-miR-4739	CLIP-seq
MIRT966290	hsa-miR-4747-5p	CLIP-seq
MIRT966291	hsa-miR-4751	CLIP-seq
MIRT966292	hsa-miR-4752	CLIP-seq
MIRT966293	hsa-miR-4756-5p	CLIP-seq
MIRT966294	hsa-miR-4758-3p	CLIP-seq
MIRT966295	hsa-miR-4763-3p	CLIP-seq
MIRT966296	hsa-miR-4769-5p	CLIP-seq
MIRT966297	hsa-miR-4770	CLIP-seq
MIRT966298	hsa-miR-4779	CLIP-seq
MIRT966299	hsa-miR-491-5p	CLIP-seq
MIRT966300	hsa-miR-506	CLIP-seq
MIRT966301	hsa-miR-520g	CLIP-seq
MIRT966302	hsa-miR-520h	CLIP-seq
MIRT966303	hsa-miR-608	CLIP-seq
MIRT966304	hsa-miR-620	CLIP-seq
MIRT966305	hsa-miR-625	CLIP-seq
MIRT966306	hsa-miR-635	CLIP-seq
MIRT966307	hsa-miR-637	CLIP-seq
MIRT966308	hsa-miR-665	CLIP-seq
MIRT966309	hsa-miR-711	CLIP-seq
MIRT966310	hsa-miR-762	CLIP-seq
MIRT966311	hsa-miR-767-3p	CLIP-seq
MIRT966312	hsa-miR-920	CLIP-seq
MIRT966313	hsa-miR-1827	CLIP-seq
MIRT966314	hsa-miR-196a	CLIP-seq
MIRT966315	hsa-miR-196b	CLIP-seq
MIRT966316	hsa-miR-3165	CLIP-seq
MIRT966317	hsa-miR-3614-5p	CLIP-seq
MIRT966318	hsa-miR-3664-3p	CLIP-seq
MIRT966319	hsa-miR-3927	CLIP-seq
MIRT966320	hsa-miR-3929	CLIP-seq
MIRT966321	hsa-miR-4419b	CLIP-seq
MIRT966322	hsa-miR-4433	CLIP-seq
MIRT966262	hsa-miR-4459	CLIP-seq
MIRT966323	hsa-miR-4478	CLIP-seq
MIRT966324	hsa-miR-4649-3p	CLIP-seq
MIRT966325	hsa-miR-4695-5p	CLIP-seq
MIRT966326	hsa-miR-4722-5p	CLIP-seq
MIRT966327	hsa-miR-4768-3p	CLIP-seq
MIRT966328	hsa-miR-485-5p	CLIP-seq
MIRT966329	hsa-miR-510	CLIP-seq
MIRT966330	hsa-miR-512-5p	CLIP-seq
MIRT966331	hsa-miR-940	CLIP-seq
MIRT1548373	hsa-miR-1281	CLIP-seq
MIRT966260	hsa-miR-4446-3p	CLIP-seq
MIRT1548374	hsa-miR-4675	CLIP-seq
MIRT1548375	hsa-miR-4741	CLIP-seq
MIRT1548376	hsa-miR-518d-5p	CLIP-seq
MIRT1548377	hsa-miR-519b-5p	CLIP-seq
MIRT1548378	hsa-miR-519c-5p	CLIP-seq
MIRT1548379	hsa-miR-520c-5p	CLIP-seq
MIRT1548380	hsa-miR-526a	CLIP-seq
MIRT1986192	hsa-miR-1193	CLIP-seq
MIRT966226	hsa-miR-1207-5p	CLIP-seq
MIRT1986193	hsa-miR-1285	CLIP-seq
MIRT1986194	hsa-miR-1291	CLIP-seq
MIRT1986195	hsa-miR-1909	CLIP-seq
MIRT966233	hsa-miR-1915	CLIP-seq
MIRT1986196	hsa-miR-2467-3p	CLIP-seq
MIRT1986197	hsa-miR-3123	CLIP-seq
MIRT1986198	hsa-miR-3158-5p	CLIP-seq
MIRT1986199	hsa-miR-3163	CLIP-seq
MIRT1986200	hsa-miR-3173-5p	CLIP-seq
MIRT1986201	hsa-miR-3184	CLIP-seq
MIRT1986202	hsa-miR-3187-5p	CLIP-seq
MIRT966248	hsa-miR-3194-3p	CLIP-seq
MIRT966250	hsa-miR-345	CLIP-seq
MIRT1986203	hsa-miR-3678-3p	CLIP-seq
MIRT1986204	hsa-miR-3691-5p	CLIP-seq
MIRT1986205	hsa-miR-3919	CLIP-seq
MIRT1986206	hsa-miR-423-5p	CLIP-seq
MIRT966255	hsa-miR-4268	CLIP-seq
MIRT1986207	hsa-miR-4292	CLIP-seq
MIRT1986208	hsa-miR-4318	CLIP-seq
MIRT966260	hsa-miR-4446-3p	CLIP-seq
MIRT966261	hsa-miR-4448	CLIP-seq
MIRT966262	hsa-miR-4459	CLIP-seq
MIRT966266	hsa-miR-4505	CLIP-seq
MIRT966268	hsa-miR-4514	CLIP-seq
MIRT966282	hsa-miR-4692	CLIP-seq
MIRT966286	hsa-miR-4726-3p	CLIP-seq
MIRT1986209	hsa-miR-4728-5p	CLIP-seq
MIRT966287	hsa-miR-4731-5p	CLIP-seq
MIRT966292	hsa-miR-4752	CLIP-seq
MIRT966295	hsa-miR-4763-3p	CLIP-seq
MIRT1986210	hsa-miR-612	CLIP-seq
MIRT966307	hsa-miR-637	CLIP-seq
MIRT966311	hsa-miR-767-3p	CLIP-seq
MIRT966331	hsa-miR-940	CLIP-seq
MIRT966228	hsa-miR-124	CLIP-seq
MIRT966236	hsa-miR-2278	CLIP-seq
MIRT2220833	hsa-miR-3166	CLIP-seq
MIRT2220834	hsa-miR-361-3p	CLIP-seq
MIRT966256	hsa-miR-4270	CLIP-seq
MIRT966259	hsa-miR-4441	CLIP-seq
MIRT2220835	hsa-miR-4468	CLIP-seq
MIRT966268	hsa-miR-4514	CLIP-seq
MIRT2220836	hsa-miR-4640-3p	CLIP-seq
MIRT966282	hsa-miR-4692	CLIP-seq
MIRT966288	hsa-miR-4733-3p	CLIP-seq
MIRT966300	hsa-miR-506	CLIP-seq
MIRT1986193	hsa-miR-1285	CLIP-seq
MIRT2448900	hsa-miR-31	CLIP-seq
MIRT2448901	hsa-miR-3121-3p	CLIP-seq
MIRT1986197	hsa-miR-3123	CLIP-seq
MIRT1986202	hsa-miR-3187-5p	CLIP-seq
MIRT2448902	hsa-miR-323-5p	CLIP-seq
MIRT2448903	hsa-miR-3622b-5p	CLIP-seq
MIRT2448904	hsa-miR-3945	CLIP-seq
MIRT2448905	hsa-miR-3976	CLIP-seq
MIRT2448906	hsa-miR-4253	CLIP-seq
MIRT2448907	hsa-miR-4659a-3p	CLIP-seq
MIRT2448908	hsa-miR-4659b-3p	CLIP-seq
MIRT2448909	hsa-miR-4677-3p	CLIP-seq
MIRT2448910	hsa-miR-4679	CLIP-seq
MIRT2448911	hsa-miR-4684-5p	CLIP-seq
MIRT2448912	hsa-miR-4742-5p	CLIP-seq
MIRT2448913	hsa-miR-548c-3p	CLIP-seq
MIRT1986210	hsa-miR-612	CLIP-seq
MIRT2448914	hsa-miR-876-3p	CLIP-seq
MIRT1986193	hsa-miR-1285	CLIP-seq
MIRT2524528	hsa-miR-1299	CLIP-seq
MIRT966313	hsa-miR-1827	CLIP-seq
MIRT966314	hsa-miR-196a	CLIP-seq
MIRT966315	hsa-miR-196b	CLIP-seq
MIRT966316	hsa-miR-3165	CLIP-seq
MIRT1986202	hsa-miR-3187-5p	CLIP-seq
MIRT2524529	hsa-miR-3202	CLIP-seq
MIRT2448902	hsa-miR-323-5p	CLIP-seq
MIRT966317	hsa-miR-3614-5p	CLIP-seq
MIRT2448903	hsa-miR-3622b-5p	CLIP-seq
MIRT966318	hsa-miR-3664-3p	CLIP-seq
MIRT2524530	hsa-miR-3672	CLIP-seq
MIRT2524531	hsa-miR-3926	CLIP-seq
