FAM98B (family with sequence similarity 98 member B)

Gene

• Entrez ID: 283742
• Gene name: Family with sequence similarity 98 member B
• Gene symbol: FAM98B
• Synonyms (NCBI Gene): -
• Chromosome: 15
• Chromosome location: 15q14

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020544	hsa-miR-155-5p	Proteomics	18668040
MIRT045397	hsa-miR-149-5p	CLASH	23622248
MIRT721433	hsa-miR-4728-3p	HITS-CLIP	19536157
MIRT721432	hsa-miR-4762-5p	HITS-CLIP	19536157
MIRT721431	hsa-miR-29a-5p	HITS-CLIP	19536157
MIRT721430	hsa-miR-8075	HITS-CLIP	19536157
MIRT721429	hsa-miR-3671	HITS-CLIP	19536157
MIRT721428	hsa-miR-607	HITS-CLIP	19536157
MIRT691472	hsa-miR-4453	HITS-CLIP	23313552
MIRT691471	hsa-miR-4538	HITS-CLIP	23313552
MIRT691470	hsa-miR-676-5p	HITS-CLIP	23313552
MIRT691469	hsa-miR-4666a-5p	HITS-CLIP	23313552
MIRT691468	hsa-miR-5579-3p	HITS-CLIP	23313552
MIRT691467	hsa-miR-6875-3p	HITS-CLIP	23313552
MIRT691466	hsa-miR-4659a-3p	HITS-CLIP	23313552
MIRT691465	hsa-miR-4659b-3p	HITS-CLIP	23313552
MIRT691464	hsa-miR-4659a-5p	HITS-CLIP	23313552
MIRT691463	hsa-miR-4659b-5p	HITS-CLIP	23313552
MIRT721433	hsa-miR-4728-3p	HITS-CLIP	19536157
MIRT721432	hsa-miR-4762-5p	HITS-CLIP	19536157
MIRT721431	hsa-miR-29a-5p	HITS-CLIP	19536157
MIRT721430	hsa-miR-8075	HITS-CLIP	19536157
MIRT721429	hsa-miR-3671	HITS-CLIP	19536157
MIRT721428	hsa-miR-607	HITS-CLIP	19536157
MIRT691472	hsa-miR-4453	HITS-CLIP	23313552
MIRT691471	hsa-miR-4538	HITS-CLIP	23313552
MIRT691470	hsa-miR-676-5p	HITS-CLIP	23313552
MIRT691469	hsa-miR-4666a-5p	HITS-CLIP	23313552
MIRT691468	hsa-miR-5579-3p	HITS-CLIP	23313552
MIRT691467	hsa-miR-6875-3p	HITS-CLIP	23313552
MIRT691466	hsa-miR-4659a-3p	HITS-CLIP	23313552
MIRT691465	hsa-miR-4659b-3p	HITS-CLIP	23313552
MIRT691464	hsa-miR-4659a-5p	HITS-CLIP	23313552
MIRT691463	hsa-miR-4659b-5p	HITS-CLIP	23313552
MIRT988889	hsa-miR-329	CLIP-seq
MIRT988890	hsa-miR-362-3p	CLIP-seq
MIRT988891	hsa-miR-3941	CLIP-seq
MIRT988892	hsa-miR-4731-3p	CLIP-seq
MIRT988893	hsa-miR-4789-3p	CLIP-seq
MIRT988894	hsa-miR-4801	CLIP-seq
MIRT988895	hsa-miR-4803	CLIP-seq
MIRT988896	hsa-miR-603	CLIP-seq
MIRT988897	hsa-miR-1297	CLIP-seq
MIRT988898	hsa-miR-26a	CLIP-seq
MIRT988899	hsa-miR-26b	CLIP-seq
MIRT988900	hsa-miR-3145-3p	CLIP-seq
MIRT988901	hsa-miR-3682-3p	CLIP-seq
MIRT988902	hsa-miR-3682-5p	CLIP-seq
MIRT988903	hsa-miR-4272	CLIP-seq
MIRT988904	hsa-miR-4465	CLIP-seq
MIRT988905	hsa-miR-4694-5p	CLIP-seq
MIRT988906	hsa-miR-567	CLIP-seq
MIRT988901	hsa-miR-3682-3p	CLIP-seq
MIRT988902	hsa-miR-3682-5p	CLIP-seq
MIRT2226963	hsa-miR-4263	CLIP-seq
MIRT2226964	hsa-miR-576-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	28040436
GO:0005634	Component	Nucleus	IDA	24608264
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	18445686, 24608264
GO:0006388	Process	TRNA splicing, via endonucleolytic cleavage and ligation	TAS
GO:0006479	Process	Protein methylation	IMP	28040436
GO:0008276	Function	Protein methyltransferase activity	IMP	28040436
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	28040436
GO:0010628	Process	Positive regulation of gene expression	IMP	28040436
GO:0042802	Function	Identical protein binding	IDA	28040436
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0072669	Component	TRNA-splicing ligase complex	IBA	21873635
GO:0072669	Component	TRNA-splicing ligase complex	IDA	21311021, 24870230

Other IDs

• MIM: 616142
• HGNC: 26773
• e!Ensembl: ENSG00000171262

Protein

• UniProt ID: Q52LJ0
• Protein name: Protein FAM98B
• Protein function: Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10239	DUF2465	17 → 331	Protein of unknown function (DUF2465)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436). {ECO:00002
• Sequence:

  MRGPEPGPQPTMEGDVLDTLEALGYKGPLLEEQALTKAAEGGLSSPEFSELCIWLGSQIK
  SLCNLEESITSAGRDDLESFQLEISGFLKEMACPYSVLISGDIKDRLKKKEDCLKLLLFL
  STELQASQILQNKKHKNSQLDKNSEVYQEVQAMFDTLGIPKSTTSDIPHMLNQVESKVKD
  ILSKVQKNHVGKPLLKMDLNSEQAEQLERINDALSCEYECRRRMLMKRLDVTVQSFGWSD
  RAKVKTDDIARIYQPKRYALSPKTTITMAHLLAAREDLSKIIRTSSGTSREKTACAINKV
  LMGRVPDRGGRPNEIEPPPPEMPPWQKRQEGGGGRGGWGGGGGGGGRGGGGGGGGRGGWG
  GGGGGWGGGGGGGGGWGGGGGGGRGGFQGRGDYGGRGGYGGRGGYGGRGYGDPYGGGGGG
  GGGGGGGGGYRRY

• Sequence length: 433

Pathways

Reactome:

tRNA processing in the nucleus

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS