FAM177A1 (family with sequence similarity 177 member A1)

Gene

• Entrez ID: 283635
• Gene name: Family with sequence similarity 177 member A1
• Gene symbol: FAM177A1
• Synonyms (NCBI Gene): C14orf24, NEDWMG
• Chromosome: 14
• Chromosome location: 14q13.2
• Summary: This gene encodes a member of a conserved protein family. Alternative splicing results in multiple transcript variants. This gene is thought to be associated with susceptibility to juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs730882244	->A	Likely-pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020986	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT021622	hsa-miR-142-3p	Microarray	17612493
MIRT002702	hsa-miR-124-3p	Microarray	18668037
MIRT002702	hsa-miR-124-3p	Microarray	15685193
MIRT045179	hsa-miR-186-5p	CLASH	23622248
MIRT703690	hsa-miR-6513-3p	HITS-CLIP	23313552
MIRT628879	hsa-miR-1306-5p	HITS-CLIP	23313552
MIRT658426	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT628878	hsa-miR-4308	HITS-CLIP	23313552
MIRT628877	hsa-miR-4292	HITS-CLIP	23313552
MIRT628876	hsa-miR-6791-5p	HITS-CLIP	23313552
MIRT658425	hsa-miR-1304-3p	HITS-CLIP	23313552
MIRT628875	hsa-miR-7113-3p	HITS-CLIP	23313552
MIRT628874	hsa-miR-4772-3p	HITS-CLIP	23313552
MIRT658424	hsa-miR-4284	HITS-CLIP	23313552
MIRT658423	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT658422	hsa-miR-8057	HITS-CLIP	23313552
MIRT628879	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT658426	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT628878	hsa-miR-4308	HITS-CLIP	23824327
MIRT628877	hsa-miR-4292	HITS-CLIP	23824327
MIRT628876	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT658425	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT628875	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT628874	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT658424	hsa-miR-4284	HITS-CLIP	23824327
MIRT658423	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT658422	hsa-miR-8057	HITS-CLIP	23824327
MIRT628879	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT628878	hsa-miR-4308	HITS-CLIP	23824327
MIRT628877	hsa-miR-4292	HITS-CLIP	23824327
MIRT628876	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT628875	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT628874	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT628873	hsa-miR-1297	HITS-CLIP	23824327
MIRT628872	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT628871	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT628870	hsa-miR-4465	HITS-CLIP	23824327
MIRT557986	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT484263	hsa-miR-4711-3p	PAR-CLIP	21572407
