Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	283537
Gene name	Solute carrier family 46 member 3
Gene symbol	SLC46A3
Synonyms (NCBI Gene)	FKSG16
Chromosome	13
Chromosome location	13q12.3
Summary	The protein encoded by this gene is a member of a transmembrane protein family that transports small molecules across membranes. The encoded protein has been found in lysosomal membranes, where it can transport catabolites from the lysosomes to the cytopl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016755	hsa-miR-335-5p	Microarray	18185580
MIRT022155	hsa-miR-124-3p	Microarray	18668037
MIRT024422	hsa-miR-215-5p	Microarray	19074876
MIRT026114	hsa-miR-192-5p	Microarray	19074876
MIRT500109	hsa-miR-99a-3p	PAR-CLIP	24398324
MIRT500108	hsa-miR-99b-3p	PAR-CLIP	24398324
MIRT500107	hsa-miR-6796-3p	PAR-CLIP	24398324
MIRT500106	hsa-miR-224-5p	PAR-CLIP	24398324
MIRT500105	hsa-miR-144-3p	PAR-CLIP	24398324
MIRT500104	hsa-miR-410-3p	PAR-CLIP	24398324
MIRT500103	hsa-miR-6826-5p	PAR-CLIP	24398324
MIRT500102	hsa-miR-128-3p	PAR-CLIP	24398324
MIRT500101	hsa-miR-216a-3p	PAR-CLIP	24398324
MIRT500100	hsa-miR-3681-3p	PAR-CLIP	24398324
MIRT500099	hsa-miR-27a-3p	PAR-CLIP	24398324
MIRT500098	hsa-miR-27b-3p	PAR-CLIP	24398324
MIRT500109	hsa-miR-99a-3p	PAR-CLIP	24398324
MIRT500108	hsa-miR-99b-3p	PAR-CLIP	24398324
MIRT500107	hsa-miR-6796-3p	PAR-CLIP	24398324
MIRT500106	hsa-miR-224-5p	PAR-CLIP	24398324
MIRT500105	hsa-miR-144-3p	PAR-CLIP	24398324
MIRT500104	hsa-miR-410-3p	PAR-CLIP	24398324
MIRT500103	hsa-miR-6826-5p	PAR-CLIP	24398324
MIRT500102	hsa-miR-128-3p	PAR-CLIP	24398324
MIRT500101	hsa-miR-216a-3p	PAR-CLIP	24398324
MIRT500100	hsa-miR-3681-3p	PAR-CLIP	24398324
MIRT500099	hsa-miR-27a-3p	PAR-CLIP	24398324
MIRT500098	hsa-miR-27b-3p	PAR-CLIP	24398324
MIRT1364633	hsa-miR-1206	CLIP-seq
MIRT1364634	hsa-miR-128	CLIP-seq
MIRT1364635	hsa-miR-1298	CLIP-seq
MIRT1364636	hsa-miR-144	CLIP-seq
MIRT1364637	hsa-miR-15a	CLIP-seq
MIRT1364638	hsa-miR-15b	CLIP-seq
MIRT1364639	hsa-miR-16	CLIP-seq
MIRT1364640	hsa-miR-195	CLIP-seq
MIRT1364641	hsa-miR-219-5p	CLIP-seq
MIRT1364642	hsa-miR-224	CLIP-seq
MIRT1364643	hsa-miR-2467-5p	CLIP-seq
MIRT1364644	hsa-miR-27a	CLIP-seq
MIRT1364645	hsa-miR-27b	CLIP-seq
MIRT1364646	hsa-miR-299-3p	CLIP-seq
MIRT1364647	hsa-miR-3188	CLIP-seq
MIRT1364648	hsa-miR-3689a-3p	CLIP-seq
MIRT1364649	hsa-miR-3689c	CLIP-seq
MIRT1364650	hsa-miR-380	CLIP-seq
MIRT1364651	hsa-miR-3908	CLIP-seq
MIRT1364652	hsa-miR-3922-5p	CLIP-seq
MIRT1364653	hsa-miR-3975	CLIP-seq
MIRT1364654	hsa-miR-410	CLIP-seq
MIRT1364655	hsa-miR-424	CLIP-seq
MIRT1364656	hsa-miR-4328	CLIP-seq
MIRT1364657	hsa-miR-4445	CLIP-seq
MIRT1364658	hsa-miR-4524	CLIP-seq
MIRT1364659	hsa-miR-4646-3p	CLIP-seq
MIRT1364660	hsa-miR-4648	CLIP-seq
MIRT1364661	hsa-miR-4649-3p	CLIP-seq
MIRT1364662	hsa-miR-4654	CLIP-seq
MIRT1364663	hsa-miR-4712-5p	CLIP-seq
MIRT1364664	hsa-miR-4728-5p	CLIP-seq
MIRT1364665	hsa-miR-4769-5p	CLIP-seq
MIRT1364666	hsa-miR-4782-3p	CLIP-seq
MIRT1364667	hsa-miR-485-5p	CLIP-seq
MIRT1364668	hsa-miR-488	CLIP-seq
MIRT1364669	hsa-miR-497	CLIP-seq
MIRT1364670	hsa-miR-503	CLIP-seq
MIRT1364671	hsa-miR-508-3p	CLIP-seq
MIRT1364672	hsa-miR-561	CLIP-seq
MIRT1364673	hsa-miR-646	CLIP-seq
MIRT1364674	hsa-miR-770-5p	CLIP-seq
MIRT1364675	hsa-miR-888	CLIP-seq
MIRT1553791	hsa-miR-125a-5p	CLIP-seq
MIRT1553792	hsa-miR-125b	CLIP-seq
MIRT1553793	hsa-miR-1273d	CLIP-seq
MIRT1553794	hsa-miR-188-5p	CLIP-seq
MIRT1553795	hsa-miR-4319	CLIP-seq
MIRT1553796	hsa-miR-4324	CLIP-seq
MIRT1553797	hsa-miR-4698	CLIP-seq
MIRT1553798	hsa-miR-4732-3p	CLIP-seq
MIRT1553799	hsa-miR-660	CLIP-seq
MIRT1553800	hsa-miR-670	CLIP-seq
MIRT1364634	hsa-miR-128	CLIP-seq
MIRT1364636	hsa-miR-144	CLIP-seq
MIRT1364642	hsa-miR-224	CLIP-seq
MIRT2108228	hsa-miR-2681	CLIP-seq
MIRT1364644	hsa-miR-27a	CLIP-seq
MIRT1364645	hsa-miR-27b	CLIP-seq
MIRT2108229	hsa-miR-3157-5p	CLIP-seq
MIRT1364654	hsa-miR-410	CLIP-seq
MIRT2108230	hsa-miR-4275	CLIP-seq
MIRT2108231	hsa-miR-4691-3p	CLIP-seq
MIRT1364634	hsa-miR-128	CLIP-seq
