Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	284110
Gene name Gene Name - the full gene name approved by the HGNC.	Gasdermin A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GSDMA
Synonyms (NCBI Gene) Gene synonyms aliases	FKSG9, GSDM, GSDM1
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.1

Show/Hide all(243)

miRTarBase ID	miRNA	Experiments	Reference
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT637708	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT637708	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT1035682	hsa-miR-1262	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035684	hsa-miR-1285	CLIP-seq
MIRT1035685	hsa-miR-1304	CLIP-seq
MIRT1035686	hsa-miR-145	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035688	hsa-miR-24	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035691	hsa-miR-3122	CLIP-seq
MIRT1035692	hsa-miR-3187-5p	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT1035694	hsa-miR-3614-5p	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT1035697	hsa-miR-3913-5p	CLIP-seq
MIRT1035698	hsa-miR-4252	CLIP-seq
MIRT1035699	hsa-miR-4433	CLIP-seq
MIRT1035700	hsa-miR-4649-3p	CLIP-seq
MIRT1035701	hsa-miR-4701-3p	CLIP-seq
MIRT1035702	hsa-miR-4712-5p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035706	hsa-miR-4786-5p	CLIP-seq
MIRT1035707	hsa-miR-4793-3p	CLIP-seq
MIRT1035708	hsa-miR-4797-5p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT1035710	hsa-miR-508-5p	CLIP-seq
MIRT1035711	hsa-miR-542-3p	CLIP-seq
MIRT1035712	hsa-miR-587	CLIP-seq
MIRT1035713	hsa-miR-612	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035715	hsa-miR-661	CLIP-seq
MIRT1035716	hsa-miR-665	CLIP-seq
MIRT1035717	hsa-miR-759	CLIP-seq
MIRT1035718	hsa-miR-766	CLIP-seq
MIRT1035719	hsa-miR-770-5p	CLIP-seq
MIRT1035720	hsa-miR-885-5p	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035684	hsa-miR-1285	CLIP-seq
MIRT1035685	hsa-miR-1304	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035692	hsa-miR-3187-5p	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT2007066	hsa-miR-3929	CLIP-seq
MIRT1035698	hsa-miR-4252	CLIP-seq
MIRT2007067	hsa-miR-4419b	CLIP-seq
MIRT2007068	hsa-miR-4478	CLIP-seq
MIRT1035700	hsa-miR-4649-3p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035706	hsa-miR-4786-5p	CLIP-seq
MIRT1035707	hsa-miR-4793-3p	CLIP-seq
MIRT2007069	hsa-miR-485-5p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT1035710	hsa-miR-508-5p	CLIP-seq
MIRT1035713	hsa-miR-612	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035716	hsa-miR-665	CLIP-seq
MIRT1035718	hsa-miR-766	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT1035682	hsa-miR-1262	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035688	hsa-miR-24	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT1035698	hsa-miR-4252	CLIP-seq
MIRT2239593	hsa-miR-4503	CLIP-seq
MIRT1035701	hsa-miR-4701-3p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035707	hsa-miR-4793-3p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT1035710	hsa-miR-508-5p	CLIP-seq
MIRT1035711	hsa-miR-542-3p	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035715	hsa-miR-661	CLIP-seq
MIRT1035718	hsa-miR-766	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035685	hsa-miR-1304	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035691	hsa-miR-3122	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT1035694	hsa-miR-3614-5p	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT1035697	hsa-miR-3913-5p	CLIP-seq
MIRT1035699	hsa-miR-4433	CLIP-seq
MIRT2450829	hsa-miR-4440	CLIP-seq
MIRT2450830	hsa-miR-4455	CLIP-seq
MIRT2450831	hsa-miR-4684-5p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT2450832	hsa-miR-548c-3p	CLIP-seq
MIRT2450833	hsa-miR-609	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035716	hsa-miR-665	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035685	hsa-miR-1304	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035691	hsa-miR-3122	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT2543317	hsa-miR-3613-3p	CLIP-seq
MIRT1035694	hsa-miR-3614-5p	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT2543318	hsa-miR-371-5p	CLIP-seq
MIRT2543319	hsa-miR-371b-5p	CLIP-seq
MIRT1035697	hsa-miR-3913-5p	CLIP-seq
MIRT1035699	hsa-miR-4433	CLIP-seq
MIRT2450829	hsa-miR-4440	CLIP-seq
MIRT2450830	hsa-miR-4455	CLIP-seq
MIRT2450831	hsa-miR-4684-5p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035708	hsa-miR-4797-5p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT2450832	hsa-miR-548c-3p	CLIP-seq
MIRT2450833	hsa-miR-609	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035716	hsa-miR-665	CLIP-seq
MIRT1035717	hsa-miR-759	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT2682112	hsa-miR-1204	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035684	hsa-miR-1285	CLIP-seq
MIRT1035685	hsa-miR-1304	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035691	hsa-miR-3122	CLIP-seq
MIRT1035692	hsa-miR-3187-5p	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT2543317	hsa-miR-3613-3p	CLIP-seq
MIRT1035694	hsa-miR-3614-5p	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT2543318	hsa-miR-371-5p	CLIP-seq
MIRT2543319	hsa-miR-371b-5p	CLIP-seq
MIRT1035697	hsa-miR-3913-5p	CLIP-seq
MIRT1035699	hsa-miR-4433	CLIP-seq
MIRT2450829	hsa-miR-4440	CLIP-seq
MIRT2450830	hsa-miR-4455	CLIP-seq
MIRT2450831	hsa-miR-4684-5p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035706	hsa-miR-4786-5p	CLIP-seq
MIRT1035708	hsa-miR-4797-5p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT2450832	hsa-miR-548c-3p	CLIP-seq
MIRT2450833	hsa-miR-609	CLIP-seq
MIRT1035713	hsa-miR-612	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035716	hsa-miR-665	CLIP-seq
MIRT1035717	hsa-miR-759	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001786	Function	Phosphatidylserine binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0012501	Process	Programmed cell death	IEA
GO:0016020	Component	Membrane	IDA	35110732, 35545676
GO:0016020	Component	Membrane	IEA
GO:0022829	Function	Wide pore channel activity	IDA	35110732, 35545676
GO:0042742	Process	Defense response to bacterium	IBA
GO:0042742	Process	Defense response to bacterium	IDA	35110732, 35545676
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	17471240
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070269	Process	Pyroptotic inflammatory response	IBA
GO:0070269	Process	Pyroptotic inflammatory response	IDA	35110732, 35545676
GO:0070273	Function	Phosphatidylinositol-4-phosphate binding	IBA