MIRT484262	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT557985	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT557984	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT484259	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT484268	hsa-miR-8485	PAR-CLIP	23592263
MIRT484267	hsa-miR-329-3p	PAR-CLIP	23592263
MIRT484266	hsa-miR-362-3p	PAR-CLIP	23592263
MIRT484265	hsa-miR-603	PAR-CLIP	23592263
MIRT484264	hsa-miR-511-3p	PAR-CLIP	23592263
MIRT484263	hsa-miR-4711-3p	PAR-CLIP	23592263
MIRT484262	hsa-miR-6867-5p	PAR-CLIP	23592263
MIRT484261	hsa-miR-3941	PAR-CLIP	23592263
MIRT484260	hsa-miR-1303	PAR-CLIP	23592263
MIRT484259	hsa-miR-574-5p	PAR-CLIP	23592263
MIRT703690	hsa-miR-6513-3p	HITS-CLIP	23313552
MIRT628879	hsa-miR-1306-5p	HITS-CLIP	23313552
MIRT658426	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT628878	hsa-miR-4308	HITS-CLIP	23313552
MIRT628877	hsa-miR-4292	HITS-CLIP	23313552
MIRT628876	hsa-miR-6791-5p	HITS-CLIP	23313552
MIRT658425	hsa-miR-1304-3p	HITS-CLIP	23313552
MIRT628875	hsa-miR-7113-3p	HITS-CLIP	23313552
MIRT628874	hsa-miR-4772-3p	HITS-CLIP	23313552
MIRT658424	hsa-miR-4284	HITS-CLIP	23313552
MIRT658423	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT658422	hsa-miR-8057	HITS-CLIP	23313552
MIRT628879	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT658426	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT628878	hsa-miR-4308	HITS-CLIP	23824327
MIRT628877	hsa-miR-4292	HITS-CLIP	23824327
MIRT628876	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT658425	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT628875	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT628874	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT658424	hsa-miR-4284	HITS-CLIP	23824327
MIRT658423	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT658422	hsa-miR-8057	HITS-CLIP	23824327
MIRT628879	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT628878	hsa-miR-4308	HITS-CLIP	23824327
MIRT628877	hsa-miR-4292	HITS-CLIP	23824327
MIRT628876	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT628875	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT628874	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT628873	hsa-miR-1297	HITS-CLIP	23824327
MIRT628872	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT628871	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT628870	hsa-miR-4465	HITS-CLIP	23824327
MIRT557986	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT484263	hsa-miR-4711-3p	PAR-CLIP	21572407
MIRT484262	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT557985	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT557984	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT484259	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT484268	hsa-miR-8485	PAR-CLIP	23592263
MIRT484267	hsa-miR-329-3p	PAR-CLIP	23592263
MIRT484266	hsa-miR-362-3p	PAR-CLIP	23592263
MIRT484265	hsa-miR-603	PAR-CLIP	23592263
