Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	284110
Gene name	Gasdermin A
Gene symbol	GSDMA
Synonyms (NCBI Gene)	FKSG9GSDMGSDM1
Chromosome	17
Chromosome location	17q21.1

243

Show/Hide all (243)

miRTarBase ID	miRNA	Experiments	Reference
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT637708	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT637708	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT628789	hsa-miR-564	HITS-CLIP	23824327
MIRT628788	hsa-miR-4284	HITS-CLIP	23824327
MIRT628787	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628786	hsa-miR-7977	HITS-CLIP	23824327
MIRT1035682	hsa-miR-1262	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035684	hsa-miR-1285	CLIP-seq
MIRT1035685	hsa-miR-1304	CLIP-seq
MIRT1035686	hsa-miR-145	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035688	hsa-miR-24	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035691	hsa-miR-3122	CLIP-seq
MIRT1035692	hsa-miR-3187-5p	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT1035694	hsa-miR-3614-5p	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT1035697	hsa-miR-3913-5p	CLIP-seq
MIRT1035698	hsa-miR-4252	CLIP-seq
MIRT1035699	hsa-miR-4433	CLIP-seq
MIRT1035700	hsa-miR-4649-3p	CLIP-seq
MIRT1035701	hsa-miR-4701-3p	CLIP-seq
MIRT1035702	hsa-miR-4712-5p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035706	hsa-miR-4786-5p	CLIP-seq
MIRT1035707	hsa-miR-4793-3p	CLIP-seq
MIRT1035708	hsa-miR-4797-5p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT1035710	hsa-miR-508-5p	CLIP-seq
MIRT1035711	hsa-miR-542-3p	CLIP-seq
MIRT1035712	hsa-miR-587	CLIP-seq
MIRT1035713	hsa-miR-612	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035715	hsa-miR-661	CLIP-seq
MIRT1035716	hsa-miR-665	CLIP-seq
MIRT1035717	hsa-miR-759	CLIP-seq
MIRT1035718	hsa-miR-766	CLIP-seq
MIRT1035719	hsa-miR-770-5p	CLIP-seq
MIRT1035720	hsa-miR-885-5p	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035684	hsa-miR-1285	CLIP-seq
MIRT1035685	hsa-miR-1304	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035692	hsa-miR-3187-5p	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT2007066	hsa-miR-3929	CLIP-seq
MIRT1035698	hsa-miR-4252	CLIP-seq
MIRT2007067	hsa-miR-4419b	CLIP-seq
MIRT2007068	hsa-miR-4478	CLIP-seq
MIRT1035700	hsa-miR-4649-3p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035706	hsa-miR-4786-5p	CLIP-seq
MIRT1035707	hsa-miR-4793-3p	CLIP-seq
MIRT2007069	hsa-miR-485-5p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT1035710	hsa-miR-508-5p	CLIP-seq
MIRT1035713	hsa-miR-612	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035716	hsa-miR-665	CLIP-seq
MIRT1035718	hsa-miR-766	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT1035682	hsa-miR-1262	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035688	hsa-miR-24	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT1035698	hsa-miR-4252	CLIP-seq
MIRT2239593	hsa-miR-4503	CLIP-seq
MIRT1035701	hsa-miR-4701-3p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035707	hsa-miR-4793-3p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT1035710	hsa-miR-508-5p	CLIP-seq
MIRT1035711	hsa-miR-542-3p	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035715	hsa-miR-661	CLIP-seq
MIRT1035718	hsa-miR-766	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035685	hsa-miR-1304	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035691	hsa-miR-3122	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT1035694	hsa-miR-3614-5p	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT1035697	hsa-miR-3913-5p	CLIP-seq
MIRT1035699	hsa-miR-4433	CLIP-seq
MIRT2450829	hsa-miR-4440	CLIP-seq
MIRT2450830	hsa-miR-4455	CLIP-seq
MIRT2450831	hsa-miR-4684-5p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT2450832	hsa-miR-548c-3p	CLIP-seq
MIRT2450833	hsa-miR-609	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035716	hsa-miR-665	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035685	hsa-miR-1304	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035691	hsa-miR-3122	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT2543317	hsa-miR-3613-3p	CLIP-seq
MIRT1035694	hsa-miR-3614-5p	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT2543318	hsa-miR-371-5p	CLIP-seq
MIRT2543319	hsa-miR-371b-5p	CLIP-seq
MIRT1035697	hsa-miR-3913-5p	CLIP-seq
MIRT1035699	hsa-miR-4433	CLIP-seq
MIRT2450829	hsa-miR-4440	CLIP-seq
MIRT2450830	hsa-miR-4455	CLIP-seq
MIRT2450831	hsa-miR-4684-5p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035708	hsa-miR-4797-5p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT2450832	hsa-miR-548c-3p	CLIP-seq
MIRT2450833	hsa-miR-609	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035716	hsa-miR-665	CLIP-seq
MIRT1035717	hsa-miR-759	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq
MIRT2682112	hsa-miR-1204	CLIP-seq
MIRT1035683	hsa-miR-1273e	CLIP-seq
MIRT1035684	hsa-miR-1285	CLIP-seq
MIRT1035685	hsa-miR-1304	CLIP-seq
MIRT1035687	hsa-miR-1827	CLIP-seq
MIRT1035689	hsa-miR-2964a-3p	CLIP-seq
MIRT1035690	hsa-miR-302f	CLIP-seq
MIRT1035691	hsa-miR-3122	CLIP-seq
MIRT1035692	hsa-miR-3187-5p	CLIP-seq
MIRT1035693	hsa-miR-3192	CLIP-seq
MIRT2543317	hsa-miR-3613-3p	CLIP-seq
MIRT1035694	hsa-miR-3614-5p	CLIP-seq
MIRT1035695	hsa-miR-3689a-3p	CLIP-seq
MIRT1035696	hsa-miR-3689c	CLIP-seq
MIRT2543318	hsa-miR-371-5p	CLIP-seq
MIRT2543319	hsa-miR-371b-5p	CLIP-seq
MIRT1035697	hsa-miR-3913-5p	CLIP-seq
MIRT1035699	hsa-miR-4433	CLIP-seq
MIRT2450829	hsa-miR-4440	CLIP-seq
MIRT2450830	hsa-miR-4455	CLIP-seq
MIRT2450831	hsa-miR-4684-5p	CLIP-seq
MIRT1035703	hsa-miR-4722-5p	CLIP-seq
MIRT1035704	hsa-miR-4728-5p	CLIP-seq
MIRT1035705	hsa-miR-4768-3p	CLIP-seq
MIRT1035706	hsa-miR-4786-5p	CLIP-seq
MIRT1035708	hsa-miR-4797-5p	CLIP-seq
MIRT1035709	hsa-miR-490-3p	CLIP-seq
MIRT2450832	hsa-miR-548c-3p	CLIP-seq
MIRT2450833	hsa-miR-609	CLIP-seq
MIRT1035713	hsa-miR-612	CLIP-seq
MIRT1035714	hsa-miR-658	CLIP-seq
MIRT1035716	hsa-miR-665	CLIP-seq
MIRT1035717	hsa-miR-759	CLIP-seq
MIRT1035721	hsa-miR-940	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001786	Function	Phosphatidylserine binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0012501	Process	Programmed cell death	IEA
GO:0016020	Component	Membrane	IDA	35110732, 35545676
GO:0016020	Component	Membrane	IEA
GO:0022829	Function	Wide pore channel activity	IDA	35110732, 35545676
GO:0042742	Process	Defense response to bacterium	IBA
GO:0042742	Process	Defense response to bacterium	IDA	35110732, 35545676
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	17471240
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070269	Process	Pyroptotic inflammatory response	IBA
GO:0070269	Process	Pyroptotic inflammatory response	IDA	35110732, 35545676
GO:0070273	Function	Phosphatidylinositol-4-phosphate binding	IBA