MIM	HGNC	e!Ensembl
611218	13311	ENSG00000167914

Protein

UniProt ID

Q96QA5

Protein name

Gasdermin-A (Gasdermin-1) [Cleaved into: Gasdermin-A, N-terminal (GSDMA-NT); Gasdermin-A, C-terminal (GSDMA-CT)]

Protein function

[Gasdermin-A]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon infection by S.pyogenes, specifically cleaved by S.pyogenes effector protein SpeB in epithelial cells, releasing the N-termina

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04598	Gasdermin	3 → 233	Gasdermin pore forming domain	Domain
PF17708	Gasdermin_C	254 → 418	Gasdermin PUB domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer

Sequence

MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTL
LDVLEPGSSPSDPTDTGNFGFKNMLDTRVEGDVDVPKTVKVKGTAGLSQNSTLEVQTLSV
APKALETVQERKLAADHPFLKEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFF
APLGLQGSINHKEAVTIPKGCVLAFRVRQLMVKGKDEWDIPHICNDNMQTFPPGEKSGEE
KVILIQASDVGDVHEGFRTLKEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLE
LALEGALDKGHEVTLEALPKDVLLSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILP
VQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALVGLSGLEVQRSGPQYMW
DPDTLPRLCALYAGLSLLQQLTKAS

Sequence length

445

Interactions

View interactions

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma, Asthma (childhood onset), Nonatopic asthma, Atopic asthma, Asthma (time to onset)	N/A	N/A	GWAS
Bipolar Disorder	Bipolar disorder	N/A	N/A	GWAS
Eczema	Eczema	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Asthma	Associate	22069270, 23209423, 28241063, 36175932, 36201519, 36967681
Ben Ari Shuper Mimouni syndrome	Stimulate	36967681
Carcinoma Hepatocellular	Associate	35242200
Carcinoma Renal Cell	Associate	35321945
Crohn Disease	Associate	22037903
Diabetes Mellitus Type 1	Associate	22069270
Inflammation	Associate	35321945
Inflammatory Bowel Diseases	Associate	26484354
Melanoma Cutaneous Malignant	Associate	34903008
Neoplasms	Associate	20410667, 23091610
Respiratory Sounds	Associate	36967681
Status Asthmaticus	Associate	36201519

GSDMA (gasdermin A)