MIRT1364636	hsa-miR-144	CLIP-seq
MIRT1364642	hsa-miR-224	CLIP-seq
MIRT1364644	hsa-miR-27a	CLIP-seq
MIRT1364645	hsa-miR-27b	CLIP-seq
MIRT2332025	hsa-miR-374a	CLIP-seq
MIRT2332026	hsa-miR-374b	CLIP-seq
MIRT1364654	hsa-miR-410	CLIP-seq
MIRT1364633	hsa-miR-1206	CLIP-seq
MIRT2626518	hsa-miR-1255a	CLIP-seq
MIRT2626519	hsa-miR-1255b	CLIP-seq
MIRT1364635	hsa-miR-1298	CLIP-seq
MIRT2626520	hsa-miR-1303	CLIP-seq
MIRT2626521	hsa-miR-146a	CLIP-seq
MIRT2626522	hsa-miR-146b-5p	CLIP-seq
MIRT2626523	hsa-miR-2278	CLIP-seq
MIRT1364643	hsa-miR-2467-5p	CLIP-seq
MIRT1364646	hsa-miR-299-3p	CLIP-seq
MIRT2626524	hsa-miR-3144-3p	CLIP-seq
MIRT1364647	hsa-miR-3188	CLIP-seq
MIRT2626525	hsa-miR-3612	CLIP-seq
MIRT2626526	hsa-miR-3617	CLIP-seq
MIRT2626527	hsa-miR-3664-3p	CLIP-seq
MIRT1364648	hsa-miR-3689a-3p	CLIP-seq
MIRT1364649	hsa-miR-3689c	CLIP-seq
MIRT1364650	hsa-miR-380	CLIP-seq
MIRT1364653	hsa-miR-3975	CLIP-seq
MIRT2626528	hsa-miR-409-3p	CLIP-seq
MIRT2626529	hsa-miR-4302	CLIP-seq
MIRT1364656	hsa-miR-4328	CLIP-seq
MIRT2626530	hsa-miR-4443	CLIP-seq
MIRT2626531	hsa-miR-4457	CLIP-seq
MIRT2626532	hsa-miR-4535	CLIP-seq
MIRT2626533	hsa-miR-4643	CLIP-seq
MIRT1364660	hsa-miR-4648	CLIP-seq
MIRT1364662	hsa-miR-4654	CLIP-seq
MIRT2626534	hsa-miR-4694-3p	CLIP-seq
MIRT2626535	hsa-miR-4694-5p	CLIP-seq
MIRT2626536	hsa-miR-4717-3p	CLIP-seq
MIRT1364664	hsa-miR-4728-5p	CLIP-seq
MIRT2626537	hsa-miR-4731-3p	CLIP-seq
MIRT2626538	hsa-miR-4761-5p	CLIP-seq
MIRT1364665	hsa-miR-4769-5p	CLIP-seq
MIRT2626539	hsa-miR-4781-3p	CLIP-seq
MIRT2626540	hsa-miR-4786-5p	CLIP-seq
MIRT2626541	hsa-miR-4800-5p	CLIP-seq
MIRT2626542	hsa-miR-4801	CLIP-seq
MIRT2626543	hsa-miR-4802-3p	CLIP-seq
MIRT2626544	hsa-miR-4802-5p	CLIP-seq
MIRT1364667	hsa-miR-485-5p	CLIP-seq
MIRT1364668	hsa-miR-488	CLIP-seq
MIRT2626545	hsa-miR-492	CLIP-seq
MIRT1364672	hsa-miR-561	CLIP-seq
MIRT2626546	hsa-miR-589	CLIP-seq
MIRT2626547	hsa-miR-590-3p	CLIP-seq
MIRT2626548	hsa-miR-641	CLIP-seq
MIRT2626549	hsa-miR-642b	CLIP-seq
MIRT2626550	hsa-miR-650	CLIP-seq
MIRT2626521	hsa-miR-146a	CLIP-seq
MIRT2626522	hsa-miR-146b-5p	CLIP-seq
MIRT1364643	hsa-miR-2467-5p	CLIP-seq
MIRT1364646	hsa-miR-299-3p	CLIP-seq
MIRT2626524	hsa-miR-3144-3p	CLIP-seq
MIRT1364647	hsa-miR-3188	CLIP-seq
MIRT2626525	hsa-miR-3612	CLIP-seq
MIRT2626526	hsa-miR-3617	CLIP-seq
MIRT1364648	hsa-miR-3689a-3p	CLIP-seq
MIRT1364649	hsa-miR-3689c	CLIP-seq
MIRT1364650	hsa-miR-380	CLIP-seq
MIRT1364653	hsa-miR-3975	CLIP-seq
MIRT2626528	hsa-miR-409-3p	CLIP-seq
MIRT2626529	hsa-miR-4302	CLIP-seq
MIRT2626530	hsa-miR-4443	CLIP-seq
MIRT2626531	hsa-miR-4457	CLIP-seq
MIRT2626533	hsa-miR-4643	CLIP-seq
MIRT1364660	hsa-miR-4648	CLIP-seq
MIRT1364662	hsa-miR-4654	CLIP-seq
MIRT2626534	hsa-miR-4694-3p	CLIP-seq
MIRT2626535	hsa-miR-4694-5p	CLIP-seq
MIRT2626536	hsa-miR-4717-3p	CLIP-seq
MIRT1364664	hsa-miR-4728-5p	CLIP-seq
MIRT2626537	hsa-miR-4731-3p	CLIP-seq
MIRT1364665	hsa-miR-4769-5p	CLIP-seq
MIRT2626539	hsa-miR-4781-3p	CLIP-seq
MIRT2626542	hsa-miR-4801	CLIP-seq
MIRT2626543	hsa-miR-4802-3p	CLIP-seq
MIRT2626544	hsa-miR-4802-5p	CLIP-seq
MIRT1364667	hsa-miR-485-5p	CLIP-seq
MIRT1364668	hsa-miR-488	CLIP-seq
MIRT1364672	hsa-miR-561	CLIP-seq
MIRT2626546	hsa-miR-589	CLIP-seq
MIRT2626548	hsa-miR-641	CLIP-seq
MIRT2626549	hsa-miR-642b	CLIP-seq
MIRT2626550	hsa-miR-650	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005375	Function	Copper ion transmembrane transporter activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	IMP	26631267
GO:0015293	Function	Symporter activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IBA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0022857	Function	Transmembrane transporter activity	IMP	26631267
GO:0034486	Process	Vacuolar transmembrane transport	IBA
GO:0034486	Process	Vacuolar transmembrane transport	IMP	26631267
GO:0035434	Process	Copper ion transmembrane transport	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:1904613	Process	Cellular response to 2,3,7,8-tetrachlorodibenzodioxine	IEA

