SYPL2 (synaptophysin like 2)

Gene

• Entrez ID: 284612
• Gene name: Synaptophysin like 2
• Gene symbol: SYPL2
• Synonyms (NCBI Gene): MG29
• Chromosome: 1
• Chromosome location: 1p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT039687	hsa-miR-615-3p	CLASH	23622248
MIRT1406982	hsa-miR-1185	CLIP-seq
MIRT1406983	hsa-miR-1253	CLIP-seq
MIRT1406984	hsa-miR-1303	CLIP-seq
MIRT1406985	hsa-miR-1305	CLIP-seq
MIRT1406986	hsa-miR-145	CLIP-seq
MIRT1406987	hsa-miR-1912	CLIP-seq
MIRT1406988	hsa-miR-198	CLIP-seq
MIRT1406989	hsa-miR-202	CLIP-seq
MIRT1406990	hsa-miR-3130-5p	CLIP-seq
MIRT1406991	hsa-miR-3148	CLIP-seq
MIRT1406992	hsa-miR-3150b-3p	CLIP-seq
MIRT1406993	hsa-miR-3179	CLIP-seq
MIRT1406994	hsa-miR-3679-5p	CLIP-seq
MIRT1406995	hsa-miR-3689d	CLIP-seq
MIRT1406996	hsa-miR-3925-5p	CLIP-seq
MIRT1406997	hsa-miR-4252	CLIP-seq
MIRT1406998	hsa-miR-4311	CLIP-seq
MIRT1406999	hsa-miR-4446-3p	CLIP-seq
MIRT1407000	hsa-miR-4468	CLIP-seq
MIRT1407001	hsa-miR-4476	CLIP-seq
MIRT1407002	hsa-miR-4482	CLIP-seq
MIRT1407003	hsa-miR-4640-3p	CLIP-seq
MIRT1407004	hsa-miR-4687-5p	CLIP-seq
MIRT1407005	hsa-miR-4689	CLIP-seq
MIRT1407006	hsa-miR-4704-5p	CLIP-seq
MIRT1407007	hsa-miR-4707-3p	CLIP-seq
MIRT1407008	hsa-miR-4709-3p	CLIP-seq
MIRT1407009	hsa-miR-4710	CLIP-seq
MIRT1407010	hsa-miR-4721	CLIP-seq
MIRT1407011	hsa-miR-4784	CLIP-seq
MIRT1407012	hsa-miR-4786-3p	CLIP-seq
MIRT1407013	hsa-miR-4789-5p	CLIP-seq
MIRT1407014	hsa-miR-4793-5p	CLIP-seq
MIRT1407015	hsa-miR-498	CLIP-seq
MIRT1407016	hsa-miR-516b	CLIP-seq
MIRT1407017	hsa-miR-526b	CLIP-seq
MIRT1407018	hsa-miR-548a-3p	CLIP-seq
MIRT1407019	hsa-miR-548e	CLIP-seq
MIRT1407020	hsa-miR-548f	CLIP-seq
MIRT1407021	hsa-miR-580	CLIP-seq
MIRT1407022	hsa-miR-626	CLIP-seq
MIRT1407023	hsa-miR-671-5p	CLIP-seq
MIRT1407024	hsa-miR-873	CLIP-seq
MIRT1406982	hsa-miR-1185	CLIP-seq
MIRT2121973	hsa-miR-124	CLIP-seq
MIRT1406984	hsa-miR-1303	CLIP-seq
MIRT1406992	hsa-miR-3150b-3p	CLIP-seq
MIRT1406993	hsa-miR-3179	CLIP-seq
MIRT2121974	hsa-miR-3190	CLIP-seq
MIRT2121975	hsa-miR-3202	CLIP-seq
MIRT1406994	hsa-miR-3679-5p	CLIP-seq
MIRT2121976	hsa-miR-383	CLIP-seq
MIRT1407001	hsa-miR-4476	CLIP-seq
MIRT2121977	hsa-miR-4533	CLIP-seq
MIRT1407005	hsa-miR-4689	CLIP-seq
MIRT1407009	hsa-miR-4710	CLIP-seq
MIRT1407011	hsa-miR-4784	CLIP-seq
MIRT2121978	hsa-miR-506	CLIP-seq
MIRT1406982	hsa-miR-1185	CLIP-seq
MIRT1406984	hsa-miR-1303	CLIP-seq
MIRT1406987	hsa-miR-1912	CLIP-seq
MIRT1406990	hsa-miR-3130-5p	CLIP-seq
MIRT1406992	hsa-miR-3150b-3p	CLIP-seq
MIRT2344281	hsa-miR-3165	CLIP-seq
MIRT2344282	hsa-miR-3173-3p	CLIP-seq
MIRT1406993	hsa-miR-3179	CLIP-seq