MIM	HGNC	e!Ensembl
611218	13311	ENSG00000167914

Q96QA5

Protein name

Gasdermin-A (Gasdermin-1) [Cleaved into: Gasdermin-A, N-terminal (GSDMA-NT); Gasdermin-A, C-terminal (GSDMA-CT)]

Protein function

[Gasdermin-A]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon infection by S.pyogenes, specifically cleaved by S.pyogenes effector protein SpeB in epithelial cells, releasing the N-termina

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04598	Gasdermin	3 → 233	Gasdermin pore forming domain	Domain
PF17708	Gasdermin_C	254 → 418	Gasdermin PUB domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer

Sequence

MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTL
LDVLEPGSSPSDPTDTGNFGFKNMLDTRVEGDVDVPKTVKVKGTAGLSQNSTLEVQTLSV
APKALETVQERKLAADHPFLKEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFF
APLGLQGSINHKEAVTIPKGCVLAFRVRQLMVKGKDEWDIPHICNDNMQTFPPGEKSGEE
KVILIQASDVGDVHEGFRTLKEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLE
LALEGALDKGHEVTLEALPKDVLLSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILP
VQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALVGLSGLEVQRSGPQYMW
DPDTLPRLCALYAGLSLLQQLTKAS

Sequence length

445

Interactions

View interactions

GSDMA (gasdermin A)