GPR17 (G protein-coupled receptor 17)

Gene

• Entrez ID: 2840
• Gene name: G protein-coupled receptor 17
• Gene symbol: GPR17
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2q14.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018345	hsa-miR-335-5p	Microarray	18185580
MIRT029794	hsa-miR-26b-5p	Microarray	19088304
MIRT1030888	hsa-miR-1236	CLIP-seq
MIRT1030889	hsa-miR-185	CLIP-seq
MIRT1030890	hsa-miR-2682	CLIP-seq
MIRT1030891	hsa-miR-34a	CLIP-seq
MIRT1030892	hsa-miR-34c-5p	CLIP-seq
MIRT1030893	hsa-miR-4269	CLIP-seq
MIRT1030894	hsa-miR-4302	CLIP-seq
MIRT1030895	hsa-miR-4306	CLIP-seq
MIRT1030896	hsa-miR-449a	CLIP-seq
MIRT1030897	hsa-miR-449b	CLIP-seq
MIRT1030898	hsa-miR-449c	CLIP-seq
MIRT1030899	hsa-miR-4514	CLIP-seq
MIRT1030900	hsa-miR-4644	CLIP-seq
MIRT1030901	hsa-miR-4692	CLIP-seq
MIRT1030902	hsa-miR-4722-5p	CLIP-seq
MIRT1030903	hsa-miR-4742-5p	CLIP-seq
MIRT1030904	hsa-miR-4768-3p	CLIP-seq
MIRT1030905	hsa-miR-510	CLIP-seq
MIRT1030906	hsa-miR-520a-5p	CLIP-seq
MIRT1030907	hsa-miR-525-5p	CLIP-seq
MIRT1030908	hsa-miR-593	CLIP-seq
MIRT2005826	hsa-miR-193a-5p	CLIP-seq
MIRT2450622	hsa-miR-136	CLIP-seq
MIRT2450623	hsa-miR-3127-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002862	Process	Negative regulation of inflammatory response to antigenic stimulus	IEA
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	TAS	8558062
GO:0005515	Function	Protein binding	IPI	36613703
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8558062
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	8558062
GO:0016020	Component	Membrane	IEA
GO:0033612	Function	Receptor serine/threonine kinase binding	IEA
GO:0048709	Process	Oligodendrocyte differentiation	IEA
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA

Other IDs

• MIM: 603071
• HGNC: 4471
• e!Ensembl: ENSG00000144230

Protein

• UniProt ID: Q13304
• Protein name: Uracil nucleotide/cysteinyl leukotriene receptor (UDP/CysLT receptor) (G-protein coupled receptor 17) (P2Y-like receptor) (R12)
• Protein function: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
• PDB: 7Y89
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	76 → 325	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain. {ECO:0000269|PubMed:16990797}.
• Sequence:

  MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENM
  LFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHF
  SGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLAC
  AFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCY
  LLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQ
  RILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESS
  LSAKSEL

• Sequence length: 367

Pathways

Reactome:

Leukotriene receptors
G alpha (q) signalling events
P2Y receptors
G alpha (i) signalling events