MIRT484264	hsa-miR-511-3p	PAR-CLIP	23592263
MIRT484263	hsa-miR-4711-3p	PAR-CLIP	23592263
MIRT484262	hsa-miR-6867-5p	PAR-CLIP	23592263
MIRT484261	hsa-miR-3941	PAR-CLIP	23592263
MIRT484260	hsa-miR-1303	PAR-CLIP	23592263
MIRT484259	hsa-miR-574-5p	PAR-CLIP	23592263
MIRT982177	hsa-miR-1206	CLIP-seq
MIRT982178	hsa-miR-1252	CLIP-seq
MIRT982179	hsa-miR-26a	CLIP-seq
MIRT982180	hsa-miR-26b	CLIP-seq
MIRT982181	hsa-miR-3149	CLIP-seq
MIRT982182	hsa-miR-3154	CLIP-seq
MIRT982183	hsa-miR-3180-5p	CLIP-seq
MIRT982184	hsa-miR-338-5p	CLIP-seq
MIRT982185	hsa-miR-3674	CLIP-seq
MIRT982186	hsa-miR-3974	CLIP-seq
MIRT982187	hsa-miR-4277	CLIP-seq
MIRT982188	hsa-miR-4732-5p	CLIP-seq
MIRT982189	hsa-miR-4735-5p	CLIP-seq
MIRT982190	hsa-miR-4775	CLIP-seq
MIRT982191	hsa-miR-4794	CLIP-seq
MIRT982192	hsa-miR-483-5p	CLIP-seq
MIRT982193	hsa-miR-513b	CLIP-seq
MIRT982194	hsa-miR-520a-5p	CLIP-seq
MIRT982195	hsa-miR-525-5p	CLIP-seq
MIRT982196	hsa-miR-587	CLIP-seq
MIRT982197	hsa-miR-590-3p	CLIP-seq
MIRT982198	hsa-miR-885-5p	CLIP-seq
MIRT982199	hsa-miR-122	CLIP-seq
MIRT982200	hsa-miR-1284	CLIP-seq
MIRT982201	hsa-miR-1289	CLIP-seq
MIRT982202	hsa-miR-3135b	CLIP-seq
MIRT982203	hsa-miR-3198	CLIP-seq
MIRT982204	hsa-miR-329	CLIP-seq
MIRT982205	hsa-miR-3652	CLIP-seq
MIRT982206	hsa-miR-3664-5p	CLIP-seq
MIRT982207	hsa-miR-4294	CLIP-seq
MIRT982208	hsa-miR-4309	CLIP-seq
MIRT982209	hsa-miR-4430	CLIP-seq
MIRT982210	hsa-miR-4534	CLIP-seq
MIRT982211	hsa-miR-4639-3p	CLIP-seq
MIRT982212	hsa-miR-4789-5p	CLIP-seq
MIRT982199	hsa-miR-122	CLIP-seq
MIRT1922032	hsa-miR-24	CLIP-seq
MIRT982202	hsa-miR-3135b	CLIP-seq
MIRT982205	hsa-miR-3652	CLIP-seq
MIRT982209	hsa-miR-4430	CLIP-seq
MIRT1991178	hsa-miR-106a	CLIP-seq
MIRT1991179	hsa-miR-106b	CLIP-seq
MIRT1991180	hsa-miR-1208	CLIP-seq
MIRT982199	hsa-miR-122	CLIP-seq
MIRT1991181	hsa-miR-1272	CLIP-seq
MIRT982200	hsa-miR-1284	CLIP-seq
MIRT982201	hsa-miR-1289	CLIP-seq
MIRT1991182	hsa-miR-150	CLIP-seq
MIRT1991183	hsa-miR-17	CLIP-seq
MIRT1991184	hsa-miR-198	CLIP-seq
MIRT1991185	hsa-miR-20a	CLIP-seq
MIRT1991186	hsa-miR-20b	CLIP-seq
MIRT1922032	hsa-miR-24	CLIP-seq
MIRT982179	hsa-miR-26a	CLIP-seq
MIRT982180	hsa-miR-26b	CLIP-seq
MIRT1991187	hsa-miR-302a	CLIP-seq
MIRT1991188	hsa-miR-302b	CLIP-seq
MIRT1991189	hsa-miR-302c	CLIP-seq
MIRT1991190	hsa-miR-302d	CLIP-seq
MIRT1991191	hsa-miR-302e	CLIP-seq
MIRT1991192	hsa-miR-3117-5p	CLIP-seq
MIRT982202	hsa-miR-3135b	CLIP-seq
MIRT1991193	hsa-miR-3159	CLIP-seq
MIRT982203	hsa-miR-3198	CLIP-seq
MIRT1991194	hsa-miR-330-3p	CLIP-seq
MIRT1991195	hsa-miR-3646	CLIP-seq
MIRT982205	hsa-miR-3652	CLIP-seq
MIRT1991196	hsa-miR-3663-3p	CLIP-seq
MIRT982206	hsa-miR-3664-5p	CLIP-seq
MIRT1991197	hsa-miR-3682-5p	CLIP-seq
MIRT1991198	hsa-miR-372	CLIP-seq
MIRT1991199	hsa-miR-373	CLIP-seq
MIRT1991200	hsa-miR-3934	CLIP-seq
MIRT1991201	hsa-miR-3973	CLIP-seq
MIRT1991202	hsa-miR-412	CLIP-seq
MIRT1991203	hsa-miR-4282	CLIP-seq
MIRT982207	hsa-miR-4294	CLIP-seq
MIRT1991204	hsa-miR-4301	CLIP-seq
MIRT982208	hsa-miR-4309	CLIP-seq
MIRT1991205	hsa-miR-4420	CLIP-seq
MIRT982209	hsa-miR-4430	CLIP-seq
MIRT982210	hsa-miR-4534	CLIP-seq
MIRT982211	hsa-miR-4639-3p	CLIP-seq
MIRT1991206	hsa-miR-4731-5p	CLIP-seq
MIRT1991207	hsa-miR-4760-3p	CLIP-seq
MIRT982212	hsa-miR-4789-5p	CLIP-seq
MIRT1991208	hsa-miR-4799-5p	CLIP-seq
MIRT1991209	hsa-miR-5095	CLIP-seq
MIRT1991210	hsa-miR-512-3p	CLIP-seq
MIRT1991211	hsa-miR-514	CLIP-seq
MIRT1991212	hsa-miR-514b-3p	CLIP-seq
MIRT1991213	hsa-miR-519d	CLIP-seq
MIRT1991214	hsa-miR-520a-3p	CLIP-seq
MIRT1991215	hsa-miR-520b	CLIP-seq
MIRT1991216	hsa-miR-520c-3p	CLIP-seq
MIRT1991217	hsa-miR-520d-3p	CLIP-seq
MIRT1991218	hsa-miR-520e	CLIP-seq
MIRT1991219	hsa-miR-520g	CLIP-seq
MIRT1991220	hsa-miR-520h	CLIP-seq
MIRT1991221	hsa-miR-548g	CLIP-seq
MIRT1991222	hsa-miR-552	CLIP-seq
MIRT982196	hsa-miR-587	CLIP-seq
MIRT1991223	hsa-miR-627	CLIP-seq
MIRT1991224	hsa-miR-656	CLIP-seq
MIRT982198	hsa-miR-885-5p	CLIP-seq
MIRT1991225	hsa-miR-93	CLIP-seq
MIRT1991226	hsa-miR-944	CLIP-seq
MIRT1991178	hsa-miR-106a	CLIP-seq
MIRT1991179	hsa-miR-106b	CLIP-seq
MIRT982177	hsa-miR-1206	CLIP-seq
MIRT2225227	hsa-miR-1207-3p	CLIP-seq
MIRT1991180	hsa-miR-1208	CLIP-seq
MIRT982199	hsa-miR-122	CLIP-seq
MIRT2225228	hsa-miR-127-5p	CLIP-seq
MIRT982201	hsa-miR-1289	CLIP-seq
MIRT1991182	hsa-miR-150	CLIP-seq
MIRT1991183	hsa-miR-17	CLIP-seq
MIRT2225229	hsa-miR-1976	CLIP-seq
MIRT1991185	hsa-miR-20a	CLIP-seq
MIRT1991186	hsa-miR-20b	CLIP-seq
MIRT1922032	hsa-miR-24	CLIP-seq
MIRT982179	hsa-miR-26a	CLIP-seq
MIRT982180	hsa-miR-26b	CLIP-seq
MIRT1991187	hsa-miR-302a	CLIP-seq
MIRT1991188	hsa-miR-302b	CLIP-seq
MIRT1991189	hsa-miR-302c	CLIP-seq
MIRT1991190	hsa-miR-302d	CLIP-seq
MIRT1991191	hsa-miR-302e	CLIP-seq
MIRT982202	hsa-miR-3135b	CLIP-seq
MIRT2225230	hsa-miR-3144-3p	CLIP-seq
MIRT2225231	hsa-miR-3156-3p	CLIP-seq
MIRT2225232	hsa-miR-3157-5p	CLIP-seq
MIRT982203	hsa-miR-3198	CLIP-seq
MIRT982184	hsa-miR-338-5p	CLIP-seq
MIRT2225233	hsa-miR-361-3p	CLIP-seq
MIRT982205	hsa-miR-3652	CLIP-seq
MIRT1991196	hsa-miR-3663-3p	CLIP-seq
MIRT982206	hsa-miR-3664-5p	CLIP-seq
MIRT1991198	hsa-miR-372	CLIP-seq
MIRT1991199	hsa-miR-373	CLIP-seq
MIRT1991200	hsa-miR-3934	CLIP-seq
MIRT1991202	hsa-miR-412	CLIP-seq
MIRT2225234	hsa-miR-4279	CLIP-seq
MIRT982207	hsa-miR-4294	CLIP-seq
MIRT1991204	hsa-miR-4301	CLIP-seq
MIRT982208	hsa-miR-4309	CLIP-seq
MIRT1991205	hsa-miR-4420	CLIP-seq
MIRT2225235	hsa-miR-4426	CLIP-seq
MIRT982209	hsa-miR-4430	CLIP-seq
MIRT982210	hsa-miR-4534	CLIP-seq
MIRT982211	hsa-miR-4639-3p	CLIP-seq
MIRT2225236	hsa-miR-4647	CLIP-seq
MIRT2225237	hsa-miR-4662b	CLIP-seq
MIRT2225238	hsa-miR-4722-3p	CLIP-seq
