ADGRD1 (adhesion G protein-coupled receptor D1)

Gene
Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
283383
Gene name Gene Name - the full gene name approved by the HGNC.
Adhesion G protein-coupled receptor D1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADGRD1
Synonyms (NCBI Gene) Gene synonyms aliases
GPR133, PGR25
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.33
Summary Summary of gene provided in NCBI Entrez Gene.
The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G p
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(48)
miRTarBase ID miRNA Experiments Reference
MIRT740339 hsa-miR-892a HITS-CLIP 19536157
MIRT740340 hsa-miR-6840-5p HITS-CLIP 19536157
MIRT740341 hsa-miR-939-3p HITS-CLIP 19536157
MIRT740342 hsa-miR-6852-5p HITS-CLIP 19536157
MIRT740343 hsa-miR-6742-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(25)
GO ID Ontology Definition Evidence Reference
GO:0004888 Function Transmembrane signaling receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity IBA
GO:0004930 Function G protein-coupled receptor activity IDA 22025619, 34022221, 35418678, 35418679, 35447113, 39884271
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity TAS 15203201
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
613639 19893 ENSG00000111452
Protein
Gene miRNA Gene ontology Other IDs Protein
UniProt ID Q6QNK2
Protein name Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) [Cleaved into: Adhesion G-protein coupled receptor D1, N-terminal fragment (ADGRD1 N-terminal fragment); Adhesion G-protein coupled receptor D1, C-t
Protein function Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone
PDB 7EPT , 7WU2 , 8X9S , 8X9T , 8X9U , 9IV1 , 9IV2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13385 Laminin_G_3 87 → 241 Domain
PF01825 GPS 508 → 550 GPCR proteolysis site, GPS, motif Motif
PF00002 7tm_2 563 → 802 7 transmembrane receptor (Secretin family) Family
Tissue specificity TISSUE SPECIFICITY: Up-regulated in CD133(+) cell population of glioblastoma. {ECO:0000269|PubMed:27775701}.
Sequence 
MEKLLRLCCWYSWLLLFYYNFQVRGVYSRSQDHPGFQVLASASHYWPLENVDGIHELQDT
TGDIVEGKVNKGIYLKEEKGVTLLYYGRYNSSCISKPEQCGPEGVTFSFFWKTQGEQSRP
IPSAYGGQVISNGFKVCSSGGRGSVELYTRDNSMTWEASFSPPGPYWTHVLFTWKSKEGL
KVYVNGTLSTSDPSGKVSRDYGESNVNLVIGSEQDQAKCYENGAFDEFIIWERALTPDEI
AMYFTAAIGKHALLSSTLPSLFMTSTASPVMPTDAYHPIITNLTEERKTFQSPGVILSYL
QNVSLSLPSKSLSEQTALNLTKTFLKAVGEILLLPGWIALSEDSAVVLSLIDTIDTVMGH
VSSNLHGSTPQVTVEGSSAMAEFSVAKILPKTVNSSHYRFPAHGQSFIQIPHEAFHRHAW
STVVGLLYHSMHYYLNNIWPAHTKIAEAMHHQDCLLFATSHLISLEVSPPPTLSQNLSGS
PLITVHLKHRLTRKQHSEATNSSNRVFVYCAFLDFSSGEGVWSNHGCALTRGNLTYSVCR
CTHLTNFAILMQVVPLELARGHQVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQ
RYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSM
VIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPA
LFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAV
NGCAVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFKHKTKVWSLTSSSARTSNAKPFH
SDLMNGTRPGMASTKLSPWDKSSHSAHRVDLSAV
Sequence length 874
Interactions View interactions
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