MIRT2121975	hsa-miR-3202	CLIP-seq
MIRT1406994	hsa-miR-3679-5p	CLIP-seq
MIRT1406997	hsa-miR-4252	CLIP-seq
MIRT2344283	hsa-miR-4265	CLIP-seq
MIRT2344284	hsa-miR-4296	CLIP-seq
MIRT2344285	hsa-miR-4320	CLIP-seq
MIRT2344286	hsa-miR-4322	CLIP-seq
MIRT2344287	hsa-miR-4417	CLIP-seq
MIRT1407001	hsa-miR-4476	CLIP-seq
MIRT1407002	hsa-miR-4482	CLIP-seq
MIRT2344288	hsa-miR-4514	CLIP-seq
MIRT1407005	hsa-miR-4689	CLIP-seq
MIRT2344289	hsa-miR-4692	CLIP-seq
MIRT1407009	hsa-miR-4710	CLIP-seq
MIRT2344290	hsa-miR-4778-3p	CLIP-seq
MIRT2344291	hsa-miR-4778-5p	CLIP-seq
MIRT1407011	hsa-miR-4784	CLIP-seq
MIRT1407023	hsa-miR-671-5p	CLIP-seq
MIRT1407001	hsa-miR-4476	CLIP-seq
MIRT2442730	hsa-miR-1265	CLIP-seq
MIRT2442731	hsa-miR-181a	CLIP-seq
MIRT2442732	hsa-miR-181b	CLIP-seq
MIRT2442733	hsa-miR-181c	CLIP-seq
MIRT2442734	hsa-miR-181d	CLIP-seq
MIRT2442735	hsa-miR-2392	CLIP-seq
MIRT2442736	hsa-miR-4262	CLIP-seq
MIRT2442737	hsa-miR-651	CLIP-seq
MIRT1406988	hsa-miR-198	CLIP-seq
MIRT2637609	hsa-miR-3620	CLIP-seq
MIRT2637610	hsa-miR-3907	CLIP-seq
MIRT2637611	hsa-miR-4731-5p	CLIP-seq
MIRT2637612	hsa-miR-541	CLIP-seq
MIRT2637613	hsa-miR-548q	CLIP-seq
MIRT2637614	hsa-miR-654-5p	CLIP-seq
MIRT2637615	hsa-miR-665	CLIP-seq
MIRT2692514	hsa-miR-1275	CLIP-seq
MIRT2692515	hsa-miR-3189-3p	CLIP-seq
MIRT2692516	hsa-miR-4260	CLIP-seq
MIRT2692517	hsa-miR-4525	CLIP-seq
MIRT2692518	hsa-miR-4665-5p	CLIP-seq
MIRT2692519	hsa-miR-4723-5p	CLIP-seq
MIRT2692520	hsa-miR-4728-5p	CLIP-seq
MIRT2692521	hsa-miR-625	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0007507	Process	Heart development	IEA
GO:0008021	Component	Synaptic vesicle	IEA
GO:0016020	Component	Membrane	IEA
GO:0021762	Process	Substantia nigra development	HEP	22926577
GO:0030672	Component	Synaptic vesicle membrane	IBA
GO:0033292	Process	T-tubule organization	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5VXT5
• Protein name: Synaptophysin-like protein 2
• Protein function: Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01284	MARVEL	30 → 232	Membrane-associating domain	Domain

• Sequence:

  MSSTESAGRTADKSPRQQVDRLLVGLRWRRLEEPLGFIKVLQWLFAIFAFGSCGSYSGET
  GAMVRCNNEAKDVSSIIVAFGYPFRLHRIQYEMPLCDEESSSKTMHLMGDFSAPAEFFVT
  LGIFSFFYTMAALVIYLRFHNLYTENKRFPLVDFCVTVSFTFFWLVAAAAWGKGLTDVKG
  ATRPSSLTAAMSVCHGEEAVCSAGATPSMGLANISVLFGFINFFLWAGNCWFVFKETPWH
  GQGQGQDQDQDQDQGQGPSQESAAEQGAVEKQ

• Sequence length: 272

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Embolism Fat	Associate	25406998	★☆☆☆☆ Found in Text Mining only
Obesity	Associate	25406998	★☆☆☆☆ Found in Text Mining only
Obesity Morbid	Associate	25406998	★☆☆☆☆ Found in Text Mining only