EXOC3L1 (exocyst complex component 3 like 1)

Gene

• Entrez ID: 283849
• Gene name: Exocyst complex component 3 like 1
• Gene symbol: EXOC3L1
• Synonyms (NCBI Gene): EXOC3L
• Chromosome: 16
• Chromosome location: 16q22.1

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000145	Component	Exocyst	IBA
GO:0000145	Component	Exocyst	IEA
GO:0000145	Component	Exocyst	ISS	18480549
GO:0000149	Function	SNARE binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0006887	Process	Exocytosis	IBA
GO:0006887	Process	Exocytosis	IEA
GO:0006887	Process	Exocytosis	ISS	18480549
GO:0030072	Process	Peptide hormone secretion	IEA
GO:0030072	Process	Peptide hormone secretion	ISS	18480549
GO:0030133	Component	Transport vesicle	IEA
GO:0030141	Component	Secretory granule	IEA
GO:0030141	Component	Secretory granule	ISS	18480549
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0051601	Process	Exocyst localization	IBA

Other IDs

• MIM: 614117
• HGNC: 27540
• e!Ensembl: ENSG00000179044

Protein

• UniProt ID: Q86VI1
• Protein name: Exocyst complex component 3-like protein (Protein Jiangli)
• Protein function: As part of the exocyst, may play a role in regulated exocytosis of insulin granules.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06046	Sec6	188 → 722	Exocyst complex component Sec6	Family

• Sequence:

  MDSAAKDEMQPALSPGPEWPEQERAEQLARGAALKWASGIFYRPEQLARLGQYRSREVQR
  TCSLESRLKSVMQSYLEGVQTGVWQLAQAIEVVQGTREALSQARGLLQGMSQALQTLEPL
  RERVAQHKQLQALSHLLPRLRAVPAAVSHTQTLIDGQQFLEAYVSLRELEQLREDTWAPL
  GGLELPVFQGLDLLFEALGQAVEAAAGAAGKLAREDPALLVAAVRVAEVETGRTTPLGQV
  PRDWRQRCLRALQEGLEQAHFGSPLLPAPGALPGWLEALRVALPVELATAEALVAPCCPP
  QYNVVQLWAHTLHSGLRRSLQNLLAGPELEAADAFALLHWALHVYLGQEMMGSLELGPEA
  DVSQLEPLLTLENIEQLEATFVANIQASVSQWLQNALDGEVAEWGREHGPNTDPSGSYYS
  PMPAIVLQILEENIRVASLVSESLQQRVHGMALSELGTFLRSFSDALIRFSRDHFRGKSM
  APHYVPYLLAALNHKSALSSSVSVLQLDGAPSGALAPVEAALDELQRRIYRLVLEALQAE
  LQPLFADLPSRQWLSSPELLQSVCERTGRFCRDFWRVRNPTVQLLLAEAERAVVLQYLSA
  LMQGRLVCRGADERTQAAERLRHDAAQLQQLFLSLGLEENAHCAPVLLALRELLNLRDPA
  LLGLEVAGLRQQFPDVSEDHVSALLGLRGDLSREQHLAALSSLQAALPPSPRASRRVLFS
  LVPAPALAPASCLPSGSCARALLLAE

• Sequence length: 746

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Clear cell carcinoma of kidney	Likely benign	rs147432381	RCV005929424
Colon adenocarcinoma	Likely benign	rs147432381	RCV005929421
Familial cancer of breast	Likely benign	rs147432381	RCV005929420
Malignant tumor of esophagus	Uncertain significance; Likely benign	rs138835488, rs147432381	RCV005930720 RCV005929422
Malignant tumor of urinary bladder	Uncertain significance	rs138835488	RCV005930719
Nonpapillary renal cell carcinoma	Likely benign	rs147432381	RCV005929423
Ovarian serous cystadenocarcinoma	Likely benign	rs147432381	RCV005929425
Thymoma	Likely benign	rs147432381	RCV005929426
Thyroid cancer, nonmedullary, 1	Likely benign	rs147432381	RCV005929427
Uterine corpus endometrial carcinoma	Uncertain significance	rs138835488	RCV005930721

Associations from Text Mining
Disease Name	Relationship Type	References
Esophageal Squamous Cell Carcinoma	Associate	36852560