Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
284434
Gene name Gene Name - the full gene name approved by the HGNC.
NACHT and WD repeat domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NWD1
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.11
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is thought to be a cytosolic protein and predicted to contain a NACHT domain and multiple WD40 repeats. Increased expression of this gene was observed in some prostate cancer cell lines. Knocking down expression of this ge
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT707124 hsa-miR-885-5p HITS-CLIP 21572407
MIRT707123 hsa-miR-548aj-5p HITS-CLIP 21572407
MIRT707122 hsa-miR-548f-5p HITS-CLIP 21572407
MIRT707121 hsa-miR-548g-5p HITS-CLIP 21572407
MIRT707120 hsa-miR-548x-5p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005524 Function ATP binding IEA
GO:0005730 Component Nucleolus IDA
GO:0005829 Component Cytosol IDA 24681825
GO:0010628 Process Positive regulation of gene expression IMP 24681825
GO:0032088 Process Negative regulation of NF-kappaB transcription factor activity IMP 24681825
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616250 27619 ENSG00000188039
Protein
UniProt ID Q149M9
Protein name NACHT domain- and WD repeat-containing protein 1
Protein function May play a role in the control of androgen receptor (AR) protein steady-state levels.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05729 NACHT 335 511 NACHT domain Domain
PF00400 WD40 900 938 WD domain, G-beta repeat Repeat
PF00400 WD40 1379 1416 WD domain, G-beta repeat Repeat
PF00400 WD40 1422 1461 WD domain, G-beta repeat Repeat
Tissue specificity TISSUE SPECIFICITY: Expressed at highest levels in prostate, followed by testis, retina, trachea and optic nerve. Also detected in brain, epididymis, lung, vagina and pituitary. In the prostate, tends to be up-regulated during malignant progression compar
Sequence
MQRGKPCRALPTLKCQTFCQRHGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDRCWKTS
IGPAFVALIGDQYGPCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYV
LQAPGTGEACEPEEATLTSVLRSGAQEARRLGLITQEQWQHYHRSVIEWEIERSLLSSED
REQGATVFLREIQDLHKHILEDCALRMVDRLADGCLDADAQNLLSSLKSHITDMHPGVLK
THRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRELDTAGQELAWLYQEIRH
HLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPR
LLGHKTVTVLRLLGTSQMSSDARGLLKSICFQVCLAYGLPLPPAQVLDAHTRVVQFFHTL
LHTVSCRNFESLVLLLDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQ
RVLLDPEAYWEVKPLSGNQGQQMIQLLLAAA
RRTLSPVHTDLLWASLPECGNPGRLRLAF
EEARKWASFTVPVPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKD
VLSLDDEVLQDVYRDWTPPSKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQL
VEVVRERYLSGSERAKRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAPQPLWFS
HTVANLRKLKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLD
SPEVGLVREALQLCRPAVELRGMERSLLYTELLARLHFFATSHPALVGQLCQQAQSWFQL
CAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQ
HVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN
LLSGQEKFTIWDGGSKNPAEPQ
IWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSR
DGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLL
EKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTEN
NLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWDLS
DAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSEIRC
LEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCEDRLAIAYDN
IVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYECATSK
AFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWD
LQARKWKFEMSYTSSYCRGVQCAC
FSKDDKYVYVGLKDRSILVWS
VLDGTLLTVQFVHAVVNRIIPTTSGFIAPTRHGYLIREN
FQCLSAKASPQDPLKNFKKAMWMVKSRQREELVAAAGAPQDLESESAQGNETKSNKCSQV
CLIV
Sequence length 1564
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease 26503814 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
COVID 19 Associate 35866388
Glaucoma Open Angle Associate 29847670
Neurodegenerative Diseases Associate 34696705