TMEM150B (transmembrane protein 150B)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
284417
Gene name Gene Name - the full gene name approved by the HGNC.
Transmembrane protein 150B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TMEM150B
Synonyms (NCBI Gene) Gene synonyms aliases
DRAM3, TMEM224, TTN2
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.42
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0000421 Component Autophagosome membrane IEA
GO:0005768 Component Endosome IEA
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA 25608530
GO:0005886 Component Plasma membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
617291 34415 ENSG00000180061
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID A6NC51
Protein name Modulator of macroautophagy TMEM150B (Protein DRAM-3) (Transmembrane protein 150B) (Transmembrane protein 224)
Protein function Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucos
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10277 Frag1 4 → 206 Frag1/DRAM/Sfk1 family Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the colon and lung with comparatively high levels also detectable in the lymph nodes, placenta, duodenum, peripheral blood mononuclear cells and spleen (PubMed:25929859). {ECO:0000269|PubMed:25929859}.
Sequence
Sequence length 233
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Mental Depression Major depressive disorder N/A N/A GWAS
Show/Hide Text Mining Associations (5)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Endometrial Neoplasms Associate 32074080
Lupus Erythematosus Systemic Associate 38347676
Neoplasms Associate 32074080
Polycystic Ovary Syndrome Associate 25994816
Primary Ovarian Insufficiency Associate 34996442