RCOR2 (REST corepressor 2)

Gene

• Entrez ID: 283248
• Gene name: REST corepressor 2
• Gene symbol: RCOR2
• Synonyms (NCBI Gene): -
• Chromosome: 11
• Chromosome location: 11q13.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023942	hsa-miR-1-3p	Microarray	18668037
MIRT1298748	hsa-miR-146a	CLIP-seq
MIRT1298749	hsa-miR-146b-5p	CLIP-seq
MIRT1298750	hsa-miR-1908	CLIP-seq
MIRT1298751	hsa-miR-298	CLIP-seq
MIRT1298752	hsa-miR-3125	CLIP-seq
MIRT1298753	hsa-miR-3141	CLIP-seq
MIRT1298754	hsa-miR-3153	CLIP-seq
MIRT1298755	hsa-miR-346	CLIP-seq
MIRT1298756	hsa-miR-3916	CLIP-seq
MIRT1298757	hsa-miR-4288	CLIP-seq
MIRT1298758	hsa-miR-4417	CLIP-seq
MIRT1298759	hsa-miR-4508	CLIP-seq
MIRT1298760	hsa-miR-4716-5p	CLIP-seq
MIRT1298761	hsa-miR-4773	CLIP-seq
MIRT1298762	hsa-miR-541	CLIP-seq
MIRT1298763	hsa-miR-583	CLIP-seq
MIRT1298764	hsa-miR-589	CLIP-seq
MIRT1298765	hsa-miR-605	CLIP-seq
MIRT1298766	hsa-miR-632	CLIP-seq
MIRT1298767	hsa-miR-654-3p	CLIP-seq
MIRT1298768	hsa-miR-654-5p	CLIP-seq
MIRT1298769	hsa-miR-663	CLIP-seq
MIRT1298770	hsa-miR-744	CLIP-seq
MIRT2313753	hsa-miR-1273g	CLIP-seq
MIRT2313754	hsa-miR-3165	CLIP-seq
MIRT2313755	hsa-miR-4286	CLIP-seq
MIRT2458003	hsa-miR-1286	CLIP-seq
MIRT2458004	hsa-miR-1912	CLIP-seq
MIRT2458005	hsa-miR-4436b-3p	CLIP-seq
MIRT2458006	hsa-miR-711	CLIP-seq
MIRT2458003	hsa-miR-1286	CLIP-seq
MIRT2458004	hsa-miR-1912	CLIP-seq
MIRT2458005	hsa-miR-4436b-3p	CLIP-seq
MIRT2458006	hsa-miR-711	CLIP-seq
MIRT2458003	hsa-miR-1286	CLIP-seq
MIRT2458004	hsa-miR-1912	CLIP-seq
MIRT2458005	hsa-miR-4436b-3p	CLIP-seq
MIRT2458006	hsa-miR-711	CLIP-seq
MIRT2458003	hsa-miR-1286	CLIP-seq
MIRT2458004	hsa-miR-1912	CLIP-seq
MIRT2458005	hsa-miR-4436b-3p	CLIP-seq
MIRT2458006	hsa-miR-711	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000118	Component	Histone deacetylase complex	IBA
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0005515	Function	Protein binding	IPI	24726434, 28420882
GO:0005634	Component	Nucleus	IEA
GO:0005667	Component	Transcription regulator complex	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0019899	Function	Enzyme binding	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA

Other IDs

• MIM: 616019
• HGNC: 27455
• e!Ensembl: ENSG00000167771

Protein

• UniProt ID: Q8IZ40
• Protein name: REST corepressor 2
• Protein function: May act as a component of a corepressor complex that represses transcription.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01448	ELM2	46 → 98	ELM2 domain	Family
  PF00249	Myb_DNA-binding	329 → 374	Myb-like DNA-binding domain	Domain

• Sequence:

  MPSVMEKPSAGSGILSRSRAKTVPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECK
  PESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEK
  SLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTR
  SRTSVMDRQARRLGGRKDKEDSDELEEGRGGVSEGEPDPADPKREPLPSRPLNARPGPGK
  KEVQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQS
  MKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGN
  KTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEV
  QITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRL
  APNQPPPPLIRPALAAPRHSARPGPQPPPTLIGTPLEPPAPSL

• Sequence length: 523

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANOREXIA NERVOSA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations