Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	2835
Gene name	G protein-coupled receptor 12
Gene symbol	GPR12
Synonyms (NCBI Gene)	GPCR12GPCR21PPP1R84
Chromosome	13
Chromosome location	13q12.13

129

Show/Hide all (129)

miRTarBase ID	miRNA	Experiments
MIRT1030031	hsa-miR-103a	CLIP-seq
MIRT1030032	hsa-miR-107	CLIP-seq
MIRT1030033	hsa-miR-122	CLIP-seq
MIRT1030034	hsa-miR-1260	CLIP-seq
MIRT1030035	hsa-miR-1260b	CLIP-seq
MIRT1030036	hsa-miR-1273f	CLIP-seq
MIRT1030037	hsa-miR-1289	CLIP-seq
MIRT1030038	hsa-miR-1290	CLIP-seq
MIRT1030039	hsa-miR-129-5p	CLIP-seq
MIRT1030040	hsa-miR-1297	CLIP-seq
MIRT1030041	hsa-miR-143	CLIP-seq
MIRT1030042	hsa-miR-188-3p	CLIP-seq
MIRT1030043	hsa-miR-1972	CLIP-seq
MIRT1030044	hsa-miR-26a	CLIP-seq
MIRT1030045	hsa-miR-26b	CLIP-seq
MIRT1030046	hsa-miR-2861	CLIP-seq
MIRT1030047	hsa-miR-3124-3p	CLIP-seq
MIRT1030048	hsa-miR-3125	CLIP-seq
MIRT1030049	hsa-miR-3135b	CLIP-seq
MIRT1030050	hsa-miR-3156-3p	CLIP-seq
MIRT1030051	hsa-miR-3185	CLIP-seq
MIRT1030052	hsa-miR-3194-3p	CLIP-seq
MIRT1030053	hsa-miR-3198	CLIP-seq
MIRT1030054	hsa-miR-3647-3p	CLIP-seq
MIRT1030055	hsa-miR-3652	CLIP-seq
MIRT1030056	hsa-miR-3675-5p	CLIP-seq
MIRT1030057	hsa-miR-377	CLIP-seq
MIRT1030058	hsa-miR-3916	CLIP-seq
MIRT1030059	hsa-miR-4252	CLIP-seq
MIRT1030060	hsa-miR-4258	CLIP-seq
MIRT1030061	hsa-miR-4269	CLIP-seq
MIRT1030062	hsa-miR-4294	CLIP-seq
MIRT1030063	hsa-miR-4301	CLIP-seq
MIRT1030064	hsa-miR-4309	CLIP-seq
MIRT1030065	hsa-miR-431	CLIP-seq
MIRT1030066	hsa-miR-4430	CLIP-seq
MIRT1030067	hsa-miR-4438	CLIP-seq
MIRT1030068	hsa-miR-4465	CLIP-seq
MIRT1030069	hsa-miR-4466	CLIP-seq
MIRT1030070	hsa-miR-4480	CLIP-seq
MIRT1030071	hsa-miR-4528	CLIP-seq
MIRT1030072	hsa-miR-4534	CLIP-seq
MIRT1030073	hsa-miR-4637	CLIP-seq
MIRT1030074	hsa-miR-4643	CLIP-seq
MIRT1030075	hsa-miR-4671-5p	CLIP-seq
MIRT1030076	hsa-miR-4694-3p	CLIP-seq
MIRT1030077	hsa-miR-4705	CLIP-seq
MIRT1030078	hsa-miR-4708-5p	CLIP-seq
MIRT1030079	hsa-miR-4714-3p	CLIP-seq
MIRT1030080	hsa-miR-4755-3p	CLIP-seq
MIRT1030081	hsa-miR-4764-3p	CLIP-seq
MIRT1030082	hsa-miR-4770	CLIP-seq
MIRT1030083	hsa-miR-4802-5p	CLIP-seq
MIRT1030084	hsa-miR-5095	CLIP-seq
MIRT1030085	hsa-miR-5096	CLIP-seq
MIRT1030086	hsa-miR-513a-3p	CLIP-seq
MIRT1030087	hsa-miR-518a-5p	CLIP-seq
MIRT1030088	hsa-miR-527	CLIP-seq
MIRT1030089	hsa-miR-590-3p	CLIP-seq
MIRT1030090	hsa-miR-605	CLIP-seq
MIRT1030091	hsa-miR-675	CLIP-seq
MIRT1030092	hsa-miR-877	CLIP-seq
MIRT1030093	hsa-miR-924	CLIP-seq
MIRT1920466	hsa-miR-3163	CLIP-seq
MIRT1920467	hsa-miR-340	CLIP-seq
MIRT1920468	hsa-miR-4668-3p	CLIP-seq
MIRT1920469	hsa-miR-4729	CLIP-seq
MIRT2005637	hsa-miR-105	CLIP-seq
MIRT2005638	hsa-miR-1200	CLIP-seq
MIRT2005639	hsa-miR-1288	CLIP-seq
MIRT1030043	hsa-miR-1972	CLIP-seq
MIRT2005640	hsa-miR-1976	CLIP-seq
MIRT2005641	hsa-miR-3155	CLIP-seq
MIRT2005642	hsa-miR-3155b	CLIP-seq
MIRT2005643	hsa-miR-3199	CLIP-seq
MIRT2005644	hsa-miR-3671	CLIP-seq
MIRT1030059	hsa-miR-4252	CLIP-seq
MIRT1030060	hsa-miR-4258	CLIP-seq
MIRT1030061	hsa-miR-4269	CLIP-seq
MIRT2005645	hsa-miR-4279	CLIP-seq
MIRT2005646	hsa-miR-4324	CLIP-seq
MIRT1030067	hsa-miR-4438	CLIP-seq
MIRT2005647	hsa-miR-4645-5p	CLIP-seq
MIRT2005648	hsa-miR-4652-5p	CLIP-seq
MIRT2005649	hsa-miR-4673	CLIP-seq
