CXCR3 (C-X-C motif chemokine receptor 3)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2833
Gene name Gene Name - the full gene name approved by the HGNC.
C-X-C motif chemokine receptor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CXCR3
Synonyms (NCBI Gene) Gene synonyms aliases
CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq13.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant)
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(25)
miRTarBase ID miRNA Experiments Reference
MIRT734913 hsa-miR-34a-5p Luciferase reporter assay, Western blotting, Microarray, qRT-PCR, Flow cytometry, ELISA 33229509
MIRT918206 hsa-miR-15a CLIP-seq
MIRT918207 hsa-miR-15b CLIP-seq
MIRT918208 hsa-miR-16 CLIP-seq
MIRT918209 hsa-miR-1910 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
TBX21 Activation 14500650;21540308
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0002685 Process Regulation of leukocyte migration IEA
GO:0004950 Function Chemokine receptor activity TAS 9064356
GO:0005515 Function Protein binding IPI 23170857, 32296183
GO:0005737 Component Cytoplasm TAS 10903743
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
300574 4540 ENSG00000186810
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P49682
Protein name C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
Protein function [Isoform 1]: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds
PDB 8HNK , 8HNL , 8HNM , 8HNN , 8K2W , 8K2X , 8XXY , 8XXZ , 8XYI , 8XYK , 8Y0H , 8Y0N
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 70 → 318 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level). {ECO:0000269|PubMe
Sequence
Sequence length 368
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Autoimmune diseases Autoimmune Diseases rs869025224 12517959
Dermatitis Dermatitis, Atopic, Contact Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 18249437, 25724174
Glomerulonephritis Glomerulonephritis rs778043831 12517959
Show/Hide Text Mining Associations (262)
Associations from Text Mining
Disease Name Relationship Type References
Ablepharon macrostomia syndrome Associate 39457093
Acute Kidney Injury Associate 35681510
Acute Lung Injury Associate 29566745
Adenocarcinoma Associate 31960110
Adenocarcinoma of Lung Inhibit 35768814
Airway Obstruction Associate 16339779
Alveolitis Extrinsic Allergic Associate 19842835
Amyotrophic Lateral Sclerosis Associate 29592817
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis Associate 34289887
Anxiety Associate 28969474