NEAT1 (nuclear paraspeckle assembly transcript 1)

Gene

• Entrez ID: 283131
• Gene name: Nuclear paraspeckle assembly transcript 1
• Gene symbol: NEAT1
• Synonyms (NCBI Gene): LINC00084, NCRNA00084, TP53LC15, TncRNA, VINC
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcription

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT731903	hsa-miR-124-3p	Luciferase reporter assay	27075229
MIRT731903	hsa-miR-124-3p	Luciferase reporter assay	27075229
MIRT731903	hsa-miR-124-3p	Luciferase reporter assay	27075229
MIRT732655	hsa-miR-205-5p	Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR, Western blotting	34101306
MIRT732796	hsa-miR-143-3p	qRT-PCR	33744906
MIRT732655	hsa-miR-205-5p	Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR, Western blotting	32065361
MIRT735010	hsa-miR-373-3p	Luciferase reporter assay, qRT-PCR, In situ hybridization, Flow cytometry	33093438
MIRT735018	hsa-miR-22-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32826883
MIRT737191	hsa-miR-21-3p	RNA-seq, qRT-PCR	31621912
MIRT756095	hsa-miR-338-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP), Immunofluorescence	38472205
MIRT756237	hsa-miR-1-3p	Luciferase reporter assay	34787068
MIRT756239	hsa-miR-26a-5p	Luciferase reporter assay, qRT-PCR	34804856
MIRT756281	hsa-miR-493-5p	Luciferase reporter assay, Northern blotting	37249278

Transcription factors

Transcription factor	Regulation	Reference
SFPQ	Unknown	24507715

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000512	Process	LncRNA-mediated post-transcriptional gene silencing	IDA	28379604
GO:0006325	Process	Chromatin organization	IEA
GO:0010793	Process	Regulation of mRNA export from nucleus	IMP	19716791
GO:0016442	Component	RISC complex	IEA
GO:0030575	Process	Nuclear body organization	IMP	19716791
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IEA
GO:0035198	Function	MiRNA binding	IDA	28379604
GO:0042382	Component	Paraspeckles	IDA	19716791
GO:0042382	Component	Paraspeckles	IEA
GO:0042382	Component	Paraspeckles	TAS	31048766
GO:0050729	Process	Positive regulation of inflammatory response	IMP	28379604
GO:0140463	Function	Chromatin-protein adaptor activity	IDA	25155612
GO:0140693	Function	Molecular condensate scaffold activity	IMP	19716791
GO:0140693	Function	Molecular condensate scaffold activity	TAS	31048766
GO:0140869	Function	MiRNA inhibitor activity via base-pairing	IDA	28379604
GO:1901647	Process	Positive regulation of synoviocyte proliferation	IMP	28379604
GO:1905172	Function	RISC complex binding	IDA	28379604
GO:2000627	Process	Positive regulation of miRNA catabolic process	IMP	28379604

Other IDs

• MIM: 612769
• HGNC: 30815
• e!Ensembl: ENSG00000245532

Interactions View interactions