PROX2 (prospero homeobox 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
283571
Gene name Gene Name - the full gene name approved by the HGNC.
Prospero homeobox 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PROX2
Synonyms (NCBI Gene) Gene synonyms aliases
PROX-2
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q24.3
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(57)
miRTarBase ID miRNA Experiments Reference
MIRT018506 hsa-miR-335-5p Microarray 18185580
MIRT525437 hsa-miR-6782-3p PAR-CLIP 22012620
MIRT525436 hsa-miR-5000-5p PAR-CLIP 22012620
MIRT525435 hsa-miR-128-3p PAR-CLIP 22012620
MIRT525434 hsa-miR-216a-3p PAR-CLIP 22012620
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(6)
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
615094 26715 ENSG00000119608
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q3B8N5
Protein name Prospero homeobox protein 2 (Homeobox prospero-like protein PROX2) (PROX-2)
Protein function Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05044 HPD 439 → 592 Homeo-prospero domain Domain
Sequence 
MDPNSILLSPQPQICSHLAEACTEGERSSSPPELDRDSPFPWSQVPSSSPTDPEWFGDEH
IQAKRARVETIVRGMCLSPNPLVPGNAQAGVSPRCPKKARERKRKQNLPTPQGLLMPAPA
WDQGNRKGGPRVREQLHLLKQQLRHLQEHILQAAKPRDTAQGPGGCGTGKGPLSAKQGNG
CGPRPWVVDGDHQQGTSKDLSGAEKHQESEKPSFLPSGAPASLEILRKELTRAVSQAVDS
VLQKVLLDPPGHLTQLGRSFQGQVAEGRSEPSPPVGGACKDPLALAALPRRVQLQAGVPV
GNLSLAKRLDSPRYPIPPRMTPKPCQDPPANFPLTAPSHIQENQILSQLLGHRYNNGHWS
SSPPQDSSSQRHPSSEPALRPWRTTKPQPLVLSQQQCPLPFTSAHLESLPLLPSVKMEQR
GLHAVMEALPFSLLHIQEGLNPGHLKKAKLMFFFTRYPSSNLLKVYFPDVQFNRCITSQM
IKWFSNFREFYYIQMEKSARQAISDGVTNPKMLVVLRNSELFQALNMHYNKGNDFEVPDC
FLEIASLTLQEFFRAVSAGRDSDPSWKKPIYKIISKLDSDIPEIFKSSSYPQ
Sequence length 592
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Neuroticism Neuroticism GWAS