PTGR3 (prostaglandin reductase 3)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 284273 |
| Gene name | Prostaglandin reductase 3 |
| Gene symbol | PTGR3 |
| Synonyms (NCBI Gene) |
PRG-3PTGR-3ZADH2
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| Chromosome | 18 |
| Chromosome location | 18q22.3 |
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miRNA
miRNA information provided by mirtarbase database.
479
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8N4Q0 | |||||||||||||||
| Protein name | Prostaglandin reductase 3 (PRG-3) (EC 1.3.1.48) (Zinc-binding alcohol dehydrogenase domain-containing protein 2) | |||||||||||||||
| Protein function | Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and i | |||||||||||||||
| PDB | 2C0C , 2WEK , 2X1H , 2X7H , 7ZEJ | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 377 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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