MIRT966319	hsa-miR-3927	CLIP-seq
MIRT966320	hsa-miR-3929	CLIP-seq
MIRT2448904	hsa-miR-3945	CLIP-seq
MIRT2448906	hsa-miR-4253	CLIP-seq
MIRT966321	hsa-miR-4419b	CLIP-seq
MIRT966322	hsa-miR-4433	CLIP-seq
MIRT966262	hsa-miR-4459	CLIP-seq
MIRT966323	hsa-miR-4478	CLIP-seq
MIRT2524532	hsa-miR-4493	CLIP-seq
MIRT2524533	hsa-miR-4533	CLIP-seq
MIRT966324	hsa-miR-4649-3p	CLIP-seq
MIRT2448911	hsa-miR-4684-5p	CLIP-seq
MIRT966325	hsa-miR-4695-5p	CLIP-seq
MIRT966327	hsa-miR-4768-3p	CLIP-seq
MIRT2524534	hsa-miR-4786-5p	CLIP-seq
MIRT966328	hsa-miR-485-5p	CLIP-seq
MIRT966329	hsa-miR-510	CLIP-seq
MIRT966330	hsa-miR-512-5p	CLIP-seq
MIRT2448913	hsa-miR-548c-3p	CLIP-seq
MIRT2524535	hsa-miR-548s	CLIP-seq
MIRT1986210	hsa-miR-612	CLIP-seq
MIRT2524536	hsa-miR-769-5p	CLIP-seq
MIRT2524537	hsa-miR-875-3p	CLIP-seq
MIRT2448914	hsa-miR-876-3p	CLIP-seq
MIRT966331	hsa-miR-940	CLIP-seq
MIRT1986193	hsa-miR-1285	CLIP-seq
MIRT2524528	hsa-miR-1299	CLIP-seq
MIRT966313	hsa-miR-1827	CLIP-seq
MIRT2680173	hsa-miR-2964a-3p	CLIP-seq
MIRT2680174	hsa-miR-302f	CLIP-seq
MIRT1986202	hsa-miR-3187-5p	CLIP-seq
MIRT2448902	hsa-miR-323-5p	CLIP-seq
MIRT2448903	hsa-miR-3622b-5p	CLIP-seq
MIRT2524531	hsa-miR-3926	CLIP-seq
MIRT2448904	hsa-miR-3945	CLIP-seq
MIRT2448906	hsa-miR-4253	CLIP-seq
MIRT966322	hsa-miR-4433	CLIP-seq
MIRT966262	hsa-miR-4459	CLIP-seq
MIRT2448911	hsa-miR-4684-5p	CLIP-seq
MIRT966326	hsa-miR-4722-5p	CLIP-seq
MIRT966327	hsa-miR-4768-3p	CLIP-seq
MIRT2524534	hsa-miR-4786-5p	CLIP-seq
MIRT2448913	hsa-miR-548c-3p	CLIP-seq
MIRT2524535	hsa-miR-548s	CLIP-seq
MIRT1986210	hsa-miR-612	CLIP-seq
MIRT2524536	hsa-miR-769-5p	CLIP-seq
MIRT2524537	hsa-miR-875-3p	CLIP-seq
MIRT2448914	hsa-miR-876-3p	CLIP-seq
MIRT966331	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IEA
GO:0005003	Function	Ephrin receptor activity	IEA
GO:0005005	Function	Transmembrane-ephrin receptor activity	IBA
GO:0005005	Function	Transmembrane-ephrin receptor activity	IDA	15777695
GO:0005005	Function	Transmembrane-ephrin receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	15777695, 25416956
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	15777695
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030425	Component	Dendrite	IBA
GO:0048013	Process	Ephrin receptor signaling pathway	IBA
GO:0048013	Process	Ephrin receptor signaling pathway	IEA

