CCDC57 (coiled-coil domain containing 57)

Gene

• Entrez ID: 284001
• Gene name: Coiled-coil domain containing 57
• Gene symbol: CCDC57
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049379	hsa-miR-92a-3p	CLASH	23622248
MIRT869312	hsa-miR-1266	CLIP-seq
MIRT869313	hsa-miR-1291	CLIP-seq
MIRT869314	hsa-miR-1321	CLIP-seq
MIRT869315	hsa-miR-146b-3p	CLIP-seq
MIRT869316	hsa-miR-1914	CLIP-seq
MIRT869317	hsa-miR-296-5p	CLIP-seq
MIRT869318	hsa-miR-4270	CLIP-seq
MIRT869319	hsa-miR-4441	CLIP-seq
MIRT869320	hsa-miR-4506	CLIP-seq
MIRT869321	hsa-miR-4518	CLIP-seq
MIRT869322	hsa-miR-4739	CLIP-seq
MIRT869323	hsa-miR-4756-5p	CLIP-seq
MIRT1957907	hsa-miR-103a	CLIP-seq
MIRT1957908	hsa-miR-107	CLIP-seq
MIRT1957909	hsa-miR-15a	CLIP-seq
MIRT1957910	hsa-miR-15b	CLIP-seq
MIRT1957911	hsa-miR-16	CLIP-seq
MIRT1957912	hsa-miR-195	CLIP-seq
MIRT1957913	hsa-miR-214	CLIP-seq
MIRT1957914	hsa-miR-3122	CLIP-seq
MIRT1957915	hsa-miR-3619-5p	CLIP-seq
MIRT1957916	hsa-miR-3689a-3p	CLIP-seq
MIRT1957917	hsa-miR-3689c	CLIP-seq
MIRT1957918	hsa-miR-3913-5p	CLIP-seq
MIRT1957919	hsa-miR-424	CLIP-seq
MIRT1957920	hsa-miR-4291	CLIP-seq
MIRT1957921	hsa-miR-4300	CLIP-seq
MIRT1957922	hsa-miR-4310	CLIP-seq
MIRT1957923	hsa-miR-4763-5p	CLIP-seq
MIRT1957924	hsa-miR-497	CLIP-seq
MIRT1957925	hsa-miR-596	CLIP-seq
MIRT1957926	hsa-miR-761	CLIP-seq
MIRT1957927	hsa-miR-920	CLIP-seq
MIRT1957928	hsa-miR-922	CLIP-seq
MIRT1957907	hsa-miR-103a	CLIP-seq
MIRT1957908	hsa-miR-107	CLIP-seq
MIRT2194908	hsa-miR-1281	CLIP-seq
MIRT1957909	hsa-miR-15a	CLIP-seq
MIRT1957910	hsa-miR-15b	CLIP-seq
MIRT1957911	hsa-miR-16	CLIP-seq
MIRT1957912	hsa-miR-195	CLIP-seq
MIRT1957913	hsa-miR-214	CLIP-seq
MIRT1957914	hsa-miR-3122	CLIP-seq
MIRT1957915	hsa-miR-3619-5p	CLIP-seq
MIRT1957916	hsa-miR-3689a-3p	CLIP-seq
MIRT1957917	hsa-miR-3689c	CLIP-seq
MIRT1957918	hsa-miR-3913-5p	CLIP-seq
MIRT1957919	hsa-miR-424	CLIP-seq
MIRT1957920	hsa-miR-4291	CLIP-seq
MIRT1957921	hsa-miR-4300	CLIP-seq
MIRT1957922	hsa-miR-4310	CLIP-seq
MIRT2194909	hsa-miR-4704-3p	CLIP-seq
MIRT1957924	hsa-miR-497	CLIP-seq
MIRT1957926	hsa-miR-761	CLIP-seq
MIRT1957927	hsa-miR-920	CLIP-seq
MIRT1957928	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	IDA	32402286
GO:0005515	Function	Protein binding	IPI	25416956, 32402286
GO:0005813	Component	Centrosome	IDA	32402286
GO:0005814	Component	Centriole	IDA	32402286
GO:0005876	Component	Spindle microtubule	IDA	32402286
GO:0007020	Process	Microtubule nucleation	IDA	32402286
GO:0007099	Process	Centriole replication	IDA	32402286
GO:0034451	Component	Centriolar satellite	IDA	32402286
GO:0045931	Process	Positive regulation of mitotic cell cycle	IDA	32402286
GO:0060271	Process	Cilium assembly	IDA	32402286

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q2TAC2
• Protein name: Coiled-coil domain-containing protein 57
• Protein function: Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis. Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to th
• Sequence:

  MLPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYN
  LQVLEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQ
  QLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFES
  KMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELER
  KLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLV
  AVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVK
  SAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLE
  RDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAV
  TLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRK
  EMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHL
  EDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLAL
  RKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAELGKHL
  RIAQHGGAEPSGRKQPPASDAVALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDALQG
  PKTQHSIHTVTCKSPRQKEDRSPKPPQAPQHPEEHGRQSHSSSSFASGTLQDMWRLLDLG
  SSPSGVTSQGDSTPELPAPPAADRRPVKMQAGIATPGMKTAAQAKAKTTGASRSHPAKAK
  GCQRPPKIRNYNIMD

• Sequence length: 915

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Acne	Acne			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Hereditary leiomyomatosis and renal cell cancer	Associate	27375065
Overweight	Associate	20679621
Prostatic Neoplasms	Associate	20679621, 23989197