Gene Gene information from NCBI Gene database.
Entrez ID 283659
Gene name Protogenin
Gene symbol PRTG
Synonyms (NCBI Gene)
IGDCC5
Chromosome 15
Chromosome location 15q21.3
Summary This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention def
miRNA miRNA information provided by mirtarbase database.
715
miRTarBase ID miRNA Experiments Reference
MIRT051907 hsa-let-7b-5p CLASH 23622248
MIRT437375 hsa-miR-9-5p ImmunocytochemistryLuciferase reporter assayqRT-PCRWestern blot 24007463
MIRT437375 hsa-miR-9-5p ImmunocytochemistryLuciferase reporter assayqRT-PCRWestern blot 24007463
MIRT437375 hsa-miR-9-5p ImmunocytochemistryLuciferase reporter assayqRT-PCRWestern blot 24007463
MIRT437375 hsa-miR-9-5p ImmunocytochemistryLuciferase reporter assayqRT-PCRWestern blot 24007463
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0005615 Component Extracellular space HDA 22664934
GO:0005886 Component Plasma membrane IEA
GO:0016020 Component Membrane IEA
GO:0038023 Function Signaling receptor activity IEA
GO:0042802 Function Identical protein binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613261 26373 ENSG00000166450
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q2VWP7
Protein name Protogenin (Protein Shen-Dan)
Protein function May play a role in anteroposterior axis elongation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07679 I-set 39 131 Immunoglobulin I-set domain Domain
PF13927 Ig_3 134 208 Domain
PF13927 Ig_3 234 308 Domain
PF07679 I-set 327 412 Immunoglobulin I-set domain Domain
PF00041 fn3 420 505 Fibronectin type III domain Domain
PF00041 fn3 518 603 Fibronectin type III domain Domain
PF00041 fn3 619 700 Fibronectin type III domain Domain
PF00041 fn3 723 807 Fibronectin type III domain Domain
PF00041 fn3 821 907 Fibronectin type III domain Domain
Sequence
MAPPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDC
QAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYG
AILSQKAHLAL
STISAFEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMD
RITALPTGVLQIYDVSQRDSGNYRCIAA
TVAHRRKSMEASLTVIPAKESKSFHTPTIIAG
PQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAG
VYVCRATT
PGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW
LKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTV
VMSEDRPS
APYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYII
DDLEPASNYTFYIVAYMPMGASQMS
DHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPI
PAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLG
ESS
VWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQ
QENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGY
QADQTVSTPGCVSVRDRMVP
PPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHM
LVQGLEPNTKYEFAVRLHVDQLSSPWS
PVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSW
KPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNE
VGEGPFS
NSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALT
CILICVLILIYRSKARKSSASKTAQNGTQQLPRTSASLASGNEVGKNLEGAVGNEESLMP
MIMPNSFIDAKGGTDLIINSYGPIIKNNSKKKWFFFQDSKKIQVEQPQRRFTPAVCFYQP
GTTVLISDEDSPSSPGQTTSFSRPFGVAADTEHSANSEGSHETGDSGRFSHESNDEIHLS
SVISTTPPNL
Sequence length 1150
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CATARACT GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Attention Deficit Disorder with Hyperactivity Associate 19076634
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Inhibit 40581983
★☆☆☆☆
Found in Text Mining only
Cleft Palate Stimulate 28425186
★☆☆☆☆
Found in Text Mining only
Dyslexia Acquired Associate 19076634
★☆☆☆☆
Found in Text Mining only
Dystonic Disorders Associate 31190668
★☆☆☆☆
Found in Text Mining only
Epilepsy Associate 31190668
★☆☆☆☆
Found in Text Mining only