MIRT1991206	hsa-miR-4731-5p	CLIP-seq
MIRT2225239	hsa-miR-4740-3p	CLIP-seq
MIRT982212	hsa-miR-4789-5p	CLIP-seq
MIRT982191	hsa-miR-4794	CLIP-seq
MIRT2225240	hsa-miR-483-3p	CLIP-seq
MIRT1991209	hsa-miR-5095	CLIP-seq
MIRT1991210	hsa-miR-512-3p	CLIP-seq
MIRT1991213	hsa-miR-519d	CLIP-seq
MIRT1991214	hsa-miR-520a-3p	CLIP-seq
MIRT1991215	hsa-miR-520b	CLIP-seq
MIRT1991216	hsa-miR-520c-3p	CLIP-seq
MIRT1991217	hsa-miR-520d-3p	CLIP-seq
MIRT1991218	hsa-miR-520e	CLIP-seq
MIRT1991219	hsa-miR-520g	CLIP-seq
MIRT1991220	hsa-miR-520h	CLIP-seq
MIRT2225241	hsa-miR-548s	CLIP-seq
MIRT1991222	hsa-miR-552	CLIP-seq
MIRT982196	hsa-miR-587	CLIP-seq
MIRT2225242	hsa-miR-646	CLIP-seq
MIRT1991224	hsa-miR-656	CLIP-seq
MIRT2225243	hsa-miR-875-5p	CLIP-seq
MIRT982198	hsa-miR-885-5p	CLIP-seq
MIRT1991225	hsa-miR-93	CLIP-seq
MIRT982199	hsa-miR-122	CLIP-seq
MIRT982202	hsa-miR-3135b	CLIP-seq
MIRT982205	hsa-miR-3652	CLIP-seq
MIRT982209	hsa-miR-4430	CLIP-seq
MIRT982199	hsa-miR-122	CLIP-seq
MIRT2225229	hsa-miR-1976	CLIP-seq
MIRT1922032	hsa-miR-24	CLIP-seq
MIRT982179	hsa-miR-26a	CLIP-seq
MIRT982180	hsa-miR-26b	CLIP-seq
MIRT982202	hsa-miR-3135b	CLIP-seq
MIRT982205	hsa-miR-3652	CLIP-seq
MIRT2225234	hsa-miR-4279	CLIP-seq
MIRT982209	hsa-miR-4430	CLIP-seq
MIRT2225238	hsa-miR-4722-3p	CLIP-seq
MIRT2225239	hsa-miR-4740-3p	CLIP-seq
MIRT982199	hsa-miR-122	CLIP-seq
MIRT1922032	hsa-miR-24	CLIP-seq
MIRT982179	hsa-miR-26a	CLIP-seq
MIRT982180	hsa-miR-26b	CLIP-seq
MIRT982202	hsa-miR-3135b	CLIP-seq
MIRT982181	hsa-miR-3149	CLIP-seq
MIRT982205	hsa-miR-3652	CLIP-seq
MIRT982185	hsa-miR-3674	CLIP-seq
MIRT982209	hsa-miR-4430	CLIP-seq
MIRT982188	hsa-miR-4732-5p	CLIP-seq
MIRT982189	hsa-miR-4735-5p	CLIP-seq
MIRT982190	hsa-miR-4775	CLIP-seq
MIRT982191	hsa-miR-4794	CLIP-seq
MIRT982197	hsa-miR-590-3p	CLIP-seq
MIRT2680592	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 32814053

Other IDs

• MIM: 619181
• HGNC: 19829
• e!Ensembl: ENSG00000151327

Protein

• UniProt ID: Q8N128
• Protein name: Protein FAM177A1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14774	FAM177	39 → 154	FAM177 family	Family

• Sequence:

  MDQEPVGGVERGEAVAASGAAAAAAFGESAGQMSNERGFENVELGVIGKKKKVPRRVIHF
  VSGETMEEYSTDEDEVDGLEKKDVLPTVDPTKLTWGPYLWFYMLRAATSTLSVCDFLGEK
  IASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPE
  TVISSSFVNVNFEMEGDSEVIMESKQNPVSVPP

• Sequence length: 213

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Dolichocephaly	Likely pathogenic	rs730882244	RCV000162180
Intellectual disability	Likely pathogenic	rs730882244	RCV000162180
Macrocephaly	Likely pathogenic	rs730882244	RCV000162180
Mild obesity	Likely pathogenic	rs730882244	RCV000162180

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	29228969
Hepatitis C	Associate	29228969
Liver Cirrhosis Biliary	Inhibit	36825008