Other IDs

• MIM: 611123
• HGNC: 19987
• e!Ensembl: ENSG00000183317

Protein

• UniProt ID: Q5JZY3
• Protein name: Ephrin type-A receptor 10 (EC 2.7.10.1)
• Protein function: Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01404	Ephrin_lbd	36 → 211	Ephrin receptor ligand binding domain	Domain
  PF00041	fn3	339 → 436	Fibronectin type III domain	Domain
  PF00041	fn3	458 → 537	Fibronectin type III domain	Domain
  PF14575	EphA2_TM	567 → 642	Ephrin type-A receptor 2 transmembrane domain	Domain
  PF07714	PK_Tyr_Ser-Thr	645 → 900	Protein tyrosine and serine/threonine kinase	Domain
  PF00536	SAM_1	932 → 995	SAM domain (Sterile alpha motif)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Mainly expressed in testis. {ECO:0000269|PubMed:15777695}.
• Sequence:

  METCAGPHPLRLFLCRMQLCLALLLGPWRPGTAEEVILLDSKASQAELGWTALPSNGWEE
  ISGVDEHDRPIRTYQVCNVLEPNQDNWLQTGWISRGRGQRIFVELQFTLRDCSSIPGAAG
  TCKETFNVYYLETEADLGRGRPRLGGSRPRKIDTIAADESFTQGDLGERKMKLNTEVREI
  GPLSRRGFHLAFQDVGACVALVSVRVYYKQCRATVRGLATFPATAAESAFSTLVEVAGTC
  VAHSEGEPGSPPRMHCGADGEWLVPVGRCSCSAGFQERGDFCEACPPGFYKVSPRRPLCS
  PCPEHSRALENASTFCVCQDSYARSPTDPPSASCTRPPSAPRDLQYSLSRSPLVLRLRWL
  PPADSGGRSDVTYSLLCLRCGREGPAGACEPCGPRVAFLPRQAGLRERAATLLHLRPGAR
  YTVRVAALNGVSGPAAAAGTTYAQVTVSTGPGAPWEEDEIRRDRVEPQSVSLSWREPIPA
  GAPGANDTEYEIRYYEKGQSEQTYSMVKTGAPTVTVTNLKPATRYVFQIRAASPGPSWEA
  QSFNPSIEVQTLGEAASGSRDQSPAIVVTVVTISALLVLGSVMSVLAIWRRPCSYGKGGG
  DAHDEEELYFHFKVPTRRTFLDPQSCGDLLQAVHLFAKELDAKSVTLERSLGGGRFGELC
  CGCLQLPGRQELLVAVHMLRDSASDSQRLGFLAEALTLGQFDHSHIVRLEGVVTRGSTLM
  IVTEYMSHGALDGFLRRHEGQLVAGQLMGLLPGLASAMKYLSEMGYVHRGLAARHVLVSS
  DLVCKISGFGRGPRDRSEAVYTTMSGRSPALWAAPETLQFGHFSSASDVWSFGIIMWEVM
  AFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPNLLHRLMLDCWQKDPGERPRFSQIHSIL
  SKMVQDPEPPKCALTTCPRPPTPLADRAFSTFPSFGSVGAWLEALDLCRYKDSFAAAGYG
  SLEAVAEMTAQDLVSLGISLAEHREALLSGISALQARVLQLQGQGVQV

• Sequence length: 1008

Pathways

Reactome:

EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Hearing loss, autosomal dominant 88	Pathogenic	rs2524422870	RCV003152640
Nonsyndromic Deafness	Pathogenic	rs2524422870	RCV002463466

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Ovarian serous cystadenocarcinoma	Likely benign	rs77925917	RCV005932860

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	35770949
Breast Neoplasms	Associate	24403271, 27566654, 33977106, 33990369
Carcinoma Non Small Cell Lung	Associate	39179608
Colitis Ulcerative	Associate	32322884
Hereditary Breast and Ovarian Cancer Syndrome	Associate	27566654
Lymphatic Metastasis	Associate	24403271
Neoplasm Invasiveness	Associate	33990369
Neoplasm Metastasis	Associate	24403271
Neoplasms	Associate	24403271
Prostatic Neoplasms	Associate	38554337