Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	284349
Gene name	Zinc finger protein 283
Gene symbol	ZNF283
Synonyms (NCBI Gene)	HZF19HZF41
Chromosome	19
Chromosome location	19q13.31

Show/Hide all (99)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037343	hsa-miR-877-5p	CLASH	23622248
MIRT647508	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635529	hsa-miR-4279	HITS-CLIP	23824327
MIRT647508	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635529	hsa-miR-4279	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635529	hsa-miR-4279	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620138	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT620137	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT620136	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT620135	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT620134	hsa-miR-5096	HITS-CLIP	23824327
MIRT620133	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT647508	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635529	hsa-miR-4279	HITS-CLIP	23824327
MIRT647508	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635529	hsa-miR-4279	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635529	hsa-miR-4279	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620138	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT620137	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT620136	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT620135	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT620134	hsa-miR-5096	HITS-CLIP	23824327
MIRT620133	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT620132	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620131	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620130	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620129	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT620128	hsa-miR-1976	HITS-CLIP	23824327
MIRT620127	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT2157324	hsa-miR-2116	CLIP-seq
MIRT2157325	hsa-miR-335	CLIP-seq
MIRT2157326	hsa-miR-513c	CLIP-seq
MIRT2157327	hsa-miR-514b-5p	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010558	Process	Negative regulation of macromolecule biosynthetic process	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q8N7M2

Protein name

Zinc finger protein 283 (Zinc finger protein HZF19)

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	72 → 113	KRAB box	Family
PF00096	zf-C2H2	207 → 229	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	263 → 285	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	291 → 313	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	347 → 369	Zinc finger, C2H2 type	Domain
PF13912	zf-C2H2_6	403 → 428		Domain
PF00096	zf-C2H2	431 → 453	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	459 → 481	Zinc finger, C2H2 type	Domain
PF13912	zf-C2H2_6	486 → 506		Domain
PF00096	zf-C2H2	543 → 565	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	571 → 593	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	599 → 621	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in prostate, testis, and pancreas. {ECO:0000269|PubMed:12743021}.

Sequence

MESRSVAQAGVQWCDLGSLQAPPPGFTLFSCLSLLSSWDYSSGFSGFCASPIEESHGALI
SSCNSRTMTDGLVTFRDVAIDFSQEEWECLDPAQRDLYVDVMLENYSNLVSLDLESKTYE
TKKIFSENDIFEINFSQWEMKDKSKTLGLEASIFRNNWKCKSIFEGLKGHQEGYFSQMII
SYEKIPSYRKSKSLTPHQRIHNTEKSYVCKECGKACSHGSKLVQHERTHTAEKHFECKEC
GKNYLSAYQLNVHQRFHTGEKPYECKECGKTFSWGSSLVKHERIHTGEKPYECKECGKAF
SRGYHLTQHQKIHTGVKSYKCKECGKAFFWGSSLAKHEIIHTGEKPYKCKECGKAFSRGY
QLTQHQKIHTGKKPYECKICGKAFCWGYQLTRHQIFHTGEKPYECKECGKAFNCGSSLIQ
HERIHTGEKPYECKECGKAFSRGYHLSQHQKIHTGEKPFECKECGKAFSWGSSLVKHERV
HTGEKSHECKECGKTFCSGYQLTRHQVFHTGEKPYECKECGKAFNCGSSLVQHERIHTGE
KPYECKECGKAFSRGYHLTQHQKIHTGEKPFKCKECGKAFSWGSSLVKHERVHTNEKSYE
CKDCGKAFGSGYQLSVHQRFHTGEKLYQRKEFGKTFTCGSKLVHERTHSNDKPYKYNECG
EAFLWTTYSNEKIDTDETL

Sequence length

679

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DIABETIC KETOACIDOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMORRHOID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	29316957	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF283 (zinc finger protein 283)