TMEM150B (transmembrane protein 150B)

Gene Gene information from NCBI Gene database.
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID 284417
Gene name Transmembrane protein 150B
Gene symbol TMEM150B
Synonyms (NCBI Gene)
DRAM3TMEM224TTN2
Chromosome 19
Chromosome location 19q13.42
Summary This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all (9)
GO ID Ontology Definition Evidence Reference
GO:0000421 Component Autophagosome membrane IEA
GO:0005768 Component Endosome IEA
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA 25608530
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
617291 34415 ENSG00000180061
Protein Protein information from UniProt database.
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
A6NC51
Protein name Modulator of macroautophagy TMEM150B (Protein DRAM-3) (Transmembrane protein 150B) (Transmembrane protein 224)
Protein function Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucos
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10277 Frag1 4 → 206 Frag1/DRAM/Sfk1 family Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the colon and lung with comparatively high levels also detectable in the lymph nodes, placenta, duodenum, peripheral blood mononuclear cells and spleen (PubMed:25929859). {ECO:0000269|PubMed:25929859}.
Sequence
Sequence length 233
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Gene Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MAJOR DEPRESSIVE DISORDER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (5)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Endometrial Neoplasms Associate 32074080
★★★★★
★☆☆☆☆
Found in Text Mining only
Lupus Erythematosus Systemic Associate 38347676
★★★★★
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 32074080
★★★★★
★☆☆☆☆
Found in Text Mining only
Polycystic Ovary Syndrome Associate 25994816
★★★★★
★☆☆☆☆
Found in Text Mining only
Primary Ovarian Insufficiency Associate 34996442
★★★★★
★☆☆☆☆
Found in Text Mining only