MIM	HGNC	e!Ensembl
616764	27501	ENSG00000139508

Q7Z3Q1

Protein name

Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)

Protein function

Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (PubMed:36741448). Mo

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07690	MFS_1	7 → 400	Major Facilitator Superfamily	Family

Sequence

MKILFVEPAIFLSAFAMTLTGPLTTQYVYRRIWEETGNYTFSSDSNISECEKNKSSPIFA
FQEEVQKKVSRFNLQMDISGLIPGLVSTFILLSISDHYGRKFPMILSSVGALATSVWLCL
LCYFAFPFQLLIASTFIGAFCGNYTTFWGACFAYIVDQCKEHKQKTIRIAIIDFLLGLVT
GLTGLSSGYFIRELGFEWSFLIIAVSLAVNLIYILFFLGDPVKECSSQNVTMSCSEGFKN
LFYRTYMLFKNASGKRRFLLCLLLFTVITYFFVVIGIAPIFILYELDSPLCWNEVFIGYG
SALGSASFLTSFLGIWLFSYCMEDIHMAFIGIFTTMTGMAMTAFASTTLMMFLARVPFLF
TIVPFSVLRSMLSKVVRSTEQGTLFACIAFLETLGGVTAVSTFNGIYSATVAWYPGFTFL
LSAGLLLLPAISLCVVKCTSWNEGSYELLIQEESSEDASDR

Sequence length

461

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CIRRHOSIS OF LIVER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	39199284	★★★★★ ★☆☆☆☆ Found in Text Mining only

SLC46A3 (solute carrier family 46 member 3)