MIRT2005650	hsa-miR-4722-3p	CLIP-seq
MIRT1030080	hsa-miR-4755-3p	CLIP-seq
MIRT2005651	hsa-miR-484	CLIP-seq
MIRT1030084	hsa-miR-5095	CLIP-seq
MIRT1030086	hsa-miR-513a-3p	CLIP-seq
MIRT2005652	hsa-miR-544b	CLIP-seq
MIRT1030089	hsa-miR-590-3p	CLIP-seq
MIRT2005653	hsa-miR-607	CLIP-seq
MIRT2005638	hsa-miR-1200	CLIP-seq
MIRT2238290	hsa-miR-1244	CLIP-seq
MIRT2005640	hsa-miR-1976	CLIP-seq
MIRT2238291	hsa-miR-421	CLIP-seq
MIRT1030060	hsa-miR-4258	CLIP-seq
MIRT1030061	hsa-miR-4269	CLIP-seq
MIRT2238292	hsa-miR-4277	CLIP-seq
MIRT2005645	hsa-miR-4279	CLIP-seq
MIRT2005646	hsa-miR-4324	CLIP-seq
MIRT1030067	hsa-miR-4438	CLIP-seq
MIRT2238293	hsa-miR-4709-5p	CLIP-seq
MIRT2005650	hsa-miR-4722-3p	CLIP-seq
MIRT2238294	hsa-miR-498	CLIP-seq
MIRT1030084	hsa-miR-5095	CLIP-seq
MIRT1030086	hsa-miR-513a-3p	CLIP-seq
MIRT2005652	hsa-miR-544b	CLIP-seq
MIRT1030089	hsa-miR-590-3p	CLIP-seq
MIRT2005641	hsa-miR-3155	CLIP-seq
MIRT2005642	hsa-miR-3155b	CLIP-seq
MIRT2005651	hsa-miR-484	CLIP-seq
MIRT1030060	hsa-miR-4258	CLIP-seq
MIRT1030061	hsa-miR-4269	CLIP-seq
MIRT1030067	hsa-miR-4438	CLIP-seq
MIRT1030084	hsa-miR-5095	CLIP-seq
MIRT2542303	hsa-miR-124	CLIP-seq
MIRT2542304	hsa-miR-2682	CLIP-seq
MIRT2542305	hsa-miR-3714	CLIP-seq
MIRT2542306	hsa-miR-3910	CLIP-seq
MIRT2542307	hsa-miR-449c	CLIP-seq
MIRT2542308	hsa-miR-506	CLIP-seq
MIRT2542303	hsa-miR-124	CLIP-seq
MIRT2542304	hsa-miR-2682	CLIP-seq
MIRT2542305	hsa-miR-3714	CLIP-seq
MIRT2542306	hsa-miR-3910	CLIP-seq
MIRT2542307	hsa-miR-449c	CLIP-seq
MIRT2542308	hsa-miR-506	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	8530049
GO:0005737	Component	Cytoplasm	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8530049
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	8530049
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0016020	Component	Membrane	IEA
GO:0031210	Function	Phosphatidylcholine binding	IEA

MIM	HGNC	e!Ensembl
600752	4466	ENSG00000132975

P47775

Protein name

G-protein coupled receptor 12

Protein function

Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.

PDB

7Y3G

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	61 → 301	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISC
ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLI
VASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWN
CLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLAT
SHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVI
YAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV

Sequence length

334

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CEREBRAL ATHEROSCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EOSINOPHILIC ESOPHAGITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING LOSS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinogenesis	Associate	33742771	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Inhibit	33742771	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypopharyngeal Neoplasms	Associate	33742771	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	33742771	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	33742771	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	33742771	★★★★★ ★☆☆☆☆ Found in Text Mining only

GPR12 (G protein-coupled receptor 12)